Summary Page Research Articles

Development of the World Federation of Hemophilia Shared Decision-Making Tool.

The use of shared decision-making (SDM) in clinical settings is becoming more prevalent. The evolving and increasingly complex treatment landscape of haemophilia management has augmented the need and desire for SDM between patients and their healthcare team. SDM tools have been used in other chronic conditions and can be an effective form of education for patients and clinicians. The World Federation of Hemophilia (WFH) partnered with people with haemophilia (PWH), patient advocacy groups, and healthcare practitioners to form an expert working group to develop an educational tool for PWH and their caregivers. The primary objectives included educating PWH on the available prophylactic treatments and facilitating discussion between PWH and their healthcare team. The tool was proposed and developed by the expert working group, workshopped at conference round tables, and evaluated in two focus groups. The interactive WFH SDM Tool guides users through the SDM treatment journey and provides an opportunity for reflection on current disease impact and treatment preferences, educational fact sheets and videos, and a comparison between treatment classes. Two forms of the SDM Tool are available: an online platform with a summary page that may be printed and shared and a printable workbook. All evidence in the tool is based on the prescribing information or phase III clinical trial publications. The Tool will be updated twice each year. The WFH SDM Tool is the first available resource that translates published guidance on SDM in haemophilia into a practical, user-friendly tool aimed at facilitating patient-centred treatment decisions.

Deciphering the Radiation Dose Summary Page in Interventional Fluoroscopy.

Fluoroscopy is an advanced medical imaging modality that utilizes x-rays to acquire real-time images throughout a medical examination. It is commonly used in various procedures such as in interventional radiology, cardiac catheterization, and gastrointestinal and genitourinary studies. While fluoroscopy is a valuable diagnostic and therapeutic tool, it exposes patients and medical staff to ionizing radiation, which carries health risks. A radiation dose summary page is a report generated by the fluoroscope that displays important information about the procedure. It provides an overview of the radiation doses administered during a fluoroscopic procedure, as well as certain technical parameters used during the irradiation events. The contents of a radiation dose summary page may vary depending on the make and model of the fluoroscope but some common elements include the cumulative reference air kerma, which serves as a surrogate of radiation dose delivered to the patient, and the dose-area product, which takes account of the x-ray beam area and is a measure of the total amount of energy imparted on the patient. Other imaging acquisition parameters may be also included in the dose summary page, including tube voltage, tube current, pulse width, pulse rate, spectral filters, primary and secondary angles, and source-to-image distance. The radiation dose summary page for fluoroscopy is a useful tool for physicians, technologists, and medical physicists, allowing them to comprehend the technical details of a fluoroscopically guided procedure. ©RSNA, 2024.

From use, value and user-centered design to context: A mixed methods analysis of a hospital electronic medical record enhancement.

This study sought to determine the use and perceived value of a user-centered electronic medical record (EMR) enhancement for stroke care and understand if its value was in alignment with its intended design. The EMR enhancement was introduced into Queensland public hospitals in Australia and included a summary page for enhanced interprofessional collaboration and data collection forms for efficient data extraction. A mixed methods design was adopted and data collected from four hospital sites. We conducted 15 semistructured interviews with multidisciplinary end-users across participating sites and analyzed this data using inductive thematic techniques. Usage log data was extracted from the EMR to determine its use. Relative use of the summary page showed moderate use, varying from 66 ± 22.5 uses for each stroke patient admission per month (Site 1) to 26.7 ± 9.1 (Site 2). Interviews identified key themes of "visibility" and providing a "quick snapshot" of patient data as the main positive attributes. Technology "functionality" was perceived negatively. Use of the data collection forms was minimal, with inconsistency across sites: (Site 3, 0% to Site 2, 47%). Negative themes of "inefficiency," poor "functionality" and the "trust" required in data entry practices were found. Despite its user-centered design, clinicians did not always use the enhancement in line with its intended design, or grasp its intended value. Our findings highlight the challenges of user-centered design to accurately reflect clinical workflows within different contexts. A greater understanding is required of how to optimize user-centered EMR design for specific hospital contexts.

Integrated oncology operational dashboard for clinical and operational quality improvement.

588 Background: MaineHealth Cancer Care Network, comprised of nine member and two affiliate cancer centers, provides care to more than 70% of analytic cancer cases in largely rural south-central Maine and eastern New Hampshire. To drive high quality and performance and harmonize care across the network, an integrated operational dashboard was created. Methods: A team of clinicians, operational leaders and business intelligence analysts identified improvement goals across clinical and operational domains. Using a Microsoft Power BI platform, an integrated dashboard with extracts from various non-interoperable data sources were migrated together to illustrate all relevant metrics. Divided into five pages, the Summary page allowed for a high level visualization of financial improvement metrics across the service line. The Growth page included trends of template utilization, provider access, encounter and financial statistics. The Service Excellence page measured diagnosis to treatment times, new patient volumes, timely chart completion rates and provider net promoter scores. Lastly, the Innovation and Transformation page measured clinical trial accruals, use of Epic TNM staging (Epic Systems, Verona, WI), Clinical Pathways (Elsevier, Amsterdam, NL) and use of NCCN distress thermometer for patient assessment. All data was searchable based on chosen fiscal years, practice locations and provider names with automated monthly data refreshes. Dashboard access to clinical and operational staff with monthly reviews drove performance improvement. Results: Since creation in January 2023, dashboard has been leveraged to improve structured Epic TNM staging by medical oncology providers from 46.9% in FY22 to 53.4% in FY23. Time to treatment data has helped identify process bottlenecks. Provider productivity metrics have been used to launch a compensation reform program incorporating production based incentives and improve patient access. Information transparency has improved team engagement and ownership. Conclusions: High quality cancer care delivery requires equal attention to clinical and operational metrics. In most organizations, this data is siloed across disparate software platforms with limited visibility and access to care team members, impeding quality initiatives. Implementation of the system-wide integrated quality dashboard has led to tangible improvements in care delivery and provider engagement. Additional work to incorporate provider well-being data is underway.

Conserved unique peptide patterns (CUPP) online platform 2.0: implementation of+1000 JGI fungal genomes.

Carbohydrate-processing enzymes, CAZymes, are classified into families based on sequence and three-dimensional fold. Because many CAZyme families contain members of diverse molecular function (different EC-numbers), sophisticated tools are required to further delineate these enzymes. Such delineation is provided by the peptide-based clustering method CUPP, Conserved Unique Peptide Patterns. CUPP operates synergistically with the CAZy family/subfamily categorizations to allow systematic exploration of CAZymes by defining small protein groups with shared sequence motifs. The updated CUPP library contains 21,930 of such motif groups including 3,842,628 proteins. The new implementation of the CUPP-webserver, https://cupp.info/, now includes all published fungal and algal genomes from the Joint Genome Institute (JGI), genome resources MycoCosm and PhycoCosm, dynamically subdivided into motif groups of CAZymes. This allows users to browse the JGI portals for specific predicted functions or specific protein families from genome sequences. Thus, a genome can be searched for proteins having specific characteristics. All JGI proteins have a hyperlink to a summary page which links to the predicted gene splicing including which regions have RNA support. The new CUPP implementation also includes an update of the annotation algorithm that uses only a fourth of the RAM while enabling multi-threading, providing an annotation speed below 1 ms/protein.

Developing Mobile Learning Application as Instructional Media for Reading Comprehension

Students nowadays are no longer enjoy reading printed books. They mostly read from their mobile phone or computers' screens. Teachers need to encourage students to read and comprehend texts. Teachers should adopt and adapt technology in teaching reading comprehension to students in light of the rapidly changing existence of technology. The purpose of this research is to develop appropriate media for learning reading. This research has employed Research and Development design based on ADDIE model. This model is used for media development by requiring 5 stages, namely: 1) Analysis, 2) Design, 3) Development, 4) Implementation, and 5) Evaluation. The research subjects are the tenth graders and the English teacher. Both the media and language experts validated the developed product. The instruments used in the needs analysis are questionnaires for the students and interviews with the English teacher. The final result is in the form of a mobile application that suits the needs of teachers and students. This media consists of 63 slides. The size of this mobile application is 52 Mb. The developed application consists of three main menus and eleven sub-menus. They are the intro page, loading section, menu page, materials page, core competence page, vocabulary building page, learning summary page, exercise page, glossary page, verb form page, user’s guide page, lesson plan page, description of the product page, and exit page. The result of this research could be seen in the enthusiasm, development, and students’ interest in mobile application media. Therefore, it is recommended for teachers to use mobile applications in teaching reading and for other developers to develop applications for the learning process.

How to Use the Candida Genome Database.

The Candida Genome Database provides access to biological information about genes and proteins of several medically important Candida species. The website is organized into easily navigable pages that enable data retrieval and analysis. This chapter shows how to explore the CGD Home page and Locus Summary pages, which are the main access points to the database. It also provides a description of how to use the GO analysis tools, GO Term Finder, and GO Slim Mapper and how to browse large-scale datasets using the JBrowse genome browser. Finally, it shows how to search and retrieve data for user-defined sets of genes using the Advanced Search and Batch Download tools.

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Development of an electronic conversation aid to support shared decision making for children with acute otitis media.

ObjectiveThe overuse of antibiotics for acute otitis media (AOM) in children is a healthcare quality issue in part arising from conflicting parent and physician understanding of the risks and benefits of antibiotics for AOM. Our objective was to develop a conversation aid that supports shared decision making (SDM) with parents of children who are diagnosed with non-severe AOM in the acute care setting.Materials and MethodsWe developed a web-based encounter tool following a human-centered design approach that includes active collaboration with parents, clinicians, and designers using literature review, observations of clinical encounters, parental and clinician surveys, and interviews. Insights from these processes informed the iterative creation of prototypes that were reviewed and field-tested in patient encounters.ResultsThe ear pain conversation aid includes five sections: (1) A home page that opens the discussion on the etiologies of AOM; (2) the various options available for AOM management; (3) a pictograph of the impact of antibiotic therapy on pain control; (4) a pictograph of complication rates with and without antibiotics; and (5) a summary page on management choices. This open-access, web-based tool is located at www.earpaindecisionaid.org.ConclusionsWe collaboratively developed an evidence-based conversation aid to facilitate SDM for AOM. This decision aid has the potential to improve parental medical knowledge of AOM, physician/parent communication, and possibly decrease the overuse of antibiotics for this condition.

BRENDA, the ELIXIR core data resource in 2021: new developments and updates.

The BRENDA enzyme database (https://www.brenda-enzymes.org), established in 1987, has evolved into the main collection of functional enzyme and metabolism data. In 2018, BRENDA was selected as an ELIXIR Core Data Resource. BRENDA provides reliable data, continuous curation and updates of classified enzymes, and the integration of newly discovered enzymes. The main part contains >5 million data for ∼90 000 enzymes from ∼13 000 organisms, manually extracted from ∼157 000 primary literature references, combined with information of text and data mining, data integration, and prediction algorithms. Supplements comprise disease-related data, protein sequences, 3D structures, genome annotations, ligand information, taxonomic, bibliographic, and kinetic data. BRENDA offers an easy access to enzyme information from quick to advanced searches, text- and structured-based queries for enzyme-ligand interactions, word maps, and visualization of enzyme data. The BRENDA Pathway Maps are completely revised and updated for an enhanced interactive and intuitive usability. The new design of the Enzyme Summary Page provides an improved access to each individual enzyme. A new protein structure 3D viewer was integrated. The prediction of the intracellular localization of eukaryotic enzymes has been implemented. The new EnzymeDetector combines BRENDA enzyme annotations with protein and genome databases for the detection of eukaryotic and prokaryotic enzymes.

Project status reporting system (PSRS) for pipeline relocation programs

PurposeSuccessful performance and execution of construction projects depend highly on a good project control system capable of tracking and reporting project status on a desired time interval. The purpose of this paper is to propose such a control system by integrating spreadsheet and Visual Basic for Application to produce a customized tracking system for Pipeline Relocation Programs under Engineering, Procurement and Construction Management (EPCM) contracts.Design/methodology/approachThe project status reporting system (PSRS) proposed here was developed to produce a single page summary report that would include scope information, financial status, descriptive status updates and top-level task schedules. This information is retrieved from various sources and transformed further utilizing specific formulas and algorithm needed to compute the budget and schedule status of the pipe relocation project. A practical case study is used to demonstrate its unique application.FindingsThe system has successfully integrated project finance and schedule information into a central control hub. Financial and schedule performance of a project is tracked and monitored by the PSRS automatically.Originality/valueThe proposed system utilizes the powerful computing capability of MS Excel and the user-friendly VBA programming tool to customize the reporting needs of a project and program environment. The proposed system, whose functionality has been validated by the intended users, tries to achieve a balance between simplicity, accuracy and effectiveness for the flow of information at a much lower cost compared to the other readily available project control software.

E-Cart Design for Controlling Cart Abandonment in E-Commerce: A Conjoint Experiment

This study attempted to understand the most important attributes and their preferred levels of an e-shopping cart for maximum utility perceptions by e-commerce customers. The research has significance in the backdrop of observations that online customers have multiple sorts of hesitation on purchase completions, and their cart abandonment tendencies are causing serious challenges to e-commerce firms across the world. Assuming that better e-cart design can minimize cart abandonment intentions, an eight attribute conjoint experiment with a total of nineteen levels was conducted to decide on an optimum cart design. The experiment concluded that online customers prefer an order summary page with product images, add to cart option without login, live chat feature in cart; add to cart button on both sidebar and top of the page; online payment options, security logo and social proof in e-cart, purchase history review option in the cart page, and delivery progress tracking bar in the cart page itself.

Nurturing the digital baby: Open innovation for development and optimization.

The primary aim around developing and optimizing an electronic health record is to improve patient care and population health. The objective of this study is to design and evaluate an action research approach for the optimization of the design of a summary page artefact within an electronic health record for newborn healthcare. An action research approach was chosen for its participatory democratic process for developing practical knowledge and solutions. Collaborative workshops lead by an independent graphic facilitator with a 'bottom up' approach, involving self-selected motivated members from multidisciplinary healthcare teams, were designed and conducted. To evaluate this approach, insights were drawn from behavioural and design science paradigms to demonstrate that knowledge and understanding of the design problem and its solution were acquired in building the optimized summary page artefact. Information system development for healthcare requires consideration not just of what we do but how and why we do things. Our analysis demonstrates that action design research represents an agile and lean approach for successful optimization and implementation of information system development in healthcare.

RNA CoSSMos 2.0: an improved searchable database of secondary structure motifs in RNA three-dimensional structures.

The RNA Characterization of Secondary Structure Motifs, RNA CoSSMos, database is a freely accessible online database that allows users to identify secondary structure motifs among RNA 3D structures and explore their structural features. RNA CoSSMos 2.0 now requires two closing base pairs for all RNA loop motifs to create a less redundant database of secondary structures. Furthermore, RNA CoSSMos 2.0 represents an upgraded database with new features that summarize search findings and aid in the search for 3D structural patterns among RNA secondary structure motifs. Previously, users were limited to viewing search results individually, with no built-in tools to compare search results. RNA CoSSMos 2.0 provides two new features, allowing users to summarize, analyze and compare their search result findings. A function has been added to the website that calculates the average and representative structures of the search results. Additionally, users can now view a summary page of their search results that reports percentages of each structural feature found, including sugar pucker, glycosidic linkage, hydrogen bonding patterns and stacking interactions. Other upgrades include a newly embedded NGL structural viewer, the option to download the clipped structure coordinates in *.pdb format and improved NMR structure results. RNA CoSSMos 2.0 is no longer simply a search engine for a structure database; it now has the capability of analyzing, comparing and summarizing search results.Database URL: http://rnacossmos.com

Incorporation of a unified protein abundance dataset into the Saccharomyces genome database.

The identification and accurate quantitation of protein abundance has been a major objective of proteomics research. Abundance studies have the potential to provide users with data that can be used to gain a deeper understanding of protein function and regulation and can also help identify cellular pathways and modules that operate under various environmental stress conditions. One of the central missions of the Saccharomyces Genome Database (SGD; https://www.yeastgenome.org) is to work with researchers to identify and incorporate datasets of interest to the wider scientific community, thereby enabling hypothesis-driven research. A large number of studies have detailed efforts to generate proteome-wide abundance data, but deeper analyses of these data have been hampered by the inability to compare results between studies. Recently, a unified protein abundance dataset was generated through the evaluation of more than 20 abundance datasets, which were normalized and converted to common measurement units, in this case molecules per cell. We have incorporated these normalized protein abundance data and associated metadata into the SGD database, as well as the SGD YeastMine data warehouse, resulting in the addition of 56 487 values for untreated cells grown in either rich or defined media and 28 335 values for cells treated with environmental stressors. Abundance data for protein-coding genes are displayed in a sortable, filterable table on Protein pages, available through Locus Summary pages. A median abundance value was incorporated, and a median absolute deviation was calculated for each protein-coding gene and incorporated into SGD. These values are displayed in the Protein section of the Locus Summary page. The inclusion of these data has enhanced the quality and quantity of protein experimental information presented at SGD and provides opportunities for researchers to access and utilize the data to further their research.

Leitorado-eleitorado:

O objetivo deste artigo é relacionar as alterações na paisagem econômica do jornalismo ao processo político. Faremos isto através de dois momentos distintos: em primeiro lugar, estabelecendo relações entre a preferências políticas dos leitores de jornais no Rio de Janeiro e seus hábitos de leitura; depois, avaliando a cobertura política dos jornais através de análise de enquadramentos. Utilizando, como ponto de partida o modelo de análise de Sparks (2000) sobre a tabloidização, buscamos desenvolver uma matriz que avalia a cobertura noticiosa de três jornais fluminenses, a saber: O Globo, Extra, e Meia Hora. Foram analisadas mais de duas mil manchetes e chamadas de primeira página destes jornais, no período entre julho e outubro de 2014, correspondente ao período de propaganda eleitoral, conforme definido pelo TSE. O passo seguinte foi relacionar de volta estas categorias com o perfil dos leitores dos jornais analisados e suas preferências políticas.

Thera-SAbDab: the Therapeutic Structural Antibody Database.

The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata.

SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia

IntroductionSkin is important in Australian Aboriginal culture informing kinship and identity. In many remote Aboriginal communities, scabies and impetigo are very common. Untreated skin infections are painful, itchy and frequently...

Heart Failure Re-Admissions: Impact of a Specialized Resident Task Force in Year Two of a Performance Improvement Project

Background Heart failure (HF) is a complex disorder that imposes substantial patient burden and entails much health care costs. Nationwide, 30 day re-admissions for HF are tracked and serve as a measure of quality of care. Efforts to minimize HF related hospital re-admissions have generally had mixed results. Hypothesis Development of a specialized, experienced team of internal medicine residents trained to educate and counsel HF patients will enhance their knowledge of the disease, improve self-care and reduce hospital re-admissions in those admitted with acute decompensated HF. Methods In August 2017 a team of 9 Internal Medicine residents were recruited to create a Specialized Resident Force (SRF). The team was expanded to 20 residents in August 2018; they received individual hands-on training sessions in counseling hospitalized HF patients from a mentor weekly initially, later monthly. Patients with HF were counseled by the SRF on diet, activity, medication use, weight monitoring and outpatient follow-up. Demographic data, comorbidities and HF specific data was gathered. Patient's cognition was evaluated. If cognitively impaired, education was offered to caregiver, if available. A tool helped document data; a booklet on HF education, counseling by the resident and a 2 page summary script were offered to patients. Other disciplines (nurse, nutritionist, cardiologist, social worker) had roles in the project. Results Enhanced SRF education was provided to 171 patients with HF between August 2018 and January 2019. Education provided by SRF resulted in declines in 30 day all cause readmissions following index HF admission (Table 1). Observations by mentor suggested enhanced practical knowledge base of SRF trainees as a result of participation. Conclusions A Specialized Resident Force with support from other disciplines helped reduce and maintain low 30 day HF hospital re-admissions consistently over a 6 month period. The project help residents acquire expertise in PI activity while also enhancing their real life experience in managing HF patients.

Day of the week to tweet: a randomised controlled trial

ObjectiveTo assess the effects of using health social media on different days of the working week on web activity.DesignIndividually randomised controlled parallel group superiority trial.SettingTwitter and Weibo.Participants194 Cochrane Schizophrenia Group...