Recently, managers and researchers have introduced the concept of Industry 5.0 that tried to improve Industry 4.0 by adding some crucial principles such as sustainability, resiliency, and human-centricity. Due to the importance of this concept, the present work develops a decision-making framework to investigate a responsive SC considering the Industry 5.0 dimensions named responsive Supply Chain 5.0 for healthcare systems. To do this, at the outset, the main related indicators and strategies are identified according to the experts and literature. Then, a new version of the best-worst method named stochastic best-worst method is developed to compute the indicators’ weights. Afterwards, by employing the Fuzzy Vlse Kriterijumsk Optimizacija Kompromisno Resenje method, the feasible alternatives are ranked. The outputs indicate that responsiveness, sustainability, resilience, and human-centricity respectively are the most important aspects. On the other side, the high service level, cost reduction, recovery, and safety are the most important criteria in their corresponding aspects. Moreover, the achieved results show that using advanced technologies and collaboration and information sharing are the best alternatives. Also, to show the capability and advantages of the proposed method, we compare this method with the traditional methods (e.g., the analytical hierarchy process and the traditional best-worst method). In terms of the theoretical implications, this work has introduced the responsive supply chain 5.0 and developed a novel method. On the other hand, in terms of the managerial implications, the present work can give a comprehensive perspective to healthcare managers for understanding the concept of Industry 5.0 in the SC problem to improve the responsiveness of their businesses.