AbstractObservations from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellites reveal a global reduction in the zonal and diurnal mean F region peak electron density (NmF2) during sudden stratosphere warmings (SSWs). The present study investigates the source of the global NmF2 decrease by performing numerical experiments with the National Center for Atmospheric Research (NCAR) thermosphere‐ionosphere‐electrodynamics general circulation model. The simulations reveal that the NmF2 reduction coincides with a depletion of thermospheric [O]/[N2], indicating that the NmF2 depletion is related to changes in thermospheric composition during SSWs. Numerical experiments further illustrate that the short‐term (∼10 day) enhancement of the migrating semidiurnal solar tide (SW2) during SSWs is the source of the variability in thermospheric composition. In particular, the enhancement of the SW2 during SSWs alters the lower thermosphere zonal mean circulation, leading to a reduction in atomic oxygen in the lower thermosphere. The atomic oxygen reduction propagates into the upper thermosphere through molecular diffusion, leading to a decrease in [O]/[N2] throughout the low‐ to middle‐latitude thermosphere. It is anticipated that the effects of the SW2 on the ionosphere and thermosphere investigated herein will be modulated by SSW related enhancements of the migrating semidiurnal lunar tide (M2). The magnitude of the combined impact of the SW2 and M2 on the ionosphere‐thermosphere mean state will depend on the relative phasing of the solar and lunar tides. The results demonstrate that in addition to modulating the low‐latitude electrodynamics, tidal variability during SSWs can significantly impact the mean state of the ionosphere and thermosphere.