Commercial production of pecan [Carya illinoinensis (Wangenh.) K. Koch.] generates significant woody biomass from hedge prunings with little economic value. Value-added uses could aid pecan growers, and one possible use is wood chips for potting substrates to lessen dependence on peatmoss, thereby aiding greenhouse growers. We evaluated vegetative growth and leaf nutrient responses of ‘Carpino’ garden chrysanthemum (Dendranthema ×grandiflorum) over a 60-day period. Plants were grown in five pecan wood chip substrate levels that substituted 0%, 25%, 50%, 75%, and 100% of peatmoss by volume. Three water soluble fertilizer (WSF) rates—N at 0, 200, or 400 mg·L−1 (0–N, 200–N, and 400–N, respectively)—were applied with each irrigation and to each of the wood substitution treatments. The WSF and wood substitution treatments interacted strongly. In the presence of wood, (25−100% substitution levels), increasing WSF to 400–N increased cumulative evapotranspiration (ET), crop height, total leaf number and area, total leaf and stem dry weight, and leaf N and P concentrations. However, with 0% wood substitution, 400−N provided little or no such enhancements. With 25% to 50% wood substitution, root dry weight increased by 61% to 91% from 0–N to 200–N, which may be an adaptive response to nutrient-limiting conditions at 200–N. Appearance of a white rot fungal species in and atop pecan wood-supplemented substrate supports the likelihood that microbial activity was, at least in part, responsible for the nutrient limitations. High WSF at 400–N in combination with 25% pecan wood substitution maintained adequate fertility and shoot growth that was comparable to the conventional peat-only substrate at 200–N. With low to moderate amounts of pecan wood, further adjustments to WSF rate and irrigation volume would support sustainable fertigation practices, reduce dependence on peatmoss by greenhouse industry, and provide a value-added recycling option for pecan growers.