Experimental data on the seismic response of a pile-group-supported structure was obtained through dynamic centrifuge model tests, and then used to evaluate a dynamic beam on a nonlinear Winkler foundation (BNWF) analysis method. The centrifuge tests included a structure supported on a group of nine piles founded in soft clay overlying dense sand. This structure was subjected to nine earthquake events with peak accelerations ranging from 0.02 to 0.7g. The centrifuge tests and dynamic analysis methods are described. Good agreement was obtained between calculated and recorded structural responses, including superstructure acceleration and displacement, pile cap acceleration and displacement, pile bending moment and axial load, and pile cap rotation. Representative examples of recorded and calculated behavior for the structure and soil profile are presented. Sensitivity of the dynamic BNWF analyses to the numerical model parameters and site response calculations are evaluated. These results provide experimental support for the use of dynamic BNWF analysis methods in seismic soil-pile-structure interaction problems involving pile-group systems.