Successful Change Research Articles

Impact of Age on Efficacy and Safety of Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel in Participants with Moderate-to-Severe Acne

Introduction: Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the first fixed-dose, triple-combination formulation approved for the treatment of acne. In three clinical studies of participants with moderate-to-severe acne, CAB gel demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability. As acne pathogenesis and treatment outcomes can vary with age, this post hoc analysis was performed to evaluate the efficacy and safety of CAB in pediatric and adolescent participants (aged 9-24 years) versus adult participants (≥25 years). This age cutoff was chosen as acne in patients aged 18-24 years is more similar to adolescents than adults, and age 25 is often used to define “adult acne”. Methods: In a phase 2 (NCT03170388) and two phase 3 (NCT04214652, NCT04214639) studies, participants aged ≥9 years with moderate-to-severe acne were randomized to once-daily CAB or vehicle gel. Endpoints included percentage of participants achieving treatment success (defined as ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin) and least-squares mean percent change from baseline in inflammatory/noninflammatory lesion counts at week 12. Treatment-emergent adverse events (TEAEs) were also assessed. Pooled data across all three studies were analyzed for participants aged 9-24 years (CAB: n=297; vehicle: n=218) or ≥25 years (n=91; n=51). Results: At week 12, approximately half of CAB-treated participants in both age groups achieved treatment success (9-24 years: 50.6%; ≥25: 49.0%) versus less than one-fourth with vehicle (15.7% and 20.6%; P<0.01, both). Treatment with CAB resulted in >70% reductions from baseline in inflammatory and noninflammatory lesions in both age groups, versus 45%-62% with vehicle (P≤0.001, all). There were no significant differences between CAB-treated participants in the two age groups across any of these efficacy endpoints (P=0.68-0.97). Most TEAEs with CAB were of mild-moderate severity, with no age-related trends in safety/tolerability. Conclusions: Fixed-dose, triple-combination CAB gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age. Approximately half of pediatric/adolescent and adult participants achieved clear/almost clear skin with CAB, and lesion count reductions of >70% were observed. Funding: Ortho Dermatologics

Religious Leaders Stewardship and COVID-19: A Sustainable Approach to Advocacy on Health Emergency Response in Kenya

Responding to public health emergencies needs efforts from all participants. Quick mobilization of people targeted a remarkable and successful change in behavior. Responding to the COVID-19 pandemic requires a strategic, sustainable approach that causes desirable outcomes. In Africa, a remarkable number of people are religious. This allows institutions of faith to be used as a set structure to reach the right target with the right information. Through the SCOPE COVID scheme, World Relief uses an elaborate and established mechanism of collaborating with the faith leaders in its planning. A qualitative approach was the main methodology of this research. SCOPE COVID Project developed sermon guides for Christian Leaders (clergy and pastors), a guide for leaders of Muslim (imams), and also a guide for Hindu leaders, respectively entitled; ‘Does Christianity advocate for COVID-19 vaccine?’, ‘Does Hinduism advocate for COVID-19 vaccine?’, and ‘Does Islam advocate for COVID-19 vaccine?’ The guides were distributed to 490 faith leaders, Christians, and Muslims in Turkana and Kajiado counties. The trained leaders of faith were given a chance to reach out to members of their faith with COVID-19 lessons as well as other preventive preventive measures. Findings show that 490 leaders of faith were trained as trainers of trainees. In a quarter, the leaders of faith were 12,670 persons with messages about vaccines, while others suggested preventive measures. The 490 faith institutions were represented by leaders trained to enable COVID-19 measures of prevention. The results indicated that faith leaders are willing to collaborate with the government and other participants in emergency response. Leaders of faith are willing to be included in health response. It can be concluded that leaders of faith have taken their responsibility of curbing COVID-19 seriously and kept off the syndrome of poor wisdom of interpreting the scourge as punishment from God to human beings.

Research on the Ddissemination Mechanism of Excellent Traditional Culture in New Media Environment based on Petri Network

To act inside and out study and investigation on the cooperation and correspondence of traditional culture, this article utilizes the Web combination advanced media strategy. The prerequisites for the Web might be communicated and depicted utilizing this primary data. The quantity of items in the network and its intricacy are developing alongside the interest for Web applications, so we can configuration proper bunching calculations to get more precise network structure data by using different kinds of semantic data in the heterogeneous data network. As a result of China s 5000-year history, the country has a variety of wonderful traditional cultures. We must thus improve the transmission of traditional culture and its legacy. Chinese traditional poetry is one of them and represents Chinese traditional culture, which has to be passed down to future generations. Our research focuses on the issues of packet loss, communication delays, and quantization errors in network-controlled systems (NCS). Regardless of the way that NCS offers a worldview for changing in accordance with the successive changes in the assembling area, displaying and overseeing tasks are testing issues due to the confounded cooperation s between framework substances and the effect of the network-prompted defer on the shut circle framework.

The Temporal and Spatial Dynamics of Succession in a Glacial Foreland in Southern Iceland: The Effects of Landscape Heterogeneity

One of the more visible consequences of anthropogenic climate change is the ongoing retreat of glaciers worldwide. Rates of primary succession in the resulting glacial forelands are commonly calculated from a single measurement set using a single set of measurements across a landscape of varying age, but repeated measurements over decadal scales may be a more effective means of examining the rates and trends of colonization and community development. Repeated measurements of vegetation groups in a glacial foreland in southern Iceland demonstrate that successional changes are measurable, as shown by the calculation of the dissimilarity index at sites over a 15 year interval. Inter-site dissimilarity validates the essential paradigm of primary succession, where vegetative coverage increases in the glacial foreland as a function of time and supports earlier interpretations saying that species richness decreases on older surfaces, even as the total vegetation cover increases. However, successional processes are subject to major abiotic factors, such as aspect, which is controlled by landscape topography, and the substrate composition. The glacial moraines and outwash plain are underlain by different substrates which produce separate successional trajectories. Succession on the moraines ultimately produces a birch-shrub-heath community, while the outwash deposits promote development of a moss-heath community.

Long‐distance movements, large population sizes and density‐dependent dispersal in three threatened butterfly species

Abstract This study investigates the ecology of three threatened butterfly species on a 60 km2 site in Gotland, Southeast Sweden, using mark–recapture methods from 2017 to 2020. Nearly 30,000 captures were recorded, with average lifespans of 6 days for Euphydryas aurinia (Lepidoptera: Nymphalidae) and Parnassius apollo (Lepidoptera: Papilionidae) and 2 days for Phengaris arion (Lepidoptera: Lycaenidae). Population size, density and maximum flight distances varied between species, with E. aurinia at 7.2 km, P. apollo at 6.4 km and P. arion at 2.5 km. Movement data showed the lognormal kernel fit better than gamma, negative exponential and half‐normal kernels for distance travelled per time unit across species and sexes. Generalised linear models revealed significant positive density‐dependent emigration and negative density‐dependent immigration in all three species. Despite available suitable habitats, these species face threats from limestone quarry expansions, agricultural intensification, modified forestry practices, natural succession and climate change, highlighting the need for proactive conservation and strategic habitat management.

Integrating Change Management with a Knowledge Management Framework: A Methodological Proposal

This study proposes the integration of change management with a knowledge management framework to address knowledge retention and successful change management in the context of Industry 5.0. Using the ADKAR model, it is suggested to implement strategies for training and user acceptance testing. The research highlights the importance of applying the human capital life cycle in knowledge and change management, demonstrating the effectiveness of this approach in adapting to Industry 5.0. The methodology includes a review of the state of the art in intangible asset management, change management models, and the integration of change and knowledge management. In addition, a case study is presented in a food production company that validates the effectiveness of the ADKAR model in implementing digital technologies, improving process efficiency and increasing employee acceptance of new technologies. The results show a significant improvement in process efficiency and a reduction in resistance to change. The originality of the study lies in the combination of the ADKAR model with intangible asset and knowledge management, providing a holistic solution for change management in the Industry 5.0 era. Future implications suggest the need to explore the applicability of the ADKAR model in different industries and cultures, as well as its long-term effects on organisational sustainability and innovation. This comprehensive approach can serve as a guide for other organisations seeking to implement successful digital transformations.

Sustaining successful organisational change through leadership competence within Bahrain oil and gas: the power of Sustainable Network Leadership approach

PurposeDespite some academic recognition that leadership is particularly significant in reshaping the oil and gas industry’s contributions to global economic development and the sustainability of global energy supplies at affordable prices (Sharma et al., 2022), the attendant problem of how the industry’s leadership contributes towards the preservation of global environment and the maintenance of ecosystems’ balance, among other sustainability challenges, remains an academic lag. This calls for the urgent need for oil and gas companies to practice effective sustainable leadership approach at multiple organisational levels to address global environmental, economic and social challenges.Design/methodology/approachThis paper adopts an interpretivist/constructivist philosophical stance, where findings have been extracted from in-depth thick descriptive qualitative research in Bahrain oil and gas industry. Companies operating within Bahrain oil and gas industry were identified as the unit of analysis. Empirical data are gathered through semi-structured interviews from senior management and analysed using thematic analysis. This paper is structured as follows: introduction, contextualisation of the UNSDGs in the oil and gas industry, literature on network leadership, research methods used to gather and analyse data from Bahrain oil and gas industry findings, contributions, limitations and trajectories for further studies.FindingsThe study’s participants argued that the emergence of transformational and Sustainable Network Leadership is essential to successfully and sustainably implementing the UN SDGs. In other words, the Sustainable Network Leadership is a contribution to the single, leadership competences approach of previous scholarship (Weber et al., 2022; Kumalo and Scheepers, 2021) partly because it evolves around the notion of positioning different network and change actors based on their capacity to lead, exchange their knowledge, effectively communicate the need to comply with SDGs and the skills to establish high density within a complex network of actors.Research limitations/implicationsThis study recognises its limitations in the sense that it is based on the single context of Bahrain oil and gas, and data were collected from senior management and executives only. Gathering data from a broader swathe of employees may have provided greater levels of leadership and organisational member nuances in both single and collective differences of leadership attributes.Practical implicationsTransformational and Sustainable Network Leadership provides a new construct in the perception (the “what”), instrumentalisation (the “how”) and theoretical re-conceptualisation of leadership within organisational change settings needing radical rethink for sustainable and successful change. The practical implications of transformational and Sustainable Network Leadership expose the way a variety of highly challenged organisational change contexts are interconnected to highlight not only their different sets of challenges but also their opportunities and the resolution mechanisms they present for organisational leaders and staff alike.Originality/valueThis paper identified the single, leadership competence approach as the dominant discourse in organisational change, leadership studies and presented an alternative collective set of leaders’ attributes. The less utilised network leadership concept was drawn upon to contribute network leadership attributes as a way of addressing the challenges faced by Bahraini oil and gas company leaders. Therefore, this study contributes to both network leadership, transformational leadership by expanding both domains to include organisational transformation and the leadership-of-risky change. This was done by identifying attributes and characteristics of Sustainable Network Leadership, then showing their significance as an approach to successfully and sustainably implementing the UNSDGs.

Environmental conditions influence host-parasite interactions and host fitness in a migratory passerine.

The study of host-parasite co-evolution is a central topic in evolutionary ecology. However, research is still fragmented and the extent to which parasites influence host life history is debated. One reason for this incomplete picture is the frequent omission of environmental conditions in studies analyzing host-parasite dynamics, which may influence the exposure to or effects of parasitism. To contribute to elucidating the largely unresolved question of how environmental conditions are related to the prevalence and intensity of infestation and their impact on hosts, we took advantage of 25 years of monitoring of a breeding population of pied flycatchers, Ficedula hypoleuca, in a Mediterranean area of central Spain. We investigated the influence of temperature and precipitation during the nestling stage at a local scale on the intensity of blowfly (Protocalliphora azurea) parasitism during the nestling stage. In addition, we explored the mediating effect of extrinsic and intrinsic factors and blowfly parasitism on breeding success (production of fledglings) and offspring quality (nestling mass on day 13). The prevalence and intensity of blowfly parasitism were associated with different intrinsic (host breeding date, brood size) and extrinsic (breeding habitat, mean temperature) factors. Specifically, higher average temperatures during the nestling phase were associated with lower intensities of parasitism, which may be explained by changes in blowflies' activity or larval developmental success. In contrast, no relationship was found between the prevalence of parasitism and any of the environmental variables evaluated. Hosts that experienced high parasitism intensities in their broods produced more fledglings as temperature increased, suggesting that physiological responses to severe parasitism during nestling development might be enhanced in warmer conditions. The weight of fledglings was, however, unrelated to the interactive effect of parasitism intensity and environmental conditions. Overall, our results highlight the temperature dependence of parasite-host interactions and the importance of considering multiple fitness indicators and climate-mediated effects to understand their complex implications for avian fitness and population dynamics.

Challenges for libraries and librarians at the nexus of the digital age and the dawn of the Fourth Industrial Revolution

PurposeThe purpose of this paper is to examine the current climate in each library sector and to determine how ready libraries and librarians might be for technological change. In particular, the author sought to determine what barriers or challenges might exist and where there are strengths.Design/methodology/approachCurrent and former library workers were surveyed via social media and by using an interview process. All were questioned about their opinions on the current situation in libraries and both the institutional and personal readiness for technological change that will result from the Fourth Industrial Revolution. Librarians and technicians from all library sectors responded. The author also included her perspectives on the issues raised.FindingsThe findings were that although there is a certain level of cross-over in the specific challenges each library sector faces, there are unique and consequential issues found in each of school, public, special and academic and research libraries. Although the problems encountered by library workers and the libraries they work for may confound their ability to lead change, the profession has a history of flexibility and resilience in the face of technological change. Readers are advised to be aware of both the difficult realities they are facing and seek ways to move forward.Originality/valueThis column is unique in that it provides insights from library workers who led and nurtured libraries through the digital revolution of the 1970s through to the early 2000s. These individuals are able to explain how libraries have changed over decades and to identify the new stresses and challenges their sector faces. Despite what may seem to be a possibly dim outlook for the future, their oral history of successful change in libraries brings light and hope for future positive outcomes in the face of the Fourth Industrial Revolution.

P-698 The ULTRA trial: transvaginal ULTRAsound-guided ovarian ablation using May Health System in women with PCOS-related infertility: clinical and endocrine outcomes of first–in-human feasibility trial

Abstract Study question What is the feasibility of transvaginal ULTRAsound (TVUS)-guided ovarian ablation using the May Health System to improve ovulation, pregnancy, and hormonal abnormalities in PCOS-related infertility? Summary answer The feasibility of TVUS-guided ovarian ablation to improve ovulation, pregnancy, and hormonal abnormalities in PCOS-related anovulatory infertility was demonstrated. A pivotal study is underway. What is known already Laparoscopic ovarian drilling (LOD) is widely accepted as an effective second line treatment in PCOS-related infertility. However, laparoscopy is an invasive procedure that requires general anaesthesia and carries significant risks. Furthermore, there is no standardization of the LOD technique among surgeons. In contrast, the May Health System has been designed to deliver a precisely calculated amount of ovarian ablation via a less invasive route without general anaesthesia. This approach therefore transforms an invasive surgical procedure to an office-based technique similar in ovarian access to the well-established oocyte retrieval. Feasibility and safety results of this trial have previously been reported. Study design, size, duration This study included two feasibility, single-arm clinical trials running in parallel in the EU and US assessing the May Health System in performing TVUS-guided ovarian ablation in anovulatory PCOS women resistant to first-line ovulation induction drugs. Sample size was up to 35 participants with post-procedure follow-up (FU) of 24 months in EU and 12 months in US. Endpoints for this study were technical success, ovulation rates, pregnancy rates, and hormonal changes. Participants/materials, setting, methods Seven fertility centres participated in the trials. Participants were clomiphene/letrozole-resistant PCOS women aged 18-40 years. PCOS was diagnosed according to Rotterdam criteria. Participants underwent TVUS-guided ovarian ablation using the May Health System. The initial five participants underwent laparoscopy concurrent with TVUS-ablation. Post-procedure, serum progesterone was measured weekly until confirmation of ovulation or up to 12 weeks. Women were evaluated at 3 and 6 month, and then telephoned at 9- 12- and 24-month (EU sites only). Main results and the role of chance Thirty-one participants (mean±sd age, 31.9±3.3 years; BMI, 29.84.7kg/m2) underwent May Health TVUS-guided ovarian ablation and 25 completed at least six-months FU, with follow-up ongoing. Fourteen (45.2%) ovulated spontaneously within 3-months. Six more participants (19.3%) ovulated between three and nine months (after restarting CC/LTZ) giving a combined ovulation rate, with and without first-line medication restart, of 64.5% (20/31). Of the 31 participants who underwent the procedure, 10 (32%) have conceived to date, with seven live births, two ongoing, and one miscarriage. In 30 cases (97%), the targeted ablation was achieved successfully, while in one case (3%) the procedure was abandoned for the second ovary due to pain (n = 1). The median (IQR) serum AMH concentrations significantly decreased from baseline 76.1 (32.0, 210.7) to 62.5 (21.2, 253.6) pmol/l at 3-month (p = 0.001) and 56.7 (11.5, 126.8) pmol/l at 6-month (p = 0.001) post-procedure (Figure 2). The magnitude of post-ablation AMH decline was significantly (p = 0.047) greater in those who ovulated (responders) (-23.7% (-36.5, 17.7)) versus non-responders (-7.3% (-25.2, -1.6)). Ovarian volume significantly (p = 0.005) decreased from 13.6±5.1 ml at baseline to 10.1±3.7 ml at 6-month FU. There were no statistically significant changes in mean circulating testosterone, LH, or FAI at 3- or 6-month. Limitations, reasons for caution A limitation of this study is the lack of a comparator treatment / placebo arm. However, this was not necessary for this feasibility trial. It is possible to assume that the post-procedure ovulation and pregnancies could be compared for each participant with pre-procedure lack of ovulation and failure to conceive. Wider implications of the findings These data suggest that the investigational May Health System may offer an effective office-based second line ovulation inducing procedure for PCOS. The observed decline in circulating AMH, which was sustained for at least six months, could be the underlying mechanism of ovarian rebalancing that leads to subsequent resumption of ovulation. Trial registration number NCT03760926

A mixed methods evaluation of patient perspectives on the implementation of an electronic health record-integrated patient-reported symptom and needs monitoring program in cancer care

BackgroundAs cancer centers have increased focus on patient-centered, evidenced-based care, implementing efficient programs that facilitate effective patient-clinician communication remains critical. We implemented an electronic health record-integrated patient-reported symptom and needs monitoring program (‘cPRO’ for cancer patient-reported outcomes). To aid evaluation of cPRO implementation, we asked patients receiving care in one of three geographical regions of an academic healthcare system about their experiences.MethodsUsing a sequential mixed-methods approach, we collected feedback in two waves. Wave 1 included virtual focus groups and interviews with patients who had completed cPRO. In Wave 2, we administered a structured survey to systematically examine Wave 1 themes. All participants had a diagnosed malignancy and received at least 2 invitations to complete cPRO. We used rapid and traditional qualitative methods to analyze Wave 1 data and focused on identifying facilitators and barriers to cPRO implementation. Wave 2 data were analyzed descriptively.ResultsParticipants (n = 180) were on average 62.9 years old; were majority female, White, non-Hispanic, and married; and represented various cancer types and phases of treatment. Wave 1 participants (n = 37) identified facilitators, including cPRO’s perceived value and favorable usability, and barriers, including confusion about cPRO’s purpose and various considerations for responding. High levels of clinician engagement with, and patient education on, cPRO were described as facilitators while low levels were described as barriers. Wave 2 (n = 143) data demonstrated high endorsement rates of cPRO’s usability on domains such as navigability (91.6%), comprehensibility (98.7%), and relevance (82.4%). Wave 2 data also indicated low rates of understanding cPRO’s purpose (56.7%), education from care teams about cPRO (22.5%), and discussing results of cPRO with care teams (16.3%).ConclusionsWhile patients reported high value and ease of use when completing cPRO, they also reported areas of confusion, emphasizing the importance of patient education on the purpose and use of cPRO and clinician engagement to sustain participation. These results guided successful implementation changes and will inform future improvements.

Sperm performance in the race for fertilization, the influence of female reproductive fluid.

In studies of sperm competition, particularly in external fertilizers, the importance of the fertilization environment on the paternity share among rival males often goes overlooked. The female reproductive fluid (FRF), produced and released by females, creates the microenvironment that sperm encounter on their quest for fertilization and can generate paternity biases by affecting key traits in sperm competition. Yet, whether there is a direct link between FRF effects on sperm traits and its effect on competitive fertilization dynamics remains to be explored. Here, using the zebrafish Danio rerio, we compare within-female paternity share among two competing males and predictors of fertilization success (i.e. sperm traits) in the presence/absence of FRF. Our results unequivocally reveal a direct link between the direction and magnitude of the effect of FRF on sperm traits and the change in the competitive fertilization success of each male. This study demonstrates that the FRF directly mediates post-mating female control through its differential effect on sperm performance and that the FRF's effect on sperm quality alone is sufficient to predict the magnitude of the fitness effects. These findings highlight the need to consider the role of FRF in fertilization, avoiding biases resulting from an exclusive focus on male intrinsic sperm quality.

코스피 200 기업에서 가치전략의 변화와 재무적 성과 사이에서 ESG 성과가 미치는 매개 역할

코스피 200 기업에서 가치전략의 변화와 재무적 성과 사이에서 ESG 성과가 미치는 매개 역할

اسماء الحسنیٰ کے باطنی پہلو اور رحمت الٰہی

The Sacred Names The sacred names of Allah Almighty reflect God's qualities. Allah Almighty 's sacred names are embodiment of His Beauty 'grace, affection or anger. If there would be element of trinity, threat and fear in a negative sense then these names could not be put in the range of beautiful or sacred names. These names contain a sense of grace and forgiveness in every aspect. By viewing the inner aspect of these names one can come to know that every sacred name has an element of love, affection and forgiveness. If there is punishment, revenge or hardness, it is in a positive sense for our betterment. There is a lesson for our eternal benefit, success, education and positive change in hardness and punishment.

Efficacy of topical treatments for mild‐to‐moderate acne: A systematic review and meta‐analysis of randomized control trials

AbstractAcne is a common skin condition, but little data exist on the comparative efficacy of topical acne therapies. We conducted a systematic review and network meta‐analysis to evaluate the efficacy of topical therapies for mild‐to‐moderate acne. Searches in PubMed/MEDLINE, Cochrane CENTRAL via Ovid, Embase via Ovid and Web of Science were conducted on 29 November 2021. Randomized controlled trials examining ≥12 weeks of topical treatments for acne vulgaris in subjects aged 12 and older were included. Main outcomes were absolute or percent change in acne lesion count and treatment success on the Investigator's Global Assessment scale. Thirty‐five randomized clinical trials with 33,472 participants comparing nine different topical agents were included. Adapalene‐benzoyl peroxide (BPO), clindamycin‐BPO and clindamycin‐tretinoin demonstrated the greatest reduction in non‐inflammatory (ratio of means [RoM] 1.76; 95% CI [1.46; 2.12], RoM 1.70; 95% CI [1.44; 2.02] and RoM 1.87; 95% CI [1.53; 2.30], respectively), inflammatory (RoM 1.56; 95% CI [1.44; 1.70], RoM 1.49; 95% CI [1.39; 1.60] and RoM 1.48; 95% CI [1.36; 1.61], respectively) and total lesion count (ROM 1.67; 95% CI [1.47; 1.90], RoM 1.59; 95% CI [1.42; 1.79] and RoM 1.64; 95% CI [1.42; 1.89], respectively) compared to placebo. All single agents outperformed placebo except tazarotene, which did not significantly outperform placebo for inflammatory and non‐inflammatory lesion count reduction. Most combination agents significantly outperformed their individual components in lesion count reduction and global assessment scores, except for clindamycin‐tretinoin and clindamycin‐BPO, which did not significantly outperform tretinoin (RoM 1.13; 95% CI [0.94; 1.36]) and BPO (RoM = 1.15, 95% CI [0.98; 1.36]), respectively, for non‐inflammatory lesion reduction. There was no significant difference amongst most single agents when evaluating lesion count reduction. Combination agents are generally most effective for mild‐to‐moderate acne; however for non‐inflammatory acne, the addition of clindamycin in topical regimens is unnecessary and should be avoided.

Leveraging Power: A Multiple Embedded Case Study of Institutional Change Efforts for Racial Equity at Four Private Universities

ABSTRACT Despite research signaling the need to advance racial equity in university policies and practices, power dynamics in institutional change processes are not well understood. Using a constructivist embedded multiple case study design, critical theoretical perspective, and explanation-building technique, we analyzed how four private institutions with demonstrable change in student success and closing racial equity gaps in graduation rates enacted diversity, equity, and inclusion efforts over the last 5 years. Findings led to understanding how institutional agents synergistically used strategies in two phases: one, advocates, partnerships and coalitions, and capacity-building; second: resources, assessment, and accountability.

Critically Unveiling Resistance: Strategies for Effective Change Management in Organizations

This article critically examines the complexities of resistance to change within organizations and the strategies to effectively manage it. Utilizing theoretical frameworks and practical case studies, the research identifies key factors contributing to resistance, including change fatigue, loyalty to the past, personality traits, uncertainty, and valuation of interests. The article further explores the significance of understanding these root causes through Morgan's metaphors and the implications for successful change implementation. The analysis underscores the importance of timely and effective communication, comprehensive training, and continuous support to mitigate resistance and promote sustainable organizational transformation.

Passive Restoration Achieved through Natural Processes over 70 Years in the Korean DMZ

The Korean Demilitarized Zone (DMZ) is an area where human disturbance has been strictly restrained for about seven decades since 1953. As a result, compared with rural and urban areas in Korea with similar ecological conditions, the landscape structure of the Korean DMZ today shows a big difference in that it has a riparian forest and lacks any of the artificial landscape elements, such as agricultural and residential areas. The vegetation maps made in the 1950s and those made in recent years of a model site that extends throughout the DMZ, the Civilian Control Zone (CCZ), and adjacent rural areas show that successional changes in the DMZ and CCZ areas are remarkable, while changes in the rural areas are not clear. Rice fields have been replaced by riparian forests, whereas young forests in areas previously subjected to excessive use and pine forests have been replaced by broad-leaved forests. Among the three landscape elements that changed, it was found that riparian zones, where natural disturbance is usually frequent, could mitigate the impacts of human disturbance and restore the original features of nature sooner than any other elements. The results of analyses on landscape change that focused on rice fields before the Korean War also showed similar results: most of these fields had turned into riparian vegetation. Stand ordination of riparian vegetation investigated in the CCZ, rural areas, and urban areas showed clear differences in species composition and diversity among regions. In this study, we confirmed the passive restoration of the Korean DMZ and CCZ through natural regeneration processes as a result of restricted human disturbance over a period of about seven decades.

Управління організаційними трансформаціями в процесі розвитку підприємства

The article explores the critical aspects of transformation processes in the contemporary business environment and the role of leadership in their successful implementation. Enterprises operating in rapidly changing market environments often need organizational transformations to adapt to new conditions and ensure competitive development. The article examines the main stages and aspects of managing organizational transformations, including analyzing the organization’s needs and opportunities, developing change strategies, and planning and implementing new initiatives. The importance of strategic leadership in the transformation process is emphasized, as well as the necessity of engaging all levels of staff for successful change implementation. Special attention is paid to the critical success factors of organizational transformations. Among them are proper strategic leadership, creating a conducive corporate culture, effective change management, employee engagement, and the flexibility and adaptability of the organization to change. The article highlights the importance of technological innovations as a critical success factor in organizational transformations. The impact of digitization and cutting-edge technologies on business processes is examined, and the necessity of integrating these innovations into strategic planning is emphasized. Furthermore, the article addresses the importance of strategic partnerships in the transformation process. Collaboration with other organizations, experts, and consultants can provide access to additional resources and expert support, facilitating the successful implementation of changes. The article also analyzes the importance of evaluating the results of transformation processes and providing feedback for continuous improvement of management strategies and practices. The author calls for systematic monitoring and assessment of change effectiveness and the use of obtained data for process and strategy enhancement. In conclusion, the article illuminates the significance of managing organizational transformations for enterprise development in the contemporary business environment. The author underscores the importance of a comprehensive approach to this process, including strategic leadership, employee engagement, effective change management, and cutting-edge technologies. Keywords: organizational transformations, enterprise development, strategic leadership, change management, corporate culture, employee engagement, technological innovations, strategic partnerships, evaluation of results, continuous improvement, business environment, competitive development, digitalization, innovation integration, strategic planning.

Dickeya fangzhongdai was prevalent and caused taro soft rot when coexisting with the Pectobacterium complex, with a preference for Araceae plants.

Bacterial soft rot caused by coinfection with Dickeya spp. and Pectobacterium spp. in hosts can cause successive changes in fields, and it is difficult to prevent the spread of and control the infection. Pectobacterium spp. are prevalent in the growing areas of tuberous crops, including taro and potato. Recently, Dickeya fangzhongdai has emerged as a virulent pathogen in taro. To determine the prevalence status of the causal agents and evaluate the potential spreading risks of D. fangzhongdai, screening and taxonomic classification were performed on phytopathogenic bacteria collected from different taro-growing areas in Guangdong Province, China, and biological and genomic characteristics were further compared among typical strains from all defined species. The causative agents were verified to be phytobacterial strains of D. fangzhongdai, Pectobacterium aroidearum and Pectobacterium colocasium. P. aroidearum and P. colocasium were found to form a complex preferring Araceae plants and show intensive genomic differentiation, indicating their ancestor had adapted to taro a long time prior. Compared with Pectobacterium spp., D. fangzhongdai was more virulent to taro corms under conditions of exogenous infection and more adaptable at elevated temperatures. D. fangzhongdai strains isolated from taro possessed genomic components of additional T4SSs, which were accompanied by additional copies of the hcp-vgrG genes of the T6SS, and these contributed to the expansion of their genomes. More gene clusters encoding secondary metabolites were found within the D. fangzhongdai strains than within the Pectobacterium complex; interestingly, distinct gene clusters encoding zeamine and arylpolyene were both most similar to those in D. solani that caused potato soft rot. These comparisons provided genomic evidences for that the newly emerging pathogen was potentially equipped to compete with other pathogens. Diagnostic qPCR verified that D. fangzhongdai was prevalent in most of the taro-growing areas and coexisted with the Pectobacterium complex, while the plants enriching D. fangzhongdai were frequently symptomatic at developing corms and adjacent pseudostems and caused severe symptoms. Thus, the emerging need for intensive monitoring on D. fangzhongdai to prevent it from spreading to other taro-growing areas and to other tuberous crops like potato; the adjustment of control strategies based on different pathopoiesis characteristics is recommended.