Purpose: Postsurgical esophageal leaks carry significant morbidity and mortality. Endoscopic closure is emerging as a noninvasive treatment option and can be achieved with stenting or full-thickness clipping. We report three cases of successful endoscopic closure of esophageal leaks: two with stenting and one with over-the-scope clip. In the first case, a 63-year-old male developed a leak after surgical repair of Boerhaave syndrome. The second case was a 44-year-old female with a leak after intra-operative repair of esophageal perforation during sleeve gastrectomy. In both cases, a 23 x 105 mm partially covered self-expandable metal stent (PCSEMS; Wallflex, Boston Scientific, Natick, MA) was placed, with leak closure confirmed on fluoroscopy. PCSEMS was chosen to decrease stent migration risk and assure a complete seal. Tissue in-growth into the stent's uncovered ends was seen on repeat endoscopy 3-4 weeks later. A 23 x 105 mm fully covered self-expandable metal stent (FCSEMS; Wallflex, Boston Scientific, Natick, MA) was then deployed within the PCSEMS resulting in necrosis of the tissue ingrowth, and both stents were removed 2-3 weeks later without difficulty. Contrast injection showed leak closure, and the patients remained asymptomatic, tolerating a diet. In the third case, a 38-yearold female with persistent leak after sleeve gastrectomy failed FCSEMS. The leak was closed with one over-the-scope clip (Ovesco Endoscopy, Tübingen, Germany). The patient remained asymptomatic, and the clip was not seen on endoscopy 6 months later. Our experience highlights the potential for endoscopic closure of esophageal leaks with combination of partially and fully covered metal stents, or with full-thickness clips.Figure: Stent-in-stent.Figure: Over-the-scope clip.