Lipid abnormalities underlie the progression of atherosclerosis. The negative impact of abnormal lipid profile (LP) on cardiovascular diseases and peripheral vascular disease is well known. However, the impact of abnormal LP on wound healing in revascularized critical limb ischemia patients is not well studied. The objective of this study was to study the effect of abnormal LP on wound healing in critical limb ischemia patients with successful infrapopliteal angioplasty in a tertiary center. In this single-center retrospective study, 231 patients who underwent successful infrapopliteal angioplasty with inflow correction for critical limb ischemia from March 2015 to March 2018 were studied. Patients with high total cholesterol (TC), triglyceride (TG), or low-density lipoprotein (LDL) levels or with low high-density lipoprotein (HDL) level were included in the abnormal LP group (n = 179). Patients with abnormal LP (n = 52) were compared with those with normal LP in respect to wound healing at the end of 6 months. Patients with a hybrid procedure or prior endovascular intervention were excluded from analysis. Among 231 patients, 179 patients were in the abnormal LP group and 52 were in the normal LP group. Both groups were comparable in age, sex, and comorbidities. Wound healing rate was better in patients with normal LP vs abnormal LP (75% vs 68.2%), low/normal LDL level vs high LDL level (69.8% vs 69.2%), normal/high HDL level vs low HDL level (76.5% vs 66%), high TC level vs normal TC level (72.7% vs 69%), and high TG level vs normal TG level (70.5% vs 69.8%), but this observed difference was not statistically significant. This study highlights that wound healing in critical limb ischemia patients with successful infrapopliteal angioplasty is not significantly affected by abnormal LP.