Subsequent Detachment Research Articles

Intravitreal Injection and Prophylactic Laser Treatment in Pediatric Vitreoretinal Pathologies

Vascular endothelial growth factor (VEGF) is an important mediator of pathological neovascularization and vascular permeability of the eye. The increasing use of intravitreal therapies targeting VEGF has revolutionized the treatment of pediatric vitreoretinal diseases. Laser photocoagulation is the standard treatment method for retinopathy of prematurity. The aim is to ablate the avascular peripheral retina, but ablation of the peripheral retina with traditional laser therapy is destructive, causes complications, and does not prevent all vision loss, especially in cases of retinopathy of prematurity affecting zone 1 of the eye. In Coats disease, retinal telangiectasias are treated early with laser photocoagulation, but with ischemia, high levels of VEGF in the ocular fluid may contribute to increased permeability of telangiectatic blood vessels, leading to lipoprotein leakage and subsequent exudative retinal detachment. Therefore, anti-VEGF has been recommended as adjuvant therapy in the treatment of Coats disease. In this review, intravitreal injection and prophylactic laser treatment applications in Retinopathy of Prematurity and Coats Disease are mentioned.

Prognostic factors associated with acute retinal necrosis treated non-surgically.

To analyse the prognostic factors for visual acuity in acute retinal necrosis (ARN) patients treated non-surgically. The clinical data of ARN patients who visited our hospital from January 2010 to January 2023 were retrospectively analysed. Twenty-four patients (29 eyes) were included. Aqueous humour samples were collected from 20 out of 29 eyes, and PCR confirmed that 85% (17/20) of the eyes had VZV infection, 10% (2/20) had CMV infection, and 5% (1/20) had HSV infection. All patients were treated with intravenous antiviral agents. Intravitreal ganciclovir and oral corticosteroids were given according to the patients' wishes. A comparison of visual acuity at the time of first identification of inactive ARN with that at the first visit revealed that 16 (55.2%) eyes improved and 13 (44.8%) did not improve. Logistic regression analysis revealed that risk factors for failure to improve vision after treatment included retinal detachment (odds ratio [OR],33.75; 95% CI, 3.245-351.067; P = 0.003), necrotising retinitis involving the posterior pole (odds ratio [OR],8.167; 95% CI, 1.297-51.403, P = 0.025), and arteritis involving the large retinal arteries (odds ratio [OR],9.167; 95% CI, 1.493-56.297; P = 0.017). The VZV viral load in the aqueous humour at initial presentation was significantly associated with visual prognosis (r = 0.688, P = 0.013), retinal detachment (τ = 0.597, P = 0.021) and the extent of retinal necrosis (τ = 0.57, P = 0.027). The neutrophil to lymphocyte ratio (NLR) of VZV-infected patients at first presentation was significantly correlated with the prognosis of visual acuity (r = 0.616, P = 0.033) and retinal detachment (τ = 0.728, P = 0.004). High NLR and viral DNA copy number in the aqueous humour at the initial presentation, as well as subsequent retinal detachment, necrotising retinitis involving the posterior pole, and arteritis involving the large retinal arteries were risk factors for poor visual prognosis in VZV-infected ARN patients.

Incidence of Akreos AO60 intraocular lens opacification after concurrent or subsequent intraocular oil or gas use.

To report the incidence of opacification in a consecutive series of 10 eyes that underwent scleral fixated Akreos AO60 placement with concurrent or subsequent contact with gas or silicone oil. Consecutive case series. Three cases of IOL opacification were noted. Two cases of opacification occurred in patients that underwent subsequent retinal detachment repair with C3F8 and one with silicone oil. One patient underwent explanation of the lens due to visually significant opacification. Scleral fixation of the Akreos AO60 IOL is associated with risk of IOL opacification when exposed to intraocular tamponade. While surgeons should consider the risk of opacification in patients at high risk of requiring intraocular tamponade, only 1 in 10 patients developed IOL opacification significant enough to require explantation.

A 3‐D Seismic Tomographic Study of Spreading Structures and Smooth Seafloor Generated by Detachment Faulting—The Ultra‐Slow Spreading Southwest Indian Ridge at 64°30′E

AbstractAt ultra‐slow spreading ridges, with full spreading rates less than ∼20 mm/yr, spreading is accommodated both by highly spatially and temporally segmented magmatism, and tectonic extension along large‐scale detachment faults that exhume ultramafic material to the seafloor. In the most magma‐poor regions, detachment faulting alternates in polarity over time, producing a “flip‐flopping” effect of subsequent detachment dips. The resulting seafloor in these regions displays a morphology termed “smooth seafloor” comprising elongate, broad ridges with peridotite/serpentinite lithologies. We conducted tomographic travel‐time inversion of a 3‐D wide‐angle seismic data set acquired over a region of smooth seafloor around 64°30′E along the Southwest Indian Ridge (SISMOSMOOTH; Cruise MD199), to produce a seismic velocity volume through the crustal section and into the uppermost mantle. We observe patterns of velocity anomalies that correspond with variations in the bathymetry arising from the mode of spreading and are interpreted as changes in the degree of alteration with depth resulting from spatial and temporal variations in fluid‐rock interaction, controlled by faulting and tectonic damage processes. The detachment faults do not show simple planar structures at depth but instead mirror the shapes of the bathymetric ridges that they exhume. Magmatic input is overall highly limited, but there is one region on the lower part of an exhumed detachment footwall where a thickness of volcanic material is observed that suggests a component of syn‐tectonic volcanism, which could contribute to detachment abandonment.

Synthesis and challenges of fluorinated divinyl urethane monomers as a strategy for masking hydrolytic sensitive methacrylate groups in resin composites

ObjectiveThe biodegradation of methacrylate (MA)-based dental restoratives has been suggested to contribute to a loss of adhesion and subsequent detachment, or secondary caries, both major causes of restoration failure. Previous studies have demonstrated that intermolecular interactions between resin monomers may affect the hydrolytic-susceptibility of composites. Altering the intermolecular interactions by shielding or masking the hydrolytically-susceptible ester groups found in MA monomers could be an effective strategy to mitigate the biodegradation of resin composites. The objective of this work was to assess whether shielding/masking MAs using fluorinated groups could improve the biostability of experimental composites. MethodsEight fluorinated monomers (FM) were synthesized, characterized (1H NMR), and formulated into experimental resin composites (FC, 65 wt%, microfill). FCs were assessed for interactions with water (water contact angle, water sorption, gel fraction), mechanical properties (both compressive and flexural strength and modulus), cytocompatibility, resistance to biodegradation using simulated human salivary esterase (SHSE) and compared to a control composite (CC) without FM. ResultsIntegration of FMs was found to generally decrease both the physical and mechanical properties under all incubation conditions when compared to the CC. Additionally, all FCs had a negative influence on composite biodegradation following immersion in SHSE when compared to the CC. SignificanceShielding/masking MA-esters inherently inserts molecular spaces between the polymer chains within the resin network, and shielding is likely not possible while also maintaining the necessary cohesive forces that regulate the physical and mechanical properties of resin composites. Novel dental resin development should seek to remove/replace vulnerable ester-containing MAs rather that adopting a shielding/masking approach.

Residual Dizziness Characteristics of Idiopathic Sudden Sensorineural Hearing Loss Patients with Benign Paroxysmal Positional Vertigo.

ISSNHL, a common clinical condition, can be accompanied by vertigo. Initially, research on sudden deafness primarily focused on the hearing loss itself, with less emphasis on episodic vertigo. However, as vertigo research has advanced, it has been recognized that BPPV is a frequent accompaniment to ISSNHL-associated vertigo. Even after treatment, some patients may experience residual dizziness. This study investigates the characteristics of patients with ISSNHL accompanied by BPPV and the impact of residual dizziness on their lives. This study is being conducted on patients with ISSNHL accompanied by BPPV, analyzing the characteristics of such patients and the impact of residual dizziness on their lives. Overall, 54 adult inpatients with ISSNHL and BPPV were included in this study. All patients received 50 mg of intravenous prednisolone for 5 consecutive days and hemodilution agents for 10 days. At the same time, BPPV was treated with repositioning by the same therapist using the SRM-IV vertigo diagnostic and treatment system, and different repositioning methods were used for different types of otolithiasis. Patients were grouped according to the absence of residual dizziness when the nystagmus disappeared at the time of discharge. There were 24 cases in the group with residual symptoms, including 10 males and 14 females. The proportion of females was 58.33%, with an average age of 46.75 ± 13.80. The group without residual symptoms consisted of 30 cases, including 13 males and 17 females. The female proportion was 56.67%, with an average age of 45.77 ± 11.86. There is no statistical significance between the two groups in the pre-treatment hearing status and DHI scores. The HAMA (Hamilton Anxiety Rating Scale) scores before treatment were compared, revealing a significant statistical difference. ISSNHL-associated BPPV may be caused by vascular embolism or thrombosis in the cochlear or spiral modiolar artery. This disrupts blood flow, leading to ischemia in the otolithic membrane and subsequent detachment of otoconia. Because this detachment often occurs within 24 h of the initial event, patients experience positional vertigo early in the course of the disease.

A Clinical Approach for the Removal of a Large Antral Pseudocyst with Simultaneous Maxillary Sinus Augmentation: A Case Series.

For a large benign lesion within the maxillary sinus, such as an antral pseudocyst, maxillary sinus floor augmentation is more commonly performed using a two-stage approach. This involves first removing the lesion, and then, re-entry following several months of healing. In this case series, we described the "one-bony-window" approach, which is a technical surgical modification of the previous one-stage approach, for simultaneous cyst removal and maxillary sinus floor augmentation. Four patients with large maxillary antral pseudocysts were included. The "one-bony-window" approach involves the preparation of a large window opening of approximately 15 mm × 20 mm at the lateral wall. A mesiodistally extended intentional perforation was made in the upper part of the exposed membrane to enhance the access for instrumentation. The antral pseudocyst was removed in its entirety without being deformed to prevent rupture or leakage of the cystic contents. Subsequent detachment and elevation of the Schneiderian membrane at the sinus floor significantly reduced the perforation site, and bone grafting with implant placement was performed simultaneously. This alleviated the need to surgically repair the perforation. The lateral opening was either uncovered or repositioned using bony window lids. Healing abutments were connected after six months, and the final prosthesis was placed after two months. At the 1-year follow-up, the antral pseudocysts had resolved with no specific recurrence, and the stability of the augmented sinus was maintained with excellent implant survival. Within the limitations of our findings, the "one-bony-window" technique can be suggested for the simultaneous removal of large antral pseudocysts and maxillary sinus floor augmentation with favorable clinical outcomes.

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions.

Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute carrier family 7 member 11 (SLC7A11) during glucose starvation. This accumulation causes extensive disulfide linkages between F-actins, resulting in their contraction and subsequent detachment from the cellular membrane, triggering cellular death. The RAC1-WRC axis is involved in this phenomenon. Disulfidptosis sparked growing interest due to its potential applications in a variety of pathologies, particularly oncology, neurodegenerative disorders, and metabolic anomalies. Nonetheless, the complexities of its regulatory pathways remain elusive, and its precise molecular targets have yet to be definitively identified. This manuscript aims to meticulously dissect the historical evolution, molecular underpinnings, regulatory frameworks, and potential implications of disulfidptosis in various disease contexts, illuminating its promise as a groundbreaking therapeutic pathway and target.

Ge-on-insulator fabrication based on Ge-on-nothing technology

Ge-on-Insulator (GOI) is considered to be a necessary structure for novel Ge-based devices. This paper proposes an alternative approach for fabricating GOI based on the Ge-on-Nothing (GeON) template. In this approach, a regular macropore array is formed by lithography and dry etching. These pores close and merge upon annealing, forming a suspended monocrystalline Ge membrane on one buried void. GOI is fabricated by direct bonding of GeON on Si carrier substrates, using an oxide bonding interface, and subsequent detachment. The fabricated GOI shows uniform physical properties as demonstrated using micro-photoluminescence measurements. Its electrical characteristics and cross-sectional structure are superior to those of Smart-CutTM GOI. To demonstrate its application potential, back-gate GOI capacitors and MOSFETs are fabricated. Their characteristics nicely agree with the theoretically calculated one and show typical MOSFET operations, respectively, which indicates promising Ge crystallinity. This method, therefore, shows the potential to provide high-quality GOI for advanced Ge application devices.

Experimental Study on Warpage Phenomenon of Wax Parts Manufactured by Fused Filament Fabrication.

Warpage is one of the prominent issues in Fused Filament Fabrication. The cause of this is the rapid cooling of the polymer during extrusion. The residual thermal stresses accumulated within the print part result in a shape distortion and subsequent detachment of the object from the print bed. In this study, both experimental and numerical approaches were used to identify the stresses due to thermal shrinking that occurs in soft polymers such as wax. A temperature sweep test was performed using a rotational rheometer to measure the magnitude of axial forces that are generated due to the thermal shrinking of a thin layer of 3D printable wax. The thermal stresses responsible for warpage were computed analytically and using the FEA. It was found that due to thermal processes, the stress magnitude can reach a value of 1.17 MPa. This value is enough to cause the plastic deformation in the wax part having a thin elongated shape. In addition, Taguchi's robust design has identified two major FFF parameters that impact the warpage in amorphous soft polymers. They are the printing speed and the print bed temperature. To achieve a low level of warpage, it is important to make sure that the layer deposition occurs at medium speeds and the print bed temperature is moderately high according to the findings of this study.

Numerical Modeling of Water Jet Plunging in Molten Heavy Metal Pool

The hydrodynamic and thermal interaction of water with the high-temperature melt of a heavy metal was studied via the Volume-of-Fluid (VOF) method formulated for three immiscible phases (liquid melt, water, and water vapor), with account for phase changes. The VOF method relies on a first-principle description of phase interactions, including drag, heat transfer, and water evaporation, in contrast to multifluid models relying on empirical correlations. The verification of the VOF model implemented in OpenFOAM software was performed by solving one- and two-dimensional reference problems. Water jet penetration into a melt pool was first calculated in two-dimensional problem formulation, and the results were compared with analytical models and empirical correlations available, with emphasis on the effects of jet velocity and diameter. Three-dimensional simulations were performed in geometry, corresponding to known experiments performed in a narrow planar vessel with a semi-circular bottom. The VOF results obtained for water jet impact on molten heavy metal (lead–bismuth eutectic alloy at the temperature 820 K) are here presented for a water temperature of 298 K, jet diameter 6 mm, and jet velocity 6.2 m/s. Development of a cavity filled with a three-phase melt–water–vapor mixture is revealed, including its propagation down to the vessel bottom, with lateral displacement of melt, and subsequent detachment from the bottom due to gravitational settling of melt. The best agreement of predicted cavity depth, velocity, and aspect ratio with experiments (within 10%) was achieved at the stage of downward cavity propagation; at the later stages, the differences increased to about 30%. Adequacy of the numerical mesh containing about 5.6 million cells was demonstrated by comparing the penetration dynamics obtained on a sequence of meshes with the cell size ranging from 180 to 350 µm.

An Arabidopsis Rab18 GTPase promotes autophagy by tethering ATG18a to the ER in response to nutrient starvation

The expansion of autophagosomes requires a controlled association with the endoplasmic reticulum (ER). However, the mechanisms governing this process are not well defined. In plants, ATG18a plays a key role in autophagosome formation in response to stress, yet the factors regulating the process are unknown. This study finds that ATG18a acts as a downstream effector of RABC1, a member of the poorly characterized Rab18/RabC GTPase subclass in plants. Active RABC1 interacts with ATG18a on the ER, particularly under nutrient starvation. In rabc1 mutants, autophagy is compromised, especially under nutrient deprivation, affecting the ER association and expansion of ATG18a-positive autophagosomes. Furthermore, both dominant-negative and constitutively active RABC1 forms inhibit autophagy. The dominant inactive RABC1 impedes the ER association of ATG18a, whereas the constitutively active RABC1 delays ATG18a detachment from the ER. Collectively, RABC1 regulates the ER association and the subsequent detachment of ATG18a-positive autophagosomes during nutrient starvation.

MURA: a Multipurpose Underwater Robotic Arm mounted on Kalypso UUV in aquaculture

Underwater vehicles utilized in net cages at aquaculture facilities are commonly utilized for the purpose of examining the deterioration of nets and the accumulation of biofouling. The implementation of a robotic system for repairing damages has the potential to decrease the expenses associated with employing divers while reducing the risk of their injury. This study details the development, fabrication, and simulation of a cost-effective subaquatic manipulator, denoted as MURA, which can be seamlessly incorporated into submersible vehicles. The Kalypso unmanned underwater vehicle (UUV) is utilized in this study. MURA exhibits a high degree of modularity, enabling seamless alteration of the end-effector tool. Additionally, its low-cost nature renders it a viable option for integration with any underwater vehicle. Three end-effectors were subjected to testing, one designed for the purpose of disposing fish morts, another intended for removing litters from net cages in fisheries, and a third for repairing net tears. This study outlines the MURA design, including the arm’s fabrication and constituent components. In addition, the modeling of the manipulator is presented accompanied by a water flow simulation of the three manipulators. Ultimately, the experimental findings are analyzed and evaluated. These include the field experiments performed at Kefalonia fisheries, along with the duration to complete each task. For instance, the capture of fish morts typically necessitates approximately 30 s, encompassing the entire process from initial targeting to actual capture. In a similar vein, the procedure of mending tears in a net necessitates an approximate duration of 70 s on average, encompassing the stages of initial identification and subsequent detachment. The suggested design exhibits adaptability and durability while upholding affordability when utilized in aquaculture.

Netzhautriss – optometrisches Management

Purpose. This case report describes the optometric manage- ment of a peripheral retinal tear that was discovered during an optometric eye examination. It is intended to sensitize optometrists and ophthalmic opticians to the topic of retinal tears and retinal detachment. Material and Methods. During an optometric eye examina- tion, the fundus was examined using an ultra-widefield laser scanning ophthalmoscope. A retinal tear was detected in the fundus periphery. Results. After the comprehensive optometric examination, the patient was informed about the finding of a peripheral retinal tear and its consequences and referred to an eye clinic. At the eye clinic, the diagnosis was confirmed. Treatment consisted of preventive laser retinopexy to reduce the risk of subsequent tear extension and retinal detachment. Conclusion. The retinal tear presented in this case report was detected as an incidental finding. The patient was referred to an eye clinic for specialist diagnosis and preventive treat- ment. The case shows that a comprehensive optometric eye examination not only enables the management of relevant refractive errors, but can also make a contribution in terms of preventive health care. Optometric involvement in eye care has the potential to lead to earlier diagnosis, allowing treatment strategies to be implemented at an earlier stage. Together, earlier diagnosis and earlier intervention can lead to better long-term health outcomes. Keywords Fundus examination, fundus periphery, retinal tear, retinal detachment, retinopexy

Scleral Buckle Removal: Long-Term Patient Outcomes

Scleral buckling has been a reliable treatment option in the repair of primary rhegmatogenous retinal detachments. Occasionally, patients require scleral buckles (SBs) to be removed for various reasons. While outcomes of SB removal have been investigated in this subset of patients, there has not been any large patient series to reach any conclusions. Long-term sequelae of SB removal are debated in the literature, specifically around the risk of redetachment. We performed a retrospective, observational study to evaluate the clinical indications for, and outcomes of, SB removal. No control patients in this retrospective, observational study. Eighty-six individuals with a history of SB removal from June 1, 2000, to January 1, 2021, were followed from a large academic center and a private, retina-only practice in Chicago. Exclusion criteria were age of < 18 years and unplanned or self-explanted SB removal. Data extracted included patient symptoms before SB removal, indications for removal, resolution of symptoms following removal, rate of redetachment, and rate of additional ocular surgery. Secondary outcomes included identifying factors associated with poorer outcomes. Eighty-six eyes with history of SB removal were included with an average follow-up of 4 years. Approximately 60% were males and the mean age at the time of SB removal was 59 years. Leading indications for removal were exposure (61.63%), infection (20.93%), and diplopia/strabismus (19.77%). The average time from SB placement to removal was 12.28 ± 11.16 years. Most patients requiring SB removal presented with symptoms, specifically of pain and discomfort (65.12%), diplopia (22.09%), and drainage/discharge (18.60%). Of these patients, 86.59% experienced symptom resolution following SB removal. Notably, 6.56% (4 eyes) of all eyes with at least 1 year of follow-up experienced a redetachment requiring surgery. Within this subset, the average time from SB placement to removal was 2.05 ± 2.01 years and time to redetachment following removal was 15.95 ± 25.71 months. Nine percent of all eyes required additional strabismus or oculoplastic surgery. Scleral buckle removal provides a high rate of symptomatic relief and low risk of subsequent detachment. Nevertheless, close monitoring is warranted to monitor for recurrent retinal detachments. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition.

Endothelial-to-hematopoietic transition (EHT) is crucial for hematopoietic stem cell (HSC) generation. During EHT, the morphology of hemogenic endothelial cells (HECs) changes from flat and adherent to spherical hematopoietic cells, which detach from the dorsal aorta. HECs attain a rounded shape in a mitosis-independent manner before cell adhesion termination, suggesting an atypical cell-rounding mechanism. However, the direct mechanisms underlying this change in cell morphology during EHT remain unclear. Here, we show that large vacuoles were transiently formed in avian HECs, and that aquaporin 1 (AQP1) was localized in the vacuole and plasma membranes. Overexpression of AQP1 in non-HECs induced ectopic vacuole expansion, cell rounding and subsequent cell detachment from the endothelium into the bloodstream, mimicking EHT. Loss of redundant AQP functions by CRISPR/Cas9 gene editing in HECs impeded the morphological EHT. Our findings provide the first evidence to indicate that morphological segregation of hematopoietic cells from endothelial cells is regulated by water influx into vacuoles. These findings provide important insights for further exploration of the mechanisms underlying cell/tissue morphogenesis through water-adoptive cellular responses.

Engineering Route for Stretchable, 3D Microarchitectures of Wide Bandgap Semiconductors for Biomedical Applications

AbstractWide bandgap (WBG) semiconductors have attracted significant research interest for the development of a broad range of flexible electronic applications, including wearable sensors, soft logical circuits, and long‐term implanted neuromodulators. Conventionally, these materials are grown on standard silicon substrates, and then transferred onto soft polymers using mechanical stamping processes. This technique can retain the excellent electrical properties of wide bandgap materials after transfer and enables flexibility; however, most devices are constrained by 2D configurations that exhibit limited mechanical stretchability and morphologies compared with 3D biological systems. Herein, a stamping‐free micromachining process is presented to realize, for the first time, 3D flexible and stretchable wide bandgap electronics. The approach applies photolithography on both sides of free‐standing nanomembranes, which enables the formation of flexible architectures directly on standard silicon wafers to tailor the optical transparency and mechanical properties of the material. Subsequent detachment of the flexible devices from the support substrate and controlled mechanical buckling transforms the 2D precursors of wide band gap semiconductors into complex 3D mesoscale structures. The ability to fabricate wide band gap materials with 3D architectures that offer device‐level stretchability combined with their multi‐modal sensing capability will greatly facilitate the establishment of advanced 3D bio‐electronics interfaces.

Outcomes of Laser Retinopexy for Retinal Tears in Pseudophakic Eyes with Multifocal Versus Monofocal Intraocular Lenses: A Matched Cohort Study

Purpose Performing laser retinopexy through multifocal intraocular lenses may be challenging due to aberrations of the peripheral retinal view. This study investigated the influence of multifocal versus monofocal intraocular lenses on outcomes of laser retinopexy for retinal tears. Methods Pseudophakic eyes (multifocal and monofocal intraocular lenses) that underwent in-office laser retinopexy for retinal tears, with a minimum follow-up of 3 months, were retrospectively analyzed. Eyes with multifocal intraocular lenses were matched to controls with monofocal intraocular lenses in a 1:2 ratio for age, gender, number, and location of retinal tears. The main outcome measure was the rate of complications. Results We included 168 eyes in the study. Fifty-six eyes (51 patients) with multifocal intraocular lenses were matched with 112 eyes (112 patients) with monofocal intraocular lenses. The mean follow-up was 26 months. Baseline characteristics were similar between two groups. No significant differences were noted in the rate of successful laser retinopexy without additional procedures (91% vs. 86% at 3 months and 79% vs. 74% during follow-up, in the multifocal intraocular lens and monofocal intraocular lens group, respectively). No significant differences were observed in the rate of subsequent rhegmatogenous retinal detachment (multifocal, 4% vs. monofocal, 6%, p=.716) or need for additional laser retinopexy for new tears (14% vs. 15%; p=.939). The surgery rates for vitreous hemorrhage (0% vs. 3%; p=.537), epiretinal membrane (2% vs. 2%; p=.553), and vitreous floaters (5% vs. 2%, p=.422) were not significantly different. Visual outcomes were also similar. Conclusion Multifocal intraocular lenses did not appear to negatively impact the outcomes of in-office laser retinopexy for retinal tears.

Философско-смисловото поле на преводаческо-интерпретативната техника на гъ-и

The Philosophical Sense of the translatory-interpretive technique of the Geyi The article aims to present the controversy surrounding the geyi's translation and interpretation technique, which was used in the third and fourth centuries in China, commonly translated as "matching concepts", which is the most distinct manifestation of the adaptation of Buddhist concepts to classical Taoist doctrines. For this purpose, its basic philological and philosophical interpretations of the term are presented. Studying the spread and adaptation of Buddhist doctrines in China gives the unique opportunity to balance these two opposing positions. The very specificity of the philosophical sense of the translator and the interpretive technique of the geyi is considered in its aspect as one of the main factors that shaped the features of Chinese Buddhism and its subsequent final detachment from its Indian equivalent. Its use and improvement mark the beginning of the formation of East Asian Buddhism as an essentially new Buddhist doctrinal strand.

Nucleation behavior and kinetics of single hydrogen nanobubble in ionic liquid system

Bubbles generated on the electrode surface have been considered one of important factors limiting the efficiency of hydrogen evolution reaction (HER). However, the bubble formation behaviors have not been clearly defined, especially nanobubbles in ionic liquid system. In this work, single H2 nanobubbles generation characters are well investigated using platinum nanoelectrodes in ionic liquid (IL) during HER. The crucial factors (i.e., critical condition, geometry, and nucleation rapid of the H2 nanobubbles) are quantitatively conducted from the voltammograms. The results reveal that the H2 nanobubbles have a small contact angle (from 152° to 160°) and large bubble height (0.5–1.1 nm), which are favorable for subsequent detachment from nanoelectrode surface. Moreover, higher nucleation energy (7.5–15.3 kT) indicates that IL can suppress bubble formation. This work has gained a fundamental insight into the dynamic formation behaviors of H2 nanobubble in IL, which can guide us to study H2 bubbles in the HER influenced by various factors.