Subjective Responses Research Articles

Cortical Auditory Evoked Potentials and Subjective Auditory Perception Responses in Children Using Cochlear Implant: A Preliminary Study

Abstract Objective: A cochlear implant (CI) is a management option for congenital severe to profound hearing loss in children with no residual hearing. Cortical auditory evoked potentials (CAEPs) have been found to be useful in evaluating the outcome using CIs. The study aimed at assessing the change in CAEPs and auditory perception using the categories of auditory perception (CAP) test with respect to the duration of auditory stimulation using a CI in children who were deaf and received a unilateral CI during childhood before the age of 5 years. Materials and Methods: Prelingually profound hearing-impaired children with normal cochlea who received a unilateral CI during childhood between 12 months and 5 years were recruited for the study. The duration of use of the implant ranged from 1 month to 5 years. Results: We found that with an increased duration of auditory stimulation using CIs, auditory responses matured regarding reduction in P1 latency and increased CAP scores. How long it takes for these children to achieve normal patterns of cortical maturation is a subject of further research.

Habitual Nocturnal Sleep, Napping Behavior, and Recovery Following Training and Competition in Elite Water Polo: Sex-Related Effects.

To examine nocturnal sleep patterns, napping behaviors, and subjective wellness responses of elite water polo players within an in-season week and to identify whether sleeping patterns differ between men and women. Sleep characteristics of 10 male and 17 female professional water polo players were objectively assessed during 1week of the in-season period, including 5 training days, 1 match day, and 1day of rest. Internal load (rating of perceived exertion × duration of training or match) was assessed 30 minutes posttraining or postmatch, and the total quality of recovery was recorded every morning. A series of multilevel models were used to analyze the data. Time in bed and wake-up time were earlier on both training (P < .001) and rest days (P < .001) than on the day of the match. Internal workload did not predict any of the players' sleeping patterns. Midday naps predicted less time in bed (P = .03) and likely less sleep time (P = .08). The total quality of recovery was predicted only by the total sleep time (P < .01). Women exhibited higher sleep efficiency (P < .001), less waking after sleep onset (P = .01), and a lower number of awakenings (P = .02) than men. The current results indicate that the nocturnal sleep patterns of elite water polo players are not associated with internal load and that women display better nocturnal sleep quality compared with men. As long naps interfere with nocturnal sleep, and total nocturnal sleep time predicts total quality of recovery, we suggest that athletes follow hygiene sleep strategies to facilitate adequate nocturnal sleep and next-day recovery.

Evaluating emotional and subjective responses in synthetic art-related dialogues: A multi-stage framework with large language models

The appearance of Large Language Models (LLM) has implied a qualitative step forward in the performance of conversational agents, and even in the generation of creative texts. However, previous applications of these models in generating dialogues neglected the impact of ‘hallucinations’ in the context of generating synthetic dialogues, thus omitting this central aspect in their evaluations. For this reason, we propose an open-source and flexible framework called GenEvalGPT framework: a comprehensive multi-stage evaluation strategy utilizing diverse metrics. The objective is two-fold: first, the goal is to assess the extent to which synthetic dialogues between a chatbot and a human align with the specified commands, determining the successful creation of these dialogues based on the provided specifications; and second, to evaluate various aspects of emotional and subjective responses. Assuming that dialogues to be evaluated were synthetically produced from specific profiles, the first evaluation stage utilizes LLMs to reconstruct the original templates employed in dialogue creation. The success of this reconstruction is then assessed in a second stage using lexical and semantic objective metrics. On the other hand, crafting a chatbot’s behaviors demands careful consideration to encompass a diverse range of interactions it is meant to engage in. Synthetic dialogues play a pivotal role in this context, as they can be deliberately synthesized to emulate various behaviors. This is precisely the objective of the third stage: evaluating whether the generated dialogues adhere to the required aspects concerning emotional and subjective responses. To validate the capabilities of the proposed framework, we applied it to recognize whether the chatbot exhibited one of two distinct behaviors in the synthetically generated dialogues: being emotional and providing subjective responses, or remaining neutral. This evaluation will encompass traditional metrics and automatic metrics generated by the LLM. In our use case of art-related dialogues, our findings reveal that the capacity to recover templates or profiles is more effective for information or profile items that are objective and factual, in contrast to those related to mental states or subjective facts. For the emotional and subjective behavior assessment, rule-based metrics achieved a 79% of accuracy in detecting emotions or subjectivity (anthropic), and an 82% on the LLM automatic metrics. The combination of these metrics and stages could help to decide which of the generated dialogues should be maintained depending on the applied policy, which could vary from preserving between 57% to 93% of the initial dialogues.

Electrophysiological auditory measures to identify potential cortical markers of tinnitus

Tinnitus, or the perception of a sound in the absence of an external acoustic stimulus, is a common condition that cannot yet be objectively diagnosed. Current diagnostic tests of tinnitus consist of case history and behavioral measures that rely on subjective responses. This study examined electrophysiological measures, specifically the auditory late response (ALR), mismatch negativity (MMN), and P300 as potential neural biomarkers of tinnitus in both a tinnitus and non-tinnitus control group while utilizing the pitch-matched tinnitus frequencies as the test stimuli. Results of this study found differences in MMN amplitudes and area under the curve, and in P300 topographic maps between tinnitus and control subjects. The differences in MMN responses across groups suggest that dysfunctional processing of acoustic stimuli located near the tinnitus frequency in individuals with tinnitus manifests as soon as 200 ms after initial onset of the stimulus. In addition, results from a global field power analysis and differences in spatial distributions on topographical maps indicate that deficits persist through higher levels of cortical processing. A secondary goal of this study was to determine if electrophysiological measures correlated with reported tinnitus severity on questionnaires. This analysis indicated that P2 latency was a significant predictor of Tinnitus Reaction Questionnaire, Tinnitus Handicap Inventory, and percent of the time participant’s tinnitus was considered bothersome, suggesting that this measure could potentially be used to assess the efficacy of treatment programs for tinnitus.

Market-Based Responses of Subjects to Taxation. Legal, Management and Economic Conditions

Market-Based Responses of Subjects to Taxation. Legal, Management and Economic Conditions

Finding a home for the video essay: Videographic criticism and the study of Chinese television drama

Although some conflate the digital humanities with data-driven quantitative research, other conceptualizations of the digital humanities emphasize post-print methods of scholarship with unprecedented reach outside of the academy. Video essays are an example of this vision for the digital humanities: they are critiques of film advanced through film itself with crossover appeal to popular audiences. This paper places the author’s personal experience creating a video essay on Chinese television in the context of the state of the field of Chinese television studies and current debates over the function of videographic criticism. Current scholarship on Chinese television often neglects the visuality of the televisual text and the individual experience of television viewing. Because video essays are themselves an audiovisual text, they foreground the visual, and their position between popular and scholarly forms of communication creates room for including subjective responses. The critical reflexivity of ‘scholarly video essays’ on Chinese television would serve as a useful complement to the vernacular audiovisual ­commentary already prevalent on the Chinese internet. By reconceptualizing the work and proper position of the scholar, videographic criticism can productively challenge the ‘regime of separation’ between researcher and object of study upon which East Asian studies is built.

Reactions to a Nicotine Reduction Policy Among Adolescents Who Smoke: A Qualitative Study.

The Biden administration is pursuing a nicotine reduction policy in the U.S. to render cigarettes less addictive. In this study, we qualitatively investigated adolescents' subjective responses to very low nicotine content (VLNC) cigarettes, reasons for incomplete adherence to using them, and their expected responses to a nicotine reduction policy. Adolescents who smoke cigarettes daily (ages 15-19; N=60) were enrolled in a three-week double-blind randomized clinical trial and assigned to smoke either normal nicotine content (NNC) or VLNC research cigarettes. Following the trial, 52 participants completed qualitative interviews about their reactions to the cigarettes and to the idea of a nicotine reduction policy. We utilized a template style approach to thematic analysis involving immersion in the data, codebook development with both inductive and deductive codes, and iterative refinement of themes. Reasons for incomplete adherence to smoking only research cigarettes focused on dislike for cigarette taste and lower satisfaction compared to usual brand cigarettes. Negative evaluations of research cigarettes were common across both groups. Many participants in both groups reported that they would decrease their smoking or quit entirely if the research cigarettes were the only ones legally available for purchase in the U.S. Adolescents may respond to a cigarette nicotine reduction policy by decreasing their cigarette smoking and eventually quitting. These findings suggest a need for public health strategies to reduce smoking initiation and progression in young people and to encourage cessation in the context of a nicotine reduction policy. Participants' negative subjective responses and challenges with research cigarette adherence offer insight into factors that might influence young people's reactions to a real-world nicotine reduction policy. Adolescents who smoke may increase their use of alternative tobacco products, especially e-cigarettes, if this policy were implemented. Specifically, themes identified across participant responses highlight important considerations for how such a policy might be implemented with specific attention to the unique smoking behaviors and needs of this vulnerable population.

Reducing flight upset risk and startle response: A study of the wake vortex alert with licensed commercial pilots

The study aimed at investigating the impact of an innovative Wake Vortex Alert (WVA) avionics on pilots' operation and mental states, intending to improve aviation safety by mitigating the risks associated with wake vortex encounters (WVEs). Wake vortices, generated by jet aircraft, pose a significant hazard to trailing or crossing aircrafts. Despite existing separation rules, incidents involving WVEs continue to occur, especially affecting smaller aircrafts like business jets, resulting in aircraft upsets and occasional cabin injuries. To address these challenges, the study focused on developing and validating an alert system that can be presented to air traffic controllers, enabling them to warn flight crews. This empowers the flight crews to either avoid the wake vortex or secure the cabin to prevent injuries. The research employed a multidimensional approach including an analysis of human performance and human factors (HF) issues to determine the potential impact of the alert on pilots' roles, tasks, and mental states. It also utilizes Human Assurance Levels (HALs) to evaluate the necessary human factors support based on the safety criticality of the new system. Realistic flight simulations were conducted to collect data of pilots' behavioural, subjective and neurophysiological responses during WVEs. The data allowed for an objective evaluation of the WVA impact on pilots' operation, behaviour and mental states (mental workload, stress levels and arousal). In particular, the results highlighted the effectiveness of the alert system in facilitating pilots' preparation, awareness and crew resource management (CRM). The results also highlighted the importance of avionics able to enhance aviation safety and reducing risks associated with wake vortex encounters. In particular, we demonstrated how providing timely information and improving situational awareness, the WVA will minimize the occurrence of WVEs and contribute to safer aviation operations.

Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes.

Extracellular ATP (eATP) released from damaged cells activates the P2X7 receptor (P2X7R) ion channel on the surface of surrounding cells, resulting in calcium influx, potassium efflux and inflammasome activation. Inherited changes in the P2X7R gene (P2RX7) influence eATP induced responses. Single nucleotide polymorphisms (SNPs) of P2RX7 influence both function and signaling of the receptor, that in addition to ion flux includes pathogen control and immunity. Subjects (n = 105) were admitted to the ICU at the University Hospital Ulm, Germany between June 2018 and August 2019. Of these, subjects with a diagnosis of sepsis (n = 75), were also diagnosed with septic shock (n = 24), and/or pneumonia (n = 42). Subjects with pneumonia (n = 43) included those without sepsis (n = 1), sepsis without shock (n = 29) and pneumonia with septic shock (n = 13). Out of the 75 sepsis/septic shock patients, 33 patients were not diagnosed with pneumonia. Controls (n = 30) were recruited to the study from trauma patients and surgical patients without sepsis, septic shock, or pneumonia. SNP frequencies were determined for 16 P2RX7 SNPs known to affect P2X7R function, and association studies were performed between frequencies of these SNPs in sepsis, septic shock, and pneumonia compared to controls. The loss-of-function (LOF) SNP rs17525809 (T253C) was found more frequently in patients with septic shock, and non-septic trauma patients when compared to sepsis. The LOF SNP rs2230911 (C1096G) was found to be more frequent in patients with sepsis and septic shock than in non-septic trauma patients. The frequencies of these SNPs were even higher in sepsis and septic patients with pneumonia. The current study also confirmed a previous study by our group that showed a five SNP combination that included the GOF SNPs rs208294 (C489T) and rs2230912 (Q460R) that was designated #21211 was associated with increased odds of survival in severe sepsis. The results found an association between expression of LOF P2RX7 SNPs and presentation to the ICU with sepsis, and septic shock compared to control ICU patients. Furthermore, frequencies of LOF SNPs were found to be higher in sepsis patients with pneumonia compared to those without pneumonia. In addition, a five SNP GOF combination was associated with increased odds of survival in severe sepsis. These results suggest that P2RX7 is required to control infection in pneumonia and that inheritance of LOF variants increases the risk of sepsis when associated with pneumonia. This study confirms that P2RX7 genotyping in pneumonia may identify patients at risk of developing sepsis. The study also identifies P2X7R as a target in sepsis associated with an excessive immune response in subjects with GOF SNP combinations.

A Study of Phenomenology and Treatment Adherence in Patients with Obsessive-compulsive Disorder during COVID-19 Pandemic

Background and Objective: The WHO declared COVID-19 to be a public health emergency which has affected every sphere of life including mental health and is expected to affect the patients of obsessive-compulsive disorder (OCD) adversely. This study aimed to study phenomenology and treatment adherence in patients with the OCD during COVID-19 pandemic. Materials and Methods: The sample consisted of 96 old and new patients of OCD between the age of 18 and 60 years, with the Yale–Brown Obsessive-Compulsive Scale (Y-BOCS) ≥16 and onset of illness prior to COVID-19 (March 2020). Diagnosis was made as per ICD-10-DCR, the likelihood of treatment adherence was assessed using the Medication Adherence Rating Scale, and the severity of OCD was assessed on Y-BOCS. The current and past phenomenologies as per D-YBOCS were compared. Among the patients adherent to treatment, subjective response on the current severity of symptoms as compared to before the onset of COVID-19 was recorded. Results: The likelihood of treatment adherence was high (according to the Medication Adherence Scale) in 59.2% of cases. Pandemic reasons were reported by 69% of patients with low likelihood of treatment adherence. Few patients developed new symptoms, but no statistically significant change was found when compared to the pre-COVID-19 phenomenology. Conclusions: Majority of the treatment adherent patients experienced a decrease or no change in their symptom severity as compared to the before COVID-19 severity, suggesting that no worsening of OCD symptoms during the pandemic was observed if the patients were adherent to medications. However, there is a need for long-term considerations and plan interventions accordingly to minimize this deleterious effect.

Human–Object Interaction: Development of a Usability Index for Product Design Using a Hierarchical Fuzzy Axiomatic Design

Consumer product usability has been addressed using tools that evaluate objects to improve user interaction. However, such diversity in approach makes it challenging to select a method for the type of product being assessed. This article compiles the concepts used since the origin of usability in product design. It groups them by attributes to formulate a usability index proposal. Due to the nature of the data, fuzzy, hierarchical, and axiomatic tools were applied to a trial group of experts and users. Three questionnaires were designed and administered throughout a five-stage process to collect and select attributes, rank them in importance, assign fuzzy values, obtain their numerical representation of use, and assign a qualitative category. By analyzing a case study, this research demonstrates the value of the index by comparing the use of computer mice. Unlike other approaches to evaluating usability, the proposed index incorporates the hierarchical importance of attributes. It allows for participants to express their opinions, transforming subjective responses into linguistic values represented in triangular areas, resulting in a more accurate representation of reality. Additionally, the complexity of the human–object interaction is treated by an information axiom to compute the usability index on a scale from 0 to 1, which reflects the probability of the product meeting the desired usability attributes.

Is Virtual Reality an Effective Experimental Tool for Window View Studies with Dynamic Content Involved?

ABSTRACT Dynamic content is a desirable quality in window views. However, most researchers have focused on static window scenes, which are inconsistent with real-world window views. The scarcity of studies involving dynamic view content is exacerbated by the lack of suitable evaluation tools, which this study aims to address. A novel method of displaying dynamic content in the virtual scene was presented. A two-stage experiment with forty-eight subjects was designed to compare subjective responses to a dynamic window scene in physical and virtual environments. Virtual reality’s effectiveness was assessed based on the consistency of their responses regarding level of satisfaction with the window view in both environments. Imaging capability, sense of presence, and sense of comfort were also adopted as evaluation criteria in the virtual environment. Responses concerning satisfaction with different view contents in the physical and virtual environments were found to have no statistically significant difference and they also achieved statistical equivalence. It was also established that the novel method used to display dynamic window scenes could retain the clarity of content and attain good scene integration. The virtual environment offered a sense of presence, although some subjects still paid attention to the physical environment. In relation to sense of comfort, most subjects found the headset’s weight to be bearable and it did not compromise the performance of tasks in the virtual environment. However, visual fatigue was identified as a notable drawback which should be addressed to improve the comfort of subjects and accuracy of results. This study affirms virtual reality’s viability as a convenient and effective tool for evaluating dynamic window views.

Investigating the impact of a large river and its surrounding contextual conditions on pedestrians’ summer thermal perceptions in a Cfa-climate city

Thermal comfort studies are usually employed to find subjective thermal responses [indicated by neutral temperature (NT), i.e. the temperature with no thermal stress] of residents from a region towards thermal environments. According to the recently published works in the literature, NTs are affected by many factors, such as geographical location and microenvironments. To elucidate the origins of these effects, the impact of microenvironment elements around a water surface on pedestrians’ thermal perceptions was systematically investigated in this work. The Fujiang River (FJR) in Mianyang City was taken as the sample site. The municipal meteorology station is located next to the site by around 2.5 km. By performing meteorology measurements combining questionnaires, it was found that the riverside NT (indicated by physiologically equivalent temperature, PET) of Mianyang in the summer of 2023 was 21.4 °C. The relationship between the distance from the water (DFW) and NT was quadratic linear. The same phenomenon took place by using either PET or Universal Thermal Climate Index (UTCI) indexes. Meanwhile, the meteorological contexts also affected NTs, including relative humidity (RH) and air velocity (Va). Regarding RH, the NPET increased from 15.2 °C (RH = 50%) to 26.9 °C (RH = 90%). In contrast, the NPET dropped from 23.0 to − 50.6 °C when the Va increased from 0.2 to 2.5 m/s, respectively. From our analysis, it was demonstrated that human thermal responses are significantly affected by both the microenvironmental and meteorological backgrounds around the water surface. Our work provides valuable insights for the proper use of water surfaces in urban design for adjusting thermal comfort.

Adaptive post-COVID-19 immune response in female subjects of the Russian arctic region.

The Arctic region's unfavorable living conditions adversely affect the spread of infectious diseases, including COVID-19, This, in turn, can also lead to increased morbidity and mortality rates in the area due to anumber of factors such as climate, environment, and high prevalence rate of pre-existing health issues like diabetes, obesity, and respiratory infections. These circumstances adversely affect maintaining the level of working capability. The aim of this paper is to investigate the ratio of immunocompetent cells involved in the adaptive post-COVID-19 immune response. The research includes an immunological assessment of 29women aged 20-40 years residing in Arkhangelsk, Russia, six months after recovering from COVID-19. The count of leukocytes in the peripheral blood and their differential were evaluated using standard methods to assess the immunological status. To delve deeper into the immunological landscape, phenotypes of lymphocytes (CD5+, CD8+, CD10+, and CD95+) were evaluated using an indirect immunoperoxidase reaction with monoclonal antibodies on dried drop lymphocyte preparations. After incubating blood with latex molecules, the activity and quantity of phagocytes were assessed using alight microscope. The neutrophil/lymphocyte ratio was found to be inverted in the female subjects under investigation. The high concentration of cytotoxic T-lymphocytes (CD8+) and lymphocytes with apoptotic receptors (CD95+) suggests apotential correlation with aconcurrent reduction in the expression of the total T-cell marker (CD5+) across all cases. This association was further linked to adecrease in lymphoproliferative activity and arelative decline in phagocytic activity. These findings led us to posit that the total recovery time after COVID-19 might extend beyond six months, indicative of aprolonged impact on the body's protective capacity. Our observations prompt the hypothesis that cellular immunity plays acrucial role in determining the severity of COVID-19 infection. Specifically, individuals with initially robust phagocytic activity may be predisposed to experiencing amilder form of the infection. However, this assumption warrants further investigation and clarification in individuals with moderate and severe disease progression (Tab. 1, Ref. 17). Keywords: arctic, COVID-19, cytotoxic t-lymphocytes, apoptosis, lymphoproliferation, cellular immunity, phagocytic activity.

Apples and oranges: PTSD patients and healthy individuals are not comparable in their subjective and physiological responding to emotion induction and bilateral stimulation.

Bilateral stimulation is a core element of Eye Movement Desensitization and Reprocessing Therapy, a psychotherapeutic intervention for the treatment of Posttraumatic Stress Disorder (PTSD). Promising previous findings showed measurable physiological effects of bilateral stimulation in healthy individuals, but studies that replicated these findings in PTSD patients are sparse. 23 patients with PTSD and 30 healthy controls were confronted with affective standard scripts (pleasant, neutral, unpleasant) while bilateral tactile stimulation was applied. Monolateral and no stimulation served as control conditions. Noise-induced startle reflex response (valence measure) and galvanic skin response (arousal measure) were used for physiological responses and the valence and arousal scale of the Self-Assessment-Manikin for subjective responses. Both groups showed a subjective distress reduction for unpleasant scripts and a subjective attention increase for positive scripts under bilateral stimulation. In healthy individuals, this was also for physiological measures, and a general startle-reducing effect of bilateral stimulation in the absence of affective stimuli was found. In PTSD patients, however, the effects were restricted on the subjective level, and no concomitant physiological effects were observed. The findings indicate, that generalizing the effects of BLS in healthy individuals to PTSD patients may be problematic. The herein-reported group differences can be explained by PTSD-specific peculiarities in emotion processing and cognitive processing style.

Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria.

Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)-infected subjects is critical for malaria control. This study aims to investigate the nutritional status and innate immune response of Pf-infected subjects in Lagos, Nigeria. A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z-score is <-2 in the participants aged <20 years. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and IL-12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system. A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30 (26.32%) were underweight, and 48 (42.11%) were wasted. Pro-inflammatory cytokine responses were not affected by the type of malaria. TNF-α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.

High-dose chemotherapy and autologous hematopoietic stem cell transplantation for progressive systemic sclerosis: a retrospective study of outcome and prognostic factors

PurposeSystemic sclerosis (SSc) is a rare autoimmune disease associated with high morbidity and mortality. SSc treatment is still challenging, and evidence is scarce. In the last decades high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT) has proven to be effective. However, treatment related morbidity and mortality (TRM) are high. We conducted a retrospective, single-center analysis of SSc patients following HD-ASCT focusing on TRM and risk factors.Methods32 patients who underwent HD-ASCT at our hospital between June 2000 and September 2020 were included. Clinical characteristics were evaluated based on chart review before and after HD-ASCT. Analyses focused on overall survival (OS), TRM, and response to HD-ASCT.ResultsMedian OS was 81 months (range 0–243). Within one year, 20 of 32 (76.9%) patients responded to HD-ASCT. Overall, 6 patients (18.8%) died in the context of HD-ASCT. Patients with subjective response to HD-ASCT (p = 0.024) and those with shorter time to platelet engraftment (p = 0.047) had significantly longer OS. Impaired renal function, age at HD-ASCT ≥ 55, disease duration < 12 months, high Hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and Charlton Comorbidity Index (CCI) scores were associated with higher TRM. Patients receiving conditioning chemotherapy with thiotepa needed longer time for neutrophil (p = 0.035) and platelet engraftment (p = 0.021).ConclusionThis study confirms the efficacy of HD-ASCT for patients with SSc in a single center real-world setting. High TRM is still a challenge. However, TRM could be reduced by exclusion of high-risk patients and attention to prognostic parameters and scores as suggested in this study.

Motor imagery of finger movements: Effects on cortical and muscle activities

PurposeThe purpose of the current study was to explore the immediate effect of motor imagery (MI) involving finger movement of a given limb on cortical response and muscle activity in healthy subjects. MethodsTwenty healthy right-handed adults (7 females and 13 males) with a mean + SD age of 22.05 + 6.08 years participated in the study. The beta-band event-related desynchronization (ERD) at the sensorimotor cortex and muscle activity during finger movement tasks using either the index, middle, or thumb digits on the non-dominant left hand were compared before and after an MI training session. Subjects underwent a pre-MI, MI training, and finally a post-MI session where they either performed or imagined performing a button-pushing action 50 times per session with each of the three digits. ResultsThe ERD power in the beta frequency band was lower in pre-MI compared to post-MI and was significantly different between the pre- and post-MI sessions for both the index and middle fingers, but not the thumb. A significant decrease was seen in the mean muscle activity during post-MI compared to pre-MI for all the digits except the thumb. ConclusionsThe results from the current study suggest that complex MI can result in motor learning and improvement in motor performance, thereby requiring less effort during motion.

Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults

BackgroundThe amygdala is highly implicated in an array of psychiatric disorders but is not accessible using currently available noninvasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) is a neuromodulatory technique that has the capability of reaching subcortical regions noninvasively. MethodsWe studied healthy older adult participants (N = 21, ages 48–79 years) who received TFUS targeting the right amygdala and left entorhinal cortex (active control region) using a 2-visit within-participant crossover design. Before and after TFUS, behavioral measures were collected via the State-Trait Anxiety Inventory and an emotional reactivity and regulation task utilizing neutral and negatively valenced images from the International Affective Picture System. Heart rate and self-reported emotional valence and arousal were measured during the emotional reactivity and regulation task to investigate subjective and physiological responses to the task. ResultsSignificant increases in both self-reported arousal in response to negative images and heart rate during emotional reactivity and regulation task intertrial intervals were observed when TFUS targeted the amygdala; these changes were not evident when the entorhinal cortex was targeted. No significant changes were found for state anxiety, self-reported valence to the negative images, cardiac response to the negative images, or emotion regulation. ConclusionsThe results of this study provide preliminary evidence that a single session of TFUS targeting the amygdala may alter psychophysiological and subjective emotional responses, indicating some potential for future neuropsychiatric applications. However, more work on TFUS parameters and targeting optimization is necessary to determine how to elicit changes in a more clinically advantageous way.

Subjective Affective Responses to Natural Scenes Require Understanding, Not Spatial Frequency Bands.

It is debated whether emotional processing and response depend on semantic identification or are preferentially tied to specific information in natural scenes, such as global features or local details. The present study aimed to further examine the relationship between scene understanding and affective response while manipulating visual content. To this end, we presented affective and neutral natural scenes which were progressively band-filtered to contain global features (low spatial frequencies) or local details (high spatial frequencies) and assessed both affective response and scene understanding. We observed that, if scene content was correctly reported, subjective ratings of arousal and valence were modulated by the affective content of the scene, and this modulation was similar across spatial frequency bands. On the other hand, no affective modulation of subjective ratings was observed if picture content was not correctly reported. The present results indicate that subjective affective response requires content understanding, and it is not tied to a specific spatial frequency range.