Statement of problemConventional fabrication of complete denture metal bases is being replaced by the computer-aided design and computer-aided manufacturing (CAD-CAM) systems. However, a comparative analysis of subtractive and additive CAD-CAM manufacturing techniques is lacking. PurposeThe purpose of this in vitro study was to compare the adaptation of complete denture metal bases fabricated by milling (subtractive manufacturing) and stereolithography apparatus (SLA) and digital light processing (DLP) (additive manufacturing). Material and methodsThirty metal bases were manufactured by using the milling (MIL group), SLA (SLA group), and DLP (DLP group) techniques. The silicone replica technique was used to evaluate the adaptation of the complete denture metal bases, and 30 silicone blocks were fabricated. The silicone block was cut equally in the canine, first molar, and second molar areas. The gap between the model and the metal base was measured by using a digital microscope at the 3 locations, and the measured data were statistically analyzed by using a statistical software program (α=.05). ResultsThe gaps measured at the 3 areas showed significant differences in all 3 groups (P<.05). At the anterior, middle, and posterior areas, the SLA group showed the narrowest gap (302 ±31 μm, 241 ±39 μm, 201 ±43 μm, respectively). The SLA group also had the narrowest total gap of the metal bases (218 ±33 μm). ConclusionsThe adaptation of the fabricated metal bases varied significantly across the techniques used but fell within a clinically allowable range. The SLA group was the most precise in the fabrication of complete denture metal bases. Further studies are required to analyze the effects of the layer thickness setting, wax elimination, and casting temperature on the adaptation of metal bases manufactured by using SLA.