The two-dimensional (2-D) system has a wide range of applications in different fields, including satellite meteorological maps, process control, and digital filtering. Therefore, the research on the stability of 2-D systems is of great significance. Considering that multiple systems exist in switching and alternating work in the actual production process, but the system itself often has external perturbation and interference. To solve the above problems, this paper investigates the output feedback robust H∞ stabilization for a class of discrete-time 2-D switched systems, which the Roesser model with uncertainties represents. First, sufficient conditions for exponential stability are derived via the average dwell time method, when the system’s interference and external input are zero. Furthermore, in the case of introducing the external interference, the weighted robust H∞ disturbance attenuation performance of the underlying system is further analyzed. An output feedback controller is then proposed to guarantee that the resulting closed-loop system is exponentially stable and has a prescribed disturbance attenuation level γ. All theorems mentioned in the article will also be given in the form of linear matrix inequalities (LMI). Finally, a numerical example is given, which takes two uncertain values respectively and solves the output feedback controller’s parameters by the theorem proposed in the paper. According to the required controller parameter values, the validity of the theorem proposed in the article is compared and verified by simulation.