Epoxy resin (EP) matrix composites are a widely used polymer-based protective coating material. However, the low lubricity leads to frictional wear problems that make their large-scale development and application a serious challenge. Based on this, a multifunctional composite coating (MPT-EP) with low wear, high lubricity, high thermal conductivity, and corrosion resistance was prepared by introducing polytetrafluoroethylene (PTFE) and lamellar Mo2Ti2C3 as a composite lubricant into epoxy resin matrix using a simple solvent dispersion method. The results showed that the introduction of the composite lubricant resulted in enhanced hardness and mechanical properties of the composite coating. Compared with the single epoxy resin coating (0.31), the friction coefficient (COF) of the composite coating was only 0.22, and the friction surface did not show obvious abrasion marks. The surface temperature of the composite coating was up to 51.4 °C when it was placed on a hot bench at 60 °C for 60 s. In addition, the COF of the composite coating did not change significantly after being immersed in acid, alkali and salt solutions. Therefore, the Mo2Ti2C3-induced multifunctional epoxy resin matrix composites have important application potential and research value in the field of ultra-wear-resistant and high lubrication protective coatings.