Our dear friend and colleague professor Anca Catrina passed away February 8, 2021 due to cancer. Anca Catrina was one of those scientists who made life and science more interesting and challenging for all who had the fortune to meet her. Anca was born in Bucharest, Romania. After medical studies at the University of Bucharest, beginning her practical training as physician, she soon became fascinated by the complexity and the unresolved questions in the field of rheumatology. In order to address both patients’ needs and to begin her scientific career, she shared her time between rheumatology specialist training in Bucharest and research training at Karolinska Institutet, Stockholm, Sweden, where she produced an outstanding thesis on rheumatoid arthritis (RA) in 2004. Soon thereafter, still in Stockholm, she established herself as a group leader in rheumatology research and as a clinician and developed a research line devoted to the understanding of the origins and effects of immunity associated with rheumatic diseases, in particular RA. Based on her conviction that effective therapy is good, but prevention better, she entered into a long and successful research program exploring the basis for the triggering of autoimmunity in RA. She performed pioneering work that increased our understanding of how external agents affecting the lungs may trigger immunity against post-translationally modified, in particular citrullinated antigens. Thus, together with several of her students, clinicians and basic scientists, she showed how citrullination [1], as well as antibody production against citrullinated antigens, may be increased in the lungs of patients with early RA [2, 3]. She also initiated a very promising research line exploring how immunity triggered in lungs may subsequently target cells in the joint giving rise to symptoms seen also in patients with emerging RA [4, 5]. In parallel with this basic work, she organised clinical studies with cohorts of patients at risk for RA to understand disease development [6], but also to use results from the basic studies for clinical trials testing preventive strategies for RA. It must also be emphasized how Anca's charisma and engagement in her fellow scientists as well as her patients made all who met her a bit more happy, a bit more energetic. She had that ability to see and respect everyone, irrespective of background and status. In the midst of all this work, after being appointed professor and head of academic rheumatology at Karolinska, and after having received much international praise and funding, for example a recent ERC grant and the position as an Executive Committee member of the European Journal of Immunology, she was struck by her disease. Typically for Anca, her passion for science and her support to students and to her many national and international collaborators, she remained active in science until the month before her death. The research group and larger scientific environment that she formed is now continuing the work that Anca was only able to start, but her visions of the power of science in improving health and enhancing international collaboration continues to inspire us and many of her friends and colleagues over the world.
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