ABSTRACT The monopile-supported offshore wind turbines (OWTs) are subjected to complex marine environment loads, the dynamic responses of wind turbine structures under wave and current loads are critical for structural safety assessment, which involves the interaction of fluid and structure fields. This study proposed an approach for simulating the two-way (T-W) fluid-structure interaction (FSI), the dynamic responses of the wind turbine support structure under the combined action of wave and current load are investigated. Subsequently, the effect of wave-current interaction, scour depth and flow velocity on the dynamic responses of monopile-supported OWTs are analysed and some useful guidelines are provided. The results indicate that the wave-current interaction can strongly influence the dynamic responses of OWTs, especially for larger scour depth and higher flow velocity. In addition, the displacement amplitude of OWT decreases by 15% under the current load in consideration of the fluid-structure interaction and the bearing performance of the pile improves accordingly.