The increasing prominence of climate change, geopolitical crises, and global economic slowdown highlights the challenges and structural deficiencies of traditional cross-border agro-food supply chains. As a result, there has been a growing consensus on the need to leverage digital technology to rebuild and innovate a safe, stable, and sustainable global food system. This study assessed the knowledge progress and development trends in the sustainable development of cross-border agro-food supply chains enabled by digital technology. A total of 352 authoritative papers from the core Web of Science database were selected for analysis. The Citespace tool was utilized to visually examine research elements. The findings reveal that research outcomes in this territory experienced a significant period of rapid growth, particularly after 2020. Sustainability and IEEE Access are the journals with the highest and second-highest number of publications. China and the France National Institute are the countries and research institutions with the largest number of publications in this field. The research hotspots are mainly the application of digital technologies, food safety, and supply chain system model innovation. In the past ten years, the research in this territory has gone through three stages: precise timeliness orientation, intelligent strategic decision-making orientation, and model predictability orientation. We further construct the ‘antecedent–practice–performance’ conceptual framework of the sustainability of the digital technology-enabled cross-border agro-food supply chain. Finally, this paper presents the potential research directions in this territory, focusing on four aspects: research method, research mechanism, research topic, and research frontier.