Surface-Piercing Propellers (SPPs) are the preferred propulsion system for light to moderately loaded high-speed applications due to the high fuel efficiency. For highly loaded applications, the efficiency of SPPs tends to decrease because of the limited submerged blade area and the presence of large suction side cavities. Moreover, it is a challenge to design large-scale SPPs that can maintain reliable fatigue strength and avoid vibration issues while maximizing the propeller thrust for a given power input. In this work, three SPP designs are presented for different size Surface Effect Ships (SESs) that can attain a maximum advance speed of 25.72 m/s (50 knots). A previously developed and validated three-dimensional (3-D) coupled boundary element method–finite element method (BEM–FEM) is used for the transient hydroelastic analysis of SPPs. The method is validated by comparing the predicted hydrodynamic performance with those obtained using a vortex-lattice method (VLM) and a Reynolds Averaged Navier–Stokes (RANS) solver. The hydrodynamic and structural dynamic performance of the SPPs are presented. Finally, challenges associated with the design related analyzes of large-scale SPPs are discussed.