Weeds exert a pronounced influence on the sugar beet yield, leading to the potential for substantial reductions in agricultural productivity. In pursuit of addressing this issue, two experiments were conducted at the Faculty of Agriculture in Giza, Egypt, during the winter seasons of 2020/2021 and 2021/2022 to investigate the efficacy of various pre- and post-herbicides applied differently in active ingredient percentages, forms, and on weed target types, and mechanical weed treatments on weed traits and sugar beet crop performance. (1) In this context, five herbicidal treatments, including pre-emergence (S-Metoachlor) and post-emergence applications of Betanal Max Pro (Desmedipham 4.7% + Ethofumesate 7.5% + Lenacil 2.7% + Phenmedipham 6%), Tegrospecial (Desmedipham 20% + Phenmedipham 20%) for total annual weeds, C Factor (Haloxyfop-R-Methyl 7.5% + Fluazifop-p-putyl 15%), and Clictar (Clethodium 24%) for grassy weeds, were assessed alongside mechanical weeding and a weedy check (control). (2) The evaluations encompassed growth parameters, juice quality, and beet yields to comprehensively assess the treatment effects. (3) Notably, weed control measures, especially regarding three total annual weeds herbicides and the cultivation when using both grassy weed herbicides, consistently produced the highest improvements in sugar beet root’s fresh and dry weights, root dimensions, sucrose content, purity, sugar recovery, as well as the root and recoverable sugar yields, across both seasons. (4) However, it is important to note that the application of Clethodium 24% and Haloxyfop-R-Methyl 7.5% + Fluazifop-p-putyl 15% resulted in elevated levels of sodium, potassium, amino nitrogen, impurities, and sucrose loss to molasses. These findings underscore the substantial influence of herbicide use and mechanical weeding on sugar beet’s growth, juice quality, and yield, with S-Metoachlor, Desmedipham 20% + Phenmedipham 20% and Desmedipham 4.7% + Ethofumesate 7.5% + Lenacil 2.7% + Phenmedipham 6%—showing promise as effective weed control options, albeit with certain associated drawbacks.