The study investigated the influence of safety climate on safety performance among employees in a multi-national gold mining company in Ghana. Safety climate was conceptualized and measured in terms of employee perceptions of management value for safety, supervisor safety practices, safety communication, safety training and safety system. Safety performance was conceptualized and measured in terms of employee safety compliance and safety participation, that is, how they make suggestions to improve safety in the mining environment. Using a cross-sectional survey design, 235 workers in the mines completed questionnaires on safety climate and safety performance. Pearson correlations and multiple regression analysis of the data indicated positive relationship between safety climate and safety performance as predicted. Safety systems predicted both safety compliance and participation. Safety communication and supervisory practices predicted safety compliance and safety participation respectively. The results are discussed in the framework of the theories of reasoned action and planned behaviour.