Concept is a very important part in the process of acquiring knowledge in various studies including science. The reality, students have not mastered the concept of science properly or have a different initial conception with the correct concept so that it has difficulty in using the concepts possessed to explain various kinds of natural phenomena in daily life. The purpose of this study is to describe that the Predict-Observe-Explain strategy can reduce student's misconceptions in elementary school. This research includes a Pre-Experiment research with One Group Pretest-Posttest Design. The subjects in this study were students of class V SDN Krembangan Selatan I Surabaya with a total of 12 children in a limited test. Data analysis techniques using quantitative descriptive analysis. The results showed that (1) the conception profile before learning with the POE strategy obtained an average of 67% of all research subjects had misconceptions for each concept item. (2) the conception profile after learning with the POE strategy obtained an average of 7.4% of all research subjects have misconceptions for each concept item (3) learning to use POE strategies can reduce student's misconceptions on science subjects material force and motion, characteristics of living things, and objects or materials