In this paper, the ultimate bearing capacities of piles of a super high-rise dual-tower building structure in Guiyang were investigated. A stepwise test procedure was developed and carried out to obtain the pile capacity because of the limitation of experimental equipment and the complicate geological conditions. In the proposed procedure, the deep plate test, side friction test, and an in-situ test of full-scale pile were all carried out in the same hole in sequence. The equipment and procedure of the stepwise test are described in details. The test results are meaningful to provide reference values for investigating mechanical behaviour of pile and statistical analysis of pile capacity in the typical karst geology of Guizhou province. Since such a large-scale field test in Guizhou is limited, some recommendation values are also given to engineers for the pile foundation design in this district.