Success Criteria Research Articles

APPLICATION OF THE ANALYSIS OF THE SUCCESS CRITERIA OF THE PROBABILISTIC ANALYSIS OF NPP SAFETY IN THE PROBABILISTIC ASSESSMENT OF THE EFFECTIVENESS OF PHYSICAL PROTECTION

Probabilistic safety analysis (PSA) is one of the tools that has been used for a long time to quantitatively assess the safety status of nuclear power plants (NPPs) around the world. However, despite all the positive aspects of the PSA of nuclear power plants, it, for example, does not take into account such a component as physical protection, which carries with it a corresponding negative effect, which is associated with the vulnerability of nuclear facilities to sabotage. It is not possible to directly involve the PSA of NPPs to evaluate the effectiveness of physical protection of nuclear facilities, since the existing methodology and procedure for applying this tool is not suitable for physical protection, which requires the development of a new methodology for the probabilistic analysis of physical protection. At the same time, it should be noted that in some cases it is possible to apply the methods of the traditional NPP PSA to perform some elements of the probabilistic analysis of physical protection without changes (for example, the analysis of equipment reliability), in other cases it is necessary to develop new methods for some of the elements of the probabilistic analysis of physical protection by analogy with the traditional NPP PSA (that is, to adapt, for example, the analysis of success criteria), and finally, in other cases, it is necessary to develop own new methods (for example, the analysis of the offender's actions) for the elements of the probabilistic analysis of physical protection, which are absent in the traditional NPP PSA. In general, the process of applying PSA of nuclear power plants to evaluate the effectiveness of physical protection systems of nuclear facilities requires not only the development of a new methodology, but also requires a rather large expenditure of time with the involvement of significant human and material resources. Therefore, for the first iterative step of using the traditional PSA of nuclear power plants to evaluate the effectiveness of physical protection of nuclear facilities, as an example, the possibility of adapting the methodology of the analysis of the success criteria of the traditional PSA of nuclear power plants for the probabilistic analysis of physical protection of nuclear facilities is considered.

Systemic Factors in Dental Implant Therapy

Objective: Dental implant therapy has emerged as a reliable and widely accepted solution for rehabilitating partially or fully edentulous patients. This review aims to explore the evolution of dental implant success metrics and the critical patient-related factors influencing implant outcomes. Background: Dental implants have undergone significant advancements since the clinical success reports in the 1970s and 1980s. The initial focus on long-term implant survival has expanded to include considerations of aesthetics, functionality, and patient satisfaction. These developments have been driven by the advent of improved implant surfaces, innovative surgical techniques, and a more comprehensive understanding of success criteria. Significance: Modern dentistry requires more than providing functional solutions for missing teeth. Patients now demand long-lasting aesthetic and functional outcomes that align with enhanced quality of life and their overall health. Thus, dental professionals must navigate a range of systemic, anatomical, and physiological factors when planning implant therapy. Conclusion: Delivering successful dental implant treatment necessitates a thorough understanding of patient-specific variables, including health conditions, longevity, and expectations. By addressing these factors, clinicians can optimize outcomes, ensuring patient satisfaction and treatment longevity.

The PAUL Glaucoma Implant in the management of uveitic glaucoma-3-year follow-up.

Evaluate the mid-term outcomes of the PAUL Glaucoma Implant (PGI) in the management of uveitic glaucoma. This was a single-centre, multi-surgeon, retrospective analysis of 50 consecutive cases of PGI for uveitic glaucoma performed between April 2019 and August 2021. Primary outcomes include: complete and qualified success (IOP ≥5 mmHg to ≤21 mmHg with ≥20% IOP reduction) or failure (IOP exceeding the success criteria, additional glaucoma procedures, no perception of light vision). Secondary outcomes included: visual acuity, IOP, medications, complications and intraluminal stent removal. We included 50 eyes of 41 patients. Mean age was 45.8 ± 19.8 years (range 6-81 years) in this heterogenous and complex cohort. Mean pre-op IOP was 30.6 ± 9.8 mmHg on 3.9 ± 0.9 medications. In total, 62% of patients were on acetazolamide, and 64% required systemic immunosuppression. At final follow-up (mean: 35.8 ± 9.8 months, range 5-58 months), IOP and medications were significantly reduced (12.2 ± 4.4 mmHg, requiring 1.1 ± 1.3 medications, p < 0.0001). Resulting in 48% complete and 92% qualified success rates. Failure occurred in 8% of cases, 6% due to hypertension but only one case of prolonged hypotony (2%). To date, this study represents the first publication looking specifically at the efficacy and safety of the PGI in the management of complex uveitic glaucoma. With an average follow-up of 3 years, it shows high levels of complete and qualified success with few complications.

Application of The Discovery Learning Model with Process Differentiation to Improve Junior High School Students' Mathematics Learning Outcomes

The aim of this research was to improve mathematics learning outcomes of class VIII A students at SMPN 14 Denpasar through the application of discovery learning with process differentiation. This type of research was classroom action research with two cycles. The research subjects were 42 students. Student’s mathematics learning outcomes data were obtained using mathematics learning outcomes tests. The collected data was analysed descriptively. The results showed that the percentage of students with mathematics learning outcomes in the complete category increased in each cycle. The success criteria were that the average student mathematics learning outcome score in each cycle increased, where the average student mathematics learning outcome was at least 80 and student’s classical learning completeness was at least 75%. Subsequently, the improvement results from each cycle could be said optimal. It could be conluded that the application of the discovery learning model with process differentiation could improve junior high school students' mathematics learning outcomes.

Exploring neurofeedback as a therapeutic intervention for subjective cognitive decline.

This study addresses the pressing issue of subjective cognitive decline in aging populations by investigating neurofeedback (NFB) as a potential early therapeutic intervention. By evaluating the efficacy of individualised NFB training compared to standard protocols, tailored to each participant's EEG profile, it provides novel insights into personalised treatment approaches. The incorporation of innovative elements and rigorous analytical techniques contributes to advancing our understanding of NFB's modulatory effects on EEG frequencies and cognitive function in aging individuals. In the context of an aging population, concerns surrounding memory function become increasingly prevalent, particularly as individuals transition into middle age and beyond. This study investigated neurofeedback (NFB) as a potential early therapeutic intervention to address subjective cognitive decline (SCD) in aging populations. NFB, a biofeedback technique utilising a brain-computer interface, has demonstrated promise in the treatment of various neurological and psychological conditions. Here, we evaluated the efficacy of individualised NFB training, tailored to each participant's EEG profile, compared to a standard NFB training protocol aimed at increasing peak alpha frequency power, in enhancing cognitive function among individuals experiencing SCD. Our NFB protocol incorporated innovative elements, including the implementation of a criterion for learning success to ensure consistent achievement levels by the conclusion of the training sessions. Additionally, we introduced a non-learner group to account for individuals who do not demonstrate the expected proficiency in NFB regulation. Analysis of electroencephalographic (EEG) signals during NFB sessions, as well as before and after training, provides insights into the modulatory effects of NFB on EEG frequencies. Contrary to expectations, our rigorous analysis revealed that the ability of individuals with SCD to modulate EEG signal power and duration at specific frequencies was not exclusive to the intended frequency target. Furthermore, examination of EEG signals recorded using a high-density EEG showed no discernible alteration in signal power between pre- and post-NFB training sessions. Similarly, no significant effects were observed on questionnaire scores when comparing pre- and post-NFB training assessments.

Polymodern Economics

Polymodernity could be defined as cultural infrastructure. It describes the cultural evolution of the human species in four cultural codes and integrates them: indigenous, traditional, modern, and postmodern. These four cultural codes very much relate to group sizes, and they represent four different kinds of social interaction, cooperation, economy, moral values, media, and much more. In this article, I describe the economy as a structure of five integrated layers. The first is nature itself; the other four are economic models with different goals, dynamics, rules, measurements, criteria for success, and opportunities for sustainability and thriving. All five layers are present in thriving economies. This article presents a suggestion for a macro-economic model that can deliberately balance them.

Class II interceptive treatment: what are the morphological characteristics of therapeutic success?

Cooperation and choice of device are not sufficient to predict the success of interceptive treatment in ClassII, 1. The aim of this study was to identify specific factors of patient morphology that predict success. A retrospective, prognostic, comparative, monocentric, intention-to-treat study was carried out. The criterion for therapeutic success was normalization of the ANB. The success and failure groups were statistically compared with an alpha risk of 5%. 95patients who underwent interceptive treatment close to their growth peak were included. The probability of successful treatment was a decreasing function of FMA, SNA, ANB and IMPA and an increasing function of SNB, ramus height and mandibular length. The proposed logistic equation offers a sensitivity of 82% and a specificity of 87%. Hyperdivergence below surgical values is not a factor in mandibular response failure. Hypodivergence is a factor in success. Astocky mandible (large ascending ramus, large horizontal ramus) responds well. Rather than ramus height, mandibular length is decisive: the greater the retromandibular height, the greater the chances of success. Pre-existing mandibular incisor vestibuloversion is a factor in failure. The accumulation of negative predictive factors may point towards an alternative therapeutic solution or prompt the patient and family to be informed of the difficulties inherent in the treatment.

Exploring the Use of AI for Enhanced Accessibility Testing of Web Solutions.

Artificial Intelligence (AI) holds significant potential for enhancing accessibility and user experience across digital products and services. However, mainstream web solutions commonly used by the general population still face accessibility barriers, hindering equal participation in the information society for people with disabilities. This article explores several promising applications of AI that can be used to create accessible solutions for people with disabilities. We also present our research, which aims to explore and demonstrate how various AI-based techniques can enhance and streamline accessibility testing for web solutions. We selected four success criteria from the Web Content Accessibility Guidelines (WCAG) that currently require extensive manual work and developed four prototypes using open-source machine-learning models to enhance conformance testing. While the prototypes need further optimization and evaluation, the results suggest that AI-based techniques can significantly reduce the need for manual work in accessibility testing.

Land rights and a national representative body: Institutionalisation as a criterion for Indigenous policy success and failure

Land rights and a national representative body: Institutionalisation as a criterion for Indigenous policy success and failure

Evaluating the clinical potential of bioceramic-rods for revascularization in osteonecrosis of the femoral head: a systematic review.

To evaluate the safety, reliability, and effectiveness of bioceramic rods (BR) in treating osteonecrosis of the femoral head (ONFH), compared with other treatments such as core decompression and autologous bone grafting. Systematic review and meta-analysis. Pubmed, Embase, and CNKI databases from January 2011 to July 2023. Included studies involved patients treated with bioceramic rods. Studies were required to have a follow-up time of more than six months and no statistically significant differences in baseline information between groups in controlled studies. Exclusions included literature reviews, case reports, conference abstracts, animal experiments, and studies without defined success criteria or lacking analysis on factors influencing efficacy. The primary outcome measure was the Harris Hip Score (HHS) improvement rate. Secondary outcomes included the femoral head stability and survival rate, alongside the hip replacement rate. The systematic review revealed significant improvements in symptom relief and functional recovery using BR for the treatment of ONFH. An average follow-up of 20.44 months showed an overall HHS improvement rate of 33.93%. Hip preservation efficacy with BR was superior to core decompression and autologous bone grafting. The overall femoral head survival rate was 84.42%, with results sustained for three years. The success rate of hip preservation was notably higher with early intervention, which showed better outcomes when the overall HHS improvement exceeded 27%, and rates of excellent and good outcomes approached 90%. Bioceramic rods offer a safe, minimally invasive, reliable, and effective treatment option for ONFH, ensuring substantial symptom relief and functional recovery. The technique's success in early disease stages suggests a strong potential for broader clinical adoption. Although additional benefits from combining BR with stem cells, platelet-rich plasma, and traditional Chinese medicine are noted, definitive conclusions on enhanced therapeutic effects remain inconclusive.

‘Green icing on the Gray Cake?’ Green infrastructure in federal enforcement action

ABSTRACT A growing number of local governments are adopting Green Infrastructure (GI) as a strategy for urban stormwater management. In the United States, GI has gained particular momentum through federal initiatives. Previous studies have identified regulatory factors playing a pivotal role in the adoption of GI at the local level. However, the integration of GI with federal enforcement actions has received limited research attention. This study examines the first generation of federal consent decrees with GI provisions to provide insights into federal GI policy and local GI planning. The findings reveal inconsistency in GI requirements, with some cases merely encouraging GI adoption, while others mandating a more specific approach to planning and implementation. Drawing on existing GI scholarship, the results of this study suggest the establishment of universal requirements, such as piloting projects, defining success criteria, and incorporating equity considerations into local GI planning.

Hands Up Program: Results of a feasibility study of a randomized controlled trial of a bone health exercise and education program for adults aged 50-65 post distal radius fracture.

Distal radius fractures (DRF) that occur from a fall from level ground are considered fragility fractures and may be the first indication that someone has compromised bone mineral density and is at risk of having osteoporosis. Women at about 50 years of age experience a dramatic increase risk of these fractures. Rehabilitation after DRF focuses on restoring range of motion and strength in the wrist, but rarely address future bone health concerns. We developed a 6-week therapist-developed remote full body exercise and osteoporosis/bone-health education program (called The Hands Up Program). This study was designed to evaluate the feasibility of a larger trial examining the effects of a whole-body exercise and education program for people 50-65 after a DRF. Community dwelling individuals between the age of 50-65 with a radiographically confirmed DRF were recruited from the Roth| McFarlane Hand and Upper Limb Center in London, Ontario. Participants were randomized in a 1:1 ratio into either the Hands Up Program which was a twice weekly exercise and education program for 6 weeks, or the control group where they proceeded with usual care. The intervention was delivered online through a website where participants created a unique username and password to access. The primary feasibility outcomes of the study were recruitment rate (74 participants in 1 year), retention rate (75% completion), and intervention adherence rate (60% of completion of the exercise program). Secondary outcomes included strength, range of motion, self-reported outcomes, and bone density. Overall, 74 participants were recruited in 14 months. Retention did not meet the criteria for success, as only 53% of the participants attended their 12-month visit. Adherence was also not met albeit close with 55% completing the exercise program. Twelve participants withdrew from the study, five due to the time commitment, four without explanation, one due to group allocation, one due to COVID and one participant moved. One participant was deemed ineligible after consent. Four of the participants that withdrew were in the intervention group, and four in the control group, five participants withdrew before they were allocated to a group. Feedback from patients indicated potential improvements to the program: lower assessment burden, spacing out the intervention so that the education portion could be delivered during the immobilization phase of recovery, and creating a more individualized program. Adherence and retention were both a challenge, although adherence was close to target. While achieving adherence to exercise in bone health is a known challenge, given the importance of prevention in the at-risk DRF population and the challenges in co-design and delivery during the pandemic, we believe evaluation of a revitalized program is warranted.

Statistics of drops generated from ensembles of randomly corrugated ligaments

The size of drops generated by the capillary-driven disintegration of liquid ligaments plays a fundamental role in several important natural phenomena, ranging from heat and mass transfer at the ocean-atmosphere interface to pathogen transmission. The inherent nonlinearity of the equations governing the ligament destabilization leads to significant differences in the resulting drop sizes, owing to small fluctuations in the myriad initial conditions. Previous experiments and simulations reveal a variety of drop size distributions, corresponding to competing underlying physical interpretations. Here, we perform numerical simulations of individual ligaments, the deterministic breakup of which is triggered by random initial surface corrugations. The simulations are grouped in a large ensemble, each corresponding to a random initial configuration. The resulting probability distributions reveal three stable drop sizes, generated via a sequence of two distinct stages of breakup. Four different distributions are tested, volume-based Poisson, Gaussian, Gamma, and Log-Normal. Depending on the time, range of droplet sizes and criteria for success, each distribution has successes and failures. However, the Log-Normal distribution roughly describes the data when fitting both the primary peak and the tail of the distribution while the number of droplets generated is the highest, while the Gamma and Log-Normal distributions perform equally well when fitting the tail. The study demonstrates a precisely controllable and reproducible framework, which can be employed to investigate the mechanisms responsible for the polydispersity of drop sizes found in complex fluid fragmentation scenarios.

Faculty Members' Perception, Implementation, and Challenges of Formative Assessment in Undergraduate Medical Education: A Cross-Sectional Study.

Medical curriculum reform requires quality assurance in all curricular activities including assessment. Such reform necessitates a shift of focus from summative assessment (SA) to formative assessment (FA). However, the implementation of FA confronts several challenges that hinder its proper application, especially with the increased number of students and the diversity of activities required from faculty members. Therefore, this study aims to explore the perception, implementation, and challenges facing faculty members during the application of FA to undergraduate medical students. This is a cross-sectional study using an online survey to collect data from the pre-clinical and clinical faculty members of the College of Medicine (CoM) at Imam Abdulrahman Bin Faisal University (IAU), Dammam, Saudi Arabia. The survey consisted of two sections. The first section focused on the demographic and academic-related data, while the second section consisted of a validated self-administered questionnaire related to FA. The questionnaire comprised six domains regarding the level of perception, implementation, and challenges facing FA applications. Among the 347 faculty members who received the research survey, 132 members participated in this study (38%). Regarding awareness, 68.9% and 67.4% of the faculty members were aware of two subdomains, namely, "functions of formative evaluation and understanding of its usefulness" and "sharing and addressing educational attention and success criteria." However, with respect to the application of FA, only one-third of the membersimplemented the FA into their teaching process. Regarding barriers to applying FA, the majority of the participants agreed on the major barriers, which included required activities from the instructors (93.2%), the number of students (87.1%), and students' engagement (84.1%). There is a fair overall awareness regarding the concept and importance of FA. Despite that, the application of such an assessment method was limited. This may be attributed to several challenges, including a large number of students and the required activities from the faculty. Further studies are recommended to investigate the implementation of an FA feedback system and its impact on the learning process in the CoM at IAU.

Optimizing development and operations from the project success perspective using the analytic hierarchy process

By merging development and operation disciplines, the approach known as development and operations (DevOps) can significantly improve the efficiency and effectiveness of software development. Despite its potential benefits, successfully implementing DevOps within traditional project management frameworks presents significant challenges. This study explores the critical factors influencing the implementation of DevOps practices from the project management perspective, specifically focusing on software development projects in the Ministry of Finance. This study utilizes the analytic hierarchy process (AHP) to prioritize the critical elements of project success criteria and DevOps factors necessary for effective implementation. The findings indicate that stakeholder satisfaction, quality, and value creation are the primary criteria for project success. Moreover, knowledge and skills, collaboration and communication, and robust infrastructure are pivotal factors for facilitating DevOps within project management. The study provides actionable insights for organizations aiming to improve their project outcomes by incorporating DevOps and offers a systematic approach to decision-making using AHP. This study recognizes limitations due to its focus on specific contexts and emphasizes the need for future research in diverse organizational environments to validate and expand these findings.

Effectiveness of the Additional Risk Minimisation Measures for Valproate Among Healthcare Professionals and Patients: A Cross-Sectional Survey in Six European Countries.

To assess the impact of the 2018 European additional risk minimisation measures (aRMMs) regarding the use of valproate in women of childbearing potential (WCBP) and during pregnancy. A cross-sectional, non-interventional survey conducted in six European countries among 1982 healthcare professionals (HCPs) (July-October 2020) and 779 WCBP treated with valproate for epilepsy, bipolar disorder or other indications (August 2020-February 2021). HCPs were prescribing physicians (neurologists, psychiatrists, paediatricians and GPs), gynaecologists and pharmacists. Prespecified criteria were defined for success in the dimensions of awareness, knowledge and behaviour (correct answers to ≥ 80% of questions at individual level) and overall success (≥ 90%/80% successful HCPs/patients respectively, in the behaviour dimension and one of the two other dimensions). HCPs and patients did not meet the success criteria either overall or in any dimension. Highest success rates were in the behaviour dimension for gynaecologists (71.7%), pharmacists (49.7%) and patients (51.2%), and in the awareness dimension for prescribing physicians (23.6%). HCPs reported being unfamiliar with some educational materials and lacked knowledge of detailed prescribing conditions for valproate and the need for contraception regardless of sexual activity. More than 50% of patients were aware of the relevant patient materials and knew about the teratogenic risks of valproate. Self-reported levels of awareness, knowledge and behaviour varied considerably by HCP type and among patient respondents. Further investigation is needed into why certain measures of the pregnancy prevention programme are not well known and followed, to improve their effectiveness. This will be addressed in a qualitative study which will be based on interviews with HCPs and patients.

Efficacy and Safety of Ab-Interno Canaloplasty in Post-Keratoplasty Patients: 3-Year Results.

To evaluate the effectiveness and safety of ab-interno canaloplasty (ABiC) for managing intraocular pressure (IOP) in patients following keratoplasty over a three-year period. This retrospective analysis focused on post-keratoplasty patients treated with ABiC with the iTrack microcatheter (Nova Eye Medical, Fremont, CA, USA) at a single institution. The study assessed the procedure's impact on IOP control, graft survival, and reliance on topical hypotensive medications, with additional observation for any postoperative complications. Surgical success criteria included the percentage of eyes with IOP ≤15mmHg, IOP ≤18mmHg, ≥20% IOP reduction, medication-free eyes, and eyes with concurrent IOP and medication reductions. ABiC was performed successfully in a cohort of 16 post-keratoplasty (7 penetrating keratoplasty and 9 endothelial keratoplasty (EK)) eyes. Preoperative mean IOP of 25.8±7.2mmHg was significantly reduced to 13.4±2.9mmHg (p<0.001) at 1 year postoperatively and maintained at 13.1±3.9mmHg (p=0.009) at 3 years postoperatively. The mean number of glaucoma medications was 3.5±1.7 at baseline, 2.8±1.3 at 1 year (p=0.107), and 2.5±1.2 at 3 years postoperatively (p=0.088). Eight eyes (66.7%) maintained IOP ≤ 15mmHg, and 10 eyes (83.3%) maintained ≥ 20% IOP reduction at 3 years. The mean IOP and medication reductions from baseline at 3 years were -49.2% and -28.6%, respectively. Graft clarity was preserved in all patients except for one case of late graft failure that necessitated a repeat EK procedure. Post-ABiC complications included transient hyphema in two patients, neither of which led to long-term adverse outcomes. ABiC appears to be an effective and safe surgical intervention for sustained IOP reduction in post-keratoplasty patients. Graft survival trends are encouraging, and there was a low incidence of complications over a three-year follow-up period.

Understanding university English instructors’ assessment literacy: a formative assessment perspective

Formative assessment is a powerful approach to inform, direct, and enhance teaching and learning. To deploy it in classrooms, teachers are expected to be assessment-capable. However, few studies have explored the extent to which teachers are literate in formative assessment applications and their levels of literacy, especially in Chinese tertiary settings. This study examined Chinese university English instructors’ assessment literacy by investigating what three participants knew, thought about, and how they applied formative assessment. A knowledge-conception-practice framework was applied to explore assessment literacy in the four formative assessment processes (i.e., design, use, interpretation, and communication) to engage student learning. Individual interviews, classroom observations, and supplementary documents were adopted as instruments for data collection. Through iterative and comparative thematic analysis, findings revealed that notwithstanding variations, all three instructors possessed basic formative assessment knowledge and were willing to design and conduct formative assessment-related activities for students’ learning engagement and enhancement. However, they held product-oriented rather than process-oriented mindsets when designing, using, interpreting, and communicating formative assessment. They also lacked sufficient assessment knowledge and strategies to effectively engage students in self-regulated learning through learner-centered task design, success criteria, and process-oriented feedback. Lastly, the study discussed theoretical and pedagogical implications regarding how to conceptualize and develop English instructors’ formative assessment literacy in mainland China and beyond.

Enhancing Indonesian EFL Students’ Reading Comprehension of Report Texts through KWL Strategy with Multimedia: A Classroom Action Research

The significance of reading is undeniable in the English learning process. Thus, students need to be equipped with reading strategies to help them develop their English language. This study sought to improve students’ reading comprehension and attitude through the use of know-want-learn (KWL) strategy in conjunction with multimedia. Classroom Action Research was employed involving 28 students in the ninth grade. Several instruments were utilized, i.e., reading comprehension tests, interview, observation checklist, and field notes. The mean scores of the reading tests increased from baseline (53) to cycle 2 (80.54) indicating that the result had achieved the criteria of success. It could be inferred that implementing KWL strategy with multimedia in the pre-reading stage enhanced students’ reading comprehension. Two factors affecting the students’ reading comprehension were identified, i.e., the teacher’s participation and topic familiarity. The strategy was also found to foster students’ participation and provide students with a concise framework to develop their English reading skills. This study therefore has contributed to the existing literature of English reading strategy and offered meaningful pedagogical implications for English teachers to harness the strategy incorporated with the use of current media such as pictures and videos to teach English reading.

7.G. Round table: Primary prevention and management of NCDs – the added value of joint actions across Europe

Abstract Two ambitious European joint action projects, funded through the EU4Health programme, are ongoing to reduce the burden of non-communicable diseases (NCDs) and related risk factors in Europe, targeting both individual and societal levels. Together, these projects aim to scale up effective prevention and management strategies, strengthen public health policies and promote equitable and sustainable healthcare systems across Europe. The Joint Action on CARdiovascular Diseases and DIabetes (JACARDI), with 21 participating countries and a total budget of over €66 million, is focusing on enhancing the implementation of evidence-based innovative pilot projects across the entire patient journey. This includes efforts to improve prevention, early diagnosis, and proactive management of NCDs. The Joint Action Prevent Non-Communicable Diseases (JA PreventNCD), with 25 participating countries and a total budget of over €95 million, particularly aims to enhance joint capacities of countries for implementing, scaling up and evaluating prevention policies and actions at various levels. These projects represent complementary responses to calls for action in Europe’s Beating Cancer Plan and the Healthier Together - EU NCD Initiative, with JA PreventNCD emphasizing primary prevention and policy while JACARDI focuses on secondary prevention and health systems strengthening. Both projects will generate new policy-relevant evidence based on implementation, monitoring and scaling-up of best and innovative practices and policies across Europe. The projects share a focus on equity, diversity, scalability and sustainability, while avoiding fragmentation and duplication of actions. Under the EU4Health programme, launched to strengthen European health collaboration in the wake of the COVID-19 pandemic, the EU has recently invested over €200 million in public health initiatives, with additional investments from national authorities participating in the joint actions. With this new wave of funding, real population impact should be anticipated, but what can we realistically expect to be the outcomes and what are the criteria for success? In this round table discussion 1) these two joint action projects will be presented, highlighting their innovative aspects; 2) views on the added value and potential in cross-national collaborations for prevention and management of NCDs will be debated, and 3) how synergies will be leveraged for maximum impact will be explored. Panelists will share their perspectives on the projects’ potential to change the public health landscape in Europe. Workshop participants will subsequently be encouraged to engage in the discussion with the objective that views and experiences are exchanged, opportunities for collaboration and engagement are shared and energy is mobilized to harness the benefits of such large-scale policy-relevant collaborations. Key messages • Synergies and collaboration to drive policy development and foster increased capacity are the pillars to build a healthier Europe. • Two large-scale Joint Actions drive impact by highlighting innovative NCD prevention strategies and fostering collaborative engagement.