Gestational Diabetes Mellitus (GDM) is increasingly recognized as a significant public health issue in Uganda, with profound implications for maternal and fetal health. Beyond the physical challenges, GDM presents substantial psychosocial burdens that are often underexplored. This review delves into the psychosocial aspects of living with GDM in Uganda, highlighting the emotional distress, social support systems, cultural influences, healthcare access, and coping strategies employed by affected women. Women with GDM face psychological challenges, including fear, anxiety, depression, and body image issues, exacerbated by societal stigma and limited healthcare support. The role of social support, both formal and informal, is crucial yet inconsistent due to cultural norms and resource limitations. Cultural beliefs and practices further complicate GDM management, influencing women’s perceptions and adherence to treatment. Healthcare access and quality in Uganda significantly impact the psychosocial well-being of women with GDM, with barriers such as distance, financial constraints, and inadequate healthcare infrastructure contributing to stress and poor health outcomes. Coping strategies vary, with women employing denial, acceptance, and problem-solving, influenced by personal resilience and social support. This review underscores the need for a holistic approach to GDM care in Uganda, integrating psychosocial support, mental health screenings, and culturally competent healthcare provision. Addressing these psychosocial aspects is essential for improving the quality of life and pregnancy outcomes for women with GDM, calling for enhanced healthcare infrastructure, policy interventions, and increased community awareness. Keywords: Psychosocial Aspects, Gestational Diabetes, Uganda, Challenges, Healthcare.