Objectives: To evaluate the positively and negatively factors associated with the subjective well-being of adults with hemophilia from two associations of patients.
 Methods: This study is a cross-sectional survey, carried out with convenience sampling in two patient associations. Data collection took place in November and December of 2015. The evaluation protocol consisted of the application of two instruments: Hemophilia Well-Being Index and a collection form of sociodemographic and clinical data.
 Results: Fifty-three adults with hemophilia, and male, participated in the study. Their age ranged from 21 to 54 years old. It was observed a higher prevalence of participants with single marital status and third education level. The age and marital status of the participants did not influence their well-being.
 Conclusion: The high level of education was positively associated with the well-being of the participants, related to the item “economic situation.” 
 Keywords: Hemophilia A; Hemophilia B; Adult; Subjective Well-Being Scale.