Abstract For decades, the arithmetic average (AA or R a ) and root sum of squares (RSS or R q ) have been the two major surface roughness measures to define a broad range of surfaces for a mechanical product. A number of drawbacks have been identified in recent years with the above measures. To map more scientifically and closely the surface roughness to the product functions and performances, ISO 13565 has defined a different set of measures, including R k , R pk , R vk , M r1 , and M r2 . This has not only made process planning different and much more difficult, but also made modeling of the relationship between these roughness measures and the machining parameters a multiple-input and multiple-output problem. While some companies are trying the traditional trial-and-error method to implement the ISO 13565 standard, this study applies artificial neural networks to develop an empirical model for the honing process of engine cylinder liners in order to help reduce emissions, improve oil efficiency, and prolong engine life. Threefold cross-validation is applied to develop the models. Hypothesis testing and the prediction error statistics are employed to select the best model. Data from industrial experiments based on fractional factorial design will illustrate th goodness of the modeling approach and the models.