This article thematizes the qualitative estimation of transmission dynamics of Dengue fever. At first, a single-compartment vector-host model for the total infective cases in one homogeneous area has been set up and simplified using a steady-state approximation. Seasonality has been considered in the transmission parameter which is modelled by a Fourier sum. The equilibria of the model and their stability as well as the computation of the basic reproductive number are presented. As a modification, models considering a segmenting of the area in separate districts and their inter-district mobility have been set up, both with and without dependence of the disease transmission parameters on the district. Those have also been analysed in terms of equilibria and stability. Parameter estimation on available Dengue data from Jakarta in the time interval of 2008–2016 using the Metropolis algorithm has been done. $${\mathscr {L}}_1$$ and $${\mathscr {L}}_2$$ comparisons show that using the multi-patch model with district-dependent parameters a decent approximation to the infection data is possible.