212 Background: Employment provides both integral psychological and financial benefits to cancer survivors and their caregivers. Yet cancer survivors often face employment disruptions, leading to worse financial hardship and deteriorated quality of life. In 2023, an advertising and public relations company launched the “Working with Cancer” global initiative, calling on companies across the globe to reduce the stigma of cancer in the workplace by pledging their commitment to building the most open, supportive and “recovery-forward” work cultures for their employees. This study examines the company pledges made in the “Working with Cancer” campaign. Methods: We performed a cross-sectional, qualitative analysis of Working with Cancer campaigns for companies. In January 2024, we identified all campaigns through web scraping. Data from a total of 1,151 employer campaign pledges were extracted, and we recorded several variables including the company location, business sector, number of employees, the pledge signer and title/role, and the action/pledge the company stated they will take to support cancer survivors at work. Campaign pledges were imported into ATLAS.ti where we performed a content analysis. Results: We collected 1,151 company campaigns in total, 46 of which (4%) were Fortune 500 companies. Of the Fortune 500 companies (n=46), themes described the commitment to taking care of employees including the offering of comprehensive benefits including include paid leave for both patients and caregivers, guaranteed pay, and mental wellbeing support. Several companies described specific initiatives their organization provided, and many described how reducing the stigma of cancer at work required an open dialogue between all employees in an organization. In addition, companies pledged to know their own specific policies, make their employees aware of their commitment, and track their progress in improving the work experiences of cancer survivors. Conclusions: Employers play a significant role in the healthcare decisions made by employees, and are increasingly responsible for determining health plan benefits, providing resources and navigating care, and otherwise supporting employees as they navigate the complexities of a healthcare system. This global initiative provides a unique opportunity to identify issues related to working with cancer, and intervene at the employer level. More research is needed on employer-led initiatives to improve employment outcomes in cancer survivors and caregivers.