Ginger Supplementation Research Articles

Therapeutic Potential of Ginger-supplemented Diet in Reversing Lead-induced Nephrotoxicity

Background: The flowering plant ginger, scientifically known as Zingiber officinale offers numerous health benefits, including immune support. Its bioactive compounds such as shogaols and gingerols, contribute to its antioxidant and anti-inflammatory properties. Objective: To access ginger (Zingiber officinale) as a protective agent against Nephrotoxicity induced by Lead by accessing the levels of inflammatory markers (Interleukin -6, Tumor Necrosis Factor), kidney function (Creatinine), and general kidney morphology. Methods: Twenty-four (24) female Wistar rats weighing 150-170g were carefully divided into four groups (6 per group) and housed in plastic cages. The groups were Groups A (Control), B (the Lead), C [Lead and ginger (1%)], and D [Lead and ginger (5%)]. The rats were treated for 28 days, the control and the Lead groups were fed with normal rat diets and distilled water, while the Lead and ginger group was fed with ginger supplemented diet. On day 29, the rats were sacrificed using cervical dislocation following animal ethical guidelines. Blood samples were collected from the apex of the heart (intracardiac puncture), stored in a heparinized bottle, and centrifuged to undergo further analysis (creatinine, interleukin 6, and Tumor Necrosis Factor). The kidney was removed and fixed in 10% neutral buffered formalin. The organ was then processed for histological analysis. Results: The results showed a statistically significant increase (P<0.05) in the levels of creatinine, Tumour Necrotic Factor Alpha (TNF-alpha), and Interleukin-6 (IL-6) in group B compared to group A. While a statistically significant decrease (P<0.05) was observed in groups C and D compared to group B. Histomorphological distortion was observed in group B compared to group A, while the lesion was reversed in groups C and D. Conclusion: This study found that ginger has substantial health benefits for kidney tissues, particularly in nephrotoxicity caused by lead. Its ability to preserve kidney tissue, decrease inflammation, and improve kidney function highlights its significance as a treatment option for preventing or lessening kidney harm associated with toxic substances or underlying health issues. Further investigations are necessary to explore the possible adverse effects or contraindications that could be associated with ginger supplements or ginger-supplemented diets in humans.

Dietary Supplementation of Red and White Ginger (Zingiber officinale) Rhizomes and Gingerol Improves Male Reproductive Capacities

Dietary Supplementation of Red and White Ginger (Zingiber officinale) Rhizomes and Gingerol Improves Male Reproductive Capacities

Dietary ginger (Zingiber officinale) enhances performance traits, biochemical and haematological indices of Turkey targeting mRNA gene expression

Ginger rich in polyphenols, possesses various biomedical properties. Researchers investigated the effects of dietary ginger supplementation on turkey performance traits, biochemical parameters, haematological parameters and mRNA gene expression. Ginger root powder was administered at different doses (0, 10, 20 and 40 g/kg) to the turkeys. Notably, the 20 g/kg group exhibited improved performance traits and a higher broiler production efficiency factor (BPEF). Importantly, ginger was found to be safe for turkeys based on serum indices. Furthermore, the expression of several growth-related genes, including growth hormone receptor (GHR), insulin-like growth factor 1 (IGF-1), adenine nucleotide translocase (ANT), cyclooxygenase 3 (COX-3) and uncoupling protein 3 (UCP-3), was upregulated in the 20 g/kg enhancing their growth performance and economic efficiency in addition to keeping their health status safe. Therefore, Ginger root powder can be supplemented for turkey at a concentration of 2% as the addition of ginger powder is a long-term process.

The Effect of Ginger (Zingiber Officinale Roscoe) and Turmeric (Curcuma Longa) Supplementation on 17-β Estradiol Level, Quality of Life and Body Composition in Postmenopausal Women: Secondary Outcomes of a Randomized, Placebo controlled Trial

The Effect of Ginger (Zingiber Officinale Roscoe) and Turmeric (Curcuma Longa) Supplementation on 17-β Estradiol Level, Quality of Life and Body Composition in Postmenopausal Women: Secondary Outcomes of a Randomized, Placebo controlled Trial

Dietary effect of turmeric and ginger powder supplementation on growth performance of Common carp (Cyprinus carpio)

A study was conducted with the aim to find out the effect of ginger and turmeric supplementation on the growth performance of Common carp fingerlings. A total of 270 fingerlings were divided into 6 groups including control (C). The group C was fed with basal feed and the treatment groups T5, T5B5, G2, G5, G8 were fed with turmeric powder @0.5%, turmeric @0.5% + black pepper powder @0.5 %, ginger powder @2%, 5% and 8%, respectively. The growth parameters, i.e Gain in weight, Feed Conversion Ratio (FCR), Specific Growth Rate (SGR), Relative Growth Ratio (RGR), Protein Efficiency Ratio (PER) and Feed Efficiency Ratio (FER) were recorded for 60 days. Measurements were taken for gain in total length (TL) and body depth (BD) after 60 days of trial. Turmeric powder supplementation @0.5% showed significantly better growth performance in Common carp fingerlings. The fingerlings of T5 group showed highest gain in weight (48.7), SGR (1.35), RGR (126), FER (48.17), PER (1.24) and improved FCR (2.23). This group also gained significantly higher TL (3.74) and BD (1.42). There was no significant difference observed in survival per cent, moisture and acid insoluble ash content of fish muscle. T5 showed the highest crude protein concentration (78.29) and significantly highest total fat concentration (11.59). Fish muscles of all the treatments had significantly higher total mineral content as compared to that of the control group.

HISTOLOGICAL CHANGES IN TESTIS OF RABBIT BUCKS FED WITH DIET CONTAINING RAW OR FERMENTED COTTONSEED CAKE SUPPLEMENTED WITH GINGER

The aim of this study was to evaluate the histological changes in testis of rabbit bucks (New Zealand White X Chinchilla) fed with raw or fermented cottonseed cake (CSC) - based diets supplemented with ginger. Solid state fermentation (SSF) was employed to biodegrade CSC using Aspergilus niger. Thirty (30) weaner rabbit bucks aged between 5 - 6 weeks were acclimatized for two weeks and allocated to five dietary treatments with equal number of animals (n=6) per treatment in a 2x2 factorial arrangement within a completely randomized design (CRD). Treatment 1, (control) had soybean meal (SBM) as protein source; other four treatments were divided into two groups. The first group comprised raw or fermented CSC without ginger supplementation while the second group comprised raw or fermented CSC with ginger supplementation. The SBM was completely replaced with CSC weight for weight in the four treatments. Ginger was supplemented at a dosage of 30mg/kg diet. Feeding trial lasted for 12 weeks. Testis samples were processed for histological evaluation. The photomicrographs of the testis revealed that feeding raw CSC diets without ginger supplementation resulted in severe testicular damage. Either the fermentation of CSC by A. niger or ginger supplementation, or their combination exhibited the potential to greatly ameliorate the adverse effects. It was therefore, concluded that feeding CSC to rabbit buck intended for breeding purpose should either be fermented with A. niger or supplemented with ginger or their combination

Effect of Ginger Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis

Background: Ginger (Zingiber officinale), as one of the herbal medicines, has high antioxidant activity. It may have protective effects against hepatotoxicity. This study seeks to perform a systematic review and meta-analysis on the impact of ginger on liver enzymes. Methods: The present systematic review and meta-analysis study adhered to the guidelines outlined in the PRISMA 2020 statement. A comprehensive literature search was carried out in the Medline database (PubMed), Google Scholar, Embase, Scopus, Web of Science, and Cochrane Library until the conclusion of February 2021. All interventional animal studies were included. The selected studies were the ones that examined the impact of ginger on serum liver enzymes. Results: Out of 741 articles, 39 studies were incorporated into the systematic review and meta-analysis. The pooled results suggested that ginger significantly reduced alanine aminotransferase (ALT) (standardized mean difference (SMD): 2.52, 95% confidence interval (CI): 2.12 to 2.93), aspartate aminotransferase (AST) (SMD: 3.03, 95% CI: 2.48 to 3.58), and alkaline phosphatase (ALP) (SMD: 2.10, 95% CI: 1.60 to 2.60). Conclusion: Ginger has favorable effects on liver enzymes. It shows potential as a beneficial complementary therapy for higher levels of ALT, AST, and ALP because of its useful effects and negligible side effects.

The application of ginger supplementation on peptic ulcer disease management: A randomized, double blind, placebo-controlled clinical trial

The application of ginger supplementation on peptic ulcer disease management: A randomized, double blind, placebo-controlled clinical trial

Genotype and dietary supplementation of ginger (Zingibar officinale) rhizome powder affect egg quality traits of layer chickens

This study evaluated the effects of ginger (Z. officinale) rhizome powder on egg qualities of aged commercial and native hens using 160 Shaver Brown (SB) and Nigerian heavy ecotype native hens (HEN). Experimental groups per genotype were control group or basal diet group, and ginger rhizome powder supplemented group (20 g/kg, ginger group). For each genotype, forty (40) hens were assigned to the control group and 120 hens to the ginger group. Each experimental group had four (4) replicates containing 10 hens each for the control groups, and 30 hens each for the ginger groups. The hens were housed individually in laying cages and fed the experimental diets at 125 g/bird/day. Water was given ad libitum and photoperiod was 12 h light and darkness. 80 eggs from SB and 40 eggs from HEN control groups, and 80 eggs/genotype from the ginger groups were used to evaluate egg qualities while 10 shell samples were used to evaluate shell mineral contents for each group. In addition, within genotypes, eggs belonging to the ginger groups were grouped into egg weight and egg shape index grades and assessed for egg qualities. SB eggs had significantly (p ≤ 0.05) higher weight (EW), length (EL), diameter (ED), surface area (ESA), volume (EV), and shape index (ESI); yolk, albumen, and shell weights (YW, AW and SW); albumen height, diameter, and ratio (AH, AD, and AR); shell volume (SV), compression fracture force (SCFF), and calcium content but lower egg specific gravity (ESG), yolk ratio (YR), yolk/albumen ratio (Y/A ratio), shell Zinc, and Phosphorus contents compared to HEN eggs. Ginger groups had higher EW, EL, ESA, EV, YW, YD, YR, AH, AI, Y/A ratio, and shell Zn but lower ESG, YH and YI compared to control groups. SB-ginger group had highest (p ≤ 0.000) AD while HEN-ginger group had highest (p ≤ 0.05) shell Zinc, and Phosphorus contents. EW grades differed significantly in EW, ESA, ESG, ESI and SCFF in the two genotypes while ESI grades differed significantly in ESI and Y/A ratio in SB but in ESI, YI and Haugh unit in HEN. In conclusion, genotype, diet, genotype x diet, EW and ESI grades influenced egg quality traits. These factors are important for egg quality evaluation and genetic improvement.

The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis

Ginger, a root originating in Southeast Asia, has several therapeutic benefits to human health, including antioxidant activity. Currently, there are discussions regarding the hypoglycemic properties of dietary supplements derived from its phenolic compounds in the management of chronic diseases. Diabetes mellitus is a chronic and complex disease that requires continuous treatment, with glycemic control being decisive in the management of hyperglycemia. This systematic review and meta-analysis aimed to identify the effects of oral supplementation of ginger in the treatment of type 2 diabetes mellitus (T2DM) in patients undergoing randomized clinical trial studies. Across the PubMed, Scopus, and Web of Science databases, randomized controlled trials that examined the role of ginger in T2DM until January 2022 were systematically researched. The parameters used to assess T2DM treatment control were Fasting Blood Glucose (FBS) and glycated hemoglobin (HbA1c). Bias risk assessment of the studies was performed using the RoB 2.0 tool. Meta-analysis was performed considering data compatibility. Five studies were included in the analysis. Capsules containing Zingiber officinale powder were supplemented twice a day. The dose ranged from 1.2 to 2g/day, and the intervention period ranged from 4 to 12 weeks. Meta-analysis results indicated no significant effect of ginger supplementation on FBS or HbA1c. However, individual studies reported mixed results, with two studies showing a significant reduction in FBS. This suggests that while ginger may have potential as an adjuvant therapy, its overall impact on glycemic control in T2DM is not statistically significant when results are pooled. Currently published articles are still limited, requiring further studies of high methodological quality to verify the effectiveness of ginger supplementation on T2DM parameters control.

Ginger (Zingiber officinale) - A Beneficial Effect on Health and Physical Activity

Introduction: Ginger (Zingiber officinale) is a member of the Zingiberaceae plant family and is indigenous to Southeast Asia. It has been widely utilized as an herbal remedy in numerous nations and is known for its beneficial properties, such as anti-inflammatory, antioxidant, and anti-apoptotic effects. Ginger is commonly consumed for its various health benefits, including alleviating coughs, reducing pain, addressing nausea, aiding digestion, and exhibiting analgesic and anti-inflammatory effects. Recently, research has begun to uncover the potential benefits of ginger on physical activity and athletic performance. Materials and methods: A comprehensive examination of scientific and medical literature was performed using the PubMed and Google Scholar databases. The search terms employed were: "ginger," "ginger anticancer," "ginger anti-inflammatory," and "ginger antiemetic." Conclusion: Ginger, scientifically known as Zingiber officinale, is a widely utilized herb with various biological effects including anti-inflammatory, antioxidant, anticancer, and antibacterial properties primarily attributed to four phenolic compounds: gingerols, shogaols, paradols, and zingerone. Notably, 6-shogaol, an active ingredient in ginger, shows promise as a natural anticancer product with potential therapeutic benefits. Also, several scientific studies have indicated that ginger supplementation may lead to reduced muscle soreness, improved endurance performance, and decreased inflammation in response to intense physical activity.

Impact of ginger powder (Zingiber officinale) supplementation on the performance, biochemical parameters, antioxidant status, and rumen fermentation in Ossimi rams.

Ginger (Zingiber officinale) has great potential as a growth promoter and immunostimulant in ruminant nutrition. This study assessed the impact of ginger powder supplementation on Ossimi rams' rumen fermentation, biochemical parameters, and antioxidant levels. Fifteen Ossimi rams, aged 10 ± 1.3 months and weighing 30 ± 1.5 kg. Rams were randomly divided into three experimental groups: The control group (G1) received standard feed, while ginger powder (5 g and 7 g/kg body weight [BW] for G2 and G3, respectively) mixed in water was administered to groups G2 and G3 before their standard feed. The control group recorded higher dry matter (DM) intake values (p < 0.05) than the ginger-treated groups. The ginger-treated groups showed superiority (p < 0.05) in weight gain and feed conversion compared to the control group. The digestion coefficients of DM, crude protein, and crude fiber were significantly (p < 0.05) increased by a high dose (7 g/Kg BW) of ginger supplementation, whereas organic matter, ether extract, and nitrogen-free extract digestibility remained unchanged. Compared to the control group, the rams given 5 g of ginger had significantly less (p < 0.05) total protein and globulin in their serum, but the rams given 7 g of ginger had significantly more (p < 0.05) of these proteins. In the ginger groups, these levels were significantly (p < 0.01) lower than those in the control group for serum creatinine, uric acid, urea, total lipids, triglycerides, total cholesterol, glucose, serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase. Rams given ginger had significant growth hormone, insulin-like growth factor-1, total superoxide dismutase, GSH-Px, TAC, immunoglobulin (Ig) A, and IgG enhancement (p < 0.01), and a decrease (p < 0.01) in malondialdehyde concentration compared to the control group. Significant increases in total short-chain volatile fatty acids, acetic, propionic, and isovaleric acids (p < 0.05), and significant decreases in NH3N and protozoa (p < 0.01). Ginger powder (5 g and 7 g) can improve growth, immune responses, antioxidant status, and ruminal parameters in rams. Further study is needed to evaluate the effect of ginger on different types of animals (cow, buffalo, and goat) to develop new feed additives.

Effects of Ginger Supplementation on Neuroinflammation and Mitochondrial Function in Spinal Cords of Rats With Neuropathic Pain: Evidence for Sex Differences

Effects of Ginger Supplementation on Neuroinflammation and Mitochondrial Function in Spinal Cords of Rats With Neuropathic Pain: Evidence for Sex Differences

Efficacy and Safety of Ginger on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Chemotherapy-induced nausea and vomiting (CINV) is a prevalent and distressing side effect. Historically, ginger has been explored as a potential remedy for various ailments, including its potential efficacy against CINV. The aim of this study was to determine whether taking ginger supplements can relieve CINV. A comprehensive search was conducted across PubMed, EMBASE, Cochrane Library, and the Wanfang database. Randomized controlled trials meeting our inclusion criteria were analyzed. The primary outcomes were the incidence and severity of CINV. The protocol was registered on PROSPERO, and the number is CRD4202232104. Of the 35 randomized controlled trials analyzed, 22 trials employed ginger capsules as the primary intervention, whereas 13 studies evaluated the prophylactic effects of ginger-partitioned moxibustion. The outcomes indicated that combining ginger capsules with standard antiemetic agents can significantly reduce the incidence of grade 3 acute nausea (Risk Ratio [RR], 0.19; P < .001) and the incidence of high-grade overall vomiting (RR, 0.47; P = .01). Moreover, ginger-partitioned moxibustion can significantly alleviate the incidence of both mild (RR, 0.56; P = .001) and severe (RR, 0.39; P < .00001) vomiting. Only 2.8% of patients experienced dizziness after ginger-partitioned moxibustion. Our findings indicate that ginger capsules, when used alongside antiemetic drugs, enhance the management of severe CINV, particularly in highly emetogenic chemotherapy regimens. Based on our findings, we recommend initiating ginger supplements before chemotherapy, in conjunction with standard antiemetics, to reduce the severity of CINV. The promising results warrant more rigorous clinical trials to firmly establish the role of ginger in CINV management.

The effect of ginger supplementation on inflammatory indicators and muscle damage after eccentric and concentric exercise in obese girls

The effect of ginger supplementation on inflammatory indicators and muscle damage after eccentric and concentric exercise in obese girls

Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes

Abstract Inflammation and muscle soreness sometimes occur after high-intensity exercise in some athletes. This study aimed to determine the effect of a ginger supplement period on serum cyclooxygenase-2 (COX2), prostaglandin E2 (PGE2), and interleukin (IL)-6 in response to exhaustive exercise in female taekwondo athletes. In this semi-experimental study, 24 semi-professional female taekwondo athletes (mean age 19.75 ± 2.03 years, height 160 ± 6 cm, weight 53.99 ± 7.49 kg) were selected voluntarily. Subjects were randomly assigned to the ginger supplement + exhaustive (GE + EE) and exhaustive exercise (EE) groups. 24 doses of 2,000 mg of pure ginger supplement (3 days/week for 8 weeks) were taken in the morning and evening (4 capsules of 500 mg: 2 in the morning and 2 in the evening). Then Bruce’s test was performed as an exhaustive exercise. Blood samples were collected in two stages before and after the intervention, and serum levels of COX2, PGE2, and IL-6 were measured using the Elisa method. T-tests and analysis of variance with repeated measures were used to examine intra-group changes and compare between groups from pre-test to post-test using SPSS version 25 software. The results showed a significant increase in the level of serum COX2 (), and no significant increase in the level of serum PGE2 () and IL-6 () in the EE group compared to baseline levels. Also, there was a significant decrease in the level of serum PGE2 (), COX2 (), and IL-6 () in the group of GE + EE compared to baseline levels. In addition, there was a significant difference between the group of GE + EE and the EE (). GE + EE group, in comparison with the EE group, partially reduced inflammation. Taking 8-weeks of ginger supplementations can effectively reduce muscle inflammation following exhaustive exercise in female taekwondo athletes.

Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma

Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera Akkermansia (p < 0.001), Bacteroides (p = 0.018), and Ruminococcus (p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of Akkermansia and Bacteroides, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas.

Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of 27 randomized controlled trials.

Ginger consumption may have an inverse relationship with obesity and metabolic syndrome parameters; however, clinical trials have reported contradictory results. To systematically review and analyze randomized controlled trials (RCTs) assessing the effects of ginger on body weight and body composition parameters. Databases were searched for appropriate articles up to August 20, 2022. All selected RCTs investigated the impact of ginger on glycemic indices in adults. A random effects model was used to conduct a meta-analysis, and heterogeneity was assessed using the I2 statistic. Net changes in body weight, body mass index (BMI), waist circumference (WC), and percent body fat were used to calculate the effect size, which was reported as a weighted mean difference (WMD) and 95% confidence intervals (CIs). The risk of bias was assessed. A total of 27 RCTs involving 1309 participants were included. The certainty in the evidence was very low for WC and BMI, and low for body weight and percent body fat as assessed by the GRADE evidence profiles. The meta-analysis showed a significant association between ginger supplementation and a reduction in body weight (WMD, -1.52 kg; 95%CI, -2.37, -0.66; P < 0.001), BMI (WMD, -0.58 kg/m2; 95%CI, -0.87, -0.30; P < 0.001), WC (WMD, -1.04 cm; 95%CI: -1.93, -0.15; P = 0.021), and percent body fat consumption (WMD, -0.87%; 95%CI, -1.71, -0.03; P = 0.042). The results of the nonlinear dose-response analysis showed a significant association between the ginger dose with body weight (Pnonlinearity = 0.019) and WC (Pnonlinearity = 0.042). The effective dose of ginger intervention for body mass reduction was determined to be 2 g/d in dose-response analysis. The duration of ginger intervention had a significant nonlinear relationship with body weight (Pnonlinearity = 0.028) with an effective duration of longer than 8 weeks. Our findings provide evidence that ginger consumption may significantly affect body composition parameters nonlinearly. More, well-constructed RCTs are needed.

Ameliorative Potential of Ginger (Zingiber officinale) following Repeated Coexposure with Fluoride and Dimethoate in Blood and Brain of Wistar Rats

Coexposure to exogenous neurotoxins, such as fluoride (F−) and dimethoate (DM), is a serious public health concern. In the current study, Wistar rats were exposed to DM (1/10th LD50) and F− (4.5 ppm) in drinking water individually as well as in combination continuously for 28 days and the effectiveness of ginger and quercetin was assessed in combating the oxidative stress-mediated combined toxic effects on blood and brain. Significant (p&lt;0.05) reductions were observed in the levels of total antioxidant status (TAS), glutathione peroxidase (GPx), blood glutathione (GSH), activities of catalase (CAT), total thiols (TTH), superoxide dismutase (SOD), aryl esterase (AE), and acetylcholinesterase (AChE) whereas significant elevations (p&lt;0.05) in malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were recorded in blood and brain of coexposed rats. Administration of ginger and quercetin significantly (p&lt;0.05) ameliorated the combined F- and DM-induced hematotoxicity as well as neurotoxicity as indicated by the levels of markers of oxidative injury in brain and blood in coexposed rats, which showed significant (p&lt;0.05) improvement. Moreover, pathological changes, such as neurodegeneration, perivascular edema, and gliosis, observed after combined F− and DM toxicity in the brain (cerebrum and cerebellum) were markedly reduced after ginger supplementation.

An Evidence-Based Practice Project on the Use of Ginger to Manage Primary Dysmenorrhea

Dysmenorrhea is a highly prevalent gynecological symptom that is widely unreported and normalized. When a woman experiences severe menstrual pain without the presence of a pelvic disorder, the pain is categorized as primary dysmenorrhea. Ginger has analgesic and anti-inflammatory properties, which when utilized for primary dysmenorrhea, shows promise in reducing pain. A literature search was conducted using several databases and hand searching to find articles that supported the following question: In adult women with primary dysmenorrhea, how does the use of ginger, compared to not using ginger, affect pain? The databases Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Library (Cochrane Reviews), Nursing and Allied Health (ProQuest), and PubMed were included. Of the 153 articles identified, the following six articles were used for this project: two systematic reviews with meta-analyses, three randomized controlled trials, and one consensus statement. Each piece of evidence utilized the Visual Analog Scale to measure pain intensity, and all the mean pain scores were found to be significantly lower in women who used ginger supplementation. Ginger was used in different doses and for different durations in each of the pieces of evidence, however there was a significant positive relationship between ginger supplementation and reduction of pain in each article. This project identified that there is strong and compelling evidence to recommend using ginger supplementation to reduce pain.