A new Harris-AE feature matching algorithm based on image edge information combined with SLIC superpixel segmentation method is proposed to achieve high-precision registration of visible and infrared images. First, perform edge enhancement and histogram equalization processing on visible light and infrared images, superpixel segmentation technology is used to eliminate sub-images with low information entropy, and then by constructing a multi-scale Gaussian pyramid to detect the Harris corners of the image edge information, using autoencoder neural network to generate feature descriptors corresponding to feature points, and match the feature points of two images through the fast nearest-neighbor algorithm with bidirectional matching strategy. Finally, the RANSAC algorithm is used to purify the matching points, and the spatial geometric change parameters between the two images are estimated by the least-squares solution to complete the registration of visible light and infrared images. Experiments have proved that this algorithm improves the accuracy of matching while shortening the registration time.