Abstract Introduction Anecdotally, patients with cardiovascular and neurological medical conditions present with sleep disturbances in duration, efficiency, and timing, or with sleep disorders such as obstructive sleep apnea. The frequency of such disturbances remains unknown as does whether they result from cardiovascular and neurological conditions or contribute to the development of these conditions. Thus, characterizing the prevalence of sleep disturbances in this unique clinical population is a first step to establishing the important role of sufficient, healthy sleep for patient care and treatment. Methods We conducted a retrospective electronic chart review of patients from the Rush Heart Center for Women (RHCW) based on the following: age, sex, race, body mass index (BMI), blood pressure (BP), sleep studies, cardiac testing, and neurologic testing. Patients were also characterized based on prevalent disease (cardiac, neurologic, or both) including the following: cardiac—coronary artery disease, ischemic vs. non-ischemic heart disease, atrial fibrillation, heart failure, etc; neurologic—vascular etiology, mild cognitive impairment, dementia, Alzheimer’s Disease, etc. We then performed a database search to identify patients who also met the criteria for sleep apnea or for whom a sleep study was ordered due to sleep disturbances. Results 103 patients (mean age±SD, 68.71±12.55 years; 78 females; mean BMI±SD, 28.65±5.28; 79 White, 14 African American, 4 Asian, 1 Native Hawaiian, 5 Other; mean BP±SD, 128/72±20/9; mean±SD Mini-Mental State Examination (MMSE), 27.47±3.24) had cardiovascular and/or neurological conditions. Of these, 53 patients (mean age±SD, 68.31±9.35 years; 40 females; mean BMI±SD, 29.91±5.73; 39 White, 7 African American, 2 Asian, 1 Native Hawaiian, 4 Other; mean BP±SD, 129/73±21/9; mean MMSE±SD, 27.67±2.99) also presented with sleep apnea symptoms or sleep disturbances. Conclusion A strikingly high percentage (51.5%) of patients at the RHWC who had cardiovascular and/or neurological conditions also presented with sleep apnea or sleep disturbance symptoms. The prevalence of this trifecta of disease (cardiovascular, neurological, and sleep apnea/disturbance) demonstrates the criticality of considering the interplay between these various domains when administering clinical care to patients. Future research capitalizing on the physiological and neurobehavioral benefits of adequate, healthy sleep in this population is warranted. Support (If Any) RMC Dean’s Award Summer Research Fellowship; NASA NNX14AN49G and 80NSSC20K0243; NIH R01DK117488