Shortage of irrigation water is a crucial prob- lem in arid and semi-arid regions. Therefore, application of wastewater in such area seems to be an indispensable so- lution. The health aspect of the application should be considered by microbial evaluation of soil and plant irri- gated with treated wastewater. In this study several irri- gation methods were used. Results showed that the filtration reduced the microbial pollution of treated mu- nicipal wastewater. The maximum soil pollution was in the surface drip and furrow irrigation with treated municipal wastewater. The least level of total and fecal coliform were in sub-surface drip irrigation at the depth of 30 cm in condition of municipal wastewater reuse. The results of plants revealed that the highest coliforms were seen at the surface drip and furrow irrigation with treated municipal wastewater. The minimum coliforms numbers were ob- served in the sub-surface drip irrigation method. Therefore, the sub-surface drip irrigation can reduce the wastewater reuse problems at soil and plant. It is the best option to avoid the contamination in landscape.