The present study performed a numerical investigation to explore the performance enhancement of a co-flow jet (CFJ) airfoil with simple high-lift device configuration, with a specific goal to examine the feasibility and capability of the proposed configuration for low-speed take-off and landing. Computations have been accomplished by an in-house-programmed Reynolds-averaged Navier-Stokes solver enclosed by k-ω shear stress transport turbulence model. Three crucial geometric parameters, viz., injection slot location, suction slot location and its angle were selected for the sake of revealing their effects on aerodynamic lift, drag, power consumption and equivalent lift-to-drag ratio. Results show that using simple high-lift devices on CFJ airfoil can significantly augment the aerodynamic associated lift and efficiency which evidences the feasibility of CFJ for short take-off and landing with small angle of attack. The injection and suction slot locations are more influential with respect to the aerodynamic performance of CFJ airfoil compared with the suction slot angle. The injection location is preferable to be located in the downstream of the pressure suction peak on leading edge to reduce the power expenditure of the pumping system for a relative higher equivalent lift-to-drag ratio. Another concluded criterion is that the suction slot should be oriented on the trailing edge flap for achieving more aerodynamic gain, meanwhile, carefully selecting this location is crucial in determining the aerodynamic enhancement of CFJ airfoil with deflected flaps.