Super-aged Society Research Articles

Integrating the Public Health Services Model into Age-Friendly Pharmacies: A Case Study on the Pharmacies in Taiwan

Taiwan is expected to become a superaged society by 2026. Community pharmacies have recently joined Taiwan’s primary care system; they have great potential to provide professional healthcare services. This study examined whether the services provided by community pharmacists enhance medication adherence, enable the identification and solution of drug therapy problems, and are accepted by community residents. The Department of Public Health, Taoyuan City, collaborated with the Taoyuan Pharmacist Association over 11 months in 2018 in enabling pharmacists to dispense prescriptions and provide medication adherence consultations, cognitive services, and home and institutional medical care services. This study designed four satisfaction questionnaires to assess the feasibility and performance of these services. Regarding the services related to medication knowledge and adherence, 92.10% of the patients reported overall satisfaction, and all understanding and ability scores were improved in more than 95% of patients. The number of patients highly cooperative regarding their medication had risen from 14 to 234 after the intervention, and the number with low medication adherence had dropped from 533 to 33. More than 90% of respondents indicated that the institutional medical care services had significantly improved their medication knowledge and behaviors. The feasibility of the incorporation of integrated the public health services model into age-friendly pharmacies was confirmed by this study.

Consideration factors of older adults seeking medical treatment at outpatient services in Taiwan

BackgroundTaiwan will become a super-aged society by 2025, leading to the more frequent use of outpatient services by older adults for medical treatment compared with other age groups. Understanding the outpatient service consideration factors of older adults seeking medical treatment can improve health care quality. This study explored the selection factors and crucial considerations of older adults for outpatient services.MethodsQualitative study was conducted. Purposive sampling was used to recruit 16 older adults over 65 years of age with chronic disease who were patients of an internal medicine department and regularly returned for checkups. Data including reasons for receiving medical treatment, factors affecting their choice of hospitals, and health care and environmental considerations were collected through structured interviews.ResultsThe older adults identified four factors. (1) The care of doctors: The doctors possessed professional skill, allocate sufficient consultation time, and undertake effective communication. (2) The care of other medical professionals: Other medical professionals provided services in a cordial manner. (3) The accessibility and convenience of outpatient services: Convenient transportation and registration as well as short consultation wait time. (4) Environment and equipment: The hospital had the novel facilities and satisfactory barrier-free equipment.ConclusionsThe older adults cared most about the adequacy of diagnosis and treatment by doctors and other medical professionals. In addition, they reported having higher satisfaction with hospitals that provide comprehensive medical facilities, fast and convenient medical procedures, and short wait times.

How to Treat Osteoporotic Vertebral Fracture?

In very elderly patients with low back pain, we must consider the possibility of osteoporotic vertebral fracture (OVF). In most patients with OVF, improvement can be observed without surgical intervention. However, even after providing the best possible conservative treatment, symptom recovery is not observed in some patients, and such patients experience delayed neurological deficits due to neural compression with the proceeding deformity of the vertebral body. Moreover, it is well known that once patients have OVF, the risk of another osteoporotic fracture in them increases. The clinical course of such patients eventually results in the loss of healthy life and increased mortality. Therefore, we should initiate medical treatment for osteoporosis at the earliest possible when OVF is detected in a patient. Patients who remain symptomatic even after undergoing adequate conservative therapy are candidates for balloon kyphoplasty. However, this minimally invasive surgery has some pitfalls. Furthermore, occasionally, we have to select instrumentation surgery for patients with delayed neurological deficits. In this "super-aged society," neurosurgeons also encounter patients with OVF not only in surgical situations but also in outpatient clinics. Thus, we should be aware about the clinical options for the management of osteoporosis.

Facilitators and barriers to physicians' entrepreneurial ventures in major Japanese cities: A qualitative study.

BackgroundThe Japanese healthcare system currently faces numerous challenges, including a super-aging society and an excessive burden on medical workers; therefore, the need for innovative solutions from healthcare ventures to tackle these issues has increased. Meanwhile, as physicians play important roles in healthcare ventures, the need for Japanese physician entrepreneurs is more important than ever. Given the lack of research examining barriers to physicians starting ventures and what skills, knowledge, and surrounding environments act as facilitators, this study aimed to identify the facilitators and barriers faced by physicians to start ventures.MethodsBetween September and November 2019 and in May 2021, qualitative interviews were conducted with 33 participants, which included eight physician entrepreneurs; two administrative officers at the Ministry of Health, Labour and Welfare and the Ministry of Economy, Trade and Industry; three faculty members at Tokyo Medical and Dental University (in-depth interviews); and 20 medical students (focus group discussions). The interviews were deductively coded based on the social ecological model. The inductive approach was applied to coding any knowledge necessary to start a business. We conducted member checking with three physician entrepreneurs and seven medical students to improve our results’ credibility.ResultsThe factors influencing a physician’s decision to launch a new business include their willingness to contribute to society, the unique environment in which an individual is placed while in medical school and afterward, negative aspects of the lack of diversity in physicians’ careers, the financial stability provided by a medical license, and self-efficacy.ConclusionsOur study revealed facilitators and barriers to physicians’ entrepreneurial ventures. Knowledge about these factors might be useful in supporting physicians to launch or become involved in healthcare ventures.

Undergraduate geriatric education in foreign countries

In Japan, which has become a super-aged society, medical care for the elderly is more important than ever before. Geriatric education for medical students and young doctors is essential to ensure the best medical care possible for the elderly. In this paper, the Working Group for Education of the Japan Geriatrics Society collected and analyzed data and information on undergraduate education in the fields of geriatrics and gerontology at medical schools in various countries through the Internet, comparing the findings with those in Japan. Of the countries surveyed, 62% had undergraduate education in geriatrics and gerontology as mandatory subjects in medical school. Countries with advanced welfare programs, such as the United Kingdom, Germany, Austria, Denmark, Finland, Sweden, the Netherlands, Spain, Canada and New Zealand, performed substantial undergraduate education in geriatrics and gerontology. A lack of available staff and time for education was cited as a hurdle in many countries. The importance of education in geriatrics and gerontology is being emphasized in many countries, but few programs are satisfactory at present. The "struggle" to improve undergraduate education in geriatrics and gerontology therefore continues. We should endeavor to improve education in the fields of geriatrics and gerontology by working hand in hand with geriatricians and gerontologists around the world.

Association between mild cognitive impairment and lumbar degenerative disease in a Japanese community: A cross-sectional study.

Lumbar degenerative disease and dementia are increasing in super-aging societies and are both related to physical dysfunction and pain. However, the relationship between these diseases remains unclear. This cross-sectional study aimed to investigate the comorbidity rates of lumbar spinal canal stenosis (LSS) and mild cognitive impairment (MCI) and clarify the association between LSS presence, lumbar symptoms, and quality of life (QOL) related to low back pain and cognitive impairment in the Japanese population. We enrolled 336 participants (men 124; women 212; mean age 72.2 years) from a medical checkup program. LSS was diagnosed using a self-administered questionnaire, and lumbar symptoms were evaluated using the visual analog scale (low back pain, and pain and numbness of the lower limb). QOL related to low back pain was evaluated using the Japanese Orthopedic Association Back-Pain Evaluation Questionnaire (JOABPEQ: pain, and lumbar, and gait function). Radiological lumbar degeneration was classified using Kellgren-Lawrence grading and lateral radiographs of the lumbar spine. Cognitive function was measured using the Mini Mental State Examination (MMSE), and MCI was defined by a summary score of MMSE ≤27. Logistic and multiple linear regression analyses were performed to analyze the association between MCI, summary score of MMSE, and lumbar degenerative disease. The comorbidity rate of MCI and LSS was 2.1%, and the rate of MCI was 41% in participants with LSS. Lumbar function in JOABPEQ was associated with MCI. The presence of LSS and lumbar function in JOABPEQ were associated with MMSE. Over one-third of the people with LSS had MCI. The presence of LSS and deterioration of QOL due to low back pain were related to cognitive impairment. We recommend evaluating cognitive function for patients with LSS because the rate of MCI was high in LSS participants.

Preventive and Ameliorating Effects of Food Factors on Obesity-related Diseases by Regulating Inflammation

Japan is currently a super-aging society, and lifestyle-related diseases that increase in incidence with age and the related rise in national medical expenses are major social problems. Preventive medicine and self-medication are becoming more important. Recently, various in vitro and in vivo studies have shown that food-derived natural compounds may contribute to the prevention and treatment of obesity-related diseases, such as diabetes mellitus. This report reviews our previous studies on the usefulness of the citrus flavonoid naringenin for obesity-related diseases. We showed that naringenin exerts an anti-diabetic effect by regulating inflammation pathways involving adipocytes and adipose tissue, and also showed an interaction between naringenin and anti-diabetic drugs. Because natural compounds are generally inexpensive and safe, they have the advantage of being easily applied to clinical applications. However, more detailed studies, such as clinical trials in humans, are required. Further research and scientific evidence will be required for the proper use of food factors in disease prevention and treatment.

Vertebral Body Bruise Resulting in Vertebral Wedging

The patient was a 77-year-old man whose head and back impacted the ground after falling from a stepladder. On arrival, plain roentgenography and whole body computed tomography failed to depict a responsible spinal lesion. As he could walk, his wound was sutured and he was discharged to home. However, on the following day, he was unable to stand due to severe back pain. Urgent magnetic resonance image (MRI) revealed a high-intensity signal in the 12th thoracic vertebral body without compressive deformity. Follow-up roentgenography at 10 days showed compressive change at the 12th thoracic vertebral body; thus, a corset was applied at the thoracolumbar position. Final lumbar roentgenography at 6 months revealed compression of the thoracic vertebral body. In the present case an elderly patient, who initially showed a bone bruise, showed delayed compressive changes in the thoracic vertebral body. In our super-aging society, further studies are required to investigate the natural history of vertebral body bruises in elderly individuals.

Incidence Rate of Acute Coronary Syndrome Including Acute Myocardial Infarction, Unstable Angina, and Sudden Cardiac Death in Nobeoka City for the Super-Aged Society of Japan.

This study aimed to calculate incidence rates (IR) of acute coronary syndrome (ACS) including acute myocardial infarction (AMI), unstable angina (UAP), and sudden cardiac death (SCD) in Nobeoka city, Japan.Methods and Results:This was an observational study based on a city-wide comprehensive registration between 2015 and 2017 in Nobeoka city, Japan, using 2 databases: all patients with cardiogenic out-of-hospital cardiac arrest in Nobeoka city and hospitalized ACS patients from Miyazaki Prefectural Nobeoka Hospital in which all ACS patients in Nobeoka city were hospitalized except for possible rare cases of patients highly unlikely to be hospitalized elsewhere. The IRs of ACS based on the population size of Nobeoka city (125,000 persons), and their age-adjusted IRs by using the direct method and the 2015 model population of Japan were calculated. There were 260 eligible patients hospitalized with first-onset ACS (age [SD]=71.1 [12.4], 34.2% women) and 107 eligible SCD patients. Crude IRs of hospitalized ACS and SCD patients, and hospitalized AMI and SCD patients, respectively, were 130.2 (183.3 for men, 85.6 for women) and 107.5 (148.4 for men, 73.2 for women) per 100,000. Crude IRs of hospitalized ACS, AMI, and UAP patients, respectively, were 92.3 (132.8 for men, 58.1 for women), 69.6 (97.9 for men, 45.7 for women), and 22.7 (35.0 for men, 12.4 for women) per 100,000. The calculated IRs can be useful in building a health strategy for treating ACS.

Disuse muscle atrophy-improving effect of ninjin'yoeito in a mouse model

Disuse syndrome indicates psychosomatic hypofunction caused by excess rest and motionless and muscle atrophy is termed disuse muscle atrophy. Disuse muscle atrophy-induced muscle weakness and hypoactivity further induces muscle atrophy, leading to a vicious cycle, and this is considered a factor causing secondary sarcopenia and subsequently frailty. Since frailty finally leads to a bedridden state requiring nursing, in facing a super-aging society, intervention for a risk factor of frailty, disuse muscle atrophy, is important. However, the main treatment of disuse muscle atrophy is physical therapy and there are fewer effective preventive and therapeutic drugs. The objective of this study was to search for Kampo medicine with a disuse muscle atrophy-improving effect. Ninjin'yoeito is classified as a qi-blood sohozai (dual supplement) in Chinese herbal medicine, and it has an action supplementing the spleen related to muscle. In addition, improvement of muscle mass and muscle weakness by ninjin'yoeito in a clinical study has been reported. In this study, the effect of ninjin'yoeito on disuse muscle atrophy was investigated.A disuse muscle atrophy model was prepared using male ICR mice. After surgery applying a ring for tail suspension, a 1-week recovery period was set. Ninjin'yoeito was administered by mixing it in the diet for 1 week after the recovery period, followed by tail suspension for 14 days. Ninjin'yoeito administration was continued until autopsy including the hindlimb suspension period. The mice were euthanized and autopsied immediately after completion of tail suspension, and the hindlimb muscles were collected. The food and water intakes during the hindlimb unloaded period, wet weight of the collected muscle, and muscle synthesis and muscle degradation-related factors in blood and muscle were evaluated.Ingestion of ninjin'yoeito inhibited tail suspension-induced reduction of the soleus muscle wet weight. In addition, an increase in the blood level of a muscle synthesis-related factor, IGF-1, and promotion of phosphorylation of mTOR and 4E-BP1 in the soleus muscle were observed.It was suggested that ninjin'yoeito has a disuse muscle atrophy-improving action. Promotion of the muscle synthesis pathway was considered the action mechanism of this.

Understanding of sarcopenia: from definition to therapeutic strategies.

Sarcopenia refers to the gradual loss of skeletal muscle mass and function along with aging and is a social burden due to growing healthcare cost associated with a super-aging society. Therefore, researchers have established guidelines and tests to diagnose sarcopenia. Several studies have been conducted actively to reveal the cause of sarcopenia and find an economic therapy to improve the quality of life in elderly individuals. Sarcopenia is caused by multiple factors such as reduced regenerative capacity, imbalance in protein turnover, alteration of fat and fibrotic composition in muscle, increased reactive oxygen species, dysfunction of mitochondria and increased inflammation. Based on these mechanisms, nonpharmacological and pharmacological strategies have been developed to prevent and treat sarcopenia. Although several studies are currently in progress, no treatment is available yet. This review presents the definition of sarcopenia and summarizes recent understanding on the detailed mechanisms, diagnostic criteria, and strategies for prevention and treatment.

Hypertension Prevalence Rates Among Urban and Rural Older Adults of China, 1991-2015: A Standardization and Decomposition Analysis.

Objectives: The prevalence of hypertension (HTN) among older adults is becoming an important issue in public health in China as it is now stepping into the super-aged society with high pressure of a chronic disease burden. With urban–rural differences in population composition and health facilities, this study aimed to assess the gaps in the prevalence trends of HTN among older adults by considering demographic factors such as age, gender, education level, and regional differences during 1991–2015 in China.Methods: We adopted the consistent sampling design and measure of HTN of the cross-longitudinal surveys of the China Health and Nutrition survey, and we compared the HTN prevalence rates between urban and rural older adults by taking each wave of the survey as a cross-sectional sample of the Chinese population by the following and supplementary samples. The classic standardization and decomposition analysis method was utilized with four factor-specific rates, and contributions were calculated, i.e., age, gender, education, and region, which reflects the aspect of demographic and social development differences between urban and rural areas of China.Results: The prevalence rates of HTN of the whole of older adults were increasing in 1991–2015. However, the gaps of prevalence rates of HTN between urban and rural areas show different trends accompanied by the health policies launched by the government. Namely, the gap was narrowed during 1993–1997 and then enlarged during 1997–2011 and narrowing again. Those trends reflect the policy effects with the health resource allocation and utilization of health services for urban and rural older adults.Conclusions: With the four factors of decomposition analysis, the differences reflect the results of health policy effects, considering the urban–rural discrepancy on older adults with different demographic characteristics. Hence, the differentiated policies should be considered with the urban–rural population, such as HTN prevention and the population health promotion.

Prevalence and Related Factors of Low Back Pain in the General Elderly Population: A Japanese Cross-Sectional Study Randomly Sampled from a Basic Resident Registry.

Low back pain (LBP) is one of the main etiologies of disability in daily life. In the face of LBP increases in super-aged societies, there are serious concerns of escalating medical costs and deteriorations in the social economy. It is therefore important to identify the factors associated with LBP for prompt preventative and therapeutic measures. This study investigated the prevalence of LBP and the impact of subject-specific factors on LBP development in Japanese community-dwelling older adults. We established eight groups based on age (50’s, 60’s, 70’s, and 80’s) and gender after random sampling from a resident registry. A total of 411 participants (201 male and 210 female) were enrolled for a whole-spine lateral radiographic examination and dual-energy X-ray absorptiometry. All subjects were evaluated for the presence and degree of LBP. We analyzed the impact of clinical factors on LBP using multivariate analysis. Fifty-three (12.9%) participants (23 (11.4%) male and 30 (14.3%) female) were found to have LBP. The prevalence of LBP tended to increase with age, and similar results were found between genders. In univariate analysis, the subject-related factors of the sagittal vertebral axis, pelvic incidence minus lumbar lordosis (PI-LL) mismatch, and aging had significant associations with LBP. PI-LL mismatch was a significant independent factor in multivariate analysis. In conclusion, this study identified LBP prevalence and subject-specific factors on a general population basis. Multivariate analysis revealed PI-LL mismatch as an independent factor associated with LBP in the healthy community-dwelling elderly.

Dealing with Patients with Traumatic Brain Injury Receiving Antithrombotic Drugs

More than half of the patients with severe head injuries are elderly people in Japan due to the impact of entering a super-aging society. Elderly people take antithrombotic drugs at a high rate. According to the Japan Neurotrauma Data Bank, many patients with head injuries taking antithrombotic drugs sustain falls, indicating an increased risk of deterioration due to low-energy trauma. It has also been pointed out that many hemorrhagic lesions occur due to the effects of antithrombotic drugs, and there is a risk that hematoma will increase later. As an appropriate response in such patients, if bleeding findings are noted on head CT, discontinuation/reversal of antithrombotic drugs should be considered even if the severity is mild. Reversal therapy should be performed in an appropriate manner as quickly and reliably as possible. Some effects of reversal therapy have been reported in small-scale observational studies. Discontinued antithrombotic drugs should be resumed in the neurotrauma subacute phase. Resuming antithrombotic drugs reduces the risk of ischemic complications, but increases the risk of bleeding complications. To summarize, the benefits of resuming antithrombotic drugs have been reported, and it is recommended that antithrombotic drugs be resumed 3-10 days after injury.

A Library of Old Photos Supporting Conversation of Two Generations Serving Reminiscence Therapy.

In Japan, a shift in family patterns has led to a sense of social isolation among older people, which increases the risk of major neurocognitive disorder. Interventions for them using old photos to implement reminiscence therapy (RT) have been proved to be effective. A super-aged society has in turn led to a shortage of medical resources and older people prefer home care over institutional care. Therefore, there is an urgent need for volunteers to help in RT. However, the age of volunteers tends to be increasingly younger. The lack of knowledge and experience of the past for the young volunteers makes it difficult for them to select appropriate stimulated materials. To improve this situation, a library of old photos for RT was developed to support conversation between the two generations. A two-factor experiment and emotion assessment scales were designed to explore the effect of different old photo types on the fluency of conversation between the two generations and their emotion. It was found that the types of old photos have little effect on older people and that conversations were almost pleasant. However, the pleasantness of older people was enhanced when using photos that they wanted to talk about (P = 0.006). Meanwhile, pleasure in conversation of the older people increased with the attention of the young people to the topic (R = 0.304, p < 0.001). Conversely, photo type has a strong impact on young people. When photos are selected that older people do not want to talk about or photos that young people do not know the content and are not interested in, concern for the topic of young people drops dramatically. Therefore, when RT, it is important to avoid using the types of photos above that cause a drop in younger people's attention.

Health Promotion for Older Population in Japan: Importance of Preventive Care and Successful Assisted Living

Japan will face a super-aged society in the near future, in which 40% of the population will be over 65 years of age. However, prolongation of life expectancy is inevitably associated with greater numbers of frail old people who need help or assistance in their daily activities. The percentage of the old-old population in 2020, comprising more frail people compared with the young-old population, exceeded 14% of the total population in Japan. In such a situation, many older Japanese wish to be healthy for their entire life and continue to live in their hometown with a sense of security until the end of their life. Under such circumstances, we should establish a society in which old people can enjoy a healthy, satisfying life through social participation and contribution. In this review article, we discuss about the importance of preventive care and successful assisted living in health promotion policy for older population in Japan, a superaged country.

Gender disparity in the individual attitude toward longevity among Japanese population: Findings from a national survey.

The unprecedented population aging brings profound influences to the social values of longevity. The individual attitudes toward the expended life time deserves scrutiny, as it reflects the impacts of social networks and social welfare on people's life and wellbeing. This study aims to examine whether and how gender disparity is affecting the individual anticipation to longevity among Japanese citizen. We used the dataset of National Survey on Social Security and Peoples Life implemented in 2017 to calculate the odds ratios (OR) of the individual anticipation to longevity. Besides gender, other demographic characteristics, physical and mental health, the experience of nursing care for the elderly, financial conditions and social networks are examined by performing the multilevel mixed-effects logistic regression analysis. The results indicate the robust effects of gender disparity on the individual aspiration for longevity. The proportion of those who inclined the positive statement on longevity was estimated to be 69.7% (95% CI: 68.6% - 70.9%) in the whole population, and 70.9% (95% CI: 69.4% - 72.5%) and 68.7% (95% CI: 67.1% - 70.2%) in male and female, respectively. Besides gender, independent factors significantly affecting the individual valuation of longevity include age, annual household income, the experience of nursing care, household saving, having a conversation with others and the availability of reliable partner(s) for relevant supports; while the common factors affecting the outcome variable were self-perceived health status and mental distress measured by K6. The interaction of gender and these significant factors were determined as well. In conclusion, with relevant representativeness and quality of data source, this analysis adds knowledge on gender disparity in the individual anticipation on longevity. The findings are suggestive to reform the social security system in the super aged society.

Factors of professional caregivers' intention to work: A qualitative study

Objectives The shortage of professional caregivers is a critical issue in care facilities, which are a key social resource in the community-based integrated care system for Japan's super-aging society. However, professional caregivers report a high intention to continue working. This study aims to reveal the factors surrounding working intentions among professional caregivers, from a positive perspective, using a qualitative design.Methods A qualitative design, based on a content analysis approach, was used in this study. From August to November 2018, semi-structured joint interviews, using the interview guide, were conducted with 14 experienced professional caregivers working in 11 care facilities for the elderly in Japan. The participants were paired, or grouped, into three groups and were interviewed. The interviews, recorded with participant approval and transcribed in their entirety, were analyzed. The researchers identified and categorized common themes emerging from the participants' responses to each question as codes. We raised the abstraction level of the codes into subcategories, and subcategories to categories. Approval was obtained from the Institutional Ethics Committee of Setsunan University (No. 2018-018).Results The average age of the participants was 35.0±6.45 years. Three categories, consisting of nine sub-categories across 27 codes, emerged as the main themes. The first was 'attachment to care work for older adults,' which consisted of three sub-categories, which included "love of and enjoyment in dealing with older adults." The second was 'cohesion in the workplace and linkage inside and outside the workplace,' which consisted of sub-categories, such as "cohesion of rational workplace members." The final category was 'supportive workplace management and human resource development from an on-site perspective,' which consisted of sub-categories, including "psychological rewards and support from superiors." These findings revealed that attachment to care work for older adults and the work environment influencing attachment are important factors concerning their work intentions.Conclusion We found that 'attachment to care work for older adults,' 'cohesion in the workplace and linkage inside and outside the workplace,' and 'supportive workplace management and human resource development from an on-site perspective' were factors that affect the work intentions of professional caregivers. The findings suggest that encouraging professional caregivers to continue working, using measures that foster attachment to work, and which develop their work environment, such as cohesion and linkage based on human relationships, are required.

Toward the development of a vibrant, super-aged society: The future of medicine and society in Japan.

Toward the development of a vibrant, super-aged society: The future of medicine and society in Japan.

Geriatrics Fact Sheet in Korea 2021.

South Korea became an aged society in 2017 and is predicted to become a super-aged society by 2025. Therefore, knowing the trends among older adults and identifying the geriatric burden are crucial for both healthcare professionals and policymakers. We previously summarized the general health and socioeconomic profiles of Korean older adults from the 2017 National Survey of Living Conditions and Welfare Needs of Older Koreans. In this update, we briefly summarized the results of the 2020 National Survey of Living Conditions and Welfare Needs of Older Koreans by categorizing them according to their general aging profile, socioeconomic status, lifestyle, and health status. In addition, we reviewed recent updates in the field of frailty and sarcopenia from population-based community cohorts in Korea. We hope this study will serve as a current reference for nationwide statistical data on common clinical and social parameters used in geriatrics and gerontology.