Surface Modification Approach Research Articles

Lipid-Based Nanoparticle Functionalization with Coiled-Coil Peptides for In Vitro and In Vivo Drug Delivery.

For the delivery of drugs, different nanosized drug carriers (e.g., liposomes, lipid nanoparticles, and micelles) have been developed in order to treat diseases that afflict society. Frequently, these vehicles are formed by the self-assembly of small molecules to encapsulate the therapeutic cargo of interest. Over decades, nanoparticles have been optimized to make them more efficient and specific to fulfill tailor-made tasks, such as specific cell targeting or enhanced cellular uptake. In recent years, lipid-based nanoparticles in particular have taken center stage; however, off-targeting side effects and poor endosomal escape remain major challenges since therapies require high efficacy and acceptable toxicity.To overcome these issues, many different approaches have been explored to make drug delivery more specific, resulting in reduced side effects, to achieve an optimal therapeutic effect and a lower required dose. The fate of nanoparticles is largely dependent on size, shape, and surface charge. A common approach to designing drug carriers with targeting capability is surface modification. Different approaches to functionalize nanoparticles have been investigated since the attachment of targeting moieties plays a significant role in whether they can later interact with surface-exposed receptors of cells. To this end, various strategies have been used involving different classes of biomolecules, such as small molecules, nucleic acids, antibodies, aptamers, and peptides.Peptides in particular are often used since there are many receptors overexpressed in different specific cell types. Furthermore, peptides can be produced and modified at a low cost, enabling high therapeutic screening. Cell-penetrating peptides (CPPs) and cell-targeting peptides (CTPs) are frequently used for this purpose. Less studied in this context are fusogenic coiled-coil peptides. Lipid-based nanoparticles functionalized with these peptides are able to avoid the endolysosomal pathway; instead such particles can be taken up by membrane fusion, resulting in increased delivery of payload. Furthermore, they can be used for targeting cells/organs but are not directed at surface-exposed receptors. Instead, they recognize complementary peptide sequences, facilitating their uptake into cells.In this Account, we will discuss peptides as moieties for enhanced cytosolic delivery, targeted uptake, and how they can be attached to lipid-based nanoparticles to alter their properties. We will discuss the properties imparted to the particles by peptides, surface modification approaches, and recent examples showing the power of peptides for in vitro and in vivo drug delivery. The main focus will be on the functionalization of lipid-based nanoparticles by fusogenic coiled-coil peptides, highlighting the relevance of this concept for the development of future therapeutics.

Surface modification of PEEKs with cyclic peptides to support endothelialization and antithrombogenicity

Synthetic polymers are often utilized in the creation of vascular devices, and need to possess specific qualities to prevent thrombosis. Traditional strategies for this include surface modification of vascular devices through covalent attachment of substrates such as heparin, antiplatelet agents, thrombolytic agents, or hydrophilic polymers. One promising prosthetic material is polyether ether ketone (PEEK), which is utilized in various FDA-approved medical devices, including vascular and endovascular prostheses. We hypothesized that surface modification of biologically inert PEEK can help improve its endothelial cell affinity and reduce its thrombogenic potential. To evaluate this, we developed an effective surface-modification approach with unique cyclic peptides, such as CCHGGVRLYC and CCREDVC. We treated the PEEK surface with ammonia plasma, which introduced amine groups onto the PEEK surface. Subsequently, we were able to conjugate these peptides to the plasma-modified PEEKs. We observed that cyclic CCHGGVRLYC conjugated on prosthetic PEEK not only supported endothelialization, but minimized platelet adhesion and activation. This technology can be potentially applied for in vivo vascular and endovascular protheses to enhance their utility and patency.

On Antimicrobial Polymers: Development, Mechanism of Action, International Testing Procedures, and Applications.

The development of antimicrobial polymeric materials has evolved into one of the more promising methods for preventing the growth of microbes and mitigating the spread of infectious diseases in several applications including the health and food packaging sectors. The outbreak of global pandemics, and particularly the recent COVID-19 pandemic, further strengthen the importance of developing such solutions. This review paper presents a fundamental understanding of how antimicrobial polymers are developed, describes the possible surface modification approaches to render polymers with antimicrobial properties, highlights the potential mechanism of action against a range of microorganisms (bacterial, viral, and fungal), and details some of the international standard protocols and procedures to evaluate the antimicrobial properties of modified materials (such as plastics and textiles). In addition, this review paper discusses the toxicity of antimicrobial additives when used in healthcare and food packaging applications.

Comparison of surface modification and corrosion resistance of Ti6Al4V alloy using matcha tea extract-based silver and copper oxide nanoparticles

In this study, our aim was to investigate the application of green-synthesized silver nanoparticles (Ag NPs) and copper oxide nanoparticles (CuO NPs) for surface modification, specifically focusing on their influence on the corrosion properties of Ti6Al4V alloy. The green NPs were thoroughly characterized, and their role in enhancing the anticorrosive performance of Ti6Al4V was carefully evaluated. Various coating methods and drying temperatures were utilized to coat Ti6Al4V samples with the NPs, aiming to assess their impact on corrosion resistance. The electrochemical corrosion behavior was examined through electrochemical polarization tests in Ringer's bio-liquid. The study underscored the significant impact of coating type, coating method, and drying temperature (25 °C and 60 °C) in achieving favorable anticorrosive performance. Notably, samples oven-dried at both temperatures and coated with Ag NPs and CuO NPs using spray coating demonstrated the most effective substrate protection, achieving protection efficiencies of 97.37 % and 90.56 %, respectively. This outcome can be attributed to the unique spherical and homogeneously dispersed particulate structure of the NPs, effectively reducing microporosity. In summary, the combination of increased surface area and reduced microporosity resulting from the surface properties of the NPs underscores the potential of well-designed surface modification approaches in advancing the development of titanium-based implants for biomedical applications.

Dodecyl methacrylate (DM) dispersion-assisted surface modification approach for increasing crystallinity of coir fibers

Coir fiber crystallinity is crucial since it widens the range of possible uses for natural fiber. To increase the crystallinity of coir fiber, the study describes an easy-to-use, simple-to-implement method that is cost-effective, eco-friendly, and highly productive. With the help of dodecyl methacrylate disperson, hydrocarbon molecules of varying chain lengths are covalently attached to the surface of coir fibers, modulating their surface wettability. There are a few different long-chain hydrocarbon compounds employed, including n-butyl methacrylate, n-octyl acrylate, and dodecyl methacrylate (DM), but DM has shown to be the most effective. The degree of grafting yield alteration is determined gravimetrically. It has been found that grafting yields of 28–30 wt.% can be used to convert hydrophilic coir fibers into water repellent crystalline fibers (water contact angle 148°). A total of 15 nm of dispersion, a disperson rate of 2 nm/min, DM concentration of 20%, and water content of 10% are fixed as key reaction parameters. Thermal and mechanical analyses show no significant changes in the fiber structure during alteration. The grafting and changes in surface wettability are well supported by the surface morphology of pure and modified coir fiber, which can be seen using scanning electron microscopy.

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

AbstractModulating cellular functions at the dental implant‐tissue interface to augment integration and prevent bacterial ingress is crucial for achieving early stability and long‐term implant success. Nano‐engineering strategies, such as anodized titanium implants with titania (TiO2) nanotubes/nanopores, are emerging as a promising dental implant surface modification approach to enhance integration and prevent infection. Achieving on‐demand therapy through electrical stimulation therapy (EST, supply of voltage/current to local tissue) may be advantageous but has not been explored for dental implants. Further, anodized implants with TiO2 nanotubes/nanopores represent a semi‐conducting modification that can impede EST effectiveness. In this pioneering study, TiO2 nanopores are converted into conducting Ti nanopores to perform EST to achieve superior soft‐tissue integration and antibacterial efficacy. In‐depth surface characterizations are followed by assays investigating the effect of EST on cultured human salivary biofilm and gingival fibroblasts. Significant bactericidal efficacy is demonstrated for EST (1.5 V for 5 min per day) using Ti nanopores. Further, EST enhanced fibroblast proliferation and collagen secretion. In summary, EST applied to Ti nanoporous implants promotes soft‐tissue healing and antibacterial functions and is proposed as a next‐generation approach in implant dentistry to achieve on‐demand therapy.

Laser-texturing and traditional surface modification to improve the adhesion of glass fiber-reinforced composite posts to resin cements

ObjectivesThe aim of this study was to perform an experimental evaluation of the synergistic effects of laser-texturing and different traditional surface modification approaches to improve the adhesion of glass fiber-reinforced composite (GFRC) posts to resin-matrix cements used in endodontically treated teeth rehabilitation. MethodsOne hundred and ten freshly extracted mandibular single-rooted premolars were endodontically treated and groups of specimens were divided according to the GFRC cementation after different surface treatment, as follow (n = 10): silane-based conditioning (SIL); 9.7 % HF acid-etching (HF); 35 % H2O2 etching (H2O2); grit-blasting (GB); HF plus H2O2 etching (HFH2O2); 6 W Nd:YAG laser-texturing (L6W); 4.5 W Nd:YAG laser-texturing (L4.5W); 3 W Nd:YAG laser-texturing (L3W); 3 W Nd:YAG plus 35 % H2O2 (L3WH2O2); 3 W Nd:YAG plus SIL (L3WSIL); and untreated (C). GFRC posts were cemented into the tooth root canals using a dual-cured resin cement. Then, specimens were cross-sectioned and mechanically assessed by push-out bond strength tests. Specimens were inspected by optical microscopy and scanning electron microscopy (SEM) at magnification from × 30 up to × 2000. The failure mode was recorded by microscopic analyses after the bond strenght tests. ResultsSurface analyses of the GFRC posts showed a rough and retentive morphological aspect with a removal of the outer epoxy matrix layer and exposure of glass fibers after laser-texturing, grit-blasting, or etching under 35 % H2O2. The highest bond strength values at 21.8 MPa was recorded for GFRC posts after laser-texturing on 3W plus silane-based conditioning followed by the group etched with 35 % H2O2 (20.5 MPa). The failure mode was microscopically characterized as cohesive and mixed pathways. The lowest bond strength values around 5 and 9 MPa and adhesive failure were recorded for the untreated GFRC group or specimens etched with HF. ConclusionsThe combination of acidic etching and silane conditioning with laser-texturing at moderate intensity promoted an adequate surface modification of GFRC posts and increased adhesion to a resin-matrix cement. Such combination of physicochemical approaches can enhance the long-term mechanical behavior of the restorative interface at endodontically treated teeth. Clinical relevanceCombining traditional and novel physicochemical approaches can provide promising adhesion pathways for glass fiber-reinforced composite posts to resin-matrix cements. A high mechanical interlocking of the resin-matrix cements and the stable retention of the teeth root intracanal posts can decrease the risks of clinical failures by fracture and detachment of the intraradicular interface.

A novel copper surface modification approach based on pinless friction stir surface processing technique with ultra-low heat input

Improving the wear and corrosion performances of widely employed copper and its alloy components can effectively extend their service life. In this study, a novel copper surface modification method based on the friction stir surface processing (FSSP) technique was achieved. Subject to FSSP with pinless tool and low heat-input process parameters (including a minimal axis tilt and extremely low rotational speed), the modified copper surface exhibited enhancement rates of 34.25 % in hardness and 44.76 % in tensile strength, and improved high wear and corrosion resistance characteristics. The research suggests that the primary reasons for the enhanced surface properties are the grain refinement strengthening effect and the rapid formation of a passive film. Additionally, the ultra-low heat input resulted in the preservation of numerous dislocation tangles and incomplete dynamic recrystallization in the modified region, which represented a microstructural evolution mechanism distinct from the traditional friction stir processing. This work provides a reference for a low-energy-consumption and easily achievable approach for enhancing the surface properties of metals.

Biological and Physical Characterization of Surface-Modified Grade V Titanium Alloy.

Surface modification and biomimetic approaches have been widely used to enhance bioinert substances. It is not very clear whether surface alterations and polymer coatings on titanium make it more biologically active and enhance cell adhesion. We tried to focus on the physical and biological characterization of surface-modified titanium disks. Four different surface modifications were done for the titanium disks, ranging from acid etching, sandblasting, polydopamine coating, and polydopamine-based chitosan coating, and were compared with disks without any surface modification. The disks were studied for physical characteristics like surface roughness and contact angle. Human gingival fibroblasts were used to investigate the biological effects of surface modification of titanium alloy surfaces. The wettability of chitosan-coated, acid-etched, and polydopamine-coated titanium was much better than that of the sandblasted surface, indicating that surface energy was higher for acid-etched and coated surfaces than others. The cell seeding with fibroblasts showed increased adhesion to the smoother surfaces as compared to the rougher surfaces. Polydopamine coatings on titanium disks showed the most favorable physical and biological properties compared to others and can be a good surface coating for in vivo implants.

Surface modification of medical grade biomaterials by using a low-temperature-processed dual functional Ag-TiO2 coating for preventing biofilm formation.

Biofilm development in medical devices is considered the major virulence component that leads to increased mortality and morbidity among patients. Removing a biofilm once formed is challenging and frequently results in persistent infections. Many current antibiofilm coating strategies involve harsh conditions causing damage to the surface of the medical devices. To address the issue of bacterial attachment in medical devices, we propose a novel antibacterial surface modification approach. In this paper, we developed a novel low-temperature based solution-processed approach to deposit silver nanoparticles (Ag NPs) inside a titanium oxide (TiO2) matrix to obtain a Ag-TiO2 nanoparticle coating. The low temperature (120 °C)-based UV annealed drop cast method is novel and ensures no surface damage to the medical devices. Various medical-grade biomaterials were then coated using Ag-TiO2 to modify the surface of the materials. Several studies were performed to observe the antibacterial and antibiofilm properties of Ag-TiO2-coated medical devices and biomaterials. Moreover, the Ag-TiO2 NPs did not show any skin irritation in rats and showed biocompatibility in the chicken egg model. This study indicates that Ag-TiO2 coating has promising potential for healthcare applications to combat microbial infection and biofilm formation.

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review.

Polymeric biomaterials are a widely used class of materials due to their versatile properties. However, as with all other types of materials used for biomaterials, polymers also have to interact with blood. When blood comes into contact with any foreign body, it initiates a cascade which leads to platelet activation and blood coagulation. The implant surface also has to encounter a thromboinflammatory response which makes the implant integrity vulnerable, this leads to blood coagulation on the implant and obstructs it from performing its function. Hence, the surface plays a pivotal role in the design and application of biomaterials. In particular, the surface properties of biomaterials are responsible for biocompatibility with biological systems and hemocompatibility. This review provides a report on recent advances in the field of surface modification approaches for improved hemocompatibility. We focus on the surface properties of polysaccharides, proteins, and synthetic polymers. The blood coagulation cascade has been discussed and blood - material surface interactions have also been explained. The interactions of blood proteins and cells with polymeric material surfaces have been discussed. Moreover, the benefits as well as drawbacks of blood coagulation on the implant surface for wound healing purposes have also been studied. Surface modifications implemented by other researchers to enhance as well as prevent blood coagulation have also been analyzed.

Reinforcing effects of nano-WC in AlSi10Mg alloy assisted by in-situ surface modification approach

A series of nano-WC surface modified AlSi10Mg powders with different WC contentswere synthesized by the electrostatic assembly method. After the selective laser melting (SLM) processing, various Al−W intermetallicswere in-situ formed in the SLM nano-WC/AlSi10Mg composites. A well-coherent Al/Al5W interface with a low lattice mismatch of 4.7% was confirmed with an orientation relationship of (002)α(Al)//(104)Al5W. The nano-WC particles and Al−W intermetallics triggeredthe columnar-to-equiaxed transition, leading to a fine equiaxed microstructure. As a result, the SLMed 3 wt.% nano-WC/AlSi10Mg composites showed remarkable mechanical properties, with an ultimate tensile strength of (464.1±8.68) MPa and elongation of (5.6±0.95)%. Additionally, the SLMed 3 wt.% WC/AlSi10Mg samples also achieved the lowest average coefficient of friction (0.429) and wear rate of 3.842×10−5 mm3/(N·m) compared to other WC/AlSi10Mg composites. The remarkable mechanical and wear properties are ascribed to fine-grain and second-phase strengthening.

Enhancing cement composite interface with waterglass modification on bamboo fiber: A viable and effective approach

Cement and cement-based composites are known for their high compressive strength but are often lacking in toughness, making them susceptible to cracking when subjected to external loads. The incorporation of bamboo fiber (BF) into cement-based composites holds promise for enhancing tensile strength and overall durability. However, a significant challenge lies in achieving a strong interfacial bond between BFs and the cement matrix. In this study, a viable and effective surface modification approach for BF has been developed. Waterglass, as an economical inorganic modifier, can be grafted with hydroxyl groups on fiber surface after hydrolysis and condensation. Simultaneously, the alkaline properties and silicate-containing characteristics of waterglass facilitate its participation in cement hydration, acting as a coupling agent to establish a robust fiber-matrix interface. To confirm the successful modification of BF with waterglass, FTIR, NMR, and XPS spectra were used to examine the chemical structure of BFs. Due to the denser bonding achieved between the fiber and cement matrix, the composites exhibit improved toughness with superior flexural strength (10.1 MPa) and splitting tensile strength (3.7 MPa). The addition of bamboo fibers also mitigates shrinkage in cement mortar, enhancing the volume stability of cement-based materials. Notably, waterglass modification led to a reduction in the hydrophilicity of BF and enhanced the compatibility between the fiber and the matrix, which further improved the overall durability of the composites, including their resistance to capillary water absorption, freezing, and carbonization.

Core‐Shell Micro‐ and Nano‐Structures for The Modification of Light‐Surface Interactions

AbstractControlling how a material interacts with light is key to optimizing its optical properties to fit a desired function or application. The most straightforward approach is to chemically or physically modify the surface exposed to incident light. An effective method of surface modification is based on the addition of core‐shell structures at the surface. Of particular importance to many technological applications are core‐shell structures with dimensions comparable to the wavelengths of light extending from the UV up to the near‐IR region of the electromagnetic spectrum, which coincides with the major part of the solar spectrum. Surface modification approaches to tailor the optical properties of materials in this range of wavelengths are increasingly relevant in the context of materials and devices used in sustainable energy applications, such as solar cells and heat‐reflective paints. These materials are useful to mitigate the current energy and climate crises by allowing for enhanced energy harvesting and improved thermal management, respectively. Here, recent progress in the fabrication and application of core‐shell micro‐/nano‐structures for the modification of light interaction with surfaces is highlighted. Some limitations and future directions for the design of core‐shell materials are also discussed.

Significant enhancement of high-temperature capacitive energy storage in dielectric films through surface self-assembly of BNNS coatings

Polymer dielectrics, serving as integral components in electrostatic capacitors, must meet the escalating demands for electrical energy storage and conversion in harsh environments. However, the current enhancement of breakdown strength in polymer composite materials often relies on intricate nanostructure designs or inorganic deposition methods, which result in high production costs, slow processing, and hinder industrial scalability. Here, we present an economically efficient and easily implementable surface modification approach. This method induces the self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions, thereby enhancing the high-temperature electrical insulation and energy storage performance of polymer dielectrics. At room temperature, the breakdown strength of the BNNS-coated polyetherimide (PEI) significantly increased to 544 MV/m, representing a 100 MV/m improvement compared to pure PEI. At elevated temperatures (200 °C), the organic insulator achieved a high breakdown strength of 439 MV/m and a high energy density of 2.59 J/cm3. The tangential orientation of the nanosheets effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer. This work provides a novel avenue for the design of high-performance polymer dielectrics for high-temperature energy storage through surface engineering.

Enhanced Adsorption of Textile Dyes by a Novel Sulfonated Activated Carbon Derived from Pomegranate Peel Waste: Isotherm, Kinetic and Thermodynamic Study

The rapid growth of the dye and textile industry has raised significant public concerns regarding the pollution caused by dye wastewater, which poses potential risks to human health. In this study, we successfully improved the adsorption efficiency of activated carbon derived from pomegranate peel waste (PPAC) through a single-step and surface modification approach using 5-sulfonate-salicylaldehyde sodium salt. This innovative and effective sulfonation approach to produce sulfonated activated carbon (S-PPAC) proved to be highly effective in removing crystal violet dye (CV) from polluted water. The prepared PPAC and S-PPAC were characterized via FESEM, EDS, FTIR and BET surface area. Characterization studies confirmed the highly porous structure of the PPAC and its successful surface modification, with surface areas reaching 1180.63 m2/g and 740.75 m2/g for the PPAC and S-PPAC, respectively. The maximum adsorption capacity was achieved at 785.53 mg/g with the S-PPAC, an increase of 22.76% compared to the PPAC at 45 °C. The isothermic adsorption and kinetic studies demonstrated that the adsorption process aligned well with the Freundlich isotherm model and followed the Elovich kinetic model, respectively. The thermodynamic study confirmed that the adsorption of CV dye was endothermic, spontaneous and thermodynamically favorable onto PPAC and S-PPAC.

Nano Metal Oxide Frameworks (NOF): Development of New Heterogeneous Catalyst for the Synthesis of Furan Derivatives from Glucose

A surface modification approach has prepared a nanostructured organic framework connecting two metal oxide NPs. The surface modifier attached two metal oxide NPs <em>via</em> molecular interaction to generate modular structures of fiber, rod, or sponge materials. Thus, obtained hybrid systems have been confirmed through FT-IR, TGA, PXRD, and SEM. Metal oxides such as Fe<sub>3</sub>O<sub>4</sub> and MgO generated mixed materials via the surface modification approach. Thus, obtained materials have been successfully used to dehydrate biomass-derived glucose. The products HMF and subsequently partially oxidized product DFF are considered to be valuable compounds not only in fuel technology but also in the pharmaceutical industry.

Metal-organic frameworks: Drug delivery applications and future prospects.

Metal-organic frameworks (MOFs) have gained incredible consideration in the biomedical field due to their flexible structural configuration, tunable pore size and tailorable surface modification. These inherent characteristics of MOFs portray numerous merits as potential drug carriers, depicting improved drug loading, site-specific drug delivery, biocompatibility, biodegradability, etc. The current review article sheds light on the synthesis and use of MOFs in drug delivery applications. In the beginning, a brief overview of the key components and efficient fabrication techniques for MOF synthesis, along with its characterization methods, have been presented. The MOFs-based formulations have been critically discussed. The application of the design of experiments (DoE) approach to optimize MOFs has been elucidated. The MOFs-based formulations, especially the application of stimuli-responsive MOFs for site-specific drug delivery, have been deciphered. Along with drug release kinetic models, several administration methods for MOFs have also been enunciated. Subsequently, MOFs as future potential drug carriers have been elaborated. Recently, MOFs have emerged as versatile drug delivery carriers possessing customization potential and meeting the needs of spatio-temporal drug delivery. Researchers have devised several environment-friendly approaches for MOF construction and surface modification. Owing to stimuli-responsive potential, MOFs have demonstrated their prominent therapeutic efficacy via several routes of administration. The numerous benefits of MOFs would certainly open up a new vista for its novel drug delivery applications.

Surface modification of Nano cellulose: The path to advanced uses of smart and sustainable bio-material

In order to develop sophisticated applications for intelligent and sustainable biomaterials, our work focuses on the surface modification of nanocellulose. Nanocellulose has the ability to be modified to improve its surface characteristics, making it appropriate for a variety of uses in industries including biomedicine, packaging, textiles, and water treatment. There have been discussions on a number of physical and chemical surface modification approaches, including mechanical treatment, high-pressure homogenization, and chemical functionalization. The study also highlights the results of different characterization methods that were employed to examine the surface-modified nanocellulose. The review addresses the difficulties in integrating nanocellulose into many applications, despite its potential, including manufacturing scale-up, standardisation, and toxicity issues. The article's conclusion highlights the need for continuing research and development of nanocellulose-based materials in order to meet these obstacles and offer long-term solutions to a range of social issues.

Surface Functionalization of Poly(lactic acid) via Deposition of Hydroxyapatite Monolayers for Biomedical Applications.

The surface modification of poly(lactic acid) (PLA) using hydroxyapatite (HAP) particles via Langmuir-Blodgett (LB) and Langmuir-Schaefer (LS) approaches has been reported. The HAP monolayer was characterized at the air/water interface and deposited on three-dimensional (3D) printed poly(lactic acid). The deposition of HAP particles using the LS approach led to a larger surface coverage in comparison to the LB method, which produces a less uniform coating because of the aggregation of the particles. After the transfer of HAP on the PLA surface, the wettability values remained within the desired range. The presence of HAP on the surface of the polymer altered the topography and roughness in the nanoscale, as evidenced by the atomic force microscopy (AFM) images. This effect can be beneficial for the osteointegration of polymeric implants at an early stage, as well as for the reduction of the adherence of the microbial biofilm. Overall, the results suggest that the LS technique could be a promising approach for surface modification of PLA by hydroxyapatite with respective advantages in the biomedical field.