Successive Episodes Research Articles

Multistage fracturing history in the Paleocene lacustrine shale oil reservoirs of the Subei Basin, Eastern China

This study examines sealed fractures in core samples from the Paleocene organic-rich lacustrine shales of the Gaoyou Depression, Subei Basin, China, using a multi-pronged approach to elucidate the interplay between fracture propagation and fluid circulation in shaly successions. Based on petrography, geochemistry, and geochronology of fracture-filling minerals, four generations of vein emplacement (denoted Types A-D) were identified. These were attributed to successive episodes of burial diagenesis, tectonism, and uplift occurring at different phases of basin evolution. These vein generations were then inserted into the temporal-spatial framework derived from basin modeling, leading to a reconstruction of the fracture diagenesis history in the Funing shales. Two of the vein generations contain evidence for two phases of oil migration marked by two types of oil inclusions with different fluorescence.It has been shown that the studied lacustrine shales were deposited at ca. 60.2–58.0 Ma. The earliest vein generation, represented by antitaxial beef calcite veins sub-perpendicular to shale bedding, propagated in incompletely consolidated shales within a regional thrust regime related to the Wubao Movement. The vein nucleation during a short-lived burial following initial deposition was also evidenced by the presence of monoliquid inclusions in the veins and calcite LA-ICP-MS U–Pb age (57.7 ± 3.7 Ma). Tectonic compressive stress together with overpressures arising from horizontal and vertical disequilibrium compaction were interpreted as being responsible for this fracturing episode. The second vein generation is bedding-parallel, oil inclusion-rich stretching calcite veins with a crack-seal texture, formed concurrently with kerogen maturation and early oil generation at moderate burial depths. The vein crack-seal fills containing yellow fluorescing oil inclusions provide evidence for episodic oil expulsion in response to cyclic rises and drops in pore pressure during the oil window. Bedding-parallel beef calcite veins characterized by antitaxial growth represent the next vein generation, emplaced during the maximum burial period (ca. 41.9 ± 2.7 Ma). The vein fibers have tracked the horizontal displacement of the wall rocks, likely related to lateral shortening before or at the initiation of Late Eocene basin inversion. The first three vein generations were generated in a relative closed fluid system, with vein fill sourced locally. Host-rock carbonate components and/or earlier diagenetic carbonates were dissolved and then mobilized into these veins. By contrast, the last vein generation with blocky calcite and barite cementation is associated with input of externally derived hydrothermal fluids. The evidence comes from abnormally high fluid-inclusion homogenization temperature (Th) and salinity data, as well as the fact that Ba and sulfate were sourced from the underlying evaporite layers rather than local shales. We thus infer that cross-stratal faulting during the uplift related to the Sanduo Movement resulted in the opening of initial hydraulically closed fluid system. This episode of tectonically-driven hydrothermal circulation from deeper locations in the basin into the Funing shales led to the mixing of oil-bearing pore fluids with exotic basinal hot brines. This also accounts for the presence of abundant blue-green fluorescing oil inclusions and significantly elevated fluid salinity. Overall, this study emphasizes that during basin evolution, differences in tectonic settings and the diagenetic boundary conditions under which veins formed results in different fracturing mechanisms and associated fluid-flow regimes in shale sequences, with consequent effects on vein attributes and mineralization.

Geophysical monitoring of a laboratory‐scale internal erosion experiment

ABSTRACTEarth dams are structures used worldwide for water management. Their failure over time is notably due to water seepage generating internal erosion. There is a growing need to detect the processes at work as early as possible. This study presents a controlled laboratory experiment aimed at detecting and monitoring water seepage into a soil sample. The experiment was monitored with electrical resistivity tomography, velocimeters and video recording. The video recording of the downstream side of the soil sample shows successive episodes of mass movements associated with a progressive water flow increase. The electrical resistivity tomography, limited by a low temporal resolution, shows an evolution of the resistivity in agreement with the evolution of the soil sample (e.g., saturation and mass movements), but with strong limitations regarding the robustness of the results. The continuous seismic recording reveals extra rupture episodes that occur inside the volume of the soil sample, which were not recorded by the video. Their distribution in time and energy illustrates strongly nonlinear changes in the soil sample, with several phases of acceleration. A controlled source monitoring using external repetitive events allows probing the medium with an enhanced temporal resolution compared to electrical resistivity tomography. The apparent seismic velocity of the soil sample reveals a nonlinear decrease, high at the beginning of the experiment, and then stalled until the different mass movements enlarge the amount of water inside the sample along with the water flow. The different techniques used, especially seismic monitoring, describe a complex and strongly nonlinear process of internal erosion centred around the coupling between water flow and internal damage. Finally, these findings suggest that seismic methods could be able to distinguish the four different phases of internal erosion (namely, initiation, continuation, progression and failure) discussed in the geotechnical literature.

A Stratigraphic Analysis Of The Khasib, Tanuma And Sa’di Formations In The Majnoon Oil Field, Southern Iraq

The carbonate platform is the environment of Khasib, Tanuma and Sa’di formations which were deposited within open shelf settings at the Majnoon oil field in eight microfacies. The deposition, based on the analysis of microfacies, took place within shallow open marine, shoal environment, deep marine and basin environments. Five third order cycles of succession consist in MJ-12 oil well and three third order cycles in the MJ-15 oil well. They represent successive episodes of sea level rise and standstills. The succession in the study area was formed in a high subsidence environment, reflecting the high subsidence as the main controlling factor in the sequence creation. Because of a significant transgression, the Khasib, Tanuma, and Sa’di formations were deposited on an extremely subsidential carbonate base, where sea level succession involved episodes of rise and standstills.

Design and Evaluation of a Conversational Agent for Facilitating Idea Generation in Organizational Innovation Processes

Large numbers of incomplete, unclear, and unspecific submissions on idea platforms hinder organizations to exploit the full potential of open innovation initiatives as idea selection is cumbersome. In a design science research project, we develop a design for a conversational agent (CA) based on artificial intelligence to facilitate contributors in generating elaborate ideas on idea platforms where human facilitation is not scalable. We derive prescriptive design knowledge in the form of design principles, instantiate, and evaluate the CA in two successive evaluation episodes. The design principles contribute to the current research stream on automated facilitation and can guide providers of idea platforms to enhance idea generation and subsequent idea selection processes. Results indicate that CA-based facilitation is engaging for contributors and yields well-structured and elaborated ideas.

Health Crisis and the Dual Reflexivity of Knowledge

Although successive pandemic episodes adversely affect populations and it remains difficult to assess their long-term extent and impact, they may, paradoxically, have a positive effect. In fact, they can promote awareness by reviving a form of reflexivity with respect to public health, economic and social policies, and by driving in-depth reflection on the measures that must be taken to limit the current and future imbalances caused by human activity. Habermas emphasises that the reflexive “push” is no longer just a matter for experts; it is also collective, historical, and political, in the sense that it involves citizens who intend to weigh in on the debate and make their voices and wishes heard by policy-makers and economic actors. Reflecting upon the ethics of responsibility (Weber) is therefore essential. If we are to follow Giddens and Habermas’ thinking, this reflexivity represents an integral part of the modern age. Our intention, in this article, is to show how major events, beyond an initial period of shock, can help to awake different levels of reflexivity in individuals.

Multiscale Aspects of the 26–27 April 2011 Tornado Outbreak. Part II: Environmental Modifications and Upscale Feedbacks Arising from Latent Processes

Abstract One of the most prolific tornado outbreaks ever documented occurred on 26–27 April 2011 and comprised three successive episodes of tornadic convection that culminated with the development of numerous long-track, violent tornadoes over the southeastern United States during the afternoon of 27 April. This notorious afternoon supercell outbreak was preceded by two quasi-linear convective systems (hereinafter QLCS1 and QLCS2), the first of which was an anomalously severe nocturnal system that rapidly grew upscale during the previous evening. Here in Part II, we use a series of RUC 1-h forecasts and output from convection-permitting WRF-ARW simulations configured both with and without latent heat release to investigate how environmental modifications and upscale feedbacks produced by the two QLCSs contributed to the evolution and exceptional severity of this multiepisode outbreak. QLCS1 was primarily responsible for amplifying the large-scale flow pattern, inducing two upper-level jet streaks, and promoting secondary surface cyclogenesis downstream from the primary baroclinic system. Upper-level divergence markedly increased after QLCS1 developed, which yielded strong isallobaric forcing that rapidly strengthened the low-level jet (LLJ) and vertical wind shear over the warm sector and contributed to the system’s upscale growth and notable severity. Moreover, QLCS2 modified the mesoscale environment prior to the supercell outbreak by promoting the downstream formation of a pronounced upper-level jet streak, altering the midlevel jet structure, and furthering the development of a highly ageostrophic LLJ over the Southeast. Collectively, the flow modifications produced by both QLCSs contributed to the notably favorable shear profiles present during the afternoon supercell outbreak. Significance Statement The tornado outbreak that impacted the United States on 26–27 April 2011 was part of an extended outbreak that produced 343 tornadoes and numerous fatalities. This paper is Part II of a study that describes the meteorological factors supporting such a prolific event. Herein we investigate the convectively forced environmental modifications that occurred during a 36-h period encompassing three successive convective episodes. The first two episodes collectively altered the upper-level flow pattern and markedly enhanced low-level winds throughout the warm sector. These modifications served as upscale feedbacks that contributed to the first episode’s exceptional severity and to the remarkable vertical shear profiles that supported numerous long-track and violent tornadoes during the final episode on the afternoon of 27 April.

Multiscale Aspects of the 26–27 April 2011 Tornado Outbreak. Part I: Outbreak Chronology and Environmental Evolution

Abstract One of the most prolific tornado outbreaks ever documented occurred on 26–27 April 2011 and comprised three successive episodes of tornadic convection that primarily impacted the southeastern United States, including two quasi-linear convective systems (hereinafter QLCS1 and QLCS2) that preceded the notorious outbreak of long-track, violent tornadoes spawned by numerous supercells on the afternoon of 27 April. The ∼36-h period encompassing these three episodes was part of a longer multiday outbreak that occurred ahead of a slowly moving upper-level trough over the Rocky Mountains. Here in Part I, we detail how the environment evolved to support this extended outbreak, with particular attention given to the three successive systems that each exhibited a different morphology and severity. The amplifying upper-level trough and attendant jet streak resulted from a Rossby wave–breaking event that yielded a complex tropopause structure and supported three prominent shortwave troughs that sequentially moved into the south-central United States. QLCS1 formed ahead of the second shortwave and was accompanied by rapid flow modifications, including considerable low-level jet (LLJ) intensification. The third shortwave moved into the lee of the Rockies early on 27 April to yield destabilization behind QLCS1 and support the formation of QLCS2, which was followed by further LLJ intensification and helped to establish favorable deep-layer shear profiles over the warm sector. The afternoon supercell outbreak commenced following the movement of this shortwave into the Mississippi Valley, which was attended by a deep tropopause fold, cold front aloft, and dryline that promoted two prominent bands of tornadic supercells over the Southeast. Significance Statement The tornado outbreak that impacted the United States on 26–27 April 2011 was part of an extended outbreak that produced 343 tornadoes and numerous fatalities. This paper is Part I of a study that describes the meteorological factors supporting such a prolific event. We focus on a 36-h period encompassing three convective episodes that impacted the Southeast and culminated in the widespread formation of long-track, violent tornadoes. Flow enhancements accompanying the first two episodes and the movement of a cold front aloft into the Southeast were found to contribute to the evolution of the final and most devastating episode. Part II describes how the first two episodes directly modified the environment to enhance the severity of this outbreak.

Seasonal Cumulative Effect of Ural Blocking Episodes on the Frequent Cold events in China during the Early Winter of 2020/21

Starting in mid-November, China was hit by several cold events during the early winter of 2020/21. The lowest temperature observed at Beijing station on 7 January reached −19.6°C. In this paper, we show that the outbreak of the record-breaking extreme cold event can be attributed to a huge merging Ural blocking (UB) ridge over the Eurasian region. The sea-ice cover in the Kara and East Siberia Seas (KESS) in autumn was at its lowest value since 1979, which could have served as a precursor signal. Further analysis shows that several successive UB episodes occurred from 1 September 2020 to 10 January 2021. The persistent UB that occurred in late September/early October 2020 may have made an important contribution to the October historical minimum of sea ice in the KESS region. Our results also show that, after each UB episode in winter, significant upward propagation of wave activity occurred around 60°E, which resulted in weakening the stratospheric vortex. Meanwhile, each UB episode also caused a significant reduction in sea-ice extent in KESS and a significant weakening of the westerly jet in mid–high-latitude Eurasia. Results suggest that the Arctic vortex, which is supposed to enhance seasonally, became weaker and more unstable than the climatic mean under the seasonal cumulative effects of UB episodes, KESS warming, and long-lasting negative-phase North Atlantic Oscillation (NAO–). Those seasonal cumulative effects, combined with the impact of La Niña winter, led to the frequent occurrence of extreme cold events.

Neuroendocrinology applied to rabbit breeding

Successful rabbit production relies heavily on the use of adequate practices that enhance specific aspects of reproduction, such as mating, ovulation and lactation. Regardless of the type of production unit or strain of rabbits used, these processes rely on a complex chain of neuroendocrine steps that include particular hormones, peripheral stimuli and activation of discrete brain regions. Such is the case, for instance, of reflex ovulation, which occurs in response to copulation but is inhibited throughout lactation. Little is known about the mechanisms mediating lactational anoestrus and the restoration of oestrus following the cancellation of a single suckling episode (biostimulation). Nevertheless, the latter procedure (adopted worldwide to accelerate reproduction) has unwanted consequences for the doe and her litter. After successive episodes of biostimulation, the former shows a loss of fertility and body mass. In the kits, alterations are observed in their neuroendocrine response to mildly aversive stimulation in adulthood, as well as reductions in sexual behaviour. In addition to milk intake, a good nest is essential for normal litter growth and development. If this is not available, or if it deteriorates, rabbit caretakers can easily (re) build one from hair sheared off other rabbits or using synthetic material. Lactating does will nurse equally well their own or ‘alien’ young, placed inside the nest. It is crucial to have a minimum of six suckling kits in the nest, as the doe relies on this stimulation to maintain a normal nursing behaviour, i.e., only once a day throughout lactation. Recent work is revealing the similarities and differences in the responsiveness to mating among oestrous, lactating and biostimulated does. The relevance of these findings for the likelihood of reflex ovulation and the additional contribution of factors contained in the semen warrant more in-depth research. New insights on these issues, essential to reproductive neuroendocrinology, can emerge by fostering a richer interaction between academic laboratories and rabbit production settings worldwide.

New Caledonian crows keep 'valuable' hooked tools safer than basic non-hooked tools.

The temporary storage and re-use of tools can significantly enhance foraging efficiency. New Caledonian crows in one of our study populations use two types of stick tools - hooked and non-hooked - which differ in raw material, manufacture costs, and foraging performance. Using a large sample of wild-caught, temporarily captive New Caledonian crows, we investigated experimentally whether individuals prefer one tool type over the other when given a choice and whether they take better care of their preferred tools between successive episodes of use, safely storing them underfoot or in nearby holes. Crows strongly preferred hooked stick tools made from Desmanthus virgatus stems over non-hooked stick tools. Importantly, this preference was also reflected in subsequent tool-handling behaviour, with subjects keeping hooked stick tools safe more often than non-hooked stick tools sourced from leaf litter. These results suggest that crows 'value' hooked stick tools, which are both costlier to procure and more efficient to use, more than non-hooked stick tools. Results from a series of control treatments suggested that crows altered their tool 'safekeeping' behaviour in response to a combination of factors, including tool type and raw material. To our knowledge, our study is the first to use safekeeping behaviour as a proxy for assessing how non-human animals value different tool types, establishing a novel paradigm for productive cross-taxonomic comparisons.

Deformation of the Shillong Group rocks, Shillong Basin, Meghalaya, north‐east India: Implication on the Proterozoic supercontinent build‐up

The effects of deformation and concomitant high‐grade metamorphism during the Cenozoic period in the active Himalayan orogen hinder the reconstruction of the original geological framework and thus the evolution history. The Shillong Group in the Shillong Plateau, northeastern India, rests unconformably above the Himalayan crystalline basement gneiss, and is divided in two formations, the Lower Metapelite Formation (LMF) and the Upper Quartzite Formation (UQF). There are three horizons of conglomerate: (a) Basal, between the basement and the Shillong Group, (b) an inter‐formational conglomerate, between the LMF and UQF, and (c) an intra‐formational conglomerate (within the UQF). The clasts of the latter two conglomerates are suitable strain markers. Principal compressional structures in the Shillong Group were developed in two successive deformation episodes during the Meso‐ to Neo‐Proterozoic period. The earlier episode was of progressive general shear deformation, while the later one possibly occurred in a transpressive mode similar to that of a fold‐thrust belt. Remarkably, both episodes underwent NW–SE regional compression. The inter‐formational conglomerate represents a flattening type strain of relatively lesser magnitude (Rf–ϕ X:Y:Z = 1.35:1:0.76), in contrast to the constriction type strain of relatively higher magnitude (Rf–ϕ X:Y:Z = 2.42:1:0.44) of the intra‐formational conglomerate. Field relations of the Shillong Group with the deformed and undeformed granite plutons suggest that the earlier deformation episode possibly took place during Rodinia assembly, due to India–Antarctica collision at 1,100 Ma, while the later one happened in a time frame close to 500 Ma, during the amalgamation of Eastern Gondwana.

Emergent properties in the responses of tropical corals to recurrent climate extremes

The frequency, intensity, and spatial scale of climate extremes are changing rapidly due to anthropogenic global warming.1,2 A growing research challenge is to understand how multiple climate-driven disturbances interact with each other over multi-decadal time frames, generating combined effects that cannot be predicted from single events alone.3-5 Here we examine the emergent dynamics of five coral bleaching events along the 2,300km length of the Great Barrier Reef that affected >98% of the Reef between 1998 and 2020. We show that the bleaching responses of corals to a given level of heat exposure differed in each event and were strongly influenced by contingency and the spatial overlap and strength of interactions between events. Naive regions that escaped bleaching for a decade or longer were the most susceptible to bouts of heat exposure. Conversely, when pairs of successive bleaching episodes were close together (1-3 years apart), the thermal threshold for severe bleaching increased because the earlier event hardened regions of the Great Barrier Reef to further impacts. In the near future, the biological responses to recurrent bleaching events may become stronger as the cumulative geographic footprint expands further, potentially impairing the stock-recruitment relationships among lightly and severely bleached reefs with diverse recent histories. Understanding the emergent properties and collective dynamics of recurrent disturbances will be critical for predicting spatial refuges and cumulative ecological responses, and for managing the longer-term impacts of anthropogenic climate change on ecosystems.

Machine learning of the Bayesian belief network as a tool for evaluating the process frequency on social network data

The paper considers the problem of evaluating frequency of the processes whose mathematical model is stochastic processes consisting of a series of sequential episodes with a known class of distributions of the length of the time interval between them. In the previously proposed approach, the input data included information about the value of the interval between the last episode and the end of the study period, which could lead to inaccurate results. This interval differs from the intervals between successive episodes, and hence its presentation and processing require approaches that take this feature into account. Accuracy of the estimation results for process frequency was improved by developing a new model based on the Bayesian confidence network that includes nodes corresponding to the intervals between the last episodes of the process, the minimum and maximum intervals between episodes, by correctly accounting for the values of the interval between the last episode and the end of the study period at the model training stage. The authors propose a Bayesian belief network that includes a random element characterizing the interval between the end of the study period and the last episode of the process during the study period; data on this interval can be available at the training stage. They used R programming and the bnlearn package to model the Bayesian belief network. A new approach to the estimation of process frequency based on the Bayesian belief network generated by machine learning methods is proposed. It allows increasing the accuracy of the results by correctly considering the value of the interval between the last episode and the end of the period under study using a special scheme in the machine learning Bayesian belief network which includes a “hypothetical” episode after the end of the study period. To test the proposed approach, data was collected on 5608 Instagram users, which included the time of posting for the year 2020 and the time of publishing the first post for the year 2021. 70 % of the sample was used to train the model, and 30 % was used to compare the posting frequency values predicted by the model with known values. The results can be used in various fields of science, where it is necessary to estimate a process frequency under information deficit, when the whole process is observed for no more than some limited time. Obtaining such estimates is often an important issue in medicine, epidemiology, sociology, etc. The approach shows good results on the comparison of the theoretical model and the results of learning from the social network data, which can automate the obtaining of process frequency estimates.

Unraveling the Complexity of Imported Malaria Infections by Amplicon Deep Sequencing.

Imported malaria and recurrent infections are becoming an emerging issue in many malaria non-endemic countries. This study aimed to determine the molecular patterns of the imported malaria infections and recurrence. Blood samples were collected from patients with imported malaria infections during 2016–2018 in Guangxi Zhuang Autonomous Region, China. Next-generation amplicon deep-sequencing approaches were used to assess parasite genetic diversity, multiplexity of infection, relapse, recrudescence, and antimalarial drug resistance. A total of 44 imported malaria cases were examined during the study, of which 35 (79.5%) had recurrent malaria infections within 1 year. The majority (91.4%) had one recurrent malaria episode, whereas two patients had two recurrences and one patient had three recurrences. A total of 19 recurrence patterns (the species responsible for primary and successive clinical episodes) were found in patients returning from malaria epidemic countries. Four parasite species were detected with a higher than usual proportion (46.2%) of non-falciparum infections or mixed-species infections. An increasing trend of recurrence infections and reduced drug treatment efficacy were observed among the cases of imported malaria. The high recurrence rate and complex patterns of imported malaria from Africa to non-endemic countries have the potential to initiate local transmission, thereby undermining efforts to eliminate locally acquired malaria. Our findings highlight the power of amplicon deep-sequencing applications in molecular epidemiological studies of the imported malaria recurrences.

Cognitive impairment associated with greater care intensity during home health care.

In Medicare-funded home health care (HHC), one in three patients has cognitive impairment (CI), but little is known about the care intensity they receive in this setting. Recent HHC reimbursement changes fail to adjust for patient CI, potentially creating a financial disincentive to caring for these individuals. This cohort study included a nationally representative sample of 1214 Medicare HHC patients between 2011 and 2016. Multivariable logistic and negative binomial regressions modelled the relationship between patient CI and care intensity-measured as the number and type of visits received during HHC and likelihood of receiving multiple successive HHC episodes. Patients with CI had 45% (P<.05) greater odds of receiving multiple successive HHC episodes and received an additional 2.82 total (P<.001), 1.39 nursing (P=.003), 0.72 physical therapy (P=.03), and 0.60 occupational therapy visits (P=.01) during the index HHC episode. Recent HHC reimbursement changes do not reflect the more intensive care needs of patients with CI.

Mesozoic structural inheritance in the Cenozoic evolution of the central Catalan Coastal Ranges (western Mediterranean): Structural and magnetotelluric analysis in the Gaià-Montmell High

The control exerted by the Mesozoic basin configuration on the Cenozoic tectonic evolution of the Catalan Coastal Ranges has been frequently recognized as a key factor to explain its present-day structure. However, details of this structural inheritance and its evolution through geological time is still under discussion. In this work we present two structural cross-sections based on fieldwork, well and magnetotelluric data in order to illustrate the structural styles and tectonic evolution of the Gaià-Montmell High. Here, the Montmell Fault not only constitutes the SW segment of one of the major Neogene faults in the Catalan Coastal Ranges (the Montmell-Vallès Fault System), but also the NW limit of a Late Jurassic-Early Cretaceous extensional basin(the Montmell-Garraf Basin), facts that denote a major role of this fault in the tectonic evolution of the area. The present-day structure of the Gaià-Montmell High resulted, therefore, from two successive episodes of inversion during the Cenozoic. The first one reactivated the Montmell Fault as compressional during the Paleogene. As a result, and among other inversion-related structures, the Gaià-El Camp Thrust developed sa major NW-directed basement footwall shortcut. Later on, the previously formed compressional structure during the Paleogene became reactivated as extensional during the Neogene. During this phase, the reactivation of the Montmell Fault looks limited and, hence, the extension is transmitted to the Baix Penedès Fault. The reactivation of the Gaià-El Camp Thrust is also manifest in the development of an array of extensional faults in the backlimb of the Carme-Cabra Anticline that corresponds to the NE-end of El Camp Fault. This episode of negative inversion developed accommodation zones between the four major faults present in the area ( Vallès-Penedès, Montmell, El Camp and Baix Penedès faults) that are characterized by the presence of relay ramps with breaching faults.

Long-term Continuity of Antipsychotic Treatment for Schizophrenia: A Nationwide Study.

Schizophrenia often requires long-term treatment with antipsychotic medication. This study aims to measure the continuity of antipsychotic treatment over the course of illness in schizophrenia, as well as factors involved in the interruption of treatment. For this, we followed up a national cohort of first-episode psychosis patients in Finland for up to 18 years. Stratified Cox proportional hazards regressions were conducted for "within-participant" risk of discontinuation of subsequent treatments compared to the first, and by specific antipsychotic compared to oral olanzapine, the most prescribed antipsychotic in this cohort. Adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) were calculated. Among 3343 participants followed up for a mean of 8 years (SD = 4.93), the median number of continuous treatment episodes was 6 (interquartile range [IQR] = 3-11) with a median duration of 11.4 months (IQR = 5.3-25.6). In the first year after diagnosis, the incidence rate of treatment discontinuation was 30.12 (95% CI = 29.89-30.35) events per 100 participant-years, decreasing to 8.90 (95% CI = 8.75-9.05) in the 10th year. The risk of discontinuation progressively decreased over successive treatment episodes (aHR = 0.30; 95% CI = 0.20-0.46 for episodes after the 15th compared to the first). Individuals were 67% less likely to interrupt treatment with long-acting injectable than oral antipsychotics (aHR = 0.33; 95% CI = 0.27-0.41). Treatment for schizophrenia over the long term is often characterized by recurrent cycles of interruptions and reintroductions of antipsychotic medication, which is typically not recommended by management guidelines. Greater utilization of long-acting injectable formulations earlier in the course of illness may facilitate the continuity of antipsychotic treatment in schizophrenia.

Frequency matters: How successive feeding episodes by blood-feeding insect vectors influences disease transmission.

Frequency matters: How successive feeding episodes by blood-feeding insect vectors influences disease transmission.

Quench Characteristics of a 2G ReBCO Roebel Cable Pancake Coil in External Fields Up to 8T

A pancake coil was wound with a length of ReBCO 2G Roebel cable consisting of 15 strands and studied in detail at different operating temperatures between 4.2 K and 77 K. The coil was impregnated with an epoxy resin and cooling achieved through conduction from current contacts. The critical current was measured with transport currents up to 1500 A and in an external axial field up to 8 T. Quench measurements were carried out following point-like disturbances initiated by a localised miniature heater embedded inside the coil. The different heat dissipation at the current contacts was dynamically controlled with axillary heaters to ensure the isothermal condition of the coil for the successive quench episodes. The minimum quench energy (MQE) was obtained at different temperatures, fields and load currents relative to the critical current. The present work is a substantive follow up of previous studies at 77 K in liquid nitrogen and in helium gas down to 60 K, where it has been established that the coil retained the critical current of the superconducting strand/cable and its quench behaviour was unaffected by the lateral cooling by the cryogen.

Game-Play Language and Game-Play Intelligence – Wording, Planning, and Enacting Action Plans in Team Sports

The purpose of this paper is to discuss, in a socio-constructivist context, the development of students’ game-play language and game-play intelligence through their wording, planning and enacting of action plans in team sports. At the beginning, the authors offer a brief recall of the basics of constructivism and social constructivism. They discuss students’ perception of game-play reality, assimilation, accommodation and adaptation in relation with learning strategies in team sports. Then, they consider the development of a common game-play language and the evolution of students’ exchanges over successive debate episodes interspersed with sequences of play. Beyond facilitating tactical learning, student construction of a common game-play language is seen as way to alleviate initial differences among students in terms of past sport experiences. Following theoretical considerations on the relationship between thinking and the development and the use of intelligence, the authors discuss the development of game-play intelligence and tactical thinking, considering the complementary use of convergent and divergent thinking. Finally, learners’ awakening to metacognition is discussed in relation with the socially shared regulation of learning one may expect in a socio-constructivist approach to tactical learning in team sports. Keywords: debate-of-ideas, divergent thinking, student/player exchanges, strategy thinking, tactical thinking