Sulfur Functionalities Research Articles

Pd‐Catalyzed Thiotritylation Cross‐Coupling of Aryl Bromides and Iodides to Access Sulfur Functional Groups

AbstractSulfur‐containing functional groups (SFGs) are increasingly important for modern medicinal chemistry and their large structural diversity provides many opportunities for lead optimization. In an effort to simplify the access to the full set of SFGs, we report herein a versatile strategy utilizing (hetero)aryl trityl sulfides (ArSCPh3) as the common precursors. We developed a mild and high yielding Pd‐catalyzed thiotritylation cross‐coupling methodology to afford ArSCPh3 compounds from (hetero)aryl bromides and iodides. Efficient chemoselective derivatizations provided access to eight different SFGs and sulfur(VI) fluorine exchange (SuFEx) hubs, which open up further downstream derivatizations towards the full set of SFGs. Thereby obtainable sulfur motifs include aryl sulfur pentafluorides (ArSF5), aryl tetrafluoro‐λ6‐sulfanyl chlorides (ArSF4Cl), aryl sulfonimidoyl fluorides (ArS(O)(NR)F), aryl sulfonyl fluorides (ArSO2F), aryl sulfonic acids (ArSO3H), and aryl sulfinyl fluorides (ArSOF), which are all valuable functional groups in modern drug discovery.

The role of carbon textile surface functionalities in reactive adsorption of vapor and liquid 2-chloroethyl ethyl sulfide: Evaluating interactions at the interface

A carbon textile (CT) was chemically modified to increase its surface activity and promote the adsorption and degradation of 2-chloroethyl ethyl sulfide (CEES) - a surrogate for mustard gas. CT was initially subjected to oxidation (CTO), and then heated under ammonia (CTON) or hydrogen sulfide (CTOS) atmosphere to incorporate nitrogen or sulfur functionalities, respectively. Detoxification experiments were performed in closed vials using either vapor or liquid forms of CEES. The maximum vapor weight uptakes on CT, CTO, CTOS, and CTON were 399, 372, 434, and 489 mg/g, respectively. All textiles were able to prevent the vaporization of CEES liquid droplets. Although similar reaction products were detected in both vapor and liquid systems, the marked differences in the extent of CEES chemical transformation on the surfaces of the textiles indicate distinct detoxification pathways influenced by surface chemistry. Even though the heterogeneous surface of CTO, enriched with oxygen surface groups, facilitated various reactions, hydrolysis was the predominant pathway. The thermal treatment, regardless of the atmosphere, reduced the oxygen content, decreasing the extent of hydrolysis. However, incorporating basic surface groups such as pyridines, amines, or weak acids such as thiols promoted dehydrohalogenation as the main detoxification pathway on these samples.

Impacts of hydrodynamic disturbance on black blooms: An in-situ study in Lake Taihu

The occurrence of black blooms, a kind of black water phenomenon, mostly formed by the decomposition of cyanobacterial blooms poses a threat to both drinking water supplies and the survival of aquatic organisms. Meteorological and hydrological conditions play a crucial role in their formation, while the specific impact of hydrodynamic disturbances on the black blooms remains unclear. The aim of this study is to investigate in depth the impact of hydrodynamic disturbances on the formation and development of black blooms, as well as their effects on the microbiota in surface sediments during the process. During the occurrence of black blooms in Lake Taihu, in-situ water and surface sediment samples were collected. By combining studies of the changes in water quality and microbial communities, the potential driving mechanisms of hydrodynamic disturbances were analyzed. The results indicate that during the outbreak stage (MS), hydrodynamic disturbances drove the release of anaerobic byproducts in sediments (NH4+-N ≥ 0.5 mg/L, TN ≥ 2.03 mg/L, TP ≥ 0.15 mg/L), and varying levels of hydrodynamic disturbance led to significant differences in microbial communities (ANOSIM, R = 0.477, p < 0.05). This influenced the abundance of microorganisms with carbon and sulfur cycling functions in sediments, where stronger hydrodynamics promoted the coupling of carbon mineralization and fermentation processes, while weaker hydrodynamic disturbances facilitated the coupling of carbon mineralization and sulfate reduction processes. Additionally, hydrodynamic disturbances influenced the potential functions of sulfate-reducing bacteria (SRB) in sediments, altering the interactions between SRB and other microorganisms. This study, for the first time, investigated the impact of hydrodynamics on the formation of black blooms from the perspective of their interaction with microorganisms. These findings broaden our understanding of the significance of hydrodynamic disturbances during black bloom occurrences and contribute to our ability to predict the formation of black blooms through modeling.

Sulfur-Functionalized Carbon Nanotubes with Inlaid Nanographene for 3D-Printing Micro-Supercapacitors and a Flexible Self-Powered Sensing System.

Digital fabrication of miniaturized micro-supercapacitors (MSCs) holds immense promise for advancing customized, integrated microelectronic systems. As potential electrode materials, carbonaceous nanomaterials, such as carbon nanotubes (CNTs), stand out due to their excellent conductivity and mechanical robustness yet suffer from low ionic storage sites, which restrict further applications. Herein, we introduce a sulfur-assisted in situ activating strategy for obtaining sulfur-functionalized carbon nanotube frameworks integrated with inlaid graphene nanosheets (S-CNT/GNS). Specifically, sulfur functionality enriches the surface charge density with improved interfacial hydrophilicity, while the inlaid nanographene sheets provide abundant ionic adsorption sites. By direct 3D printing of the S-CNT/GNS ink, planar MSCs were fabricated with desirable functionality and outstanding electrochemical performance. Notably, the developed MSCs exhibit a high areal capacitance of 0.47 F cm-2, an exceptional energy density of 64.6 μWh cm-2, and a high-power density of 34.2 mW cm-2. Furthermore, an all-flexible self-powered sensing system with photovoltaic cells and a stretchable sensor was built upon the customized S-CNT/GNS MSCs, demonstrating a highly effective capability for real-time monitoring of human physiological signals and body movements. This work not only presents a promising approach for the development of high-performance MSCs but also lays the groundwork for the creation of advanced wearable/flexible microelectronics systems.

Efficient CO2 removal enabled by N, S co-doped hierarchical porous carbon derived from sustainable lignin

Biomass-derived heteroatoms-doped hierarchical porous carbon materials are highly regarded as promising CO2 adsorbents. However, these materials cannot simultaneously exhibit advanced porosity, high yield, and high heteroatom content. Herein, a series of N, S co-doped hierarchical porous carbons with advanced porosity (narrow micropore: 0.37–0.42 cm3/g), high heteroatom content (N content: 8.54 at% and 8.87 wt% and S content: 0.86 at% and 1.73 wt%) and remarkable yield (57.12–69.13 wt%) was produced using lignin as the raw material via a synergistic strategy involving melamine modification and CuCl2 activation. Notably, melamine modification not only introduced mesopores, but also promoted the effect of CuCl2 activation to generate additional micropores. Importantly, the advanced porosity required a low dosage of CuCl2. The optimized adsorbent (NHPC-850) exhibits outstanding CO2 adsorption capacity (6.87 mmol/g at 273 K and 100 kPa, 3.57 mmol/g at 303 K and 100 kPa), a moderately high heat of adsorption (34.7 kJ/mol), and an extraordinary CO2/N2 selectivity (132 at 273 K/81 at 303 K). These excellent properties are attributed to the well-developed micropores and suitable mesopores of carbon materials, as well as rich nitrogen and sulfur functionality in the carbon structure. Collectively, this work offers new insights into a simple and easy-to-scale strategy for the preparation of biomass-derived N, S co-doped hierarchical porous carbon.

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes.

Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective selective treatments that could improve the 5-year survival rate. Consequently, the pathophysiological processes within leukemia cells are the focus of critical research. Enzymes such as cystathionine beta-synthase and sulfurtransferases like thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine gamma-lyase play a vital role in cellular sulfur metabolism. These enzymes are essential to maintaining cellular homeostasis, providing robust antioxidant defenses, and supporting cell division. Numerous studies have demonstrated that cancerous processes can alter the expression and activity of these enzymes, uncovering potential vulnerabilities or molecular targets for cancer therapy. Recent laboratory research has indicated that certain leukemia cell lines may exhibit significant changes in the expression patterns of these enzymes. Analysis of the scientific literature and online datasets has confirmed variations in sulfur enzyme function in specific leukemic cell lines compared to normal leukocytes. This comprehensive review collects and analyzes available information on sulfur enzymes in normal and leukemic cell lines, providing valuable insights and identifying new research pathways in this field.

Regulating Reactive Oxygen Intermediates of Fe–N–C SAzyme via Second‐Shell Coordination for Selective Aerobic Oxidation Reactions

Reactive oxygen species (ROS) regulation for single‐atom nanozymes (SAzymes), e.g., Fe–N–C, is a key scientific issue that determines the activity, selectivity, and stability of aerobic reaction. However, the poor understanding of ROS formation mechanism on SAzymes greatly hampers their wider deployment. Herein, inspired by cytochromes P450 affording bound ROS intermediates in O2 activation, we report Fe–N–C containing the same FeN4 but with tunable second‐shell coordination can effectively regulate ROS production pathways. Remarkably, compared to the control Fe–N–C sample, the second‐shell sulfur functionalized Fe–N–C delivered a·2.4‐fold increase of oxidase‐like activity via the bound Fe=O intermediate. Conversely, free ROS (•O2‐) release was significantly reduced after functionalization, down to only 17% of that observed for Fe–N–C. The detailed characterizations and theoretical calculations revealed that the second‐shell sulfur functionalization significantly altered the electronic structure of FeN4 sites, leading to an increase of electron density at Fermi level. It enhanced the electron transfer from active sites to the key intermediate *OOH, thereby ultimately determining the type of ROS in aerobic oxidation process. The proposed Fe–N–Cs with different second‐shell anion were further applied to three aerobic oxidation reactions with enhanced activity, selectivity, and stability.

Regulating Reactive Oxygen Intermediates of Fe-N-C SAzyme via Second-Shell Coordination for Selective Aerobic Oxidation Reactions.

Reactive oxygen species (ROS) regulation for single-atom nanozymes (SAzymes), e.g., Fe-N-C, is a key scientific issue that determines the activity, selectivity, and stability of aerobic reaction. However, the poor understanding of ROS formation mechanism on SAzymes greatly hampers their wider deployment. Herein, inspired by cytochromes P450 affording bound ROS intermediates in O2 activation, we report Fe-N-C containing the same FeN4 but with tunable second-shell coordination can effectively regulate ROS production pathways. Remarkably, compared to the control Fe-N-C sample, the second-shell sulfur functionalized Fe-N-C delivered a 2.4-fold increase of oxidase-like activity via the bound Fe=O intermediate. Conversely, free ROS (⋅O2 -) release was significantly reduced after functionalization, down to only 17 % of that observed for Fe-N-C. The detailed characterizations and theoretical calculations revealed that the second-shell sulfur functionalization significantly altered the electronic structure of FeN4 sites, leading to an increase of electron density at Fermi level. It enhanced the electron transfer from active sites to the key intermediate *OOH, thereby ultimately determining the type of ROS in aerobic oxidation process. The proposed Fe-N-Cs with different second-shell anion were further applied to three aerobic oxidation reactions with enhanced activity, selectivity, and stability.

Enhancing sulfur absorption in soybean rhizosphere through arbuscular mycorrhizal fungi inoculation: Implications for soil health and crop growth

Soybean, a sulfur-loving cash crop, suffers from declining soil sulfur with continuous cropping, hindering its growth and development. Arbuscular mycorrhizal fungi (AMF) form beneficial partnerships with plant roots, aiding in nutrient uptake and promoting plant growth. Recent research has increasingly focused upon AMF's potential to enhance sulfur absorption through increased rhizosphere microbial activity. This study investigated the impact of AMF inoculation on soil organic sulfur mineralization, microbial community composition, and sulfur cycle function genes in the continuous cropping soybean rhizosphere. 16 S rRNA sequencing and high-throughput qPCR revealed changes in microbial community composition and the expression of sulfur cycle genes. ICP-MS measured total soil sulfur, and the BaSO4 turbidimetric method determined available sulfur. Following inoculation of continuous cropping soybean soil with AMF, it was observed that OTU1851, OTU1897, OTU2148, OTU3303, and OTU3738, five specific rhizospheric soil sulfur cycling microbial communities, were enriched. And AMF inoculation enhanced sulfur cycle function, the abundance of aspA, soxY and yedZ increased by 143.23 %, 236.04 % and 436.64 %. This led to increased soil arylsulfatase (S-ASF) activity (from 39.17 to 49.82 μg/(mL·h)), available sulfur content (from 12.88 to 17.55 mg/kg), and ultimately, improved soybean sulfur absorption and growth. Therefore, this study holds significant implications for improving available sulfur content and utilization in sulfur-deficient soils. Furthermore, it provides a theoretical basis for using AMF as a biofertilizer to remediate sulfur -deficiency, offering a sustainable and environmentally friendly solution.

Compositional and functional succession of soil bacterial communities during long-term rice cultivation on saline-alkali soils: Insights derived from a new perspective of the core bacterial taxa

The conversion of saline-alkali soils into paddy fields for long-term rice cultivation involves multiple disturbances, and as a result, soil microbial communities are altered to adapt to a changing environment. A comprehensive understanding of the succession of soil bacterial communities that occurs during this process, however, is still lacking. In the present study, we utilized data obtained from rice paddies of different cultivation years to investigate the compositional and functional succession of the soil bacterial community. We focused on core bacterial taxa that were specifically enriched at different successional stages. Generalized joint attribute modeling (GJAM) was used to identify core bacterial taxa. Results indicated that bare saline-alkali soils shared few core amplicon sequence variants (ASVs) with paddy fields. Longimicrobiaceae from the phylum Gemmatimonadetes was dominant in bare saline-alkali soils, while their dominance was subsequently replaced by Burkholderiaceae and Pedosphaeraceae, phyla affiliated with the Proteobacteria and Verrucomicrobia, after 5 years and 23 years of rice cultivation, respectively. The abundance of nitrogen metabolism functions in the core bacterial community present in bare saline-alkali soils were higher than they were in other successional stages, while sulfur metabolism functions exhibited the opposite trend. These data indicate that the role of the core bacterial taxa in mediating nutrient cycling also changed and adapted to changing soil conditions as rice cultivation became established. Redundancy analysis (RDA) indicated that the compositions of the core bacterial community in Y0, Y5s, Y10s, and Y20s groups were driven by nitrate-nitrogen content, soil pH, available phosphorus content, and the ratio of total carbon to total nitrogen, respectively. In summary, the present study provides insights into the succession of soil bacterial communities and core bacterial taxa that occur during long-term rice cultivation.

In situ constructing of sulfur bedecked ZIF-67 with ultrahigh and selectivity UO22+ immobilization capability from seawater

Uranium, a strategically significant resource, is estimated to contain approximately 4.5 billion tons of unconventional uranium in seawater, which can be extracted as a sustainable fuel source for nuclear power plants. In this work, a sulfur bedecked ZIF-67 (SF@ZIF-67) uranium adsorbent were successfully fabricated by employing a facile hydrothermal sulfur functionalization approach. Sequential batch experiment showed that the SF@ZIF-67 specimen displayed a broader pH response range, exceptional UO22+ harvesting efficiency (Uinitial = ∼5–10 ppm, ∼90.68 %–93.79 %) and ultra-high uranium capture capacity (qmax = 769.23 mg/g). Remarkably, due to the strong affinity between sulfur functional groups and uranyl, the SF@ZIF-67 sample exhibited exceptional selectivity with a Kd value exceeding 104 mL/g even in the presence of diverse interfering ions. Moreover, the SF@ZIF-67 specimen showed a sustained uptake efficiency of 66.61 % with close 104 KdU value in a 3000-fold VO43− system. In natural uranium spiked-seawater (Uinitial = ∼10–1000 μg/L), SF@ZIF-67 can capture ∼21–2484.5 μg/g uranium after 24 h contact. Mechanism analysis confirmed that excellent uranyl fixation ability is attributed to the coordination of sulfur and oxygen terminals with uranyl, as well as the redox processes of S2− and U6+. This hydrothermal functionalization technique offers novel insights into the potential application of MOF materials for uranium extraction from seawater.

Electronic Effects in a Green Protocol for (Hetero)Aryl-S Coupling.

Aryl and heteroaryl iodides have been efficiently converted into the corresponding thioacetates in cyclopentyl methyl ether (CPME), a green solvent, under Cu catalysis. The chemoselectivity of the reaction is mainly controlled by electronic factors, enabling the conversion of both electron-rich and electron-deficient substrates into the corresponding thioacetates in good to excellent yields. The products can be easily deprotected to the corresponding thiolates to carry out additional synthetic transformations in situ. Surprisingly, despite CPME's relatively low dielectric constant, the reaction rate significantly increased when conducted under microwave irradiation conditions. This synthetic methodology exhibits a remarkable tolerance to functional groups, mild reaction conditions, and a wide substrate scope, utilizing a safe and inexpensive CuI pre-catalyst in the green solvent CPME. A non-aqueous workup allowing for the complete recovery of both catalyst and solvent makes this approach an environmentally sustainable protocol for C(sp2) sulfur functionalization. Additionally, the reaction shows selective cross-coupling with iodides in competition with chlorides and bromides, allowing its use in multistep syntheses. To demonstrate the potential of this methodology, it was applied to the high-yield synthesis of a photochromic dithienylethene, where a selective synthesis had not been reported before.

Maximizing Thiophene–Sulfur Functional Groups in Carbon Catalysts for Highly Selective H2O2 Electrosynthesis

Maximizing Thiophene–Sulfur Functional Groups in Carbon Catalysts for Highly Selective H₂O₂ Electrosynthesis

Removal capacities and varying characteristics of substrates and microbial community structure in simultaneous sulfide and nitrate biological removal process

Under the background of carbon neutrality, resource and energy utilization technologies have become the focus of future research. The paper investigated the removal efficiencies and varying characteristics of substrates and microbial community structure in the simultaneous sulfide and nitrate biological removal (SSNBR) process. The results showed that the sulfide and nitrate removal loads reached 2.998 kg m−3∙d−1 and 1.011 kg m−3∙d−1 respectively when HRT was 2.4 h. The sulfide and nitrate molar ratios (S/N ratios) hardly influenced the removal efficiencies of sulfide and nitrate. However, the reaction products sulfate and nitrite concentrations in the effluent became higher as the S/N ratios decreased. Under the S/N ratio of 5:5, when the influent sulfide and nitrate concentrations were improved from 100 mg L−1 to 600 mg L−1 and from 87.5 mg L−1 to 306.25 mg L−1, respectively, the sulfide removal efficiencies were all above 99%, but the nitrate removal efficiencies reduced from 95.53% to 55.54%. Sulfide removal effect was better than nitrate. HRT had great effect on the nitrate removal efficiencies, but hardly affected the sulfide removal. When HRT was shortened from 12 h to 2.4 h, the sulfide removal efficiencies were all above 99%, while the nitrate removal efficiencies decreased from 93.14% to 77.04%. The main functional genera included Exiguobacterium, Clostridium, Bacillus, Thiobacillus and Sphingomonas, all of which had the nitrogen and sulfur removal functions.

Chemoselective Heterogeneous Hydrogenation of Sulfur Containing Quinolines under Mild Conditions.

Sulfur, alongside oxygen and nitrogen, holds a prominent position as one of the key heteroatoms in nature and medicinal chemistry. Its significance stems from its ability to adopt different oxidation states, rendering it valuable as both a polarity handle and a hydrogen bond donor/acceptor. Nevertheless, the poisonous nature of its free electron pairs makes sulfur containing substrates inaccessible for many catalytic protocols. Strong and (at low temperatures) irreversible chemisorption to the catalyst's surface is in particular detrimental for heterogeneous catalysts, possessing only few catalytically active sites. Herein, we present a novel heterogeneous Ru-S catalyst that tolerates multiple sulfur functionalities, including thioethers, thiophenes, sulfoxides, sulfones, sulfonamides, and sulfoximines, in the hydrogenation of quinolines. The utility of the products was further demonstrated by subsequent diversifications of the sulfur functionalities.

Electronic, optical and charge transport properties of Zn-porphyrin-C60 MOFs: a combined periodic and cluster modeling.

Density functional theory (DFT) calculations were performed on the 5,15 meso-positions of nine porphyrin-containing MOFs; Zn2(TCPB)-(NMe2-ZnP); (H4TCPB = 1,2,4,5-tetrakis(4-carboxyphenyl)benzene), (NMe2-ZnP = [5,15-bis[(4-pyridyl)-ethynyl]-10,20-bis-(dimethylamine) porphinato]zinc(II)) functionalized with nitrogen-, oxygen-, and sulfur-containing groups to study their effects on the electronic, optical and transport properties of the materials. The properties of these materials have also been investigated by encapsulating fullerene (C60) in their pores (C60@MOFs). The results indicate that the guest C60 in the MOF generates high photoconductivity through efficient porphyrin/fullerene donor-acceptor (D-A) interactions, which are facilitated by oxygen and sulfur functionalities. DFT calculations show that C60 interacts favorably in MOFs due to negative Eint values. Encapsulated C60 molecules modify the electronic band structure, affecting the conduction band and unoccupied states of MOFs corresponding to C60 p orbitals. TD-DFT calculations show that incorporating C60 promotes D-A interactions in MOFs, leading to charge transfer in the near-infrared and visible photoinduced electron transfer (PET) from porphyrins to C60. Nonequilibrium Green's function-based calculations for MOFs with sulfur group, with and without C60, performed using molecular junctions with Au(111)-based electrodes show increased charge transport for the doped MOF. These insights into tuning electronic/optical properties and controlling charge transfer can aid in the design of new visible/near-infrared MOF-based optoelectronic devices.

The interplay between surface area and sulfur doping of carbon support on Pt NPs nucleation and growth: A synergistic enhancement of catalytic activity for oxygen reduction

Metal–carbon interaction plays a fundamental role in tuning the electrocatalytic behavior of metal nanoparticles (NP). The aim of this study is to emphasize the effective synergy between sulfur doping and the porous structure of the carbon support on the Pt NPs morphology and dimension. Thiophenic-like defects exert a metal-support interaction that affects Pt NPs nucleation and growth and their catalytic activity versus the oxygen reduction reaction (ORR), which makes them promising candidates for the cathode side of PEMFC. Pt NPs defectivity, size, and size dispersion were asserted by using synchrotron wide-angle X-ray total scattering and advanced data analysis. The analyses confirm a mutual correlation between the carbon surface area and the density of sulfur groups with the Pt-specific surface area and with their electrocatalytic properties. The catalytic activity for ORR reaches its peak when a balance is struck between the mesoporosity and the sulfur functionalization of the carbon support.

Synthesis of N-Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One-Pot Sulfur-Arylation and Dealkylation.

A general one-pot approach to diverse N-acylsulfenamides from a common S-phenethylsulfenamide starting material is reported. This approach was demonstrated by C-S bond formation utilizing commercially abundant (hetero)aryl iodides and boronic acids to provide sulfilimine intermediates that undergo thermal elimination of styrene. In contrast, all prior approaches to N-acylsulfenamides rely on thiol inputs to introduce sulfenamide S-substituents. A broad scope of reaction inputs was demonstrated including for approved drugs and drug precursors with dense display of functionality. Several different types of sulfur functionalization were performed on a sulfenamide derived from a complex precursor of the blockbuster anticoagulant drug apixaban, highlighting the utility of this approach for the introduction of high oxidation state sulfur groups in complex bioactive compounds. Mechanistic studies established that the key styrene elimination step proceeds by a concerted elimination that does not require reagents or catalysts, and therefore, this one-pot approach should be applicable to the synthesis of N-acylsulfenamides utilizing diverse electrophiles and reaction conditions for C-S bond formation.

Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation

AbstractA general one‐pot approach to diverse N‐acylsulfenamides from a common S‐phenethylsulfenamide starting material is reported. This approach was demonstrated by C−S bond formation utilizing commercially abundant (hetero)aryl iodides and boronic acids to provide sulfilimine intermediates that undergo thermal elimination of styrene. In contrast, all prior approaches to N‐acylsulfenamides rely on thiol inputs to introduce sulfenamide S‐substituents. A broad scope of reaction inputs was demonstrated including for approved drugs and drug precursors with dense display of functionality. Several different types of sulfur functionalization were performed on a sulfenamide derived from a complex precursor of the blockbuster anticoagulant drug apixaban, highlighting the utility of this approach for the introduction of high oxidation state sulfur groups in complex bioactive compounds. Mechanistic studies established that the key styrene elimination step proceeds by a concerted elimination that does not require reagents or catalysts, and therefore, this one‐pot approach should be applicable to the synthesis of N‐acylsulfenamides utilizing diverse electrophiles and reaction conditions for C−S bond formation.

Sulfur-Doped porous carbon Adsorbent: A promising solution for effective and selective CO2 capture

The effective and selective capture of CO2 through the rational design of microstructures and the synthesis of carbon materials with enriched surface functionality is of utmost importance in mitigating CO2 emissions. In this study, we successfully prepared a novel type of S-doped porous carbon material with a high surface area and a significant volume of micropores in a straightforward manner. This was achieved by pyrolyzing carbonized coconut shells (CS) with potassium thiosulfate K2S2O3 (PT) as an activating and sulfur supply agent. By adjusting the pyrolysis temperature within the range of 650–750 °C, we obtained carbon materials with varying surface areas (887–1924 m2/g), pore volumes (0.35–0.95 cm3 g−1), and a homogeneous distribution of sulfur content (up to 12.26 wt%) within the carbon framework. The optimal S-doped porous carbon demonstrated the adsorption capacities of 3.59 mmol g−1 at 25 °C and 5.31 mmol g−1 at 0 °C under 1 bar. Additionally, the prepared sorbent exhibited favorable CO2/N2 selectivity, high isosteric heat, and stable cycling performance. These excellent CO2 capture properties can be attributed to the materials' high microporosity and well-dispersed sulfur functionality in the carbon framework. Collectively, these findings highlight the potential of these novel carbon materials with heteroatom doping as efficient adsorbents for the selective capture of CO2, presenting a viable solution in the quest for effective CO2 mitigation.