High Temperature Superconducting (HTS) cables are emerging as the alternate to the conventional cables for power transmission and distribution due to their higher efficiency with fewer losses and robustness in handling large current densities with lower cross sectional area of the conductor. However, these cables encounter the AC losses due to Joules heating while carrying the transport current. In addition, these cables receive the heat loads from the ambient through the cable shield as heat intrusions. Hence, these cables are internally cooled with forced flow of LN2 to maintain the temperature of the superconductor below to its critical temperature. Due to the forced circulation of LN2 and heat loads, thermal and velocity gradients are developed in the HTS cables which accounts to entropy generation rate. The heat loads, frictional losses due to turbulent flow of LN2 in the corrugated former and entropy generation rate rises the temperature of LN2 above to its saturation temperature and boiling takes place. Hence, the current carrying capability of HTS tapes and the ability of electrical insulation of insulating layers in HTS cable will be reduced. To operate such cable efficiently for long length requires larger pump work for circulating LN2 between the terminations. Further, the losses in the pump work due to frictional entropy generation and losses in the heat transfer rate due to thermal entropy generation leads to quenching of HTS tapes and higher energy consumption thereby reduction in the efficiency of the HTS cable which is not advisable. Motivated by the challenges in reducing the pump work with higher cooling capacity, in this present work a novel method is proposed to estimate the loss contribution in thermohydraulic characteristics in HTS cables during the forced convective cooling at different heat loads.A computational domain is modeled, meshed and analyzed using commercial software ANSYS®. The analysis is carried out with time averaged Reynolds averaged Navier-Stokes (RANS) equations which are solved using Finite Volume Method (FVM) of discretization with κ−εturbulent scheme. In the present analysis, temperature dependent thermophysical properties of LN2 are considered at an operating temperature of 77 K and pressure of 2.7 bar. Further, the flow rates ranging from 11–20 L/min and the heat loads ranging from 1–3 W/m are considered to estimate the entropy generation rate and exergy destruction due to losses. The results obtained from the computational investigation are validated with the experimental results that are available in the literature. From the analysis, it is identified that higher the heat loads higher will be the entropy generation and exergy destruction. Further, the minimum exergy destruction is identified due to contributions of thermal and frictional losses. Furthermore, the exergy efficiency and irreversibility distribution ratio are estimated to identify the influence of thermal losses at different heat loads. It is observed that increase in the heat loads increases the thermal losses thereby contributing to lower efficiency of HTS cable.