Objectives Superior restorative methods for effectively strengthening pulpless teeth need to be identified, since vertical root fractures of pulpless teeth are still a major problem in everyday clinical practice. The present study tested the null hypothesis that there were no differences in static and fatigue fracture resistances of pulpless teeth restored with different types of post–core systems. Methods Extracted human premolars were restored with a combination of either a fiber post or metallic post and a composite resin core. Teeth with full crown preparations without post–core restorations served as a control. A 90° vertical or 45° oblique static compressive load was applied to restored teeth, and fracture loads and modes of fracture were recorded. Fatigue fracture tests were conducted by applying sinusoidal cyclic loads to restored teeth from vertical or oblique directions. Fatigue limits for each restoration were calculated using the staircase approach. Results In both static and fatigue fracture testing under vertical or oblique loadings, the fracture loads of teeth restored with fiber posts were significantly greater than those of teeth restored with metallic posts. The fatigue limits of teeth restored with fiber and metallic posts were 112 kgf and 82 kgf respectively under vertical loadings and 26 kgf and 20 kgf under oblique loadings. Significance The combination of a fiber post and a composite resin core showed superior fracture resistance against both static and fatigue loadings compared to restorations using a metallic post, and is therefore recommended in restoring pulpless teeth.