Sum Of Effects Research Articles

Минимально допустимый расход наружного воздуха для удаления из помещения веществ с учетом эффекта суммации вредного действия

For the first time it was proposed when assessing safety of the air environment by the sum of relative concentrations of the harmful substances with the effect of summation of action, to consider not only the substances emitted in the room, but also other substances entering the room only with the supply air. To calculate minimum allowable intake air flow rate L, which ensures safety of the substances with the summation of the action, the formula is proposed, which is obtained by jointly solving the air safety conditions, and the dependences of the concentrations of harmful substances in the working area on the air flow rate, its contamination, and other factors. The example of an illustrative calculation of the minimum allowable intake air flow rate for three substances with a summation of the harmful effect is given. Of these, the first two substances are released in the room and come with the supply air, and the third substance enters the room only with the supply air. It is shown that when the air flow rate is found, the sum of the relative concentrations of three substances in the room is equal to one, that is, the safety condition is met at the limit. At the same time considering the substance in the supply air, which was not released in the room, required (in the example considered) an increase in the air consumption L by 20 %. Similar calculations L were performed based on the method of SP 60.13330.2020, according to which, when several harmful substances with the effect of summation of action are released in the room, the air exchange L should be determined by the sum of the air consumption Lв calculated for each substance. It was established that the expenses found by this method turned out to be 20–30 % less safe, therefore, they are not correct and do not ensure safety. The new method for calculating L, described in the article, is proposed to be considered in the regulatory documents.

The COVID-19 incidence in Italian regions correlates with low temperature, mobility and PM10 pollution but lethality only with low temperature.

Background: The aim was to verify whether the density of particulate matter (PM10), the climate, and the mobility of people can influence the pandemic in the 19 regions and in the two autonomous Italian provinces as incidence rate and lethality.Design and Methods: The incidence rates per 100,000 inhabitants and the case fatality ratio (CFR) (dependent variables) in all Italian regions were calculated in January 2021 at John Hopkins University Coronavirus Center. The independent variables were: Minimum average temperatures in the same month (January) of 2020; average pollution of PM10 in the air in each region in the last year available reported on a 0-10 scale to 0 = total absence of PM10 to 10 maximum pollutions; number of places in hotels occupied per inhabitants in 2020. Linear regression and Multiple Regression Analysis were carried out.Results: The spread of the COVID-19 in the Italian regions seems to be related to pollution of PM10, the number of beds occupied in hotels (as an index of mobility and temperature (indirect correlation). On the contrary, the CFR correlates inversely with temperature but not with pollution. Measuring the concomitant effect of two independent variables by means of Multiple Regression Analysis, temperature and pollution show a synergistic effect on COVID-19 incidence.Conclusions: The study seems to confirm the literature on the influence of temperature on the lethality of COVID-19 but adds the new results of an inverse relationship between the spread of the virus and low temperature in regions between the Mediterranean area (which includes southern Italy and Sicily and Sardinia islands) and the cold European temperate zone which includes the northern regions under the Alps. A new date also concerns the summation effect of the risk between cold weather and PM10 air pollution was found. Due to several methodic weakness the study has an exploratory than conclusive relevance. Significance for public health This paper has an exploratory value because a homogeneous population is taken into account. Presented results that basically contain the combined effect of cold climate (and pollution by PM10) on COVID-19 must be confirmed.

Transcriptional effects of binary combinations of PFAS in FaO cells

Per- and polyfluoroalkyl substances (PFAS) represent a large class of structurally diverse chemicals of increasing public concern, mostly due to their chemical stability and undetermined toxicity profiles. In laboratory animals, adverse effects implicated for certain PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in particular, include liver toxicity and the associated metabolic dysregulation, immune and thyroid alterations, reproductive toxicity, and selected tumors. The broad commercialization and environmental distribution of PFAS has drawn attention to the need for understanding risks associated with combined exposure to multiple PFAS in complex mixtures. The purpose of this investigation is to determine whether binary combinations of PFAS elicit a molecular response that is either greater than or less than the sum of the individual responses. Exposure of FaO rat hepatoma cells for 24 h to 25 μM–200 μM of the 4- and 8-carbon perfluorocarboxylic acids (PFBA and PFOA) or the 4, 6, and 8-carbon perfluorosulfonic acids (PFBS, PFHxS, and PFOS, respectively) individually caused a dose-dependent increase in PPARα-regulated expression of peroxisomal bifunctional enzyme (Ehhadh). Potency increased with carbon number, with the carboxylates eliciting a greater transcriptional response than the corresponding sulfonates. Combined exposure to PFOA and PFBA produced an effect that was significantly less than the sum of the individual responses. The response to the combination of PFOA and PFOS produced a summative effect at concentrations that were not cytotoxic. Combined exposures to PFOS and either PFBS or PFHxS at low noncytotoxic concentrations produced a transcriptional effect that was significantly less than the sum of the individual effects. The results demonstrate that among the five structurally related perfluoroalkyl acids included in this investigation, PPARα transcriptional activation in response to combined binary exposures is consistently at or below that predicted by the sum of the individual effects.

Lower Internal Additive Noise and Better Perceptual Template Characterize Binocular Contrast Sensitivity Summation.

Binocular summation is generally defined as the superiority of binocular over monocular performance. Here, we investigated how external noise modulates the effect of binocular summation on the contrast sensitivity function (CSF) and clarified the corresponding mechanisms with a perceptual template model (PTM). The contrast sensitivity (CS) over 10 spatial frequencies and three external noise levels was assessed under one binocular and two monocular viewing conditions. The binocular summation ratio (BSR) was calculated by dividing the area under the log CSF (AULCSF), or the CS of using both eyes, by that of only using the “good eye” (BSRG) or the “bad eye” (BSRB), respectively. We found that: (1) based on the AULCSF, the BSRB was higher than the BSRG; (2) based on the AULCSF, the BSR was more pronounced under zero-noise than under low-noise conditions, but the BSR was not higher than 1 under high-noise conditions due to a large individual difference; (3) based on the CS, with increasing spatial frequencies, the BSRB steadily increased; (4) both decreased internal additive noise and an improved perceptual template accounted for the gain in binocular summation. These results help us better understand the features of binocular CS and shed light on the clinical studies on populations with monocular CS loss.

Evaluation of adhesive bone conduction hearing aid in pediatric patients with unilateral congenital aural atresia

Objective: To evaluate the auditory efficacy and subjective satisfaction of adhesive bone conduction hearing aid in children with unilateral congenital aural atresia (UCAA). Methods: Ten subjects (5 males and 5 females) diagnosed with UCAA with an average age of 8.3 years old (ranged from 5 to 15) were included in Beijing Tongren Hospital, Capital Medical University from January to August 2019. The free sound field hearing threshold, word recognition score in quiet, speech reception threshold in noise and sound localization ability (results were measured by RMS error) tests were performed in unaided and aided situation, respectively. Subjective satisfaction questionnaires were also distributed to subjects. Paired t test and Wilcoxon signed rank test were used as statistical analysis methods. Results: The average hearing threshold in aided condition was improved by (21.9±4.4) dB (t=15.8，P<0.05). Speech recognition abilities were generally improved both under quiet and noise (P<0.05);however, when the binaural summation, squelch and head shadow effects were analyzed respectively, the binaural squelch effect was not statistically improved (P>0.05), while the other effects were improved in aided condition (P<0.05). In sound localization test, there was no significant difference of the RMS error value between the unaided and aided situation (P>0.05). The subjects got high satisfaction rates in three subjective questionnaires. Conclusion: The adhesive bone conduction hearing aid can provide significant audiological benefit for children with UCAA as well as raising the quality of their life.

Contrast adaptation improves spatial integration

The effects of contrast adaptation and contrast area summation (spatial integration) were investigated using a contrast discrimination task. The task consisted of a target of variable size, and a pedestal with a fixed base contrast. Discrimination performance was examined for a condition in which the pedestal size was fixed, equal to the largest target size, and for a condition in which the pedestal size matched the target size and thus varied with it. Repeated performance of the task produced rapid within-session improvements for both conditions. For stimuli with a matching size of target and pedestal, the performance improved only for the larger targets, indicating the development of spatial integration, which was initially absent for these stimuli. However, the improvements were mostly temporary, and were not fully retained between subsequent daily sessions. The temporary nature of the sensitivity gains implies that they resulted, at least in part, from rapid adaptation to the stimulus contrast. We suggest that adaptation decorrelates and thus reduces the spatial noise generated by a high-contrast pedestal, leading to improved spatial integration (area summation) and better contrast sensitivity. A decorrelation model successfully predicted our experimental results.

Renin-Angiotensin Aldosterone System Inhibitors in Primary Prevention and COVID-19.

BackgroundConsidering the widespread risk of collider bias and confounding by indication in previous research, the associations between renin‐angiotensin aldosterone system (RAAS) inhibitor use and COVID‐19 remain unknown. Accordingly, this study tested the hypothesis that RAAS inhibitors influence the summation effect of COVID‐19 and its progression to severe outcomes.Methods and ResultsThis nationwide cohort study compared all residents of Sweden, without prior cardiovascular disease, in monotherapy (as of January 1, 2020) with a RAAS inhibitor to those using a calcium channel blocker or a thiazide diuretic. Comparative cohorts were balanced using machine‐learning‐derived propensity score methods. Of 165 355 people in the analysis (51% women), 367 were hospitalized or died with COVID‐19 (246 using a RAAS inhibitor versus 121 using a calcium channel blocker or thiazide diuretic; Cox proportional hazard ratio [HR], 0.97; 95% CI, 0.74–1.27). When each outcome was assessed separately, 335 people were hospitalized with COVID‐19 (HR, 0.92; 95% CI, 0.70–1.22), and 64 died with COVID‐19 (HR, 1.22; 95% CI, 0.68–2.19). The severity of COVID‐19 outcomes did not differ between those using a RAAS inhibitor and those using a calcium channel blocker or thiazide diuretic (ordered logistic regression odds ratio, 1.01; 95% CI, 0.89–1.14).ConclusionsDespite potential limitations, this study is among the best available evidence that RAAS inhibitor use in primary prevention does not increase the risk of severe COVID‐19 outcomes; presenting strong data from which scientists and policy makers alike can base, with greater confidence, their current position on the safety of using RAAS inhibitors during the COVID‐19 pandemic.

Impact of Harmonic Currents of Nonlinear Loads on Power Quality of a Low Voltage Network–Review and Case Study

The paper presents a power-quality analysis in the utility low-voltage network focusing on harmonic currents’ pollution. Usually, to forecast the modern electrical and electronic devices’ contribution to increasing the current total harmonic distortion factor (THDI) and exceeding the regulation limit, analyses based on tests and models of individual devices are conducted. In this article, a composite approach was applied. The performance of harmonic currents produced by sets of devices commonly used in commercial and residential facilities’ nonlinear loads was investigated. The measurements were conducted with the class A PQ analyzer (FLUKE 435) and dedicated to the specialized PC software. The experimental tests show that the harmonic currents produced by multiple types of nonlinear loads tend to reduce the current total harmonic distortion factor (THDI). The changes of harmonic content caused by summation and/or cancellation effects in total current drawn from the grid by nonlinear loads should be a key factor in harmonic currents’ pollution study. Proper forecasting of the level of harmonic currents injected into the utility grid helps to maintain the quality of electricity at an appropriate level and reduce active power losses, which have a direct impact on the price of electricity generation.

Type 2A and 2M von Willebrand Disease: Differences in Phenotypic Parameters According to the Affected Domain by Disease-Causing Variants and Assessment of Pathophysiological Mechanisms.

Type 2A and 2M von Willebrand disease (VWD) broadly show similar phenotypic parameters, but involve different pathophysiological mechanisms. This report presents the clinical and laboratory profiles of type 2A and type 2M patients genotypically diagnosed at one large center. Higher bleeding score values and a higher incidence of major bleeding episodes were observed in type 2A compared with type 2M, potentially reflective of the absence of large and intermediate von Willebrand factor (VWF) multimers in 2A. In type 2A, most of disease-causing variants (DCVs) appeared to be responsible for increased VWF clearance and DCV clustered in the VWF-A1 domain resulted in more severe clinical profiles. In type 2M, DCV in the VWF-A1 domain showed different laboratory patterns, related to either reduced synthesis or shortened VWF survival, and DCV in the VWF-A2 domain showed patterns related mainly to shortened survival. VWF-type 1 collagen binding/Ag (C1B/Ag) showed different patterns according to DCV location: in type 2A VWD, C1B/Ag was much lower when DCVs were located in the VWF-A2 domain. In type 2M with DCV in the VWF-A1domain, C1B/Ag was normal, but with DCV in the VWF-A2 domain, C1B/Ag was low. The higher frequency of major bleeding in VWD 2M patients with DCV in the VWF-A2 domain than that with DCV in the VWF-A1 domain could be a summative effect of abnormal C1B/Ag, on top of the reduced VWF-GPIb binding. In silico modeling suggests that DCV impairing the VWF-A2 domain somehow modulates collagen binding to the VWF-A3 domain. Concomitant normal FVIII:C/Ag and VWFpp/Ag, mainly in type 2M VWD, suggest that other nonidentified pathophysiological mechanisms, neither related to synthesis/retention nor survival of VWF, would be responsible for the presenting phenotype.

Distribution and internal correlations of corneal astigmatism in cataract patients

The aim of the study is to explore the distribution patterns and internal correlations of the morphological parameters of the cornea in patients with age-related cataract. The Pentacam HR was used to measure anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), total corneal astigmatism (TCA) and keratometric corneal astigmatism (KCA). With age, the proportion of with-the-rule (WTR) ACA decreased from 65.31% to 23.63%, while the against-the-rule (ATR) ACA increased from 26.53% to 56.20%. PCA exceeded 0.50 D in 9.14% of eyes, while 76.35% of them were ATR. The magnitude of ACA was positively correlated with PCA in the whole sample, with a more significant correlation in WTR eyes (sr = 0.349, P < 0.001). The vector summation effect of PCA to ACA changed from compensation to augmentation with aging. In 57.53% of WTR eyes, KCA was overestimated by an average of 0.21 ± 0.17 D, while it was underestimated by 0.38 ± 0.27 D in 87.62% of ATR eyes. In conclusion, among age-related cataract patients, ACA and TCA gradually shifted from WTR to ATR with aging, while most PCA remained as ATR. Ignoring the age-related changes and real PCA might cause overestimation of WTR astigmatism and underestimation of ATR astigmatism.

Training and Detraining Effects of a Rehabilitation Program with or without Electro-Cryotherapy in Patients with Anterior Knee Pain: A Randomized Trial

We investigated the effect of ten-sessions (with or without receiving modalities) of training and 4-weeks of detraining in individuals with anterior knee pain (AKP). Thirty patients with AKP (19 males; 11 females; pain duration: 46 months) were randomly assigned to either a rehabilitation program (with or without pre-exercise modality). Quadriceps (strength, activation, power, and endurance) and self-reported functions (pain perception and functional outcomes) were recorded pre- and post-rehabilitation and detraining (4-weeks). The application of electro-cryotherapy did not produce a summative effect on quadriceps or self-reported functions (condition × time: F2,56 &lt; 2.27, p &gt; 0.11 for all tests). Regardless of the modality application (time effect), quadriceps (strength: 12%, p = 0.06; power: 20%, p = 0.006; endurance: 13%, p = 0.0002) and self-reported (pain perception during daily activities: −70%, p &lt; 0.0001; at least: −44%, p = 0.04; at worst: −43%, p &lt; 0.0001; functional outcome scores: 13%, p = 0.0003) functions improved after ten sessions of rehabilitation. The improved values were maintained after 4-weeks of detraining, but functional outcome scores showed an 8% further increase (p = 0.02). Regardless of electro-cryotherapy application prior to voluntary exercises at each session, quadriceps and self-reported function improved after ten sessions of rehabilitation for AKP. Improved functioning lasted throughout a 4-week detraining period.

Association between anti-thyroid antibodies and quality of life in patients with Hashimoto thyroiditis: a systematic review and meta-analysis.

The aim of this review was to evaluate the association between anti-thyroid antibodies and quality of life in people with euthyroid Hashimoto thyroiditis. Patients with Hashimoto thyroiditis report symptom distress more often than those with non-autoimmune thyroid disorders. Therefore, anti-thyroid antibodies may be related to decreased quality of life in persons with Hashimoto thyroiditis. The etiology of lingering symptoms, even in euthyroidism, remains unknown. The relationship between anti-thyroid antibodies and quality of life for people with Hashimoto thyroiditis has not been evaluated in a systematic review. The participants were males and females at least 12 years of age, in any country, with Hashimoto thyroiditis. Participants not in a euthyroid state were excluded from this review. In this review, the exposure was the presence of anti-thyroid antibodies and the primary outcome was quality of life as measured by a validated scale. A three-step search strategy was implemented with an initial search of PubMed and CINAHL. A comprehensive database search using all identified keywords and index terms was undertaken in March 2019 for relevant published literature, gray literature, and clinical trial registries. The final updates to the search strategies were conducted in December 2019. The search was limited to studies published in English after 1956. Two independent reviewers completed screening for inclusion and utilized the recommended JBI approach to critical appraisal, study selection, data extraction, and data synthesis. The findings are presented in a meta-analysis and in a narrative synthesis, which includes tables and figures. All 13 studies had high methodological quality. Four studies found a significant correlation (P < 0.05) between the presence of anti-thyroid antibodies and quality of life. A fifth study found a significant correlation (P < 0.001) between higher antibody levels and quality of life. A meta-analysis was conducted using two cross-sectional studies, which revealed that the summative small effect size was statistically significant and suggested a lower quality of life in antibody-positive patients. Due to the heterogeneity of the studies, a narrative synthesis was conducted for the three secondary outcomes: symptom distress, executive function, and mental health. Three studies found a statistically significant (P < 0.05) correlation between symptom distress and antibodies, two studies found a statistically significant (P < 0.05) association between executive function and antibodies, and all but one study found a statistically significant (P < 0.05) relationship between mental health and antibodies. The findings in this review did not reveal a definitive relationship between antibodies and quality of life. However, our meta-analysis suggested a link between anti-thyroid antibodies and decreased quality of life in euthyroid children and adults. Though not conclusive, poor mental health and symptom distress may be associated with anti-thyroid antibodies. Therefore, it may be beneficial to periodically evaluate the quality of life and mental health in euthyroid patients with positive antibodies. It is unlikely that antibodies and executive functions are related. The studies and our review's limitations require replication of findings to confirm a connection between antibodies, quality of life, and the secondary outcomes. Future research should continue to evaluate the relationship between anti-thyroid antibodies and the quality of life in individuals with euthyroid Hashimoto thyroiditis. PROSPERO CRD42018084663.

Prenatal programming of depression: cumulative risk or mismatch in the Ontario Child Health Study?

Consistent with cumulative risk hypotheses of psychopathology, studies examining prenatal adversity and later mental health largely suggest that pre and postnatal stress exposures have summative effects. Fewer data support that a mismatch in stress levels between pre- and postnatal life increases risk (the mismatch hypothesis). In this retrospective cohort study using data from the 1983 Ontario Child Health Study (OCHS), we examined interactions between birth weight status and childhood/adolescent stress to predict major depression in adulthood. Ninety-five participants born at low birth weight (LBW; <2500 g) and 972 normal birth weight (NBW) control participants completed the Composite International Diagnostic Interview Short-Form Major Depression module at 21-34 years of age. A youth risk scale consisting of five stressful exposures (family dysfunction, socioeconomic disadvantage, parental criminality, maternal mental illness, exposure to other life stresses) indexed child/adolescent adversity. Birth weight groups did not differ by childhood risk score nor depression levels. A significant interaction was observed between birth weight and the youth risk scale whereby exposure to increasing levels of exposure to childhood/adolescent adversity predicted increased levels of depression in the NBW group, but lower rates in those born at LBW. Consistent with the mismatch hypothesis, data from a large, longitudinally followed cohort suggest that the mental health of adults born LBW may be more resilient to the adverse effects of childhood/adolescent stress. Taken in the context of previous studies of low birth weight infants, these findings suggest that the nature of associations between gestational stress and later mental health may depend on the magnitude of prenatal stress exposure, as well as the degree of resilience and/or plasticity conferred by their early-life environment.

Prospective Analysis Utilizing Intraoperative Neuromonitoring for the Evaluation of Inter-Burst Frequencies.

BackgroundIntraoperative neuromonitoring (IONM) for spinal cord stimulation (SCS) uses electromyography (EMG) responses to determine myotomal coverage as a marker for dermatomal coverage.ObjectiveThese responses can be utilized to evaluate the effects of stimulation platforms on the nervous system.MethodsEight patients were tested at inter-burst frequencies of 10 Hz, 20 Hz, 30 Hz, and 40 Hz using DeRidder Burst stimulation to determine the amplitude of onset of post-synaptic signal generation. Three patients had additional data recording amplitude of onset of tonic stimulation prior to and post DeRidder Burst stimulation at each inter-burst frequency. This represented post-synaptic excitability.ResultsIn all patients, the DeRidder Burst waveform generated EMG responses under all inter-burst frequencies including temporal summation, deeper fiber recruitment, and compounded action potentials. There was a non-significant decrease of 7.6–7.8% in amplitudes to generate response under 40 Hz, compared to the other frequencies. However, there was a 73.1% reduction in energy requirements at 10 Hz. The enhanced post-synaptic excitability effect was demonstrated at all frequencies.ConclusionDeRidder Burst has similar effects of temporal summation, deeper fiber recruitment, and compounded action potentials under IONM at 40 Hz, 30 Hz, 20 Hz, and 10 Hz. In addition, the hyperexcitability phenomenon was also observed regardless of the frequency. This demonstrates that postsynaptic responses captured via IONM may be a sensitive biomarker to SCS mechanism of action. In addition, lower inter-burst frequencies may have a similar clinical effect on pain relief thus reducing power consumption even further than current dosing paradigms.

Using a cochlear implant processor as contralateral routing of signals device in unilateral cochlear implant recipients

PurposeIn unilateral cochlear implant (CI) recipients, a contralateral routing of signals (CROS) device enables to receive auditory information from the unaided side. This study investigates the feasibility as well as subjective and objective benefits of using a CI processor as a CROS device in unilateral CI recipients.MethodsThis is a single-center, prospective cohort study. First, we tested the directionality of the CROS processor in an acoustic chamber. Second, we examined the difference of speech perception in quiet and in noise in ten unilateral CI recipients with and without the CROS processor. Third, subjective ratings with the CROS processor were evaluated according to the Client Oriented Scale of Improvement Questionnaire.ResultsThere was a time delay between the two devices of 3 ms. Connection of the CROS processor led to a summation effect of 3 dB as well as a more constant amplification along all azimuths. Speech perception in quiet showed an increased word recognition score at 50 dB (mean improvement 7%). In noise, the head shadow effect could be mitigated with significant gain in speech perception (mean improvement 8.4 dB). This advantage was reversed in unfavorable listening situations, where the CROS device considerably amplified the noise (mean: – 4.8 dB). Subjectively, patients who did not normally wear a hearing aid on the non-CI side were satisfied with the CROS device.ConclusionsThe connection and synchronization of a CI processor as a CROS device is technically feasible and the signal processing strategies of the device can be exploited. In contra-laterally unaided patients, a subjective benefit can be achieved when wearing the CROS processor.

Psychotic Disorders in Epilepsy: Do They Differ from Primary Psychosis?

Any attempt to compare the definitions of symptoms listed for "primary psychoses" with those adopted in studies of psychoses in patients with epilepsy (PWE) will encounter problems of heterogeneity within both conditions. In this manuscript, five psychotic illnesses listed in Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5), that is, brief psychotic illness, schizophreniform disorder, schizophrenia, delusional disorder, and schizoaffective disorder are compared with postictal (or periictal) and interictal psychotic disorders in PWE. After examining definitions of primary psychoses, definitions of psychoses adopted in the papers dealing with postictal and interictal psychoses are summarized. Further, diagnostic criteria of five types of psychotic disorders in PWE proposed in 2007 by Krishnamoorthy et al. are also discussed, which include postictal psychosis, comorbid schizophrenia, iatrogenic psychosis caused by antiepileptic drugs (AEDs) (AED-induced psychotic disorder: AIPD), and forced normalization. Evidently, a comparison between postictal psychosis and schizophrenia is pointless. Likewise, schizophrenia may not be an appropriate counterpart of forced normalization and AIPD, given their acute or subacute course.Based on these preliminary examinations, three questions are selected to compare primary psychoses and psychoses in PWE: Is postictal psychosis different from a brief psychotic disorder? Does epilepsy facilitate or prevent the development of psychosis or vice versa? Is interictal psychosis of epilepsy different from process schizophrenia? In conclusion, antagonism between psychosis and epileptic seizures in a later stage of active epilepsy seems not to be realized without reorganization of the nervous system promoted during an earlier stage. Both genetic predisposition and the summated effects of epileptic activity must be taken into consideration as part of a trial to explain interictal psychosis. Interictal psychosis is an aggregate of miscellaneous disorders, that is, co-morbid schizophrenia, AED-induced psychotic disorders, forced normalization, and "epileptic" interictal psychosis. Data are lacking to conclude whether differences exist between process schizophrenia and "epileptic" interictal psychosis in terms of negative symptoms, specific personal traits, and the "bizarre-ness" of delusory-hallucinatory contents. These discussions may shed light on the essence of process schizophrenia, thus allowing it stand out and receive increased focus.

Threshold vision under full-field stimulation: Revisiting the minimum number of quanta necessary to evoke a visual sensation

At the absolute threshold of vision, Hecht, Shlaer and Pirenne estimate that 5–14 photons are absorbed within a retinal area containing ~500 rods. Other estimates of scotopic threshold vision based on stimuli with different durations and focal areas range up to ~100,000 photons. Given that rod density varies with retinal eccentricity and the magnitude of the intrinsic noise increases with increasing stimulus area and duration, here we determine whether the scotopic threshold estimates with focal stimuli can be extended to full-field stimulation and whether summation explains inter-study differences. We show that full-field threshold vision (~1018 mm2, 10 ms duration) is more sensitive than at absolute threshold, requiring the absorption of ~1000 photons across ~91.96 million rods. A summation model is presented integrating our and published data and using a nominal exposure duration, criterion frequency of seeing, rod density, and retinal area that largely explains the inter-study differences and allows estimation of rods per photon ratio for any stimulus size and duration. The highest signal to noise ratio is defined by a peak rod convergence estimated at 53:4:1:2 (rods:rod bipolar cells:AII amacrine cells:retinal ganglion cells), in line with macaque anatomical estimates that show AII amacrine cells form the bottleneck in the rod pathway to set the scotopic visual limit. Our model estimations that the rods per photon ratio under full-field stimulation is ~3000X higher than at absolute threshold are in accordance with visual summation effects and provide an alternative approach for understanding the limits of scotopic vision.

Cochlear Implant and Hearing Aid: Objective Measures of Binaural Benefit.

Cochlear implants (CI) improve hearing for the severely hearing impaired. With an extension of implantation candidacy, today many CI listeners use a hearing aid on their contralateral ear, referred to as bimodal listening. It is uncertain, however, whether the brains of bimodal listeners can combine the electrical and acoustical sound information and how much CI experience is needed to achieve an improved performance with bimodal listening. Patients with bilateral sensorineural hearing loss undergoing implant surgery were tested in their ability to understand speech in quiet and in noise, before and again 3 and 6 months after provision of a CI. Results of these bimodal listeners were compared to age-matched, normal hearing controls (NH). The benefit of adding a contralateral hearing aid was calculated in terms of head shadow, binaural summation, binaural squelch, and spatial release from masking from the results of a sentence recognition test. Beyond that, bimodal benefit was estimated from the difference in amplitudes and latencies of the N1, P2, and N2 potentials of the brains’ auditory evoked response (AEP) toward speech. Data of fifteen participants contributed to the results. CI provision resulted in significant improvement of speech recognition with the CI ear, and in taking advantage of the head shadow effect for understanding speech in noise. Some amount of binaural processing was suggested by a positive binaural summation effect 6 month post-implantation that correlated significantly with symmetry of pure tone thresholds. Moreover, a significant negative correlation existed between binaural summation and latency of the P2 potential. With CI experience, morphology of the N1 and P2 potentials in the AEP response approximated that of NH, whereas, N2 remained different. Significant AEP differences between monaural and binaural processing were shown for NH and for bimodal listeners 6 month post-implantation. Although the grand-averaged difference in N1 amplitude between monaural and binaural listening was similar for NH and the bimodal group, source localization showed group-dependent differences in auditory and speech-relevant cortex, suggesting different processing in the bimodal listeners.

Dynamic network connectivity alteration predicts cognitive decline in Alzheimer’s disease spectrum

AbstractBackgroundBrian network integrity plays a pivotal role in the regulation of high‐order cognitive function and emotion for human brain. Disrupted functional coupling within‐ and between resting‐state networks (RSNs) are selectively vulnerable for neurodegenerative disease, such as Alzheimer’s disease. However, dynamic network alteration and its molecular pathological basis following the disease course in the AD spectrum still remain unclear. Currently, we integrated a new method combination of large‐scale network analysis and canonical correlation analysis (CCA) to explore dynamic spatiotemporal patterns within‐ and between RSNs and their significance in the AD spectrum.MethodWe analyzed data from the Alzheimer’s Disease Neuroimaging Initiative 1, GO and 2 datasets. A total of 160participants (59 cognitively normal (CN) participants, 49 patients with early mild cognitive impairment (EMCI), 28 patients with late mild cognitive impairment (LMCI) and 24 AD patients) completed fMRI scan, 3T MRI brain scan, CSF biomarkers and genes which strongly tied to AD risk detection and cognitive function assessment (MMSE and ADAS‐Cog scores). We studied group differences in within‐ and between RSNs. For cognitive function, genes and biomarkers, we did canonical correlation analysis between gene scores, cognitive scores , the biomarker levels and network variables across disease spectrum.ResultWe identified that all RSNs represented the increase connectivity within networks by enhancing inner cohesive ability, while seven out of ten RSNs were characterized by the decreased connectivity between networks, which indicates weaken connector ability among networks from the early stage to dementia. This dichotomous mode presenting large‐scale dynamic network abnormality was significantly correlated with the levels of molecular biomarkers (amyloid‐β, Tau, p‐Tau), cognitive performance, as well as accumulating effects of AD‐related ten genetic risk factors. This study implicated that spatiotemporal pattern of large‐scale network connectivity failure was not cascading, but represented a bouncing mode with the progression of cognitive decline. Taken together, we identified the determinants of the spread of disrupted network incoherence, molecular correlates, and summative effects of genetic variants on the RSNs.ConclusionThese findings provide novel insights for better understanding the mechanism underlying large‐scale network disruption linking molecular biomarkers and phenotypic variations in the AD spectrum.

Study on valorization of coconut (Cocos nucifera) husk into biochar for soil amendment and its effect on sorghum (Sorghum bicolor)

Biochar is one of the significant soil amendments. A lot of research has already done in the field of biochar. But very few studies have mentioned the effect of pyrolysis temperature on the plant growth. To the best of our knowledge we have not yet come across any systematic study elaborating the effect of various pyrolysis temperature of coconut husk biochar on seed germination and plant growth. Therefore, the experiment was conducted during 2019 to 20 at Institute of Chemical Technology, Mumbai, India to explore the effect of coconut husk biochar produced at various pyrolysis temperatures (300, 400, 500 and 600°C) individually and along with the nitrogen fertilizer (urea) on the growth of sorghum. Maximum biochar yield of 54.67 % was obtained at 300°C. The ash content, pH, and EC (electrical conductivity) of biochar significantly increased with increasing pyrolysis temperature, maximum ash content (31.4 %), pH (9.9) and EC (2.48 mS/cm) were observed at 600°C pyrolysis temperature. Bulk density and nitrogen concentration of biochar reduced with increasing pyrolysis temperature. Highest nitrogen concentration of 0.62% was detected in biochar produced at 300°C. Surface area of the biochar increased with an increase in the pyrolysis temperature giving a surface area of 213.91 m2/g at 600 °C pyrolysis temperature. The germination percentage was adversely affected by the use of biochar and nitrogen fertilizer combination treatment. Maximum shoot and root biomass of sorghum were obtained with the use of biochar produced at 300°C. Similarly, plant height, leaf area and stem diameter were significantly high in the treatment containing biochar obtained at 300°C pyrolysis temperature. Nevertheless, combining biochar and nitrogen fertilizer had no synergic and summative effect on sorghum growth. The findings of the present study thus demonstrate that biochar obtained at low pyrolysis temperature can be a practical approach to enhance crop biomass growth and possibly yield.