Successful Management Research Articles

Managing Classroom Using Real-life Experience: The concept of Freedom in Learning Implementation

Teaching-learning activities involve various elements, such as classroom management. Learning approach is a way for teachers to manage the class because it assists them in learning activity. This study was qualitative study using data obtained from documentation and observation. Score average and percentage were employed as research technique to determine the correlation between learning approach in classroom management and learning success. This study aims to find out how real-life experience can be used as learning approach in managing art class. Accordingly, the results indicated that implementing a real-life experience-based approach in managing art classes showed a positive but insignificant effect. It seen from good category (an average of 3.00-3.75) and midterm scores that show 52.9% scored higher than 65 (passing mark), while 47.1% scored less than 65. It indicates although the approach had positive influence, it was not significant in improving students’ results.

Examining the bonus mechanisms’ role in real earnings management dynamics in an Indonesian manufacturing company

Real Earnings Management (REM) and financial success may have different relationships depending on how managers act. Bonus mechanisms are a significant factor that influences management behavior. The study seeks to examine the impact of bonus systems on the correlation between financial performance and REM practices in manufacturing companies in Indonesia. Moderated Regression Analysis (MRA) is employed to evaluate the influence of bonus mechanisms in moderating the association of financial performance on REM. The technique of purposive sampling was used to pick the sample. The study utilized data from manufacturing firms listed on the Indonesian Stock Exchange from 2017 to 2021, including a total of 400 observed data points. The research findings demonstrate that sales growth is the sole factor that significantly influences REM in manufacturing organizations, as indicated by a p-value below 10%. Other financial performance factors, on the other hand, with p-values for each variable above 10%, have not been shown to have a significant impact on REM. These factors include ROA, leverage, operating cash flow, and cash. The findings also demonstrate that, with a p-value for each variable above 10%, the bonus mechanism is a variable that modifies the effect of all financial performance variables on REM.

Analysis of Factors Influencing Community Participation in Sustainable Forest Management in BKPH Mojorayung, Madiun

The success of sustainable forest management is inseparable from community participation as the leading actor in the Social Forestry Program. Various factors, including internal factors from the community and external factors, affect the participation of the community. Factors impacting community participation in sustainable forest management were analyzed in this study. The study was conducted at BKPH Mojorayung, KPH Madiun, East Java Regional Division Perum Perhutani, from April to June 2022, using a survey method with 242 randomly selected respondents. Partial Least Squares (PLS) analysis was conducted with the SmartPLS software. Based on the results, it was found that three factors impact the community's participation in forest management: the empowerment process accuracy, the role of community empowerment workers, and the support of group leaders. The characteristics of the communities around the forest did not affect community participation in forest management. Community participation also affects the sustainability of forests.

Abstract 5448: Malignant RNA editing by inflammation-responsive RNA editase ADAR1 drives T-cell leukemia relapse via attenuating dsRNA sensing

Abstract Leukemia-initiating cells (LICs) play a crucial role in leukemia research and treatment, being considered the source of relapse and resistance, posing a substantial challenge for successful management of the disease. It's crucial to identify the key factors that drive LIC self-renewal to develop targeted methods for eliminating LICs and preventing relapse. In this study, we demonstrate that the RNA editing enzyme ADAR1 plays a vital role as a determinant of stemness, promoting LIC self-renewal by reducing the detection of abnormal double-stranded RNA (dsRNA). As a result, ADAR1-knockdown significantly impairs the ability of LICs to self-renew and extends survival in T-ALL PDX models. We performed RNA-seq studies on enriched T-ALL LICs (CD34+Lin-). The lentivirus-to-cell ratio was optimized to achieve a 50% reduction in ADAR1, resulting in differential expression of 661 genes, with downregulation of critical self-renewal genes in ADAR1-deficient leukemia-initiating cells. Importantly, additional data indicated that ADAR1 likely influences self-renewal gene expression independently of A-to-I RNA editing, revealing novel regulatory mechanisms in leukemia. Knockdown of MDA5 and ADAR1 in patient-derived xenograft (PDX) T-ALL leukemia-initiating cells (LICs) revealed diverse rescue effects on self-renewal in different PDX models. The differential response was associated with variations in gene expression patterns in Rig-I-Like signaling and cytosolic sensing pathways, suggesting intrinsic differences in IFN signaling properties among patients. Moreover, the study proposes a patient-specific reliance on the ADAR1 p150-MDA5 axis for promoting self-renewal, as evidenced by differential rescue effects and varying expression levels of ADAR1 isoforms and MDA5 in T-ALL patient samples and cell lines. ADAR1, beyond its role in RNA editing, acts as a dsRNA binding protein, exerting RNA editing-independent functions to suppress aberrant IFN signaling and promote cancer progression. Using Jurkat cells with high intrinsic MDA5 levels, an ADAR1 knockout (KO) was generated, revealing that ADAR1 is upregulated by IFN treatment, predominantly the p150 isoform. We explored the dual roles of ADAR1—RNA editing-dependent and -independent—in suppressing IFN-induced apoptosis, demonstrating the necessity of both for optimal function. Additionally, ADAR1 was found to suppress cytoplasmic dsRNA sensing pathways, such as RIG-I and PKR, and its RNA editing-independent activity contributes significantly to the suppression of interferon-stimulated gene (ISG) expression in T-ALL. In summary, our findings reveal that ADAR1 acts as a factor that promotes self-renewal while limiting the recognition of naturally occurring dsRNA. Therefore, targeting ADAR1 emerges as a safe and effective therapeutic approach for eradicating LICs in T-ALL. Citation Format: Maria Dolores Rivera, Haoran Zhang, Qingchen Zhou, Jessica Pham, Jane Isquith, Roman Sasik, Adam Mark, Sabina Enlund, Frida Holm, Ma Wenxue, Kathleen Fisch, Dennis Kuo, Catriona Jamieson, Qingfei Jiang. Malignant RNA editing by inflammation-responsive RNA editase ADAR1 drives T-cell leukemia relapse via attenuating dsRNA sensing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5448.

Evaluation of management of CT scan proved solid organ injury in blunt injury abdomen-a prospective study.

Trauma especially road traffic injury is one of the major health-related issues throughout the world, especially in developing countries like India (Mattox 2022). Solid organ injury is the most common cause of morbidity and mortality in patients with blunt abdominal trauma. The non-operative management (NOM) is being consistently followed for hemodynamically stable patients with respect to solid organ injuries. This study aims to provide an evidence base for management modalities of solid organ injuries in blunt abdominal trauma. The aim of this study is to evaluate the effectiveness of various treatment modalities for solid organ injury in blunt abdominal trauma. Evaluating the characteristics of blunt abdominal injury with respect to age and gender; distribution, mode of injury, most common organ injured, and severity of injury; effect of delay in getting treatment on the management outcome for patients with solid organ injury; evaluating the various modalities of treatment of CT-proven solid organ injury; incidence of complications in different modes of treatment. All patients aged more than 18years and suffering from CT-proven solid organ injury secondary to blunt abdominal trauma between February 2021 and September 2022 were included in this prospective observational study. Sixty-five patients were enrolled in the study after meeting the inclusion criteria. Details such as age, gender, mechanism of injury, the time between injury to first hospital contact, presenting complaints, organ and grade of injury, Revised Trauma Score (RTS), Trauma Score and Injury Severity Score (TRISS), management, and outcomes were collected using self-designed pro forma and analyzed. Different modalities of treatment were evaluated and patients undergoing operative and non-operative management were compared. Patients in whom non-operative management failed were compared with patients with successful non-operative management. The mean age of patients involved were 36.8years with a male:female ratio of 7.125:1 and the most common age group affected being between 21 and 30years. The most common mode of injury was noted to be road traffic accidents (72.3%). The most common presenting complaints were abdominal pain (64.6%) followed by chest pain (29.2%) and vomiting (13.8%). There was no significant relationship between latent period and type of intervention or failure of non-operative management. FAST positivity rate was noted to be 92.3%. Chronic alcoholism and bronchial asthma were significant predictors for patients undergoing upfront surgery (p = 0.003 and 0.006 respectively). The presence of pelvic and spine injury was statistically significant for predicting mortality in polytrauma patients (p = 0.003). Concurrent adrenal injury was found in 24.6% of patients but was not related to failure of non-operative management or mortality. RTS significantly predicts the multitude of organ involvement (p = 0.015). The liver was the most common organ injured (60%) followed by the spleen (52.3%) and the kidney (20%). The liver and the spleen (9.2%) were noted to be the most common organ combination involved. No specific organ or organ injury combination was noted to predict failure of non-operative management or mortality. But the multitude of organ involvement was statistically significant for predicting patients undergoing upfront surgery (p = 0.011). Out of 65 patients enrolled in the study, 7 patients (10.8%) underwent immediate surgery, and 58 patients (89.2%) underwent non-operative management. Among the 68 chosen for non-operative management, 6 patients (9.2%) failed non-operative management and 52 patients (80%) had success of non-operative management. A significant drop in hemoglobin (83.3%) on day 1 (66.6%) was seen to be the commonest reason for failure of non-operative management. The spleen was noted to be the most commonly involved organ intra-operatively (61.5%) followed by the liver (30.8%). Concordance between pre-operative and intra-operative grading of organ injuries was highest for liver and kidney injuries (100%) and lowest for pancreatic injuries (0%). Requirement of blood transfusion and liver injuries were significant factors for failure of non-operative management (p = 0.012 and 0.045 respectively). The presence of pancreatic leak was significant between the non-operated patients and patients operated upfront (p = 0.003). Mortality was noted to be 10.8% (7 patients) in our study. Solid organ injury in blunt abdominal trauma is an important cause of morbidity and mortality. RTS was noted to be a good predictor for solid organ injury in blunt abdominal trauma. Pancreatic injuries are notorious for being under-staged on CT findings; hence, the need arises for multimodality imaging for suspected pancreatic injuries. Non-operative management is a successful modality of treatment for majority of patients suffering from multiple solid organ injuries in blunt abdominal trauma provided serial close monitoring of patient's clinical signs and hemoglobin is instituted along with the presence of an emergency surgery team.

Analysis of Participatory Approaches of Community-Based Sustainable Marine Protected Area Management Groups

This study was conducted to see the role of community participation in the management of community-based marine protected areas. In addition, this study also shows the impact of conservation area management on improving community welfare and improving the quality of the environment. The research design used is a mixed method which is a combination of qualitative and quantitative analysis. Qualitative analysis uses in-depth interview methods with resource persons, while quantitative analysis uses the one-sample test method to test respondents' perceptions related to research variables. The research sample consisted of the Head of the Management Group, Village Head, Traditional Head, Religious Leaders, and Community Member Representatives in Roon District, Teluk Wondama Regency, West Papua, Indonesia. Research findings show that the role of the community in the management of conservation areas is very high, this can be seen from the supervisors of conservation area management groups consisting of Government, Religious, and Social groups. In addition, active participation from the community around the conservation area is also the key to the success of good area management. The findings of one sample test showed, that 1) The participation of members of the Marine Protected Area group has been classified as high, 2) Sasi culture has been proven to affect the income level of the community, 3) Member participation has been proven to be active in decision making, 4) The existence of Sasi has been proven to increase the sustainability of natural resources, 5) Proven to successfully contribute to the achievement of SDG number 14.

Successful demand management in diagnostic immunology testing

AimsWe investigated whether we could have a material and sustained impact on immunology test ordering by primary care clinicians by building evidence-based and explanatory algorithms into test ordering software.MethodsA service...

Successful management of an advanced interstitial ectopic pregnancy in a resource-limited setting: a case report

BackgroundInterstitial ectopic pregnancy is an ectopic gestation developing in the uterine part of the fallopian tube. The condition is rare and presents challenges for clinical as well as radiological diagnosis. This case report presents a rare case of interstitial ectopic pregnancy diagnosed intraoperatively.Case presentationA 36-year-old Black woman, referred from a peripheral health facility, presented at the emergency department with severe abdominal pains, vaginal spotting, nausea, and vomiting, with a 2-month history of irregular menstrual flow. Clinical and laboratory findings were suggestive of an acute abdomen likely due to a ruptured ectopic pregnancy (ultrasound was not available). An emergency exploratory laparotomy was done, which revealed a right adnexal ruptured interstitial pregnancy of a lifeless female fetus weighing 500 g (estimated mean gestational age of 22–23 weeks). The left fallopian tube looked normal. The site of rupture was repaired, followed by cleaning and closure of the abdomen. The post-operative period was uneventful, and the patient was discharged on postoperative day 7.ConclusionInterstitial pregnancies are uncommon and rarely attain advanced gestational ages, as in this case, compared with other tubal ectopic pregnancies. However, women presenting with signs of hypovolemic shock and acute abdomen, with a positive pregnancy test, warrant a high index of suspicion.

Implementation of Islamic Boarding School Cooperative Management in Forming the Entrepreneurial Spirit of Santri

Islamic boarding schools have various functional units, apart from the existing Islamic boarding school education, there are business units called cooperation. The success of management in cooperation cannot be separated from the skills of the management elements in managing the cooperation. One aspect that needs to be considered is the formation of the entrepreneurial spirit of the students. This research aims to find out how the management of the Ainul Hasan Islamic boarding school cooperation (Koperasi Pondok Pesantren/Kopontren) is implemented, and to find out the role of the Ainul Hasan Islamic boarding school Cooperation (Kopontren) in forming the entrepreneurial spirit of students. The research method used is a qualitative method with a case study approach. Data were collected through interviews, observation and documentation with Islamic boarding school caregivers, Kopontren administrators, alumni and several students of the Ainul Hasan Islamic boarding school. The research results showed that the management of the Ainul Hasan Islamic boarding school cooperation (Kopontren) is quite good in implementing its management system because it is seen from the management function which really supports management activities so that the desired goals can be achieved well. The implementation of Ainul Hasan's Islamic boarding school cooperation management (Kopontren) in forming the entrepreneurial spirit of students is by holding entrepreneurship training for students to make brooches from flannel which is held once a week. By implementing good Islamic boarding school cooperation management and entrepreneurship training, students can form the entrepreneurial spirit and help students become successful entrepreneurs in the future.

What Is Allopurinol Failure and What Should We Do About It?

Allopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout management.

Implications of the scale of detection for inferring co-occurrence patterns from paired camera traps and acoustic recorders.

Multifunctional landscapes that support economic activities and conservation of biological diversity (e.g., cattle ranches with native forest) are becoming increasingly important because small remnants of native forest may comprise the only habitat left for some wildlife species. Understanding the co-occurrence between wildlife and disturbance factors, such as poaching activity and domesticated ungulates, is key to successful management of multifunctional landscapes. Tools to measure co-occurrence between wildlife and disturbance factors include camera traps and autonomous acoustic recording units. We paired 52 camera-trap stations with acoustic recorders to investigate the association between 2 measures of disturbance (poaching and cattle) and wild ungulates present in multifunctional landscapes of the Colombian Orinoquía. We used joint species distribution models to investigate species-habitat associations and species-disturbance correlations. One model was fitted using camera-trap data to detect wild ungulates and disturbance factors, and a second model was fitted after replacing camera-trap detections of disturbance factors with their corresponding acoustic detections. The direction, significance, and precision of the effect of covariates depended on the sampling method used for disturbance factors. Acoustic monitoring typically resulted in more precise estimates of the effects of covariates and of species-disturbance correlations. Association patterns between wildlife and disturbance factors were found only when disturbance was detected by acoustic recorders. Camera traps allowed us to detect nonvocalizing species, whereas audio recording devices increased detection of disturbance factors leading to more precise estimates of co-occurrence patterns. The collared peccary (Pecari tajacu), lowland tapir (Tapirus terrestris), and white-tailed deer (Odocoileus virginianus) co-occurred with disturbance factors and are conservation priorities due to the greater risk of poaching or disease transmission from cattle.

Exploring the both-and success paradox in mega construction projects: multi-dimensional assessments of paradoxical leadership, project agility and megaproject success

PurposeOrganizations are full of contradictions and leadership dilemmas. Managers often face challenges such as selecting between two contradicting options such that which one is more important can hardly be judged. To manage contradicting dynamics, today’s managers can adopt the paradoxical leadership approach. We build a theoretical model to investigate the influence of paradoxical leadership on multi-dimensional project agility (proactivity, adaptability, and resilience), and multi-dimensional project success (management, investment, and ownership success).Design/methodology/approachDrawing on survey-based data from the China–Pakistan Economic Corridor (CPEC) megaproject (N = 209), we performed covariance-based structural equation modeling to test the conceptual model.FindingsThe findings show that (1) paradoxical leadership has a significant positive impact on megaproject success, (2) paradoxical leadership has a significant positive influence on project agility, (3) project agility has a significant positive effect on megaproject success, and (4) project agility has a significant effect that mediates the link between paradoxical leadership and megaproject success. This research provides a theoretical and practical comprehension of paradoxical leadership with a new perspective on megaprojects.Originality/valueThis study provides an extension of the existing studies on paradoxical leadership and identifies the role of contradicting dynamics and their impact on multiple facets of megaproject success. It not only clarifies the relationship between paradoxical leadership and megaproject success, but also identifies the mediating role of project agility that can play an effective role in mobilizing success in megaprojects.

Ureteral wall thickness as a predictor for non-invasive treatment success for steinstrasse. Can we save time?

PurposeWe aimed to define factors affecting the non-invasive overall treatment success (medical expulsive therapy (MET) ± shock wave lithotripsy (SWL)) for uncomplicated ureteral steinstrasse (SS) clearance.MethodsWe retrospectively evaluated consecutive patients who underwent SWL for renal stones between 2017 and 2021. Patients with uncomplicated SS were included. All patient’s demographic and radiological data, e.g., age, gender, pre-SWL stenting, SS site, type, leading stone size in widest diameter (< 10 mm and ≥ 10 mm), ureteral wall thickness (UWT) in mm against the leading stone were collected. If SS was diagnosed, medical treatment was given for 4 weeks. In case of MET failure, either SWL for the leading stones + MET or direct URS was done. Non-invasive treatment success (SFR) was considered if complete clearance of SS occurred with no complications or the need for invasive intervention.ResultsA total of 145 patients were included with mean age of 45.9 ± 12.4 years. SFR in case of MET only occurred in 27.9%. Complications happened in 26 patients (17.9%). Non-invasive treatment SFR was achieved in 78 patients (53.8%) totally where SS type I, leading stone size ≤ 10 mm type and decreased UWT around the leading stone increased treatment success.ConclusionUreteral wall thickness is an important factor predicting SS management success. Besides the decreased UWT, non-invasive management should be offered for type I SS with leading stone ≤ 10 mm.

'We no longer experience the same pain': a cross-sectional study assessing the impact of Heart and Sole Africa's podoconiosis prevention education program.

Podoconiosis is a non-infectious neglected tropical disease caused by long-term exposure to irritant volcanic soils. It results in severe physical, psychological and financial consequences. Heart and Sole Africa (HASA) is a non-governmental, community-based organization providing management to podoconiosis patients in Rwanda. We sought to analyze the impact of their program on the lives of patients. Quantitative surveys recorded the participants' demographics, adherence to HASA's management recommendations and changes in quality of life (QOL). Qualitative questions were used to gather respondent perspectives on HASA programming. We interviewed 127 patients from HASA's Musanze (n=47) and Burera (n=80) clinics. Almost all participants (98.4%) reported statistically significant (p<0.01) improvements in their QOL, and more than one-half (51.2%) had a favorable adherence score of >80%. Qualitative feedback identified specific challenges to adherence and recognition of program success in symptom management. Our study demonstrated the value of community-based podoconiosis programming in improving the lives of patients. Practices such as regular feet washing, emollient application, shoe wearing and limb raising can result in a marked reduction of morbidity. Our findings support the argument for scaling up these management practices across Rwanda.

Unravelling the nexus: exploring the dynamics of knowledge hoarding, and project success in the IT sector

ABSTRACT This study examines the complicated links between knowledge hoarding, knowledge management, knowledge worker productivity, and project success. It aims to investigate the detrimental effects of knowledge hoarding on knowledge management, as well as the correlation between the knowledge management process and project success as measured through knowledge worker productivity. Knowledge hoarding is described in this study through the lens of cognitive motivational relational theory, and as a knowledge management barrier is explained through the lens of the knowledge-based perspective of the firm. Questionnaires are utilised to survey 405 Pakistani IT personnel via convenience sampling. For the analysis of data, Smart PLS-4 is employed, and Structured Equation Modelling is conducted. It is evident that knowledge hoarding does not affect IT firm knowledge management and project success. Productivity partially mediates the relationship between knowledge management process and project success. Finally, theoretical contributions and practical implications are discussed besides future research directions.

Assessing risk of recurrent small bowel obstruction after non-operative management in patients with history of intra-abdominal surgery: a population-based comprehensive analysis in Taiwan.

Despite a significant 30% ten-year readmission rate for SBO patients, investigations into recurrent risk factors after non-operative management are scarce. The study aims to generate a risk factor scoring system, the 'Small Bowel Obstruction Recurrence Score' (SBORS), predicting 6-month recurrence of small bowel obstruction (SBO) after successful non-surgical management in patients who have history of intra-abdominal surgery. We analyzed data from patients aged ≥ 18 with a history of intra-abdominal surgery and diagnosed with SBO (ICD-9 code: 560, 568) and were successful treated non-surgically between 2004 and 2008. Participants were divided into model-derivation (80%) and validation (20%) group. We analyzed 23,901 patients and developed the SBORS based on factors including the length of hospital stay > 4 days, previous operations > once, hemiplegia, extra-abdominal and intra-abdominal malignancy, esophagogastric surgery and intestino-colonic surgery. Scores > 2 indicated higher rates and risks of recurrence within 6 months (12.96% vs. 7.27%, OR 1.898, p < 0.001 in model-derivation group, 12.60% vs. 7.05%, OR 1.901, p < 0.001 in validation group) with a significantly increased risk of mortality and operative events for recurrent episodes. The SBORS model demonstrated good calibration and acceptable discrimination, with an area under curve values of 0.607 and 0.599 for the score generation and validation group, respectively. We established the effective 'SBORS' to predict 6-month SBO recurrence risk in patients who have history of intra-abdominal surgery and have been successfully managed non-surgically for the initial obstruction event. Those with scores > 2 face higher recurrence rates and operative risks after successful non-surgical management.

How to measure employees’ interests so as to be a more socially-responsible employer: A proposal of a new scale and its validation

Research background: Many authors emphasize that successful human resource management (HRM) practices align with employees’ needs associated with the construct of employees’ interests. In particular, the importance of considering employees’ interests is emphasized in the process of shaping the architecture of Socially Responsible Human Resource Management (SR-HRM) systems. Purpose of the article: The aim of the article is to contribute to understanding employees’ interests by designing and validating a measure to recognize these interests. Methods: Through the use of literature sources and expert opinions, the authors developed a list of employee interests. Empirical data collected via the survey method in Poland was used to statistically verify the measurement scale. In particular, exploratory factor analysis and exploratory structural equation modelling were applied. Findings &amp; value added: This article shows that it is important to create a comprehensive list of interests, as well as validate the research tool used. The newly developed scale has 22 items and five dimensions: support and development at the level of the enterprise, employee participation, support and development at the departmental level, employment security, working conditions and remuneration. It may be used in a variety of companies, as well as in complex research models, and developed further taking into consideration the context of other countries.

Successful management of massive digoxin overdose using DIGIFab and therapeutic plasma exchange: a case report

BackgroundDespite the efficacy and safety of DIGIFab, it is relatively expensive and has limited availability. In addition, alternative interventions, such as therapeutic plasma exchange, may need to be considered in massive digoxin overdoses. Although few case reports describe its efficacy.Case presentationWe report a case of a 17-year-old white male patient brought by family members to our emergency department in Riyadh, Saudi Arabia. After intentionally ingesting 48 mg of digoxin tablets to commit suicide, the patient’s initial digoxin serum level was 8.04 ng/mL. The patient was resuscitated in the emergency department. After admission to the intensive care unit, the patient underwent therapeutic plasma exchange, because of insufficient DIGIFab doses. Afterward, the serum digoxin levels drastically decreased, and his symptoms reverted. The patient was successfully managed and discharged 7 days after admission.ConclusionDespite insufficient evidence and a limited number of case reports describing the use of extracorporeal treatment in digoxin overdose, we noted the significant impact of therapeutic plasma exchange on our patient. However, therapeutic plasma exchange’s use in routine treatment requires stronger evidence to confirm its benefits.

Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management.

Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating side effect of antiresorptive and antiangiogenic agents that can lead to progressive bone destruction in the maxillofacial region. Dental surgery, including tooth extractions, commonly trigger the onset of MRONJ. While guidelines suggest avoiding extraction when possible, complete avoidance is not always feasible, as necrosis can develop from dental and periodontal disease without dental procedures. The goal of this article is to provide an update review of current preventive and therapeutic approaches for MRONJ. A comprehensive electronic search was conducted on PubMed/MEDLINE, Embase, and Scopus databases. All English articles encompassing randomized controlled trials, systematic reviews, observational studies, and case studies were reviewed. The current medical treatments and adjuvant therapies for managing MRONJ patients were critically assessed and summarized. Pentoxifylline and alpha tocopherol (PENT-E), teriparatide, photobiomodulation (PBM), photodynamic therapy (PDT), and the use of growth factors have shown to enhance healing in MRONJ patients. Implementing these methods alone or in conjunction with surgical treatment has been linked to reduced discomfort and improved wound healing and increased new bone formation. While several adjuvant treatment modalities exhibit promising results in facilitating the healing process, current clinical practice guidelines predominantly recommend antibiotic therapy as a non-surgical approach, primarily addressing secondary infections in necrotic areas. However, this mainly addresses the potential infectious complication of MRONJ. Medical approaches including PENT-E, teriparatide, PBM, and PDT can result in successful management and should be considered prior to taking a surgical approach. Combined medical management for both preventing and managing MRONJ holds potential for achieving optimal clinical outcomes and avoiding surgical intervention, requiring further validation through larger studies and controlled trials.

The Importance of Effective Management in Driving Economic Growth in Developing Countries

This article discusses the crucial role of effective management in spurring economic growth in developing countries. Good management is the basis for designing, implementing and optimizing economic policies that support the development of key sectors, factors such as operationally efficient human resource management, innovation and stability. proven to be a key driver in achieving sustainable growth through case study analysis and literature review. This article outlines the positive impact of effective management on company productivity and national economic growth. A comparison of successful management practices with less successful cases provides insight into the strategic importance of directed management and adaptive in facing economic challenges. Apart from that, this article highlights the importance of building managerial capacity through education and training. Improving material skills at various levels of the organization can strengthen economic foundations and open up new opportunities for innovation and investment. Based on these findings, this article concludes that effective management is not only the key to company success but also the main factor that can encourage economic growth in developing countries. Therefore, stakeholders from both the public and private sectors need to work together to strengthen managerial capacity and create an environment which supports exclusive and sustainable economic growth