Sum Beamforming Research Articles

Pixel-based approach to delay multiply and sum beamforming in combination with Wiener filter for improving ultrasound image quality

Unified pixel-based (PB) beamforming has been implemented for ultrasound imaging, offering significant enhancements in lateral resolution compared to the conventional dynamic focusing. However, it still suffers from clutter and off-axis artifacts, limiting the contrast resolution. This paper proposes an efficient method to improve image quality by integrating filtered delay multiply and sum (F-DMAS) into the framework. This hybrid strategy incorporates the spatial coherence of the received data into the beamforming process to improve contrast resolution and clutter rejection in the generated image. We also integrate a Wiener filter to suppress the spatiotemporal spreading using signals echoed from a single scatterer at the transmit focus as a kernel for the deconvolution. The Wiener filter is applied to the received waveforms before performing the hybrid strategy. The Wiener filter is shown to reduce interference due to the interaction between the excitation pulse and the transfer functions of the transducer elements, thus benefiting the axial resolution of the generated images. We validate the proposed method and compare it with other beamforming strategies through a series of experiments, including simulation, phantom, and in vivo studies. The results show that our approach can substantially improve both spatial resolution and contrast over the unified PB algorithm, while still maintaining the good features of this beamformer. The simplicity and good performance of our method show its potential for use in clinical applications.

Spatial-coherence-based beamforming for image quality enhancement in high frame-rate ultrasound imaging

Several high frame-rate ultrasound imaging techniques have been recently proposed which allow to increase image acquisition rates by transmitting multiple focused beams simultaneously or defocused waves, and reconstructing multiple scan lines in parallel. These methods, which include for example multi-line transmission, plane/diverging wave imaging, and parallel beamforming, have proved to be successful in increasing the frame-rate, but on the other hand they have also showed some limitations in terms of the achievable image quality, partly degrading image contrast and resolution. Different solutions have been proposed to address this problem so far, such as the use of advanced receive beamforming algorithms able to improve the beam shape and the quality of the obtained image. Among these, beamformers based on backscattered signals spatial coherence, as e.g. Filtered Delay Multiply and Sum beamforming, Coherence-Factor-based methods, and Short Lag Spatial Coherence Imaging, have gained increasing attention for their ability to enhance image contrast and suppress clutter. In this presentation, an overview of some recent results obtained by jointly exploiting high frame-rate ultrasound imaging and coherence-based beamforming methods will be presented, showing through experimental tests the performance improvement achievable with these techniques.

Narrowing the distribution of ultrasound image quality using machine learning and deep learning

Ultrasound image quality varies substantially across different subjects. In some cases, this means ultrasound images are non-diagnostic. Overcoming these non-diagnostic exams is a common goal for advanced ultrasound beamforming algorithms. Recently, new beamforming approaches using machine learning and deep learning have been proposed by a number of groups to overcome ultrasound’s image quality issues. Our group has proposed several methods relying on both machine learning and deep learning approaches. We will also show how physics-based machine learning methods can lead directly to deep learning methods, and we can use the development and performance of these methods to generate insight into the underlying structure of ultrasound data. We will also show that rather than leading to artificial gains, deep learning methods can be used to actually increase the available information in the form of improved dynamic range compared to delay and sum beamforming. The improvement is 15–20 dB, and we can achieve this improvement in both clean and highly cluttered data. Finally, we will show that ultrasound beamformers can be trained with unlabeled in vivo data in order to learn the underlying distribution of clutter in particular in vivo scenarios (e.g. echocardiography). This leads to improvements in imaging performance and can be used to generate insight into the interaction of different sources of image degradation in vivo.

A nonlinear beamforming for enhanced spatiotemporal sensitivity in high frame rate ultrasound flow imaging

Typically, an ultrasound flow imaging system employs the conventional delay and sum (DAS) beamformer due to its inherent low complexity. But the conventional DAS technique offers poor contrast, low imaging resolution, and limited spatiotemporal sensitivity. This article attempts to improve the spatiotemporal sensitivity of the conventional flow imaging with a novel multiply and sum based nonlinear high-resolution (NLHR) beamforming approach. The major advantages of the proposed beamformer are the harmonic generation and the enhanced coherence in beamformed signals that improve the spatiotemporal sensitivity towards flow transients. We demonstrate the proposed beamformer for a directional cross-correlation as well as an autocorrelation based velocity estimator with simulated parabolic flow profiles of different velocities and flow directions, an in-vitro rotating disk dataset, and pulsatile flow experiments. The sensitivity of NLHR beamforming towards the flow transients is validated in-vitro with a sudden reversal of flow direction and air bubble tracking experiments. The comparison between the time–frequency plots of DAS and NLHR beamforming indicates that the impulsive spatiotemporal changes induced by the flow of air bubbles are clearly characterized by nonlinear beamforming than that of DAS beamforming. Furthermore, better spatiotemporal velocity tracking of a single air bubble and a clear distinguishability between the tracking of two proximal air bubbles are observed in-vitro. Preliminary studies on the in-vivo carotid data also show comparable, if not better, results than that of the DAS algorithm. Detailed results for each test case in simulation, phantom, and in-vivo studies are available as movies with the supplementary material and online [Online Link].

Acoustic Estimation of the Direction of Arrival of an Unmanned Aerial Vehicle Based on Frequency Tracking in the Time-Frequency Plane.

The development of unmanned aerial vehicles (UAVs) opens up a lot of opportunities but also brings some threats. Dealing with these threats is not easy and requires some good techniques. Knowing the location of the threat is essential to deal with an UAV that is displaying disturbing behavior. Many methods exist but can be very limited due to the size of UAVs or due to technological improvements over the years. However, the noise produced by the UAVs is still predominant, so it gives a good opening for the development of acoustic methods. The method presented here takes advantage of a microphone array with a processing based on time domain Delay and Sum Beamforming. In order to obtain a better signal to noise ratio, the UAV’s acoustic signature is taken into account in the processing by using a time-frequency representation of the beamformer’s output. Then, only the content related to this signature is considered to calculate the energy in one direction. This method enables to have a good robustness to noise and to localize an UAV with a poor spectral content or to separate two UAVs with different spectral contents. Simulation results and those of a real flight experiment are reported.

Sign coherence factor‐based double‐stage delay multiply and sum beamforming algorithm for breast cancer detection

AbstractThe delay‐multiply‐and‐sum (DMAS) beamforming algorithm has been extensively used in medical imaging. In this study, we proposed a fast double‐stage DMAS beamformer for breast cancer detection, combined with the sign coherence factor (SCF), namely SCF‐DMAS. The performance of this method was evaluated on a three‐dimensional‐printed breast phantom surrounded by evenly spaced circular array antennas. The results show that the proposed algorithm outperforms the other beamformers involved with respect to the signal‐to‐clutter Ratio, signal‐to‐mean ratio, and localization error. To summarize, the SCF‐DMAS improves the resolution and sidelobe suppression without significantly increasing the computational complexity.

Double-Stage DMAS With Fresnel Zone Filtering in Guided Waves Damage Imaging.

Digital beamforming methods in plate-like structures are widely exploited for Lamb waves-based damage imaging. Among them, the delay and sum (DAS) imaging technique is the most popular thanks to its low-computational cost and ease of implementation. However, the imaging outputs are low quality due to the high levels of side lobes and limited off-axis signal rejection, which leads to limited image resolution and contrast. Recently, the delay multiply and sum (DMAS) beamforming has been applied to nondestructive testing (NDT) field as a promising DAS alternative able to enhance the imaging reconstruction in terms of contrast and damage detectability. However, DMAS is still affected by high levels of artifacts. To tackle this aspect, literature offers a beamforming algorithm called double-stage DMAS (DS-DMAS), first introduced in photoacoustic imaging and medical ultrasound imaging. In this article, the DS-DMAS performance is analyzed for Lamb waves inspection, to provide an exhaustive comparison between DAS, DMAS, and DS-DMAS. As a further step, a filtering process addressed as Fresnel zone filtering (FZF) is used to restrict the beamforming partial sums in a physical way to the area around the scattering point. The proposed approach is an adaptation of a well-established technique in seismic data processing called Fresnel migration, able to suppress artifacts and enhance the quality of the imaging. The algorithms have been compared and characterized by exploiting an online free dataset for guided waves inspection (ht.tp://openguidedwaves.de/) which collects piezo pitch-catch signals traveling through a quasi-isotropic carbon fiber-reinforced plate (CFRP) at different actuated frequencies and damage positions.

An Affordable Streamflow Measurement Technique Based on Delay and Sum Beamforming

At the local scale, environmental parameters often require monitoring by means of affordable measuring techniques and technologies given they need to be frequently surveyed. Streamflow in riverbeds or in channels is a hydrological variable that needs to be monitored in order to keep the runoff regimes under control and somehow forecast floods, allowing prevention of damage for people and infrastructure. Moreover, measuring such a variable is always extremely important for the knowledge of the environmental status of connected aquatic ecosystems. This paper presents a new approach to assessing hydrodynamic features related to a given channel by means of a beamforming technique that was applied to video sensing. Different features have been estimated, namely the flow velocity, the temperature, and the riverbed movements. The applied beamforming technique works on a modified sum and delay method, also using the Multiple Signal Classification algorithm (MUSIC), by acting as Synthetic Aperture Radar (SAR) post-processing. The results are very interesting, especially compared to the on-site measured data and encourage the use of affordable video sensors located along the channel or river course for monitoring purposes. The paper also illustrates the use of beamforming measurements to be calibrated by means of conventional techniques with more accurate data. Certainly, the results can be improved; however, they indicate some margins of improvements and updates. As metrics of assessment, a histogram of greyscale/pixels was adopted, taking into account the example of layers and curve plots. They show changes according to the locations where the supporting videos were obtained.

Performance Enhancement of Functional Delay and Sum Beamforming for Spherical Microphone Arrays

Functional delay and sum (FDAS) beamforming for spherical microphone arrays can achieve 360° panoramic acoustic source identification, thus having broad application prospects for identifying interior noise sources. However, its acoustic imaging suffers from severe sidelobe contamination under a low signal-to-noise ratio (SNR), which deteriorates the sound source identification performance. In order to overcome this issue, the cross-spectral matrix (CSM) of the measured sound pressure signal is reconstructed with diagonal reconstruction (DRec), robust principal component analysis (RPCA), and probabilistic factor analysis (PFA). Correspondingly, three enhanced FDAS methods, namely EFDAS-DRec, EFDAS-RPCA, and EFDAS-PFA, are established. Simulations show that the three methods can significantly enhance the sound source identification performance of FDAS under low SNRs. Compared with FDAS at SNR = 0 dB and the number of snapshots = 1000, the average maximum sidelobe levels of EFDAS-DRec, EFDAS-RPCA, and EFDAS-PFA are reduced by 6.4 dB, 21.6 dB, and 53.1 dB, respectively, and the mainlobes of sound sources are shrunk by 43.5%, 69.0%, and 80.0%, respectively. Moreover, when the number of snapshots is sufficient, the three EFDAS methods can improve both the quantification accuracy and the weak source localization capability. Among the three EFDAS methods, EFDAS-DRec has the highest quantification accuracy, and EFDAS-PFA has the best localization ability for weak sources. The effectiveness of the established methods and the correctness of the simulation conclusions are verified by the acoustic source identification experiment in an ordinary room, and the findings provide a more advanced test and analysis tool for noise source identification in low-SNR cabin environments.

The Spectrum-Beamformer for Conventional B-Mode Ultrasound Imaging System: Principle, Validation, and Robustness.

Fast and efficient imaging techniques are important for real-time ultrasound imaging. The delay and sum (DAS) beamformer is the most widely-used strategy in focused ultrasound imaging (FUI) modality. However, calculating the time delays and coherently summing the amplitude response in DAS is computationally expensive and generally require a high-performance processor to realize real-time processing. In this study, an efficient spectrum beamformer, namely full-matrix capture (FMC)-stolt, is proposed in FUI system with a linear phased array. The imaging performance of FMC-stolt was validated with the point-scatter simulation and in vitro point and cyst phantoms, and then compared with that of five beamformers, that is, Multiline acquisition (MLA), retrospective transmit beamforming (RTB) in the FUI modality, as well as DAS, Garcia's frequency-wavenumber (f-k), Lu's f-k in the coherent plane wave compounding imaging (CPWCI) modality, under specific conditions. We show that the imaging performance of FMC-stolt is better than MLA-DAS in non-transmit-focal regions, and comparable with RTB-DAS at all imaging depths. FMC-stolt also shows better discontinuity alleviation than MLA and RTB. In addition, FMC-stolt has similar imaging characteristics (e.g., off-axis resolution, computational cost) as the f-k beamformers. The computational complexity and actual computational time indicate that FMC-stolt is comparable to Garcia's f-k, Lu's f-k, and faster than RTB and CPWCI-DAS if the transmitting numbers are close for FUI and CPWCI. The study demonstrates that the proposed FMC-stolt could achieve good reconstruction speed while preserving high-quality images and thus provide a choice for software beamforming for conventional B-mode ultrasound imaging, especially for hand-held devices with limited performance processors.

Dual-Mode Volumetric Optoacoustic and Contrast Enhanced Ultrasound Imaging With Spherical Matrix Arrays.

Spherical matrix arrays represent an advantageous tomographic detection geometry for non-invasive deep tissue mapping of vascular networks and oxygenation with volumetric optoacoustic tomography (VOT). Hybridization of VOT with ultrasound (US) imaging remains difficult with this configuration due to the relatively large inter-element pitch of spherical arrays. We suggest a new approach for combining VOT and US contrast-enhanced 3D imaging employing injection of clinically-approved microbubbles. Power Doppler (PD) and US localization imaging were enabled with a sparse US acquisition sequence and model-based inversion based on infimal convolution of total variation (ICTV) regularization. In vitro experiments in tissue-mimicking phantoms and in living mouse brain demonstrate the powerful capabilities of the new dual-mode imaging approach attaining 80 μm spatial resolution and a more than 10 dB signal to noise improvement with respect to a classical delay and sum beamformer. Microbubble localization and tracking allowed for flow velocity mapping up to 40 mm/s.

Application of condition coherence factor based on truncated composite method in ultrasound imaging

The coherence factor (CF) can improve the image contrast and side lobe suppression ability of traditional delay and sum (DAS) beamformer. However, it always leads to dark-region artifacts. In this paper, in order to reduce the dark-region artifacts while maintaining the image resolution and contrast as much as possible, a truncated-composite-based condition coherence factor (TC-CCF) is proposed for ultrasound imaging. Initially, the condition coherence factor (CCF) is defined as the ratio between the number of sampling time which should satisfy the condition of sign consistency and the total number of sampling time within the duration of a transmitting pulse. Then, setting a truncation threshold to truncate the CF and CCF, and the proposed truncated-composite condition coherence factor is obtained by combining the two truncated coherence factor. To evaluate the performance of the proposed methods, the simulation, the geabr_0 experiment, and the in vivo rat mammary tumor study is conducted. The simulated cyst indicates that TC-CCF can obtain better performance than CF and SCF in speckle quality. The geabr_0 experimental results demonstrate that the TC-CCF can gain 34.1% lower full width at half-maximum (FWHM) and 41.7% higher contrast ratio (CR) than traditional DAS. Furthermore, for experimental cysts, a maximal improvements of noise contrast ratio (CNR) and speckle signals-to-noise ratio (sSNR) is 137% and 114.5% respectively. In general, the proposed methods can effectively address the inherent limitation of the standard CF to improve the speckle quality.

High-spatial-resolution, instantaneous passive cavitation imaging with temporal resolution in histotripsy: a simulation study.

PurposeIn histotripsy, a shock wave is transmitted, and the resulting inertial bubble cavitation that disrupts tissue is used for treatment. Therefore, it is necessary to detect when cavitation occurs and track the position of cavitation occurrence using a new passive cavitation (PC) imaging method.MethodsAn integrated PC image, which is constructed by collecting the focused signals at all times, does not provide information on when cavitation occurs and has poor spatial resolution. To solve this problem, we constructed instantaneous PC images by applying delay and sum beamforming at instantaneous time instants. By calculating instantaneous PC images at all data acquisition times, the proposed method can detect cavitation when it occurs by using the property that when signals from the cavitation are focused, their amplitude becomes large, and it can obtain a high-resolution PC image by masking out side lobes in the vicinity of cavitation.ResultsUltrasound image simulation confirmed that the proposed method has higher resolution than conventional integrated PC imaging and showed that it can determine the position and time of cavitation occurrence as well as the signal strength.ConclusionSince the proposed novel PC imaging method can detect each cavitation separately when the incidence of cavitations is low, it can be used to monitor the treatment process of shock wave therapy and histotripsy, in which cavitation is an important mechanism of treatment.

Regional-Lag Signed Delay Multiply and Sum Beamforming in Ultrafast Ultrasound Imaging.

Ultrafast ultrasound imaging provides very high frame rates but provides poor imaging quality due to unfocused beams. The delay multiply and sum (DMAS) beamformer has been used to improve ultrafast ultrasound imaging contrast but is always accompanied by oversuppression, which produces low-quality speckle images and degrades the contrast performance. A smaller maximum lag in the signed DMAS (sDMAS) contributes better speckle preservation but lower resolution for hyperechoic scatters. To overcome this tradeoff, a regional-lag signed delay multiply and sum (rsDMAS) beamformer is proposed in this article. Innovatively, a region discrimination tool realized by the generalized coherence factor (GCF) is used to limit the maximum lag for spatial coherence estimation. Subaperture coherence smoothing estimates the short-lag coherence instead of multiplication in pairs, thereby reducing calculation complexity and smoothing the speckle texture. Normalization and sign correction are also introduced to achieve better beamforming output. The simulated, phantom, and in vivo data are adopted to evaluate the effectiveness of the proposed beamformer. Numerical results show that the proposed method achieves improvements of the contrast ratio (CR) by 9%, contrast-to-noise ratio (CNR) by 41%, speckle signal-to-noise ratio (sSNR) by 41%, and generalized contrast-to-noise ratio (gCNR) by 0.0004 compared with DMAS (in simulation). Resolution experiments show that the proposed method obtains a loss of 0.07 mm in the full width at half maximum (FWHM) and the same separability of close point scatters as DMAS. These findings indicate that the proposed method achieves higher contrast performance at less obvious sacrifice of the lateral resolution than DMAS.

Wedge two-layer medium ultrasonic plane wave compounding imaging based on sign multiply coherence factor combined with delay multiply and sum beamforming

Ultrasonic phased array coherent plane wave compounding has a fast imaging speed, but the imaging quality is severely affected by noise, especially the imaging quality in the case of wedge two-layer medium, which is a problem worthy of study. In this paper, a wedge two-layer medium ultrasonic coherent plane wave compounding imaging based on the sign coherence weighting delay multiply and sum (DMAS) beamforming is proposed. The sign multiply coherence factor (SMCF) is proposed according to the correlation of the received data. The experimental results show that the SMCF weighted DMAS (DMAS-SMCF) method can significantly improve the contrast ratio and resolution of wedge two-layer medium plane wave imaging, and show its application capability in related applications.

Spatial Coherence Beamforming With Multi-Line Transmission to Enhance the Contrast of Coherent Structures in Ultrasound Images Degraded by Acoustic Clutter.

This work demonstrates that the combination of multi-line transmission (MLT) and short-lag spatial coherence (SLSC) imaging improves the contrast of highly coherent structures within soft tissues when compared to both traditional SLSC imaging and conventional delay and sum (DAS) beamforming. Experimental tests with small (i.e., [Formula: see text]-3 mm) targets embedded in homogeneous and heterogeneous backgrounds were conducted. DAS or SLSC images were reconstructed when implementing MLT with varying numbers of simultaneously transmitted beams. In images degraded by acoustic clutter, MLT SLSC achieved up to 34.1 dB better target contrast and up to 16 times higher frame rates when compared to the more conventional single-line transmission SLSC images, with lateral resolution improvements as large as 38.2%. MLT SLSC thus represents a promising technique for clinical applications in which ultrasound visualization of highly coherent targets is required (e.g., breast microcalcifications, kidney stones, and percutaneous biopsy needle tracking) and would otherwise be challenging due to the strong presence of acoustic clutter.

Near-Surface Geological Structure Seismic Wave Imaging Using the Minimum Variance Spatial Smoothing Beamforming Method

Erecting underground structures in regions with unidentified weak layers, cavities, and faults is highly dangerous and potentially disastrous. An efficient and accurate near-surface exploration method is thus of great significance for guiding construction. In near-surface detection, imaging methods suffer from artifacts that the complex structure caused and a lack of efficiency. In order to realize a rapid, accurate, robust near-surface seismic imaging, a minimum variance spatial smoothing (MVSS) beamforming method is proposed for the seismic detection and imaging of underground geological structures under a homogeneous assumption. Algorithms such as minimum variance (MV) and spatial smoothing (SS), the coherence factor (CF) matrix, and the diagonal loading (DL) methods were used to improve imaging quality. Furthermore, it was found that a signal advance correction helped improve the focusing effect in near-surface situations. The feasibility and imaging quality of MVSS beamforming are verified in cave models, layer models, and cave-layer models by numerical simulations, confirming that the MVSS beamforming method can be adapted for seismic imaging. The performance of MVSS beamforming is evaluated in the comparison with Kirchhoff migration, the DAS beamforming method, and reverse time migration. MVSS beamforming has a high computational efficiency and a higher imaging resolution. MVSS beamforming also significantly suppresses the unnecessary components in seismic signals such as S-waves, surface waves, and white noise. Moreover, compared with basic delay and sum (DAS) beamforming, MVSS beamforming has a higher vertical resolution and adaptively suppresses interferences. The results show that the MVSS beamforming imaging method might be helpful for detecting near-surface underground structures and for guiding engineering construction.

Optimally-weighted non-linear beamformer for conventional focused beam ultrasound imaging systems

A novel non-linear beamforming method, namely, filtered delay optimally-weighted multiply and sum (F-DowMAS) beamforming is reported for conventional focused beamforming (CFB) technique. The performance of F-DowMAS was compared against delay and sum (DAS), filtered delay multiply and sum (F-DMAS), filtered delay weight multiply and sum (F-DwMAS) and filter delay Euclidian weighted multiply and sum (F-DewMAS) methods. Notably, in the proposed method the optimal adaptive weights are computed for each imaging point to compensate for the effects due to spatial variations in beam pattern in CFB technique. F-DowMAS, F-DMAS, and DAS were compared in terms of the resulting image quality metrics, Lateral resolution (LR), axial resolution (AR), contrast ratio (CR) and contrast-to-noise ratio (CNR), estimated from experiments on a commercially available tissue-mimicking phantom. The results demonstrate that F-DowMAS improved the AR by 57.04% and 46.95%, LR by 58.21% and 53.40%, CR by 67.35% and 39.25%, and CNR by 44.04% and 30.57% compared to those obtained using DAS and F-DMAS, respectively. Thus, it can be concluded that the newly proposed F-DowMAS outperforms DAS and F-DMAS. As an aside, we also show that the optimal weighting strategy can be extended to benefit DAS.

Optimizing the lateral beamforming step for filtered-delay multiply and sum beamforming to improve active contour segmentation using ultrafast ultrasound imaging

As an alternative to delay-and-sum beamforming, a novel beamforming technique called filtered-delay multiply and sum (FDMAS) was introduced recently to improve ultrasound B-mode image quality. Although a considerable amount of work has been performed to evaluate FDMAS performance, no study has yet focused on the beamforming step size, Δx, in the lateral direction. Accordingly, the performance of FDMAS was evaluated in this study by fine-tuning Δx to find its optimal value and improve boundary definition when balloon snake active contour (BSAC) segmentation was applied to a B-mode image in ultrafast imaging. To demonstrate the effect of altering Δx in the lateral direction on FDMAS, measurements were performed on point targets, a tissue-mimicking phantom and in vivo carotid artery, by using the ultrasound array research platform II equipped with one 128-element linear array transducer, which was excited by 2-cycle sinusoidal signals. With 9-angle compounding, results showed that the lateral resolution (LR) of the point target was improved by 67.9% and 81.2%, when measured at −6 dB and −20 dB respectively, when Δx was reduced from λ to λ/5. Meanwhile the image contrast ratio (CR) measured on the CIRS phantom was improved by 10.38 dB at the same Δx reduction and the same number of compounding angles. The enhanced FDMAS results with lower side lobes and less clutter noise in the anechoic regions provides a means to improve boundary definition on a B-mode image when BSAC segmentation is applied.

A broadband MVDR beamforming core for ultrasound imaging

The Minimum Variance Distortion less Response (MVDR) beamformer is an attractive alternative to conventional delay and sum (DAS) beamformers in medical ultrasound imaging. However, it is not widely employed in medical ultrasound imaging due to its computational complexity. In this paper, we intend to present a novel broadband MVDR beamformer architecture and its implementation for up to 32 channel ultrasound imaging system. The proposed architecture is based on the subarray MVDR and Dichotomous Coordinate Descent (DCD) iteration based adaptive weight computation. A Field Programmable Gate Array (FPGA) based ultrasound system prototype set up is designed, and the proposed MVDR beamforming Core is emulated on the FPGA. The proposed beamforming core could achieve up to 65.5 fps for a 640 x 480 ultrasound frame. The ultrasound system prototype operates at 20 MHz sampling frequency, and the FPGA implementation resulted in approximately 35% of FPGA resources (Xilinx Kintex-7 410T). Image quality comparisons in terms of Contrast Ration (CR) and Contrast to Noise Ratio (CNR) were performed with MATLAB™ MVDR model ported on the Verasonics™ Vantage-64 ultrasound research platform.