Malnutrition is a common finding in hemodialysis patients and can increase oxidative stress and inflammation levels. A randomized, controlled, nonblinded, parallel trial. 92 hemodialysis patients from a single center with malnutrition according to subjectiveglobal assessment (SGA) score (SGA score > 7). 3 treatment groups (23 patients each) received 220mL of fermented vitamin E-fortified whey beverage (15g of whey protein concentrate+ 600IU of vitamin E) or 220mL of fermented whey beverage (15g of whey protein concentrate) or vitamin E (600IU) 3 times a week for 8 weeks. The control group (23 patients) received no intervention. Primary outcomes were change in SGA score and malnutrition-inflammation score (MIS) from baseline to the end of the trial. At the end of the study, 83 patients were analyzed (2, 3, 1, and 3 patients left the study in the vitamin E-fortified whey beverage, whey beverage, vitamin E, and control groups, respectively). Changes in SGA scores were-3.48 (95% CI,-4.90 to-2.00),-3.22 (95% CI,-4.13 to-2.30),-1.70 (95% CI,-3.20 to-0.24), and 1.56 (95% CI, 0.60 to 2.50) for the vitamin E-fortified whey beverage, whey beverage, vitamin E, and control groups, respectively (overall P<0.001; P≤0.001 for each treatment group vs control). Changes in MISs were-3.17 (95% CI,-4.40 to-1.90),-1.83 (95% CI,-2.50 to-1.10),-2.30 (95% CI,-3.50 to-1.10), and 1.48 (95% CI, 0.65 to 2.30) for the vitamin E-fortified whey beverage, whey beverage, vitamin E, and control groups, respectively (overall P<0.001; P<0.001 for each treatment group vs control). Few adverse effects were reported in any group. Lack of blinding, small sample size, and short duration. Whey protein in the form of a new fermented whey beverage and vitamin E supplementation may improve SGA score and MIS in the short term.