Abstract In contrast to surface greenhouse warming, surface greenhouse cooling has been less explored, especially on multi-century timescales. Here, we assess the processes controlling the pacing and magnitude of the multi-century surface temperature response to instantaneously doubling and halving atmospheric carbon dioxide concentrations in a modern global coupled climate model. Over the first decades, surface greenhouse warming is larger and faster than surface greenhouse cooling both globally and at high northern latitudes (45–90° N). Yet, this initial multi-decadal response difference does not persist. After year 150, additional surface warming is negligible, but surface cooling and sea ice expansion continues. Notably, the equilibration timescale for high northern latitude surface cooling (∼437 years) is more than double the equivalent timescale for warming. The high northern latitude responses differ most at the sea ice edge. Under greenhouse cooling, the sea ice edge slowly creeps southward into the mid-latitude oceans amplified by positive lapse rate and surface albedo feedbacks. While greenhouse warming and sea ice loss at high northern latitudes occurs on multi-decadal timescales, greenhouse cooling and sea ice expansion occurs on multi-century timescales. Overall, this work shows the importance of multi-century timescales and sea ice processes for understanding high northern latitude climate responses.