Spatiotemporal variations of Chinese Loess Plateau vegetation cover during 1981-2006 have been investigated using GIMMS and SPOT VGT NDVI data and the cause of vegetation cover changes has been analyzed, considering the climate changes and human activities. Vegetation cover changes on the Loess Plateau have experienced four stages as follows: (1) vegetation cover showed a continued increasing phase during 1981-1989; (2) vegetation cover changes came into a relative steady phase with small fluctuations during 1990-1998; (3) vegetation cover declined rapidly during 1999-2001; and (4) vegetation cover increased rapidly during 2002-2006. The vegetation cover changes of the Loess Plateau show a notable spatial difference. The vegetation cover has obviously increased in the Inner Mongolia and Ningxia plain along the Yellow River and the ecological rehabilitated region of Ordos Plateau, however the vegetation cover evidently decreased in the hilly and gully areas of Loess Plateau, Liupan Mountains region and the northern hillside of Qinling Mountains. The response of NDVI to climate changes varied with different vegetation types. NDVI of sandy land vegetation, grassland and cultivated land show a significant increasing trend, but forest shows a decreasing trend. The results obtained in this study show that the spatiotemporal variations of vegetation cover are the outcome of climate changes and human activities. Temperature is a control factor of the seasonal change of vegetation growth. The increased temperature makes soil drier and unfavors vegetation growth in summer, but it favors vegetation growth in spring and autumn because of a longer growing period. There is a significant correlation between vegetation cover and precipitation and thus, the change in precipitation is an important factor for vegetation variation. The improved agricultural production has resulted in an increase of NDVI in the farmland, and the implementation of large-scale vegetation construction has led to some beneficial effect in ecology.