Subsequent Episodes Research Articles

Preeclampsia and Long-term Kidney Outcomes: An Observational Cohort Study

Preeclampsia is a pregnancy-related complication characterized by acute hypertension and end-organ dysfunction. We evaluated the long-term association between preeclampsia and the risk of developing chronic hypertension and kidney disease. Observational cohort study. 27,800 adults with deliveries in the Geisinger Health System between 1996 and2019. Preeclampsia. Hypertension, reduced estimated glomerular filtration rate (eGFR)<60mL/min/1.73m2), and albuminuria>300mg/g. Propensity-score matching and Cox proportional hazards models to evaluate the association between preeclampsia and incident hypertension, reduced eGFR, and albuminuria. Of 27,800 adults with pregnancies during the study period (mean age, 28 years; 3% Black race), 2,977 (10.7%) had at least 1 pregnancy complicated by preeclampsia. After matching for multiple characteristics, individuals with preeclampsia had a higher risk of developing chronic hypertension (HR, 1.77 [95% CI, 1.45-2.16]), eGFR<60mL/min/1.73m2 (HR, 3.23 [95% CI, 1.64-6.36]), albuminuria (HR, 3.60 [95% CI, 2.38-5.44]), and a subsequent episode of preeclampsia (HR, 24.76 [95% CI, 12.47-48.36]), compared with matched controls without preeclampsia. Overall, postpartum follow-up testing was low. In the first 6 months after delivery, 31% versus 14% of individuals with and without preeclampsia had serum creatinine tests, respectively, and testing for urine protein was the same in both groups, with only 26% having follow-up testing. Primarily White study population, observational study, reliance on ICD codes for medical diagnosis. Individuals with a pregnancy complicated by preeclampsia had a higher risk of hypertension, reduced eGFR, and albuminuria compared with individuals without preeclampsia. Preeclampsia is a significant contributor to perinatal and maternal morbidity and is marked by new-onset hypertension and end-organ damage, including acute kidney injury or proteinuria. To gain insight into the long-term kidney effects of the disease, we compared adults with deliveries complicated by preeclampsia with those without preeclampsia in the Geisinger Health System, while also assessing postpartum testing rates. Our results demonstrate that pregnant individuals with preeclampsia are at a heightened risk for future hypertension, reduced eGFR, and albuminuria, with overall low rates of postpartum testing among both individuals with and without preeclampsia. These findings underscore the need to consider preeclampsia as an important risk factor for the development of chronic kidney disease. Further studies are required to determine optimal postpreeclampsia monitoring strategies.

Factors associated with maternal depressive symptoms up to 25 years after childbirth: A longitudinal prospective cohort study

AbstractDepression is one of the most common mental disorders among women and previous depression increases the risk for new episodes. Little is known about which factors are associated with maintained or recurrent depression in women, and studies with longer follow‐up time, 20 years or more, are scarce. Thus, the aim of the study was to identify factors associated with repeated self‐reports of depressive symptoms. The hypothesis was that factors such as young age at childbirth, divorce, unemployment, low social support, prior depression, or experience of stressful life events would increase the risk of repeatedly reporting depressive symptoms. The South East Sweden Birth Cohort study is a longitudinal, prospective cohort study. Out of the 1694 mothers enrolled at baseline, 649 participated in the 25‐year follow‐up. A total of 450 mothers participated in all three follow‐ups. The mothers reported symptoms of depression using validated instruments at 3 months (Edinburgh Postnatal Depression Scale), 12 years (Hopkins Symptom Checklist 25 items), and 25 years postchildbirth (Patient Health Questionnaire). Logistic regression was performed to evaluate the odds ratios of having depressive symptoms, whereas multinomial logistic regression was used to evaluate independent factors' association with the number of episodes with depressive symptoms. High life stress around pregnancy and childbirth and earlier depressive symptoms were associated with depressive symptoms at the 25‐year follow‐up. Similarly, high life stress around pregnancy and childbirth and the experience of divorce were associated with repeated self‐reports of depressive symptoms. Stressful life events are important predictors of depressive symptoms and repeated episodes of depressive symptoms from the postnatal period until 25 years later. Moreover, previous depressive symptoms increase the risk for subsequent episodes. The results further stress the importance of identifying mothers experiencing depressive symptoms postpartum to enable treatment and early intervention.

Does the syn- versus post-rift thickness ratio have an impact on the inversion-related structural style?

Abstract. Many extensional basins worldwide are modified by subsequent compressional episodes, which lead to inverted structures. The structures associated with the reactivation of pre-existing faults are critically important in the formation of suitable subsurface traps for hydrocarbons. Major concerns regarding inverted structures are the trap integrity and fault seal. In general, the preferred structures have simple four-way closures due to the minor forced folding of the post-rift cover, as opposed to (reverse) fault-related structures, which have a higher risk of breaching. Such reverse-fault-bounded structures have been generally observed in basins with a thick syn-rift fill and a relatively thin post-rift sequence at the time of inversion (Mode I). In contrast, gentle/open forced folds have been described in basins with thicker post-rift sequences than the syn-rift basin fill (Mode II). Five physical sandbox models, coupled with particle image velocimetry (PIV) analysis, have been performed to address the influence of the syn- versus post-rift thickness ratio on the inversion-related structural style of the post-rift cover. The main control on the development of Mode I or Mode II inversion structures within the post-rift sequence appears to be different due to the amount of compressional displacement accommodated by the inherited listric fault and the thickness of the post-rift cover. These observations do have a direct impact on the understanding of the geo-energy systems associated with inverted structures and are broadly comparable with natural data examples from Aotearoa/New Zealand, Israel, Romania, and the Republic of Türkiye.

Clinical characteristics and outcomes of patients with recurrent status epilepticus episodes

BackgroundMultiple studies have focused on medical and pharmacological treatments and outcome predictors of patients with status epilepticus (SE). However, a sufficient understanding of recurrent episodes of SE is lacking. Therefore, we reviewed recurrent SE episodes to investigate their clinical characteristics and outcomes in patients with relapses.MethodsIn this retrospective, multicenter study, we reviewed recurrent SE patient data covering 2011 to 2017 from the university hospitals of Frankfurt and Marburg, Germany. Clinical characteristics and outcome variables were compared among the first and subsequent SE episodes using a standardized form for data collection.ResultsWe identified 120 recurrent SE episodes in 80 patients (10.2% of all 1177 episodes). The mean age at the first SE episode was 62.2 years (median 66.5; SD 19.3; range 21–91), and 42 of these patients were male (52.5%). A mean of 262.4 days passed between the first and the second episode. Tonic–clonic seizure semiology and a cerebrovascular disease etiology were predominant in initial and recurrent episodes. After subsequent episodes, patients showed increased disability as indicated by the modified Rankin Scale (mRS), and 9 out of 80 patients died during the second episode (11.3%). Increases in refractory and super-refractory SE (RSE and SRSE, respectively) were noted during the second episode, and the occurrence of a non-refractory SE (NRSE) during the first SE episode did not necessarily provide a protective marker for subsequent non-refractory episodes. An increase in the use of intravenous-available anti-seizure medication (ASM) was observed in the treatment of SE patients. Patients were discharged from hospital with a mean of 2.8 ± 1.0 ASMs after the second SE episode and 2.1 ± 1.2 ASMs after the first episode. Levetiracetam was the most common ASM used before admission and on discharge for SE patients.ConclusionsThis retrospective, multicenter study used the mRS to demonstrate worsened outcomes of patients at consecutive SE episodes. ASM accumulations after subsequent SE episodes were registered over the study period. The study results underline the necessity for improved clinical follow-ups and outpatient care to reduce the health care burden from recurrent SE episodes.

Early longitudinal changes in brain structure and cognitive functioning in remitted patients with recently diagnosed bipolar disorder

BackgroundPatients with bipolar disorder (BD) who are presenting with cognitive impairment and associated structural brain abnormalities have generally a poorer clinical outcome. This study aims to map the early longitudinal trajectories in brain structure and cognition in patients with recently diagnosed BD. MethodsFully or partially remitted patients with a recent diagnosis of BD and matched healthy controls (HC) underwent structural MRI and neuropsychological testing at baseline (BD n = 97; HC n = 66) and again following an average of 16 (range 6–27) months (BD n = 50; HC n = 38). We investigated the differential trajectories in BD vs. HC in cortical gray matter volume and thickness, total cerebral white matter, hippocampal and amygdala volumes, estimated brain age, and cognitive functioning using linear mixed models. Within patients, we further investigated whether brain structural abnormalities detected at baseline were associated with subsequent mood episodes. ResultsCompared to HC, patients showed a decline in total white matter volume over time and they had a larger amygdala volume, both at baseline and at follow-up time. Patients further showed lower cognitive performance at both times of investigation with no significant change over time. There were no differences between patients and HC in cortical gray matter volume or thickness, hippocampal volume, or brain-aging patterns. ConclusionsCognitive impairment and amygdala enlargement may represent stable markers of BD early in the course of illness, whereas subtle white matter decline may result from illness progression.

Low prevalence of bacterial vaginosis in Kenyan adolescent girls and rapid incidence after first sex

Bacterial vaginosis (BV) is a risk factor for sexually transmitted infections (STI) including HIV. Adult African women have high prevalence of BV, but it is not known when first BV occurs. We sought to describe BV in younger African women, before and after first sex, and to determine incidence of BV and significant correlates of BV incidence and recurrence. In a prospective observational cohort study enrolling adolescents with limited sexual experience, young women ages 16-21 were recruited in Thika, Kenya. Eligible participants were HIV and HSV-2 seronegative and reported zero or one lifetime sexual partner. Nugent score was determined at quarterly visits from vaginal Gram stains. Trends in BV were described over time; hazard ratios were calculated using Cox regression and relative risk of BV was estimated using generalized estimating equations and Poisson regression. We enrolled 400 participants with a median age of 18.6 years (IQR 16-21). The majority (322, 80.5%) reported no history of sex, while 78 (19.5%) reported sex with 1 partner. At enrollment, BV (Nugent score ≥7) was uncommon (21 of 375, 5.6%). Overall, 144 participants had BV at least once, for an incidence rate of 16.5 cases per 100 person-years. Prior to first sex, BV was present at 2.8% of visits, compared to 13.7% of visits post-first sex. An adjusted model of BV incidence observed that first sex was associated with more than twofold increased BV risk (aHR 2.44, p=0.009, CI 1.25-4.76). Chlamydia diagnosis (aHR 1.73, p=0.02, CI 1.1-2.8) and HSV-2 seropositivity (aHR 2.88, p=0.021, CI 1.17-7.09) were both associated with incident BV. A multivariate GEE model including all episodes of BV demonstrated risk factors including first sex, STIs, urban residence, recent sex and no income; the most important risk factor was first sex (aRR 1.92, p=0.018, CI 1.12-3.31). Probability of BV increased with each subsequent episode; mean Nugent scores increased after each BV episode. Using detailed longitudinal observation, we found that Kenyan adolescents have almost no BV prior to first sex, and that initiation of sexual activity was the strongest risk factor for both prevalent and incident BV.

Isolation of Multidrug-Resistant Organisms in Surveillance Stool Culture at Diagnosis Fails to Predict Mortality or Subsequent Sepsis due to Multidrug-Resistant Organisms in Children with Acute Leukemia: A Single-Center, Prospective, Observational Study.

The utility of surveillance stool culture (SSC) to guide antibiotics for febrile neutropenia (FN) is unresolved in non-transplant settings. The prospective study explored the prevalence of multidrug-resistant organisms (MDRO) in SSCs, its correlation with mortality, and the concordance of SSCs with cultures obtained during subsequent episodes of FN amongst children with acute leukemia. SSCs were obtained at presentation and 2 mo into chemotherapy. Seventy-nine patients (mean age: 5.9±3.2 y) with acute lymphoblastic leukemia (ALL) (80%), acute myeloid leukemia (AML) (16%), or biphenotypic leukemia (4%) were enrolled. MDROs were isolated from 14 (17.5%) patients in the first SSCs, including E.coli (80%), K. pneumoniae (10%), and E. faecium (10%). Three (3.8%) patients developed MDRO sepsis; none concorded with the SSCs. Eleven (14%) patients died; 4/14 (28.5%) with MDRO-colonization vis-à-vis 7/66 (10.6%) without MDRO-colonization (OR: 3.37, 95% CI: 0.8-13.6; p = 0.095). MDRO-colonization failed to predict MDRO-sepsis, bloodstream infection, or mortality. SSC failed to guide the choice of antibiotics for FN in children with acute leukemia.

Evaluation of the prehospital use of a Valsalva assist device in the emergency treatment of supraventricular tachycardia (EVADE SVT): study protocol for a stepped wedge cluster randomised controlled trial

IntroductionPatients with episodes of supraventricular tachycardia (SVT), a common heart arrhythmia, are often attended by ambulance services. International guidelines advocate treatment with the Valsalva manoeuvre (VM), but this simple physical...

P333 A RARE CAUSE OF SHOCK: AORTO–PULMONARY FISTULA AS AORTIC ANEURYSM COMPLICATION

Abstract Clinical case A 69–year–old man with right shoulder discomfort, malaise for one hour and hemodynamic instability was admitted to our Emergency Department (ED). The patient had a history of arterial hypertension, diabetes, renal failure on peritoneal dialysis and ischemic cardiomyopathy with preserved ejection fraction treated by angioplasty and stent implantation on right coronary. At first medical contact out of hospital the patient appeared confused with severe hypotension (BP 70/40 mmHg). ECG transmitted to our Cardiology Unit showed sinus tachycardia with repolarization abnormalities consistent with diffuse ischemia. The patient was centralized with clinical suspicion of acute coronary syndrome complicated by cardiogenic shock. In ED, BP was 65/35 mmHg. On physical examination extremities were cold and mottled, crackles in the lower lung zones and turgid jugulars were present. Pulses were weak but present. ECG was repeated and no evolutive signs were detected. Echocardiography finding were: not dilated left ventricle with global systolic function at the lower limits, moderate aortic insufficiency, right ventricle with dimensions at the upper limits and hypocontractile, moderate tricuspid regurgitation, inferior vena cava dilated with preserved inspiratory collapse. Aortic root was non dilatated but aortic arch was 55 mm with no images of dissection flap. At blood test lactates were 4,2 with metabolic acidosis, troponin was just above the upper limit, inflammation indices were negative and electrolytes were in range. Vasopressor support with norepinephrine was started. With the high suspicion of acute aortic disease, CT angiography was performed showing a voluminous aneurysm of the aortic arch of 70x56 mm rupturing into the left pulmonary artery (Figure 1,2). Concomitant bilateral iliac artery dissection was detected. Cardiac and Vascular Surgeons were promptly alerted to plan tan emergent surgical intervention whose complexity was increased by the difficult vascular cannulation for iliac dissection. However, the patient‘s hemodynamic rapidly deteriorated requiring intubation and, after subsequent episodes of cardiac arrest in pulseless electrical activity (PEA), his death was assessed.

P37 MULTIMODALITY DIAGNOSTIC APPROACH TO A JUVENILE CASE OF SUSTAINED VENTRICULAR TACHYCARDIA

Abstract Clinical case 31–year–old male subject, former competitive athlete, with family history of coronary artery disease and no further cardiovascular risk factors or previous cardiac events. Previous SARS–CoV2–related paucisymptomatic infection (January 2022) and subsequent episode of fever (August 2022) with negative SARS–CoV2 nasal swab. In September 2022 he reported sudden onset of palpitations after hearty meal. Because of such symptoms, the patient underwent Holter ECG showing 90 episodes of ventricular tachycardia (VT) and one episode of sustained VT. Based on such evidence, the patient went to the emergency room (ER). During the ER stay, blood exams (blood count, high–sensitivity troponin, BNP, CRP, D–dimer) and ECG were normal and SARS–CoV2 test was negative. The patient was then hospitalized in cardiac ICU. The echocardiogram showed left ventricle with normal dimension, thickness and wall motion (EF: 65%, mean GLS: –20%), trivial mitral and aortic regurgitation, no pericardial effusion. Subsequently, a cardiac coronary CT scan was performed showing absence of atherosclerotic lesions and myocardial bridge of the middle segment of LAD artery. The diagnostic pathway went on with cardiac magnetic resonance (CMR) demonstrating focal hypokinesia and wall thickness reduction of the anteroseptal–anterior junctional wall at middle–distal level (minimum thickness: 3 mm) where a millimetric area of late gadolinium enhancement with transmural distribution was described; absence of myocardial oedema. In addition, an EPS was performed with electroanatomical high–density/definition mapping of the left ventricle showing normal volumes, signals and activation and absence of LAVA/LV. Taking into account such findings, a subcutaneous defibrillator was implanted for primary prevention and a control CMR was scheduled in the follow–up period. Conclusions This case underlines the central role of CMR in identifying areas of myocardial fibrosis that can represent the electroanatomical substrate for triggering ventricular arrhythmias. In this case, the arrhythmic events are associated with a focal area of transmural fibrosis and wall thinning, usually indicating ischaemic damage, nonetheless in the presence of normal coronary arteries.

Recurrent Bell’s palsy; a single institutional experience

Background and objectives: Bell's palsy is the commonest disease of the facial nerve. The aim is to analyze several clinical and epidemiologic aspects of the recurrent Bell's palsy in Erbil city. Methods: This cross-sectional study was conducted at outpatient clinic from October 2019 to October 2020. Twenty-five patients, who had developed a recurrent Bell’s palsy, aged 17-70 years old, were consecutively enrolled. Neurological examination and lab tests were conducted. Results: Out of 25 patients, 15 (60%) of them were female and 10 (40%) were male. 20 (80%) of patients with recurrent Bell's palsy the subsequent episodes were on the same side, and five (20%) of the episodes were contralateral to the primary one, of these five patients, four of them were female and one was male. 12 patients had a history of hyperacusis, 10 of them reported in females and two in males with significant differences between both genders (p&lt;0.029). A high number of facial palsy related to the side of the face affected was found on the left side 13 (52%). The facial palsy was found to be more severe in females. Recurrence of Bell's palsy was more common in the first two years from the initial episode. Conclusion: The study showed a significant recurrence of Bell's palsy more in the initial two years from the onset of the first attack. The recurrence was more likely to occur at the same side of the initial episode and it was the commonest in females and younger age groups.

758 Correlation between initial and diagnostic bronchoalveolar lavage isolates among patients with inhalation injury and pneumonia

Abstract Introduction Inhalation injury is associated with increased risk of pneumonia. Bronchoscopy with bronchoalveolar lavage (BAL) is commonly used to diagnose and grade inhalation injury while obtaining a microbiological sample. It has been shown that a quarter of patients with inhalation injury have a single bacteria isolated from initial BAL within 12-48 hours of injury. The clinical significance of this and role of antibiotics in this setting are unknown. We investigated the incidence that bacteria isolated during a pneumonia episode were previously isolated on surveillance BAL among patients with inhalation injury. Methods Among patients with inhalation injury admitted to a large ABA-verified burn center from 2009-2022, microbiological isolates from initial BAL and subsequent culture obtained during a pneumonia episode (BAL, sputum), were extracted from medical records. Abbreviated injury severity score (AIS) was used to grade inhalation injury. Hospital-acquired pneumonia (HAP) was defined using CDC PNU1 criteria, and ventilator-associated pneumonia (VAP) was defined using PNU2 criteria with BAL cutoff &amp;gt;10,000 colony forming units (CFU). Results Two-hundred forty-eight patients with inhalation injury who underwent bronchoscopy for airway inspection and surveillance BAL within 48 hours of injury were included in the analysis. Of the 111 who had a bacterial isolate from initial BAL, 23 (21%) subsequently developed HAP or VAP during the hospitalization. Median (IQR) days between bronchoscopy and pneumonia diagnosis was six (2-8.5). In three of the 11 VAP cases (27%), the organisms identified at pneumonia diagnosis matched the organisms identified on initial BAL. Antibiotic use on admission was not associated with re-culture of initial BAL organism during a subsequent pneumonia episode (p=0.071). Conclusions Among patients with inhalation injury and bacteria isolated on surveillance BAL, 21% developed pneumonia during their hospital stay, usually with different bacteria than those isolated at initial bronchoscopy. There was no association between empiric antibiotic use and incidence of initial BAL organisms re-cultured during subsequent pneumonia episode. Applicability of Research to Practice Findings suggest initial BAL isolates cannot guide empiric coverage of pneumonia for patients with inhalation injury. This remains an important area of future research.

Management of children with febrile seizures: a Greek nationwide survey

The purpose of this study was to investigate knowledge, principles, and practices concerning the management of children with febrile seizures among pediatricians in Greece. A cross-sectional study was performed across Greece. Pediatricians completed an anonymous and voluntary 11-item questionnaire about their knowledge, attitudes, and practices with respect to the management of febrile seizures; the survey also collected demographic data. It was first administered in paper form in October 2017. This was followed by an online survey performed between June and August of 2018 and publicized by medical boards across Greece. Descriptive statistics and comparisons between groups were conducted with the significance level set at p ≤ 0.05. We recorded 457 responses. Pediatricians admitted to modifying their advice to the parents of children with febrile seizures by suggesting more “aggressive” fever management at low temperatures or systematically (63%), referral to a specialist after any episode of febrile seizures (63%), or hospitalization in a subsequent episode (67%), even though 72% admitted these practices were of no efficacy. Almost one in three pediatricians (28%) believed aggressive management of fever could delay the onset of febrile seizures; increasing age was associated with this perception. A minority (28%) would make parents aware of febrile seizures before a first episode regardless of family history; 38% would do so in the event of family history.Conclusions: Several pediatricians in Greece use outdated and ineffective practices for the management of febrile seizures, despite the availability of updated evidence-based guidelines. Further training of practitioners is needed to bridge this gap.What is Known:•Aggressive management of fever at low temperatures with antipyretics, referral to a neurologist, and hospitalization are not supported by evidence or recent guidelines on childhood febrile seizures.•Febrile seizures are especially disturbing to uninformed parents, who may be inclined to pursue aggressive but ineffective treatments as a result.What is New:•Pediatricians in Greece use non-evidence-based practices for the management of febrile seizures, even when they are aware that these practices are not effective.•Older age increases the likelihood that a pediatrician will pursue guideline non-compliant practices in Greece. At the same time, physicians with over 20 years of experience are more likely to inform parents in advance about febrile seizures.

PO-02-152 EFFECTS OF SYMPATHETIC STIMULATION ON REPOLARIZATION AND ARRHYTHMOGENESIS DURING LEFT LATERAL MYOCARDIAL ISCHEMIA

Left stellate ganglion stimulation (LSGS) is arrhythmogenic during acute myocardial ischemia of the anterior wall of the left ventricle. We hypothesized, as a counterpart, that right stellate ganglion stimulation (RSGS) is proarrhythmic when ischemia is produced by occlusion of the circumflex coronary artery. In 7 anesthetized female open-chested pigs, ventricular repolarization was measured in unipolar electrograms from 128 epicardial sites on the left lateral ventricular wall in an electrode grid of 14x30 mm (interelectrode distance 2 mm). Seven subsequent episodes of 5 minutes of acute ischemia (5 minutes occlusion of the circumflex coronary artery with 20 minutes reperfusion). Right atrial pacing was performed throughout the experiment at cycle length of 450 ms. The second occlusion served as a control. During the third and fourth occlusion, left or right stellate ganglion stimulation (LSGS or RSGS), respectively, was initiated after 3 minutes of ischemia for 30 seconds. The protocol was repeated after decentralization of both stellate ganglia and bilateral cervical vagotomy. Between 3 and 5 minutes of ischemia, RSGS caused a median of 9 (interquartile range 3-12), ventricular premature beats and in 2 instances ventricular tachycardia and fibrillation. The number of ventricular premature beats was significantly less during LSGS and control conditions (Figure, panel A), during which no ventricular tachycardia or fibrillation occurred. Following decentralization, RSGS was no longer significantly more arrhythmogenic than LSGS or control conditions (Figure, panel A). Additionally, we found that LSGS-induced changes in repolarization are evident in non-ischemic tissue, but not in ischemic tissue, during coronary occlusion (Figure, panel B, note the overlapping T-waves in the ischemic region). LSGS no longer has an effect on myocardium that has been ischemic for 3 minutes by occlusion of the circumflex coronary artery. RSGS was arrhythmogenic in this setting, while LSGS was not. This supports the clinical findings that bilateral sympathectomy is superior to left sympathectomy alone.

An electronic operation note proforma improves the quality of operation notes in burns surgery.

An Operation Note should provide a comprehensive account of the details of a surgical procedure performed and document clinically relevant events which occur throughout the procedure. The Royal College of Surgeons of England, in 2014, updated guidelines on specific criteria to be included in operation notes. Standardisation using procedure-specific operation notes has been shown to significantly improve adherence to these guidelines. The aim of this study was to evaluate the quality of operation notes in the Irish National Burns Unit before and after the design and implementation of an electronic patient record and the subsequent introduction of an operation template and a burns surgery specific checklist, within the electronic system. A 30-point checklist was designed based on existing sources. Operation notes prior to and following the adoption of a electronic-based operation note were analysed, and then reanalysed following the introduction of a procedure-specific operation note. Ninety-three operation notes were included for analysis. An electronic operation record significantly improved the quality of documentation within our unit. The subsequent procedure specific operation note had a significant improvement across all areas and achieved 100% compliance in many categories. The use of an electronic patient record to document a patient's procedure has been shown to significantly improve the quality of documentation. One could expect this to result in an improved patient hand-over and subsequent episode of care. We highlight a number of initial pit-falls that others may avoid in their implementation of a digital record.

Preventing acute diverticulitis. any roles for non-absorbable antibiotics? in search of evidence: a systematic review, meta-analysis, and trial sequential analysis

BackgroundHospital admissions for diverticulitis, a complication of diverticular disease, are very much on the increase. Prevention of diverticulitis could cut costs and save lives.AimsTo identify whether the risk of the first episode of diverticulitis (primary prevention) or recurrence of diverticulitis (secondary prevention) can be reduced in patients with diverticular disease using non-absorbable antibiotics (mainly rifaximin).MethodsThe studies were identified by searching PubMed and CENTRAL from 1990 to May 2022. The methodological quality of each study was also evaluated. The outcome of the meta-analysis was the occurrence of a first or subsequent episode of diverticulitis. In addition, a trial sequential analysis was performed to evaluate whether the results would be subject to type I or type II errors.ResultsPrimary prevention: the risk difference was statistically significant in favor of rifaximin (-0,019, or -1.9%, CI -0,6 to -3,3%). There was no evidence of heterogeneity (I2 0%). At one year, two years, and eight years of age, the NNT was 62, 52, and 42, respectively. The level of evidence had a moderate degree of certainty. Secondary prevention: the risk difference was statistically significant in favor of rifaximin (- 0,24, or -24%, CI -47 to -2%). There was evidence of heterogeneity (I2 92%); NNT resulted in 5. The grade level was low.ConclusionsRifaximin can lower the risk of a first episode of diverticulitis. However, the cost-benefit ratio currently appears too high. Rifaximin could also reduce the risk of a second episode, but the quality of the evidence is low.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022379258.

Management of Shoulder Instability in Patients with Seizure Disorders

Patients with seizure disorders commonly suffer shoulder dislocations and subsequent instability. Due to high rates of recurrence and bone loss, management of this instability and associated pathology has proven to be more complex than that of patients without seizure disorders. The ultimate goal of this review is to outline the various treatment modalities and their respective outcomes in this complex patient population. Optimization of medical management of seizure disorders is imperative. However, despite these efforts, the incidence of post-operative seizure activity continues to be a concern. These subsequent episodes increase the risk of further instability and failure of surgical procedures. Overall, the use of soft tissue procedures has proven to result in increased recurrence of instability compared to bone-block augmenting and grafting procedures. There are a variety of bone-block procedures that have been described for anterior and posterior instability. Despite their success in decreasing further instability, they are associated with several complications that patients should be informed of. There is no consensus regarding the optimal surgical management of shoulder instability in patients with seizure activity. A multidisciplinary approach to the management of the seizure activity is paramount to the success of their treatment. Further studies are required to evaluate the optimal timing and type of surgical intervention for individualized cases.

Validation of an ICD-9-Based Algorithm to Identify Stillbirth Episodes from Medicaid Claims Data.

In administrative data, accurate timing of exposure relative to gestation is critical for determining the effect of potential teratogen exposure on pregnancy outcomes. To develop an algorithm for identifying stillbirth episodes in the ICD-9-CM era using national Medicaid claims data (1999-2014). Unique stillbirth episodes were identified from clusters of medical claims using a hierarchy that identified the encounter with the highest potential of including the actual stillbirth delivery and that delineated subsequent pregnancy episodes. Each episode was validated using clinical detail on retrieved medical records as the gold standard. Among 220 retrieved records, 197 were usable for validation of 1417 stillbirth episodes identified by the algorithm. The positive predictive value (PPV) was 64.0% (57.3-70.7%) overall, 80.4% (73.8-87.1%) for inpatient episodes, 28.2% (14.1-42.3%) for outpatient-only episodes, and 20.0% (2.5-37.5%) for outpatient episodes with overlapping hospitalizations. The absolute difference between the dates of the algorithm-specified stillbirth delivery and the medical record-based event was 4.2±24.3 days overall, 1.7±7.7 days for inpatient episodes, 14.3±51.4 days for outpatient-only episodes, and 1.0±2.0 days for outpatient episodes that overlapped with a hospitalization. Excluding all outpatient episodes, as well as pregnancies involving multiple births, the PPV increased to 82.7% (76.8-89.8%). Our algorithm to identify stillbirths from administrative claims data had a moderately high PPV. Positive predictive value was substantially increased by restricting the setting to inpatient episodes and using only input diagnostic codes for singleton stillbirths.

The role of online reviews in restaurant selection intentions: A latent growth modeling approach

Despite the significant research regarding online reviews, one area remains under investigated: how the trust-behavioral intentions linkage formed by online reviews changes during subsequent restaurant consumption episodes. Using the latent growth curve at three time intervals, this study contributes to the research by highlighting (1) the mean change patterns of three specific review types, (2) the significant change rate between online reviews and trust in restaurants, and (3) the insignificant change rate between all review types and behavioral intentions during subsequent restaurant visits. Our findings showed that while consumers’ perceptions initially declined, they rose as consumption experience increased. Although this U-shaped curve appears for both pure text and text reviews with photos, perceptions of rating reviews continued to decline. Additionally, we found that all online review types directly impact increases or decreases in the change rate related to restaurant trust during subsequent visits. Finally, we observed no significant change rates between the three online review types and behavioral intentions.

Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.

Second malignant neoplasms (SMNs) are one of the most severe late complications after pediatric cancer treatment. However, the effect of genetic variation on SMNs remains unclear. In this study, we revealed germline genetic factors that contribute to the development of SMNs after treatment of pediatric solid tumors. We performed whole-exome sequencing in 14 pediatric patients with SMNs, including three brain tumors. Our analysis revealed that five of 14 (35.7%) patients had pathogenic germline variants in cancer-predisposing genes (CPGs), which was significantly higher than in the control cohort (p < 0.01). The identified genes with variants were TP53 (n=2), DICER1 (n=1), PMS2 (n=1), and PTCH1 (n=1). In terms of the type of subsequent cancer, leukemia and multiple episodes of SMN had an exceptionally high rate of CPG pathogenic variants. None of the patients with germline variants had a family history of SMN development. Mutational signature analysis showed that platinum drugs contributed to the development of SMN in three cases, which suggests the role of platinum agents in SMN development. We highlight that overlapping effects of genetic background and primary cancer treatment contribute to the development of second cancers after treatment of pediatric solid tumors. A comprehensive analysis of germline and tumor samples may be useful to predict the risk of secondary cancers.