Suitable Pore Size Research Articles

Removing mesopores from metal-organic framework MIL-100(Cr) membranes for superior CO2 separation

Membranes with high CO2 permeance and satisfactory CO2/N2 selectivity have been in demand for industrial applications, especially for the first stage of two-stage membrane-based process. MOF membranes with abundant pores have the potential to achieve high CO2 permeance, but most current MOF membranes fall short of the requirements (CO2 permeance > 3000 GPU). Research on novel MOF membranes is urgently needed. Here, a new kind of non-crystalline (NC) MIL-100(Cr) membrane removed mesopores is fabricated by a non-fine assembly process. NC-MIL-100(Cr) possesses similar bonding structure and surface properties to crystalline MIL-100(Cr), but delivers more suitable pore size and high processibility for membrane formation. NC-MIL-100(Cr) membranes are prepared under different Cr3+ concentrations in reaction solution and secondary growth durations, among which NC-MIL-100(Cr) membranes prepared with Cr3+ concentration of 2 mmol/mol DMF and secondary growth duration of 36 h display CO2 permeance of about 4638 GPU and CO2/N2 selectivity of about 35 for mixed CO2/N2 (15/85, v/v) separation, as well as CO2 permeance of about 8670 GPU for single CO2 permeation.

Magnetic biocatalytic nanoreactors based on graphene oxide with graded reduction degrees for the enzymatic synthesis of phytosterol esters

As we know, the carriers of enzymatic nanoreactors with different amphipathy have significant influence on the interfacial enzyme activities and its performance. In this study, the magnetic graphene oxide (GO) enzyme carriers were constructed by assembling graphene oxide with different reduction degrees (rGO(x)) and polyethyleneimine (PEI) modified nano-flowery Fe3O4 into composite materials through electrostatic interactions, and x here represents the reduction reaction hours of GO. The SEM, TEM, contact angles and BET tests qualified the ideal enzyme carrier, PEI-Fe3O4-rGO(12), by adsorption-crosslinking method, the Candida rugosa lipase (CRL) was immobilized to obtain the lipase nanoreactor, PEI-Fe3O4-rGO(12)@CRL. The nano-sheet and nano-flower structures provided a larger specific surface area and suitable pore size, and the CRL had higher protein load on the carrier material (163.11 mg/g). In addition, using hydrolyzed p-nitrophenol palmitate as the model, the PEI-Fe3O4-rGO(12)@CRL can still show 76.5 % residual activity after 8 repeated uses. At the same time, the immobilized lipase showed good catalytic performance in the biosynthesis of phytosterol esters. The optimal esterification conditions were determined by single factor experiment (isooctane, sterol concentration 150 μmol/mL, alkyd molar ratio 1:2, enzyme dosage 120 mg, 26 h, 55 °C, the esterification rate was 76.24 %). Therefore, the optimal biocatalyst PEI-Fe3O4-rGO(12)@CRL may has good performance in the biosynthesis of other novel foods.

Reinforcement of biodegradable SiO2NPs-modified cellulose-gelatin hydrogel films with antioxidant and antibacterial properties as potential food packaging composite

This study proposed an innovative approach to the development of sustainable and biodegradable food packaging materials by incorporating inexpensive nano-silica (SiO2NPs) in designed hydrogel (CSG) film employing biodegradable polymers: synthetic polymer polyvinyl alcohol (PVA), natural polymer - carboxymethyl cellulose (CMC) and protein-based bio-polymer –gelatine, and a commercial crosslinker, tetraethoxysilane (TEOS) through a conventional air-dry casting technique. The CSG hydrogel blends were modified with varying amounts of SiO2NPs (0.05g, 0.1g, 0.15g and 0.2g) and compared with the blend without SiO2NPs to determine the effect of SiO2NPs loading through various characterisation techniques and applications including antioxidant and antimicrobial activity. Comprehensive characterizations of the CSG films revealed that CSG 0.1 (containing 0.1g SiO2NPs) exhibited the most favourable functional properties, low crystallinity, high flexibility, suitable pore size, thermal stability, adequate tensile strength, elongation at the breaking point and maximum stability by swelling and diffusion test. The addition of SiO2NPs consistently enhanced thermal and mechanical stability in all CSG films. Further, these CSG films were implemented for antioxidant test and antimicrobial activity against gram-positive Bacillus cereus and gram-negative Escherichia coli. SiO2NPs integration significantly elevated the antioxidant capacity in all films, with CSG 0.1 showing ⁓7% improvement. The antimicrobial activity of SiO2NPs-modified CSG films was also notable, with CSG 0.1 effectively inhibiting B. cereus by 1.2cm zone and E. coli by 0.5cm zone. A soil burial test was performed to pattern the biodegradability of CSG hydrogels. Therefore, the outstanding improvements in the intrinsic properties of CSG films, owing to SiO2NPs modification, positioned these CSG hydrogels as promising candidates for advanced food packaging materials in various industries.

One‐Step Butadiene Purification in a Sulfonate‐Functionalized Metal‐Organic Framework through Synergistic Separation Mechanism

Porous materials that could recognize specific molecules from complex mixtures are of great potential in improving the current energy‐intensive multistep separation processes. However, due to the highly similar structures and properties of the mixtures, the design of desired porous materials remains challenging. Herein, a sulfonate‐functionalized metal‐organic framework ZU‐609 with suitable pore size and pore chemistry is designed for 1,3‐butadiene (C4H6) purification from complex C4 mixtures. The sulfonate anions decorated in the channel achieve selective recognition of C4H6 from other C4 olefins with subtle polarity differences through C‐H···O‐S interactions, affording recorded C4H6/trans‐2‐C4H8 selectivity (4.4). Meanwhile, the shrunken mouth of the channel with a suitable pore size (4.6 Å) exhibits exclusion effect to the larger molecules cis‐2‐C4H8, iso‐C4H8, n‐C4H10 and iso‐C4H10. Benefiting from the moderate C4 olefins binding affinity exhibited by sulfonate anions, the adsorbed C4H6 could be easily regenerated near ambient conditions. Polymer‐grade 1,3‐butadiene (99.5%) is firstly obtained from 7‐component C4 mixtures via one adsorption‐desorption cycle. The work demonstrates the great potential of synergistic recognition of size‐sieving and thermodynamically equilibrium in dealing with complex mixtures.

One-Step Butadiene Purification in a Sulfonate-Functionalized Metal-Organic Framework through Synergistic Separation Mechanism.

Porous materials that could recognize specific molecules from complex mixtures are of great potential in improving the current energy-intensive multistep separation processes. However, due to the highly similar structures and properties of the mixtures, the design of desired porous materials remains challenging. Herein, a sulfonate-functionalized metal-organic framework ZU-609 with suitable pore size and pore chemistry is designed for 1,3-butadiene (C4H6) purification from complex C4 mixtures. The sulfonate anions decorated in the channel achieve selective recognition of C4H6 from other C4 olefins with subtle polarity differences through C-H···O-S interactions, affording recorded C4H6/trans-2-C4H8 selectivity (4.4). Meanwhile, the shrunken mouth of the channel with a suitable pore size (4.6 Å) exhibits exclusion effect to the larger molecules cis-2-C4H8, iso-C4H8, n-C4H10 and iso-C4H10. Benefiting from the moderate C4 olefins binding affinity exhibited by sulfonate anions, the adsorbed C4H6 could be easily regenerated near ambient conditions. Polymer-grade 1,3-butadiene (99.5%) is firstly obtained from 7-component C4 mixtures via one adsorption-desorption cycle. The work demonstrates the great potential of synergistic recognition of size-sieving and thermodynamically equilibrium in dealing with complex mixtures.

Designing Urchin-Like S@SiO2 with Regulated Pores Toward Ultra-Fast Room Temperature Sodium-Sulfur Battery.

Captured by high theoretical capacity and low-cost, Sodium-Sulfur (Na-S) batteries have been deemed as promising energy-storage systems. However, their electrochemical properties, containing both cycling and rate properties, still suffer from the notorious "shuttle effect" of polysulfide. Herein, through the effective regulation of pore sizes, a series of S@SiO2 cathode materials are obtained. Benefitting from the abundant pore channels of SiO2 particles, the sulfur loading is as high as 76.3%. Importantly, a suitable pore size can lead to adequate reaction and rapid diffusion behaviors, resulting in excellent electrochemical performances. Specifically, at 2.0Ag-1, the initial capacity of the as-optimized sample can be up to 1370.6mAhg-1. Surprisingly, even after 1050 cycles, it could achieve a high reversible capacity of 1280.8mAhg-1 with an attenuation rate of 0.089%. At 5.0Ag-1, after 500 cycles, the capacity can still remain ≈ 1132.6mAhg-1 (capacity retention rate, 97.5%). Given this, the work is anticipated to offer an effective strategy for advanced electrodes for Na-S batteries.

Sulfonate Functional Ultramicroporous Materials with Suitable Pore Size and Layer-Stacked Structure for C4 Olefins Purification.

Selective recognition of 1,3-butadiene from complex olefin isomers is vital for 1,3-butadiene purification, but the lack of porous materials with suitable pore structures results in poor selectivity and low capacity in C4 olefin separation. Herein, two sulfonate-functionalized organic frameworks, ZU-601 and ZU-602, are designed and show impressive separation performance toward C4 olefins. Benefiting from the suitable aperture size caused by the flexibility of coordinated organic ligand, ZU-601, ZU-602 that are pillared with different sulfonate anions could discriminate C4 olefin isomers with high uptake ratio: 1,3-butadiene/1-butene (207), 1,3-butadiene/trans-2-butene (10.1). Meanwhile, their layer-stacked structure enables the utilization of both intra- and interlayer space, enhancing the accommodation of guest molecules. ZU-601 exhibits record high 1,3-butadiene adsorption capacity of 2.90 mmol g-1 (0.5 bar, 298 K) among the reported flexible porous materials with high 1,3-butadiene/1-butene selectivity. The breakthrough experiments confirm their superior separation ability even for all five C4 olefin isomers, and the molecular-level structural change is well elucidated via powder, crystal analysis, and simulation studies. The work provides ideas toward advanced materials design with simultaneous high separation capacity and high separation selectivity for challenging separations.

Advancements in the Research of COF-Based Materials for Uranyl Enrichment

As a critical fuel for nuclear power operations, uranium plays an important role in ensuring the sustainable development of nuclear energy. In China, the demand for uranium resources is expected to reach 1.0-2.0 million tons per year by 2030. Currently, the principal methods employed for the enrichment of uranyl ions include photocatalysis, electrocatalysis, and adsorption. Covalent organic frameworks (COFs) have emerged as a popular choice for uranyl ion enrichment due to their suitable pore size, substantial specific surface area, and exceptional electrical conductivity. This review primarily focuses on the evaluation and characterization methods pertaining to uranyl enrichment, as well as the utilization of COFs-based materials for uranyl enrichment.

Coupling effect of vacancy defects and multi-adsorption sites in porous carbon cathode for high-performance aqueous zinc-ion hybrid capacitors

Aqueous zinc-ion hybrid capacitors (AZICs) are considered to be an auspicious electrochemical energy storage device due to their superior cycling stability and high power density, but the inadequate electrolyte ions storage active sites and inconsistent pore sizes of porous carbon materials result in poor energy storage performance. Thus, unveiling the interplay between the heteroatom dopant, carbon vacancy defects, and pore sizes in carbon cathode is essential for promoting the Zn2+ and SO42− ions storage capability. In this work, N, S co-doped multi-adsorption sites porous carbon materials with abundant vacancy defects (HC-0.2) are successfully prepared by a facile direct activating/annealing method, which exhibit strong interaction adsorption ability and boost ion and electron transfer. In terms of zinc storage performance, the HC-0.2 cathode exhibits a high capacity of 245.8mAh/g at 0.2A/g and a long cycling stability with 82.3 % capacity retention over 10,000 cycles at 10A/g. Moreover, the HC-0.2//Zn device has a supreme energy density of 164.1Wh/kg and an ultrahigh power density of 30.1 kW/kg. Meanwhile, through theoretical calculations, the N, S multi-adsorption sites, a suitable pore size, and vacancy defects of the HC-0.2 cathode are crucial for improving the Zn2+ and SO42− ions storage capability. This work can provide a comprehensive understanding of the coupling effect of the multi-adsorption sites and vacancy defects of N, S co-doped porous carbon materials on energy storage capability.

Vascular tissue-derived hard carbon with ultra-high rate capability for sodium-ion storage

Vascular tissue helps quickly pass the nutrients and water through the plant. Inspiringly, the transport of electrolyte solutions within such biological tissue may also play an essential role in governing the high-current performance of sodium-ion storage. Herein, we report a facile and efficient approach to fabricate a vascular tissue-derived hard carbon (VHC) by an integrated procedure of leave stripping, carbonization and alkali/acid washing. By meticulously adjusting the pyrolysis temperatures, hierarchical microchannel carbon with abundant turbostratic nanodomains, suitable pore size and special surface functional groups can be obtained, enabling high specific capacity and excellent rate performances. It is believed that the vascular tissue-derived carbon can significantly shorten sodium ion transport paths and further enhance the storage performance on the surface and within the electrode materials, making it a promising candidate for sodium-ion batteries.

Ultrarapid Gelation of Porous Ti3C2Tx MXene Monoliths Induced by Ionic Liquids.

Gelation is a promising method to assemble 3D macroscopic structures from MXene sheets for various applications. However, the fine control and scalable manufacturing of 3D MXene monoliths remains a great challenge. Herein, the controllable gelation of Ti3C2Tx MXene initiated by various ionic liquids (ILs) is first proposed, where the IL serve as linkers to bond the nanosheets together through electrostatic and hydrogen bonding interactions, forming 3D monoliths with well-adjustable structure. Furthermore, density functional theory calculations and experiments further reveal the cross-linking effect of different ILs. Typically, 3D porous structure with high specific surface area, suitable pore size, and improved electrolyte affinity is designed through the cross-linking of Ti3C2Tx with 1-vinyl-3-ethylimidazole bromide ([C2VIm]Br-Ti3C2Tx). Due to the strong coupling, the as-synthesized monolith possesses excellent rate performance and high energy density. The methodology is quite flexible, controllable, and universal that provides a new perspective for promoting innovative applications of 2D materials.

Synthesis and characterization of Co3O4 nanoneedle structures for enhancing the supercapacitive performance

The present study focuses on the synthesis of Co3O4 nanoneedles utilizing a deep eutectic solvent (DES) comprising choline chloride and urea, renowned for its environmentally advantageous characteristics. The deposition time was modified to achieve the desired Co3O4 nanoneedle structure, as indicated by several analyses including structural, vibrational, morphological, elemental, surface area, and pore distribution examinations. Following the initial characterization, other electrochemical storage characterizations were conducted. Experimentally it has been found that the optimum Co3O4 samples yielded 1-D mesoporous nanoneedle structure with the features like (i) a substantial presence of oxygen vacancies, (ii) a relatively greater surface area, and (iii) a suitable pore size. As a result, of which it shows significant specific capacitance of 880 Fg−1 when subjected to a current density of 0.66 Ag−1 in a 2 M KOH aqueous electrolyte. Additionally, it displayed excellent retention of 118% at 60 mVs−1 scan rate after undergoing 5000 cycles. Moreover, a symmetric supercapacitor with a liquid electrolyte was constructed using identical nanoneedle Co3O4 materials as both the cathode and anode. The experimental results demonstrated a specific capacitance of 98.39 Fg−1 at a current density of 0.66 Ag−1. Furthermore, the device exhibited an energy density of 18 Whkg−1 along with a power density of 200 Wkg−1, demonstrating exceptional cycling stability of 94% over a span of 5,000 cycles.

Fabrication of Soft-Hard Heterostructure Porous Carbon with Enhanced Performance for High Mass-Loading Aqueous Supercapacitors.

With the increasing attention to energy and environmental issues, the high value-added utilization of biomass and pitch to functional carbon materials has become an important topic in science and technology. In this work, the soft-hard heterostructure porous carbon (NRP-HPC) is prepared by bio-template method, in which biomass and pitch are used as hard carbon and soft carbon precursors, respectively. The prepared NRP-HPC-4 shows high specific surface area (2293m2 g-1 ), suitable pore size distribution, good conductivity (0.25Ωcm-1 ), and strong wettability. The synergistic effect of soft carbon and hard carbon ensures the composite material exhibiting excellent electrochemical performance for high mass loading (12.0mgcm-2 ) aqueous supercapacitor, i.e., high specific capacitance (304.69Fg-1 at 0.1Ag-1 ), high area capacitance (3.67Fcm-2 at 0.1Ag-1 ), high volumetric specific capacitance (202.74Fcm-3 at 0.1Ag-1 ), low open-circuit voltage attenuation rate (21.04mVh-1 ), good voltage retention (79.12%), and excellent cyclic stability (92.04% capacitance retention and 100% coulombic efficiency after 20000 cycles). The composite technology of soft carbon and hard carbon not only ensures the prepared porous carbon electrode materials with enhanced electrochemical performance, but also realizes the high value-added coupling utilization of biomass and pitch.

Heteroatom-doped porous carbon materials for high performance supercapacitors

Heteroatom-doped carbon materials have considerable potential for applications in energy storage devices (ESDs). In this study, an interconnected B/N/O/P co-doped porous carbon materials (B5-CPPCN-700) was synthesised using a simple one-step method with zinc nitrate hexahydrate and 4′-(4-phosphonylphenyl)−3,2′:6′,3″-terpyridine as raw materials through KOH activation. The as-prepared B5-CPPCN-700 had a large specific surface area, rough surface for ion adsorption, and suitable pore size distribution for electron transport. Moreover, the co-doped B/N/O/P species—particularly the B species—in B5-CPPCN-700 provided active sites and additional pseudocapacitance. These structural and morphological features ensured a high specific capacitance of 503.3 F/g at 0.5 A/g. Furthermore, the assembled symmetric supercapacitor delivered a satisfactory specific energy, specific power (14.98 Wh/kg at 300 W/kg and 6.97 Wh/kg at 22,800 W/kg), and specific capacitance (149.8 F/g at 0.5 A/g and 77.2 F/g at 40 A/g). This study paves the way for the preparation of high-capacitance porous carbon materials for ESDs.

Rationally designed nanotrap structures for efficient separation of rare earth elements over a single step

Extracting rare earth elements (REEs) from wastewater is essential for the growth and an eco-friendly sustainable economy. However, it is a daunting challenge to separate individual rare earth elements by their subtle differences. To overcome this difficulty, we report a unique REE nanotrap that features dense uncoordinated carboxyl groups and triazole N atoms in a two-fold interpenetrated metal-organic framework (named NCU-1). Notably, the synergistic effect of suitable pore sizes and REE nanotraps in NCU-1 is highly responsive to the size variation of rare-earth ions and shows high selectivity toward light REE. As a proof of concept, Pr/Lu and Nd/Er are used as binary models, which give a high separation factor of SFPr/Lu = 796 and SFNd/Er = 273, demonstrating highly efficient separation over a single step. This ability achieves efficient and selective extraction and separation of REEs from mine tailings, establishing this platform as an important advance for sustainable obtaining high-purity REEs.

Application of Covalent Organic Framework-Based Solid-Phase Microextraction for Efficient and Direct Analysis of Neurotransmitters in the Striatum of Nicotine-Addicted mice

This study developed and validated a novel solid-phase microextraction (SPME) method based on covalent organic framework (COF) for the simultaneous analysis of 10 neurotransmitters (NTs) in mice brain tissue using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The synthesized COF was utilized as SPME fiber coating, exhibited a suitable pore size and macromolecule exclusion capability, ensuring excellent thermal stability and high adsorption efficiency for NTs. This allowed direct extraction from brain homogenates, eliminating the need for protein precipitation. And the COF-based SPME fiber exhibited good reusability throughout eight successive recycling cycles. The SPME-UHPLC method demonstrated excellent linearity (correlation coefficients > 0.99), low intra- and inter-day precision (RSDs ≤ 9.5 % and ≤ 10.6 %, respectively), and acceptable matrix effects (ranging 84.3 % to 117.3 %). The developed method was then applied to analyze NTs in the striatum of nicotine-addicted mice, and the statistical analysis revealed significant shifts in the concentrations of dopaminergic, serotonergic, glutamatergic, addiction and deepened the understanding of addiction's neurobiology. This method offers a sensitive and efficient approach for extracting polar NT analytes in complex matrices, profiling NT alterations linked to addiction, and holds potential for early detection and treatment of addiction disorders. It could contribute significantly to addiction neurobiology and neurological disease research.

One Scalable and Stable Metal-Organic Framework for Efficient Separation of CH4/N2 Mixture.

Separating CH4 from coal bed methane is of great importance but challenging. Adsorption-based separation often suffers from low selectivity, poor stability, and difficulty to scale up. Herein, a stable and scalable metal-organic framework [MOF, CoNi(pyz-NH2)] with multiple CH4 binding sites was reported to efficiently separate the CH4/N2 mixture. Due to its suitable pore size and multiple CH4 binding sites, it exhibits excellent CH4/N2 selectivity (16.5) and CH4 uptake (35.9 cm3/g) at 273 K and 1 bar, which is comparable to that of the state-of-the-art MOFs. Theoretical calculations reveal that the high density of open metal sites and polar functional groups in the pores provide strong affinity to CH4 than to N2. Moreover, CoNi(pyz-NH2) displays excellent structural stability and can be scale-up synthesized (22.7 g). This work not only provides an excellent adsorbent but also provides important inspiration for the future design and preparation of porous adsorbents for separations.

Advancements in 3D-printed artificial tendon.

Millions of people have been reported with tendon injuries each year. Unfortunately, Tendon injuries are increasing rapidly due to heavy exercise and a highly aging population. In addition, the introduction of 3D-printing technology in the area of tendon repair and replacement has resolved numerous issues and significantly improved the quality of artificial tendons. This advancement has also enabled us to explore and identify the most effective combinations of biomaterials that can be utilized in this field. This review discusses the recent development of the 3D-printed artificial tendon; where recently, some research investigated the most suitable pore sizes, diameter, and strength for scaffolds to have high tendon cells ingrowth and proliferation, giving a better understanding of the effects of densities and structure patterns on tendon's mechanical properties. In addition, it presents the divergence between 3D-printed tendons and other tissue and how the different 3D-printing techniques and models participated in this development.

Synergistic Boosting Capture Ability of Thiophene Sulfur with a Novel Dual-Amino-Functionalized MOF-on-MOF Adsorbent.

A single metal-organic framework (MOF) exhibits some drawbacks in deep adsorptive desulfurization such as insufficient functional active sites, water instability, low surface area, etc. Herein, a dual-amino-functionalized (ZIF-8-NH2)-PVP-(Cu-BTC-NH2) core-shell dual MOF adsorbent was first synthesized by the hydrothermal growth method. The adsorption performance of thiophene sulfur (ThS) is systematically investigated and evaluated at mild temperatures through batch tests. The (ZIF-8-NH2)-PVP-(Cu-BTC-NH2) exhibits good adsorption ability toward ThS, which is attributed to the associative effects of dual MOFs with structure features such as hydrogen bond, open metal active sites, suitable pore sizes and π-π conjugation, etc. Meanwhile, the (ZIF-8-NH2)-PVP-(Cu-BTC-NH2) embedded 25 wt % water still remains crystal intact and good adsorption desulfurization performance, which is attributed to the NH2- functional groups. After five recycles, more than 90% ThS uptake onto (ZIF-8-NH2)-PVP-(Cu-BTC-NH2) could be recovered, exhibiting good reuse performance. This study presents a new strategy for grafting MOF-on-MOF with specific functional groups to improve the abilities of desulfurization and water resistance.

Local multi-drug delivery and osteogenesis in bone metastasis of prostate cancer by a core-shell 3D printed scaffold

Prostate cancer is the most common cancer in men. Approximately 80 % of people with advanced prostate cancer reportedly develop bone metastasis. Common treatments of bone metastasis of prostate cancer (BM-PC) cause severe adverse effects. Besides, there is a high probability of metastatic bone tumor recurrence after tumor resection surgery. Thus, local drug delivery is an alternative way to prevent the difficulties as mentioned earlier. In this study, a bilayer core-shell 3D-printed scaffold was prepared. The outer layer of the scaffold serves as the drug delivery vehicle, and the internal layer creates a platform for preosteoblasts’ migration to substitute the resected tumor with healthy bone in BM-PC.First, PLGA microspheres of triptorelin (TRP-PLGA microsphere) and albumin-bound paclitaxel nanoparticles (NAB-PTX) were prepared for the assessment of their synergistic effect against DU-145 cells. To obtain the optimal combination, both microspheres and nanoparticles were loaded in the outer layer of a scaffold based on Gelatin MethAcryloyl (GelMA) hydrogel using the 3D printing method. The inner layer of the scaffold was based on GelMA and alginate containing hydroxyapatite nanoparticles (nHA). The effect of nHA in the internal layer of the scaffold was assessed through osteogenesis in vitro analyses. The 75 % inhibitory concentrations (IC75) for TRP and PTX combination were 58.75 μM and 1.94 nM, respectively, while this value was obtained at 235 μM and 39 nM for TRP and PTX, respectively, which indicates a synergistic effect and reduction in the required dose of two drugs. The outer layer of the scaffold had a mechanical strength of 25 kPa and a suitable pore size for drug delivery in 21 days. On top of that, the inner layer showed an enhanced mechanical strength of 190 kPa, which is ideal for osteogenesis. Furthermore, biodegradation of the outer layer in 3 weeks and the inner layer in 10 weeks is proportional to their objective. The presence of nHA in the internal layer of the scaffold enhanced bone regeneration (146 %), increased ALP activity (150 %), and doubled the calcium deposition within 14 days. It also led to the upregulation of RUNX2, COL1A1, and OPN genes about 86, 60, and 14 fold, respectively, within 21 days, indicating osteogenic differentiation. In conclusion, this scaffold will successfully prevent bone tumor recurrence and then enhance bone regeneration at the site.