Many online health information sources are generic and difficult to understand, but consumers want information to be personalized and understandable. Smartphone health applications (apps) offer personalized information to support health goals and reduce preventable chronic conditions. This study aimed to determine how the HealthyMe/MiSalud personalized app (1) engaged English-speaking African American and Spanish-speaking Hispanic adults, and (2) motivated them to set goals and follow preventive recommendations. Our study adds to the literature on digital health, health information seeking, and prevention. We used a multi-method approach, including community and participatory design principles, to learn about potential African American and Hispanic adult health app users and evaluate the app in two usability tests and a 12-month field test. Ninety-six African American and Hispanic adults downloaded the HealthyMe/MiSalud app and used it for a minimum of 36 weeks. We found they wanted personalized information on core prevention topics, and their health histories and goals affected how they rated topic relevance. African American females ages 18-34 were more likely to save an article aligned with family health history, and African American females aged 35-49, males age 50-64, and African American males overall were more likely to save an article aligned with their health goals. Our study revealed that a prevention app with personalized recommendations can support health information seeking and health literacy. These findings can help app developers, public health practitioners, and researchers when designing apps for groups of varying identities.
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