Successful Transfer Research Articles

From admission to discharge: a systematic review of clinical natural language processing along the patient journey

BackgroundMedical text, as part of an electronic health record, is an essential information source in healthcare. Although natural language processing (NLP) techniques for medical text are developing fast, successful transfer into clinical practice has been rare. Especially the hospital domain offers great potential while facing several challenges including many documents per patient, multiple departments and complex interrelated processes.MethodsIn this work, we survey relevant literature to identify and classify approaches which exploit NLP in the clinical context. Our contribution involves a systematic mapping of related research onto a prototypical patient journey in the hospital, along which medical documents are created, processed and consumed by hospital staff and patients themselves. Specifically, we reviewed which dataset types, dataset languages, model architectures and tasks are researched in current clinical NLP research. Additionally, we extract and analyze major obstacles during development and implementation. We discuss options to address them and argue for a focus on bias mitigation and model explainability.ResultsWhile a patient’s hospital journey produces a significant amount of structured and unstructured documents, certain steps and documents receive more research attention than others. Diagnosis, Admission and Discharge are clinical patient steps that are researched often across the surveyed paper. In contrast, our findings reveal significant under-researched areas such as Treatment, Billing, After Care, and Smart Home. Leveraging NLP in these stages can greatly enhance clinical decision-making and patient outcomes. Additionally, clinical NLP models are mostly based on radiology reports, discharge letters and admission notes, even though we have shown that many other documents are produced throughout the patient journey. There is a significant opportunity in analyzing a wider range of medical documents produced throughout the patient journey to improve the applicability and impact of NLP in healthcare.ConclusionsOur findings suggest that there is a significant opportunity to leverage NLP approaches to advance clinical decision-making systems, as there remains a considerable understudied potential for the analysis of patient journey data.

The [formula omitted]-RWELL for future HEP challenges

The challenges posed by the forthcoming High-Energy Physics experiments require advanced particle detection technologies that are industrially scalable. The μ-RWELL, a single-amplification stage resistive MPGD utilizing sequential build-up (SBU) technology, addresses these needs. This paper reviews the main characteristics of the detector, the design of high-rate layouts, and their testing at INFN-LNF. It provides a detailed description of the detector construction processes at ELTOS and the CERN MPT Workshop. The findings highlight the industrial feasibility of detector construction, offering benefits in production time and cost. A significant focus is on the production of large DLC foils, which are essential for the detector’s amplification stage. This was facilitated by the acquisition of a DC-magnetron sputtering machine through a CERN-INFN collaboration. Detailed test results using an X-ray gun at LNF and particle beams at the CERN North Area clearly show that the detector achieves a gas gain of 104 and a rate capability greater than 1 MHz/cm2, while the efficiency of the optimized high-rate layout is about 98%. Preliminary outcomes from the 2023 co-production pilot test show a production yield larger than 90%. This successful technology transfer marks a step towards building larger detectors for future HEP challenges.

LAPAROSCOPIC DIAGNOSIS OF ENDOMETRIOSIS-ASSOCIATED INFERTILITY

The purpose of the study – to generalize the laparoscopic manifestations of genital andextragenital endometriosis in women with infertility, followed by the determination of itsbelonging to international classifications of pathology for the possibility of choosing fullfledged methods of influencing the focus of the disease.Materials and methods. The study was conducted in two stages: a detailed analysis ofscientific studies on the issue of classification of endometriosis R-AFS, Enzian, EFI witha generalization of the main search criteria during laparoscopy; a study based on themedical center «Yuzko» in Chernivtsi, in which 42 women who contacted about infertilitytook part. In the practical part of the work, clinical and paraclinical methods of diagnosis,laparoscopic revision were used, followed by the formation of diagnoses according to themain classifiers of endometriosis, determination of the fertility index and generalizationof the form of endometriosis as a cause of infertility.Research results. Endometriosis is a chronic pathology of the female reproductive system,which often leads to infertility and is accompanied by various clinical manifestations inthe form of pain and menstrual dysfunction. For the purpose of a complete diagnosis ina specific case, an important stage is the determination of the depth and stage of developmentof the endometrioid focus based on the results of laparoscopy according to the classificationproposed by the American Fertility Society (R-AFS classification), Enzian, followed bythe determination of the fertility index (EFI) in order to choose individual managementtactics of each patient. A study was conducted at Yuzko Medical Center, in which 42 womenof various ages who complained of infertility took part. In the course of laparoscopicoperations, various methods of removing endometrioid foci were implemented depending onthe specific clinical case, after which the stage of endometriosis was determined according to the Enzian, R-AFS classification, and a conclusion was formed about the directdependence of the risk of infertility and the depth of the spread of endometriosis foci.Conclusion. The stage and depth of endometriosis plays a decisive role in the developmentof female infertility, which requires careful diagnosis according to modern classificationsand the implementation of a specific treatment program with the aim of developinga natural pregnancy or successful embryo transfer during in vitro fertilization.

Continuity of medication information transfer and continuous medication supply during hospital-to-home transitions - nationwide surveys in hospital and community pharmacies after implementing new legal requirements in Germany

BackgroundWhile successful information transfer and seamless medication supply are fundamental to medication safety during hospital-to-home transitions, disruptions are frequently reported. In Germany, new legal requirements came into force in 2017, strengthening medication lists and discharge summaries as preferred means of information transfer. In addition to previous regulations – such as dispensing medication at discharge by hospital pharmacies – hospital physicians were now allowed to issue discharge prescriptions to be supplied by community pharmacies. The aim of this survey study was to gain first nationwide insights into how these requirements are implemented and how they impact the continuity of medication information transfer and continuous medication supply.MethodsTwo nationwide self-administered online surveys of all hospital and community pharmacies across Germany were developed and conducted from April 17th to June 30th, 2023.ResultsOverall, 31.0% (n = 111) of all German hospital pharmacies and 4.5% (n = 811) of all community pharmacies participated. The majority of those hospital pharmacies reported that patients who were discharged were typically provided with discharge summaries (89.2%), medication lists (59.5%) and if needed, discharge prescriptions (67.6%) and/or required medication (67.6%). About every second community pharmacy (49.0%) indicated that up to half of the recently discharged patients who came to their pharmacy typically presented medication lists. 34.0% of the community pharmacies stated that they typically received a discharge summary from recently discharged patients at least once per week. About three in four community pharmacies (73.3%) indicated that most discharge prescriptions were dispensed in time. However, one-third (31.0%) estimated that half and more of the patients experienced gaps in medication supply. Community pharmacies reported challenges with the legal requirements – such as patients´ poor comprehensibility of medication lists, medication discrepancies, unmet formal requirements of discharge prescriptions, and poor accessibility of hospital staff in case of queries. In comparison, hospital pharmacies named technical issues, time/personnel resources, and deficits in patient knowledge of medication as difficulties.ConclusionAccording to the pharmacies´ perceptions, it can be assumed that discontinuation in medication information transfer and lack of medication supply still occur today during hospital-to-home transitions, despite the new legal requirements. Further research is necessary to supplement these results by the perspectives of other healthcare professionals and patients in order to identify efficient strategies.

Large and interactive pipefish females display ornaments for longer with many males around

Why do animals display sexual ornaments – to attract mates, to compete for access to them, or both? In the broad-nosed pipefish (Syngnathus typhle), ornamented females commonly compete for access to males, whereas choosy males provide uniparental care. During courtship, females show a dynamic ornament, consisting of a row of dark B-shaped signs along the sides of their trunk. Here, we focus on the social context of female ornamentation and mating success (egg transfer) under experimentally female and male biased adult sex ratios. We found that the duration of female B-sign displays was not explained by adult sex ratios alone, but rather by sex ratios in combination with female body length and the number of female interactions. In detail, duration of B-sign display increased more steeply with the number of female-female interactions under the male biased adult sex ratio: that is, when more mating opportunities were available. Similarly, display duration increased with female body length, but only under the male biased adult sex ratio. In addition, successful egg transfer occurred more often in the male biased treatment and correlated significantly with female display duration in the same treatment. Taken together, these results suggest that in the context of the broad-nosed pipefish, the ornamental B-signs in females primarily serve as a sexually selected attractive signal. Our results highlight the importance of an interactive mating environment, male availability, and female size.

Does the Dual Representation System of Player Agents in International Football Benefit Players? An Economic Analysis

It is common in international football for the same agent to be paid both commission fees by the purchasing club for negotiating a player salary and a transfer fee. This dual representation creates a potential conflict of interest for the agent. The agent may not negotiate the highest salary for the player if a higher salary reduces the likelihood of a successful transfer by lowering the resources available for the transfer fee. We construct a gamble model of the transfer process and simulate the ex-ante agent commissions rates, expected player salary, transfer fee and club profit under the assumption of dual representation where the buying club pays all agent commissions. The assumption that the quality of the agent increases with the commission rate is essential to the model. Both the player and the club are better off when the club pays both commissions, however the agent is worse off.

Combined paravertebral and erector spinae plane block in non-intubated video-assisted thoracoscopic wedge resection: a case report

Thoracic surgery is often performed under general anesthesia, with intubation required. Less invasive surgical and anesthesiology approaches, such as a combination of video-assisted thoracic surgery (VATS) and regional nerve blocks, have been utilized to facilitate early recovery. In this case report, a patient undergoing VATS will be presented using thoracic paravertebral block (TPVB) and erector spinae plane blocks (ESPB) as the primary anesthesia approach. A twenty-eight-year-old male patient with no known comorbidity had been evaluated for VATS to undergo wedge resection of the right middle lobe due to non-resolving repeated pneumothorax. As the patient had bullous lung presence at the contralateral side as well, invasive ventilation was deemed risky, and, as an alternative approach, real-time ultrasound-guide TPV and ESPB block were performed with intravenous midazolam 2 mg and fentanyl 50 mcg utilized to prevent anxiety and pain control. A total of 20 ml bupivacaine and 10 mL 2% lidocaine were used for nerve blocks and for maintenance of sedation; 2 mg midazolam, 50 mg ketamine, 50 mcg fentanyl, and 150 mg propofol were used within 90 minutes of operation. After VATS, the patient was admitted to the surgical intensive care unit, and no complication was observed post-operatively, with a successful transfer to the ward afterward. Maintenance of an unproblematic perioperative period is as paramount as the surgery itself. A combination of protocols, with the limitation of post-operative opioid usage by sedation and less invasive surgical methods, such as non-intubated VATS being presented in this case report, allows an earlier recovery period and less complication by preserving lung function. TPV and ESPB, in this case, granted exclusion of intubation, less invasive to thoracic epidural anesthesia, and control of possible complications due to an already bullous lung.

CuO/Sb2S3 Nanoarchitectures for Enhanced Charge Generation/Separation for Photoelectrochemical Hydrogen Evolution

Developing an efficient photocathode system using abundant earth materials is crucial for the effective process of Photoelectrochemical (PEC) water splitting. Achieving successful charge transfer between heterojunctions is a key consideration in creating an innovative photocathode that considers cost-effectiveness, material abundance, and PEC performance. In our study, we synthesized a p-type narrow band gap photocathode using copper oxide (CuO) with an energy gap (Eg) of 1.5 eV through a hydrothermal method. We then enhanced its performance by decorating it with antimony sulfide (Sb2S3) nanospheres (NSs) using a simple chemical bath deposition (CBD) technique, resulting in the formation of a CuO/Sb2S3 NSs heterojunction.The fabricated heterojunction demonstrated superior PEC performance compared to the bare CuO. Specifically, we observed a significant increase in photocurrent density for the CuO/Sb2S3 NSs photocathode (J = -1 mA.cm-2) compared to CuO alone (J = -0.3 mA.cm-2) at a standard potential of 0 V vs RHE in a 0.5 M Na2SO4 solution with a pH of 6.85. This improvement can be attributed to the enhanced generation and separation of charge carriers. Furthermore, the CuO/Sb2S3 heterojunction exhibited remarkable photostability over a period of 2.5 h, with no degradation in photocurrent density. The Sb2S3 acted as a sensitizer, reducing the recombination rate of electron-hole pairs (e-/h+) within the CuO/Sb2S3 NSs, thereby enhancing the overall performance. The CuO/Sb2S3 NSs photocathode exhibited an ABPE% of 0.1%, while the ABPE% for CuO alone was 0.03%. This indicates a significant improvement in the performance of the CuO/Sb2S3 NSs photocathode. Onset potential (Eonset) was also observed to shift in a positive direction in CuO/Sb2S3 NSs as compared to CuO only. Eonset for the films followed a trend having CuO/Sb2S3 NSs (0.85 VRHE) > CuO (0.78 VRHE). Notably, this improvement is attributed to increased light absorption and a reduced recombination rate compared to the pristine CuO photocathode. Moreover, electrochemical impedance spectroscopy (EIS) studies provided evidence of enhanced electron transfer rates occurring at the interface between the heterojunction and the electrode/electrolyte interface. UV-Visible and photoluminescence (PL) emission spectra results indicated that the CuO/Sb2S3 NSs heterojunction exhibited an extended absorption spectrum and a reduced rate of recombination, further supporting the enhanced performance. Additionally, electrochemical impedance spectroscopy studies revealed lower charge transfer resistance in the CuO/Sb2S3 NSs heterojunction compared to CuO alone.These findings open up new avenues for the development of novel photocathodic materials and heterojunctions utilizing copper-based binary oxides/chalcogenides for efficient solar harvesting applications.References(1) Kumar, M.; Singh, A.; Meena, B.; Sahu, P. K.; Subrahmanyam, C. Decoration of Spherical Sb2S3 over CuO Nanoflakes for Efficient Photoelectrochemical Hydrogen Generation. Results Eng. 2023, 101513. https://doi.org/10.1016/j.rineng.2023.101513.(2) Kumar, M.; Meena, B.; Subramanyam, P.; Suryakala, D.; Subrahmanyam, C. Emerging Copper-Based Semiconducting Materials for Photocathodic Applications in Solar Driven Water Splitting. Catalysts 2022, 12 (10), 1198. https://doi.org/10.3390/catal12101198.(3) Kumar, M.; Meena, B.; Subramanyam, P.; Suryakala, D.; Subrahmanyam, C. Recent Trends in Photoelectrochemical Water Splitting: The Role of Cocatalysts. NPG Asia Mater. 2022, 14 (1), 88. https://doi.org/10.1038/s41427-022-00436-x. Figure 1

Electric buses as an air pollution and meteorological observation network: Methodology and preliminary results

Many local agencies in the United States and other countries are tasked to install air pollution monitoring systems of highly accurate sensors that have high acquisition, operating, and maintenance costs. The need for expanded coverage of air quality measurements across Salt Lake County (SLCO), Utah is being met by mounting air quality and temperature sensors on an expanding fleet of battery electric buses (BEBs). Monitoring air quality from a mobile sensor network provides real-time insights into air pollution patterns at high temporal and spatial resolution. Mobile measurements contribute to assessing residents' exposure to air pollution, facilitating the implementation of cost-effective public health policies and highlighting disparities. The Electric Bus Air Quality Observation Project was launched in SLCO during July 2021 and has collected millions of observations to date. A BEB traveling at typical traffic speeds (~10 m s−1) can provide multiple measurements along city block lengths of up to ~200 m. With careful analysis that factors in the time response of the differing sensors, variability from block-to-block may be attributed to fine-scale factors (e.g., pollution and heat sources, tree shading and urban vegetation, etc.). Preliminary findings showcase the value of increased coverage and resolution. During an extreme heat event in July 2023, both the morning and afternoon temperature readings showed differences of over 6.5 °C (12 °F), primarily as an east-west gradient with similar gradients in ozone. We conclude that temperature and pollutant concentration readings, at fine spatial and temporal resolutions, will facilitate future health studies and equitable policy and mitigation strategies. Our study demonstrates that our partnerships established with governmental, non-profit, and transit agencies facilitate the successful transfer of research and development to operational real-time mobile air quality monitoring.

OmniJet-α: the first cross-task foundation model for particle physics

Abstract Foundation models are multi-dataset and multi-task machine learning methods that once pre-trained can be fine-tuned for a large variety of downstream applications. The successful development of such general-purpose models for physics data would be a major breakthrough as they could improve the achievable physics performance while at the same time drastically reduce the required amount of training time and data. We report significant progress on this challenge on several fronts. First, a comprehensive set of evaluation methods is introduced to judge the quality of an encoding from physics data into a representation suitable for the autoregressive generation of particle jets with transformer architectures (the common backbone of foundation models). These measures motivate the choice of a higher-fidelity tokenization compared to previous works. Finally, we demonstrate transfer learning between an unsupervised problem (jet generation) and a classic supervised task (jet tagging) with our new OmniJet-α model. This is the first successful transfer between two different and actively studied classes of tasks and constitutes a major step in the building of foundation models for particle physics.

Antibody-mediated autoimmunity in symptom-based disorders: position statement and proceedings from an international workshop.

A 2-day closed workshop was held in Liverpool, United Kingdom, to discuss the results of research concerning symptom-based disorders (SBDs) caused by autoantibodies, share technical knowledge, and consider future plans. Twenty-two speakers and 14 additional participants attended. This workshop set out to consolidate knowledge about the contribution of autoantibodies to SBDs. Persuasive evidence for a causative role of autoantibodies in disease often derives from experimental "passive transfer" approaches, as first established in neurological research. Here, serum immunoglobulin (IgM or IgG) is purified from donated blood and transferred to rodents, either systemically or intrathecally. Rodents are then assessed for the expression of phenotypes resembling the human condition; successful phenotype transfer is considered supportive of or proof for autoimmune pathology. Workshop participants discussed passive transfer models and wider evidence for autoantibody contribution to a range of SBDs. Clinical trials testing autoantibody reduction were presented. Cornerstones of both experimental approaches and clinical trial parameters in this field were distilled and presented in this article. Mounting evidence suggests that immunoglobulin transfer from patient donors often induces the respective SBD phenotype in rodents. Understanding antibody binding epitopes and downstream mechanisms will require substantial research efforts, but treatments to reduce antibody titres can already now be evaluated.

Intermediaries (not) in action: Impediments to initiating the utilization of public research

This paper addresses a critical research gap in the field of university-industry knowledge transfer, with a particular focus on the often-neglected initiation stage from a failure analysis perspective. A workshop and follow-up interviews were conducted to systematically explore the motivations and abilities of both the knowledge senders and the recipients for initiating knowledge transfer processes in the field of intelligent mobility. In contrast to conventional approaches, our study does not presuppose successful knowledge transfer initiation; instead, it offers a unique opportunity to investigate the phenomenon of its omission. The intricate interplay among actors and their differing perceptions of research applicability, which leads to specific tasks for intermediaries in initiating knowledge transfer processes, is analyzed. The findings of this study indicate that both internal and external intermediaries encounter challenges in fulfilling their roles, particularly in initiating the utilization of public research. The key challenges identified include a flawed understanding of scientific research, a lack of initiative spirit, and a disregard for actual responsibilities. This study offers valuable insights that can inform the development of evidence-based policies aimed at initiating the utilization of public research.

Cooperative Binding and Chirogenesis in an Expanded Perylene Bisimide Cyclophane.

The encapsulation of more than one guest molecule into a synthetic cavity is a highly desirable yet a highly challenging task to achieve for neutral supramolecular hosts in organic media. Herein, we report a neutral perylene bisimide cyclophane, which has a tailored chiral cavity with an interchromophoric distance of 11.2 Å, capable of binding two aromatic guests in a π-stacked fashion. Detailed host-guest binding studies with a series of aromatic guests revealed that the encapsulation of the second guest in this cyclophane is notably more favored than the first one. Accordingly, for the encapsulation of the coronene dimer, a cooperativity factor (α) as high as 485 was observed, which is remarkably high for neutral host-guest systems. Furthermore, a successful chirality transfer, from the chiral host to encapsulated coronenes, resulted in a chiral charge-transfer (CT) complex and the rare observation of circularly polarized emission originating from the CT state for a noncovalent donor-acceptor assembly in solution. The involvement of the CT state also afforded an enhancement in the luminescence dissymmetry factor (glum) value due to its relatively large magnetic transition dipole moment. The 1:2 binding pattern and chirality-transfer were unambiguously verified by single-crystal X-ray diffraction analysis of the host-guest superstructures.

Synaptic weight dynamics underlying memory consolidation: implications for learning rules, circuit organization, and circuit function.

How are memories transformed over time? We propose a simple organizing principle for how long term memories are moved from an initial to a final site of storage. We show that successful transfer occurs when the late site of memory storage is endowed with synaptic plasticity rules that stably accumulate changes in activity occurring at the early site of memory storage. We instantiate this principle in a simple computational model that is representative of brain circuits underlying a variety of behaviors. The model suggests how a neural circuit can store new memories while preserving core features of older ones, and suggests novel roles for core elements of the cerebellar circuit.

Designing a model for enhancing intention to accept renewable energy technologies in rural communities of Ilam province, Iran

Purpose The purpose of this research is to investigate factors influencing the intention of villagers to use renewable energy. In this regard, by using the modified model of planned behavior, perceived behavioral control factors, perceived usefulness, perceived ease, mental norm and attitude toward energy sources for the intention of villagers to use energy sources. Therefore, the impact of each of these five variables was investigated in the form of research hypotheses. Design/methodology/approach This research has been done using a quantitative paradigm and a descriptive-correlation method. The statistical population of the study consisted of households (384) living in rural areas of Ilam province. A multistage cluster method was used to select the sample size. The data collection tool was a researcher-made questionnaire that was developed based on the research background and research problem. Face validity of the research tool by professors of Islamic Azad University of Ilam and construct validity and reliability of research tools were confirmed by Cronbach’s alpha coefficient and composite reliability. Data were analyzed statistically using SPSS26 and SmartPLS3 software. Findings The results showed that the intention to use renewable energies (REs) among the rural peoples of Ilam province is affected by factors such as mental norms, attitude, perceived usefulness and perceived behavioral control and there is a positive and significant relationship between them. Originality/value In Iran, there is a lot of potential for usage of RE in rural communities, but compared to fossil fuels, had a small share in the current energy supply (Rezaei et al., 2022). RE technologies have not been sufficiently accepted and used by Iranian rural people (Rezaei and Ghafranfarid, 2018). Se the public acceptance of RE technologies is vital for successful process energy transfer (Huijts et al., 2012), non-acceptance of RE by society is a major obstacle to establishing RE technologies in Iran (Savari and Razmavar, 2022). It is expected that this research will fill the gap in the research literature.

NC Meets CN: Porous Photoanodes with Polymeric Carbon Nitride/ZnSe Nanocrystal Heterojunctions for Photoelectrochemical Applications.

The utilization of photoelectrochemical cells (PEC) for converting solar energy into fuels (e.g., hydrogen) is a promising method for sustainable energy generation. We demonstrate a strategy to enhance the performance of PEC devices by integrating surface-functionalized zinc selenide (ZnSe) semiconductor nanocrystals (NCs) into porous polymeric carbon nitride (CN) matrices to form a uniformly distributed blend of NCs within the CN layer via electrophoretic deposition (EPD). The achieved type II heterojunction at the CN/NC interface exhibits intimate contact between the NCs and the CN backbone since it does not contain insulating binders. This configuration promotes efficient charge separation and suppresses carrier recombination. The reported CN/NC composite structure serves as a photoanode, demonstrating a photocurrent density of 160 ± 8 μA cm-2 at 1.23 V vs a reversible hydrogen electrode (RHE), 75% higher compared with a CN-based photoelectrode, for approximately 12 h. Spectral and photoelectrochemical analyses reveal extended photoresponse, reduced charge recombination, and successful charge transfer at the formed heterojunction; these properties result in enhanced PEC oxygen production activity with a Faradaic efficiency of 87%. The methodology allows the integration of high-quality colloidal NCs within porous CN-based photoelectrodes and provides numerous knobs for tuning the functionality of the composite systems, thus showing promise for achieving enhanced solar fuel production using PEC.

Preparation of brittle ITO microstructures using Laser-Induced forward transfer technology

The performance of transparent conductive microstructures plays a significant role in determining the device efficiency. The fabrication of ITO microstructures on the flexible optoelectronic devices remains challenging because of the high-temperature processing requirements and brittleness of the ceramic material. This paper highlights a three-dimensional microfabrication technique that combines sacrificial layer etching and laser-induced transfer. By studying the donor material thickness and the laser energy density, control of the sacrificial layer transfer thrust was achieved to yield an optimal microstructure performance. Different shapes of ITO transparent conductive microstructures were fabricated on polydimethylsiloxane (PDMS) surfaces, demonstrating structural integrity, visible light transmittances > 90 %, and resistivities of ≤ 8 × 10−4 Ω·cm. Finite element analysis was employed to simulate the impact transfer of the donor material onto the receiving substrate, thereby elucidating the energy-absorbing protective role of the flexible PDMS layer. Effective control of the transfer force was identified as a crucial factor in achieving the successful transfer of brittle films. This high-precision and rapid array processing approach meets the demands of automated batch manufacturing, indicating its potential for use in patterned processing on flexible substrates, as an alternative to lithographic techniques. This technique could be applied in the preparation of electronic skins and flexible devices. Additionally, for the first time, a 3 × 3 pixel resistive array sensor was integrated on a Ag nanowires/PDMS surface, demonstrating array pressure-sensing capabilities at pressures of 0–80 kPa. This study represents a significant step towards the development of multifunctional flexible optoelectronic devices.

Photoacoustic Imaging Using Polysaccharide-Porphyrin Complexes by Photoirradiation at Long Wavelengths.

Photoacoustic (PA) imaging is a novel biological imaging technique with superior depth resolution compared to fluorescence imaging. The efficacy of PA imaging depends on contrast agents that possess considerable absorbance at longer wavelengths, coupled with high permeability in biological tissue and minimal fluorescence, achieved through mitigating aggregation-caused quenching (ACQ) that attenuates PA intensity. Despite the successful transfer of porphyrin 2 featuring amino moieties from polysaccharides to liposomes, most of 2 incorporated within λ-carrageenan (CGN-2 complex) remained in CGN under acidic lysosomal conditions (pH 5.0). Consequently, the CGN-2 complex exhibited a strong PA signal under 680 nm photoirradiation in Colon26 cells owing to the ACQ of 2. Moreover, the PA intensity of the CGN-2 complex was further enhanced under 780 nm photoirradiation owing to the increased absorbance at 780 nm facilitated by the redshift of the Q-band at pH 5.0.

P-402 Comparison of uterine contractions in artificial hormone treatment versus aromatase inhibitor stimulated frozen embryo transfer cycles

Abstract Study question does uterine contractions differ between aromatase inhibitor stimulated (AIS) or artificial hormone treatment (AHT) Frozen Embryo transfer (FET) cycles Summary answer uterine contraction activity did not show any difference between artificial hormone treatment and aromatase inhibitor stimulated FET cycles What is known already FET cycles are prepared by different protocols. aromatase inhibitor stimulated (AIS) or artificial hormone treatment (AHT) protocols are two common protocols among others. These protocols have different cycle dynamics and might differ in pregnancy rates and different effects on perinatal outcomes. Although embryo related factors are most important for implantation endometrial receptivity and therefore uterine contractions might have a role in implantation. English literature provides scarce data on uterine contractions and pregnancy outcomes. Presence of prominent contractions were related to poor pregnancy outcomes in some studies whereas other few studies failed to show any effect in this sense Study design, size, duration this study is an observational cohort study of successive frozen embryo transfer (FET) cycles of eligible patients between 1st of july 2023 to 31th of October 2023 in a tertiary university hospital in vitro fertilization clinic with ultrasonographic video recordings at transfer day. During study period of four months, 147 out of 265 consecutive FET cycles were included in this study and study is approved by local ethical committee of the affiliated university (KA23/388). Participants/materials, setting, methods Total study group was composed of 99 artificial hormone treatment cycles and 48 aromatase inhibitor stimulated FET cycles after exclusion of patients with uterine congenital malformations, uterine fibroids,adenomyosis patients and patient with previous uterine surgery. Implantation rates, pregnancy rates and clinical pregnancy rates were recorded. Transvaginal ultrasonographic sagittal uterine video image recordings were obtained at transfer day one hour before embryo transfer. Recordings were reviewed by two researchers and uterine contractions were documented by agreement. Main results and the role of chance This is the first study comparing different FET cycles and uterine contraction activities. Patient characteristics were similar between two groups. Artificial hormone treatment and aromatase inhibitor stimulated cycle groups showed similar endometrial thicknesses (11.47±1.92 and 11.24±1.02, respectively p = 0.42) and top quality embryo transfer rates (22.6 % and 26.8% p = 0.82). Although AIH group showed a statistically insignificant advantage, clinical and ongoing pregnancy rates were similar between protocols (supplementary data). Uterine peristaltic activity was not statistically different between aromataze inhibitor stimulated and artificial hormone treatment FET cycle (1.54±1.75 versus 1.63±2.15 p = 0.81 recpectively). Furthermore uterine persistalsizm were similar in pregnant and non-pregnant patients /1.52±2.07 vs 1.72±1.93 p = 0.57). However as far as Aromatase inhibitor stimulated FET cycles were considered; pregnant patients had less uterine peristaltic activity when compared ton non-pregnant patient (45.7% and 15.4%, respectively p = 0.054 ) although this difference was at the border of statistical significance. Limitations, reasons for caution This is an observational study of relatively short duration with limited number of patients. Our study in AIS cycles have a tendency to fewer contractions in cycles ended up in pregnancy. Larger series of FET cycles might prove differences in uterine contraction frequencies and pregnancy outcomes in AIS FET cycles. Wider implications of the findings Our study supported new information on uterine contractility in different FET cycles protocols. Further large scale studies might provide new insights to uterine factor and its role in implantation as far as uterine contraactions are concerned. Trial registration number (KA23/388) local ethic committee approval

Investigating Patterns of Donor and Recipient Sports of Talent Transfer Paralympians.

Talent transfer has enabled elite athletes to be successful in another sport, with great potential in para-sport. Previous research suggests that similarities between donor and recipient sports may facilitate talent transfer; however, this remains unclear in para-sport. This study investigated patterns between donor and recipient sports' characteristics, identifying the impact on talent transfer in para-sport. An Australian case study utilizing secondary data of 38 Australian Paralympians who competed at the Paralympic Games from 2000 through 2020 was analyzed. Results demonstrated that similarities between sports were not significantly associated with successful talent transfers between Paralympic sports. Understanding patterns associated with successful Paralympic talent transfers offers a foundation of knowledge for designing and developing future talent-transfer pathways and research. Based on this study, it is recommended that sport administrators and practitioners explore greater opportunity for talent transfer in para-sport, rather than limiting talent-transfer opportunities based on athletes' donor sports.