Event Abstract Back to Event Functional supermolecular composites of silk fibroin/poly(3,4-ethylenedioxythiophene) and its applications: a multifunctional drug-embedded live-cell sensor for monitoring neuronal differentiation. Ta-Chung Liu1, San-Yuan Chen1 and Chao-Yi Chu1 1 National Chiao-Tung University, Material Science and Engineering, Taiwan Organic-inorganic composites synthesized by self-assembly supermolecular interactions are important for constructing biomimic materials in specific applications. Both structures and mechanical properties of silk fibroin with amphiphilic properties and variable charge can be tunable by pH values. Supermolecular mechanisms between silk fibroin and conductive polymer poly(3,4-ethylenedioxythiophene) are utilized to generate a new group of multifunctional biomimic materials. Here we have established a live-cell sensor for real-time monitoring of neural differentiation using this newly-developed conductive biomimic membrane by electrodeposition. This membrane displays highly biocompatible to neural cells and can recognize targeted cells specifically to allow intimate electrical communication over long periods of time. In addition, this membrane with neurotrophic factor trapped in hydrogels can be controllably released by electrically stimulation to enhance neurite outgrowth. Impressively, a further combination with this new biomaterial such as metal ions, enzymes, small molecule drugs, or even plasmid DNA by self-assembly interaction extends the versatility of this nanocomposite, providing a biodegradable, structural-controllable and charge-tunable biomaterial platform, thus rendering potential broad applications in specific neuroscience. Ministry of Science and Technology Keywords: Cell Differentiation, self-assembly, Biodegradable material Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Nano-structured materials for unique functions Citation: Liu T, Chen S and Chu C (2016). Functional supermolecular composites of silk fibroin/poly(3,4-ethylenedioxythiophene) and its applications: a multifunctional drug-embedded live-cell sensor for monitoring neuronal differentiation.. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02651 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ta-Chung Liu San-Yuan Chen Chao-Yi Chu Google Ta-Chung Liu San-Yuan Chen Chao-Yi Chu Google Scholar Ta-Chung Liu San-Yuan Chen Chao-Yi Chu PubMed Ta-Chung Liu San-Yuan Chen Chao-Yi Chu Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.