This study investigated the high dropout rates among girls in secondary schools in Mariani Ward, a critical issue observed in many developing regions. The specific objectives of the study were to assess how household income, parental education, and family structure influence girls’ dropout rates. The study was grounded in the Relative Deprivation theory and utilized a descriptive survey design, involving a sample of 385 respondents selected from a larger population of 10,202 through cluster sampling method to ensure representation of various groups within the population. Within the target population, five clusters or sub-locations were identified based on their diverse characteristics. The sample included female dropouts as well as key informants such as head teachers, household heads, and local leaders. Data collection was achieved through questionnaires and interviews, and quantitative analysis was performed using SPSS version 25. The study employed inferential statistical methods, including correlation analysis, chi-square tests, and binomial logistic regression, to assess the impact of socio-economic factors on dropout rates. The results revealed significant positive correlations between dropout rates and household income (0.684), parental education status (0.547), and family structure (0.761). Binomial logistic regression analysis further confirmed the substantial influence of these factors on dropout rates. In addition to these factors, the study also indicated the presence of other unidentified variables affecting dropout rates. This highlights the necessity for further research to explore these additional influences. Based on these findings, the study recommends implementing targeted interventions to address the identified socio-economic challenges. These recommendations include developing financial support programs for low-income families, enhancing parental education and involvement, and fostering supportive family environments. Such measures are essential for reducing dropout rates and promoting sustained educational participation among girls in Mariani Ward. The study provides actionable insights for educators, policymakers, and stakeholders to effectively improve girls' access to education and support their academic persistence.